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Medicare costs analysis indicates need to decrease use of biopsies as diagnosis tool for lung cancer

More than 43 percent of $38.3 million in diagnostic costs attributed to biopsies for patients with ultimately negative lung cancer diagnosis

2014-10-30
(Press-News.org) Chicago, October 30, 2014—Biopsies were found to be the most costly tool prescribed in lung cancer diagnosis, according to research presented today at the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology. The Symposium is sponsored by the American Society of Clinical Oncology (ASCO), the American Society for Radiation Oncology (ASTRO), the International Association for the Study of Lung Cancer (IASLC) and The University of Chicago Medicine.

The study examined the utilization rates and estimated the Medicare costs of the lung cancer diagnostic workup in patients who had an abnormal chest computed tomography (CT) scan. The results of this study show that the total diagnostic workup cost for the study sample of patients was $38.3 million. Of the total diagnostic workup cost, 43.1 percent ($16.5 million) is attributed to the biopsy costs for the 761 patients in the study sample who had negative biopsies and who were not diagnosed with lung cancer during the following year.

The retrospective study used a random 5 percent sample of Medicare beneficiaries from January 1, 2009 through December 31, 2011. From that sample, 8,979 eligible patients were identified who were 65 to 74 years old with an abnormal chest CT scan between July 1, 2009 and December 31, 2010. The date of a patient's abnormal chest CT scan was defined as the index date, and an abnormal scan was described as a scan showing swelling, a mass or lump on the lung, or other respiratory symptoms or diseases within seven days of the CT scan. Patients were excluded from the study if during the six month pre-index period they had a diagnosis of any cancer, pneumonia, atelectasis (a complete or partial collapse of a lung or lung lobe), and/or tuberculosis or if they were not continually eligible during the pre-index period and the 12-month follow-up period.

Of the patients included in the analysis, the mean age was 69.3 (standard deviation (SD) 2.9), and 56.4 percent (5,064) of patients were female. During a 12-month period, 13.9 percent (1,249) of patients were diagnosed with lung cancer, and the median time from abnormal chest CT scan to lung cancer diagnosis was 11 days.

Diagnostic tests used until a patient was diagnosed with lung cancer included chest CT scans, chest X-rays, lung biopsies and positron emission tomography (PET) scans. Chest X-rays were used for 54.4 percent (4,885) of patients, chest CT scans were ordered for 32.9 percent (2,954) of patients, and lung biopsies were utilized for 19.4 percent of patients (1,742). PET scans were used for 0.4 percent (36) of patients. Of the patients who had lung biopsies, 43.7 percent (761) had negative findings and were not diagnosed with lung cancer during follow-up.

The study calculated the associated Medicare procedure costs for each of the diagnostic tests used in this cohort of patients. For lung biopsies, the cost analysis combined the procedure costs and all incidental costs including physician costs, anesthesia services and adverse event costs. For patients diagnosed with lung cancer, the average total cost of the diagnostic workup was $7,567 (standard deviation (SD) = $11,062). In patients not diagnosed with lung cancer, the average total cost of the diagnostic workup was $3,558 (SD = $23,089).

The median cost of each biopsy procedure was $3,784, with a mean cost of $14,634 (SD = $32,271). The average cost of a lung biopsy with complications (adverse events) was approximately four times higher than a complication-free biopsy ($37,745 vs. $8,869). Adverse events were reported in 19.3 percent (336) of patients who underwent a lung biopsy.

From this analysis, it was found that the National Comprehensive Cancer Network (NCCN) lung cancer screening guidelines were not followed, which resulted in many patients who ultimately had a negative lung cancer diagnosis undergoing unnecessary biopsies. The NCCN guidelines call for low-dose computed tomography of the chest followed by a PET scan to identify patients for biopsy.

"This study provides a baseline of current costs for the lung cancer diagnostic workup prior to the introduction of major lung cancer screening programs. Biopsy costs comprise a significant proportion of the overall cost of diagnosing lung cancer," said lead author Tasneem Lokhandwala, MS, PhD, a data analyst at Xcenda, an AmerisourceBergen company, in Palm Harbor, Florida. "These results suggest that since NCCN guidelines are not being followed, there is a need to develop more precise risk stratification tools to better identify patients who require lung biopsies. Reducing the number of patients who are referred for lung biopsies has the potential to decrease Medicare costs and ultimately improve patient outcomes."

INFORMATION:

The abstract, "Costs of the Diagnostic Workup for Lung Cancer – A Medicare Claims Analysis," will be presented during the Poster Viewing Session at 5:00 p.m. Central time on Thursday, October 30, 2014. To speak with Dr. Lokhandwala, please call or email Michelle Kirkwood.

The 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology will provide a clinically relevant, multidisciplinary update on the scientific progress in treating thoracic malignancies. The symposium brings together physician specialists and practicing clinicians of the multidisciplinary care team to discuss the evolving management of thoracic cancers. The Symposium integrates scientific abstract presentations with accompanying discussions, poster abstract presentations, as well as "challenging case" presentations in interactive tumor board-style forums. The two keynote speakers for the Symposium are Kenneth Rosenzwieg, MD, FASTRO, of Mount Sinai School of Medicine in New York, and Corey J. Langer, MD, of Abramson Cancer Center in Philadelphia. Dr. Rosenzwieg will discuss the use of mutational analysis to guide systemic therapy; and Dr. Langer will review the cutting edge, lung cancer research presented at recent national meetings – ASCO, ASTRO and STS (Society of Thoracic Surgeons).

2014 Chicago Multidisciplinary Symposium in Thoracic Oncology News Briefing, Thursday, October 30, 2014, 7:00 a.m. Central time

Poster Presentation: Thursday, October 30, 2014, 5:00 p.m. CT, Chicago Ballroom, Chicago Marriott Downtown Magnificent Mile

103 Costs of the Diagnostic Workup for Lung Cancer - A Medicare Claims Analysis

Author Block: T. Lokhandwala1, R. Dann2, M. Johnson2, A. O. D'Souza1, 1Xcenda, Palm Harbor, FL, 2GE Healthcare, Chalfont St Giles, United Kingdom

Purpose: To obtain utilization rates and estimate costs of diagnostic tests leading up to diagnosis of lung cancer in patients with an abnormal chest computed tomography (CT) scan.

Methods: A retrospective cohort study design utilizing the 5% Medicare random national sample data from Jan 1, 2009 through Dec 31, 2011 was employed. Patients aged 65-74 years with an abnormal chest CT scan between July 1, 2009 and Dec 31, 2010 were identified. The index date was the date of the abnormal chest CT scan defined as having a diagnosis code for abnormal findings such as swelling, mass or lump on the lung and other unspecified respiratory diseases (ICD-9 CM: 793.1x, 786.6x, 518.89, 519.8x, 519.9x) within 7 days of the CT scan (identified using procedure codes). Patients with a diagnosis of any cancer, pneumonia, atelectasis, and/or tuberculosis during the pre-index period, and without continuous eligibility during the 6-month pre-index and 12-month follow-up period were excluded. Lung cancer diagnosis rate over 12 months and at every 3-month interval was computed. The use of diagnostic tests, including chest CT scans, PET scans, chest X-rays and lung biopsies, up to diagnosis of lung cancer with the associated costs (USD 2013) was also computed. The cost of a diagnostic test was computed as the procedure cost except for biopsies. Biopsy costs included both procedure costs and all incidental costs occurring during the entire visit for that biopsy including adverse event (AE) costs.

Results: Of the 8,979 patients identified with an abnormal chest CT scan, the majority was female (56.4%), Caucasian (86.5%), with a mean age (SD) of 69.3 (2.9) years. The lung cancer diagnosis rate over 12 months was 13.9% (n=1,249), with median time from the index abnormal CT scan to diagnosis =11 days. Chest X-rays were the most common from index until lung cancer diagnosis (54.4%), followed by chest CT scans (32.9%), biopsies (19.4%), and PET scans (0.4%). Of those that underwent a biopsy, 761 (43.6%) were not diagnosed with lung cancer during follow-up. The average (SD) total diagnostic workup cost per patient was $7,567 ($11,062) for those with lung cancer and $3,558 ($23,089) for those without lung cancer. Among patients not diagnosed with lung cancer, the median diagnostic cost per patient for those with biopsy were ~28 times higher ($4,732 vs $169) than for those without biopsy. The median cost per biopsy procedure was $3,784 with a mean (SD) of $14,634 (32,271). The average biopsy cost with an AE, reported in 19.3% of those with a biopsy, was ~ 4 fold ($37,745 vs $8,869) that of an AE-free biopsy.

Conclusion: The total lung cancer diagnostic cost was $38.3M in the defined patient population, of which 43.1% was accounted for by negative biopsies. Decreasing biopsy referrals with better risk stratification is likely to decrease health care costs and improve patient outcomes.

Author Disclosure Block: T. Lokhandwala: A. Employee; Xcenda. R. Dann: A. Employee; GE Healthcare. N. Stock Options; GE Healthcare. S. Leadership; WIN Consortium. M. Johnson: A. Employee; GE Healthcare. A.O. D'Souza: A. Employee; Xcenda.



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[Press-News.org] Medicare costs analysis indicates need to decrease use of biopsies as diagnosis tool for lung cancer
More than 43 percent of $38.3 million in diagnostic costs attributed to biopsies for patients with ultimately negative lung cancer diagnosis