Contact Information:

Media Contact

Paul Scotti
scotti.paul@mayo.edu
904-953-0199

Twitter: MayoClinic

http://www.mayoclinic.org/news




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Livers donated after cardiac death are safe to use in liver cancer patients

On a transplant list, Mayo Clinic study finds


2015-05-19
(Press-News.org) JACKSONVILLE, Fla. -- Patients with liver cancer can be cured with a liver transplant. But because of the shortage of donated organs, these patients often die waiting for a liver. That's because most transplant centers predominantly use livers from donors who die from brain death.

But in the largest study of its kind, transplant physicians at Mayo Clinic in Florida have found that liver cancer patients have the same beneficial outcomes using organs donated by patients who died of cardiac death. The study was recently published online in the American Journal of Transplantation.

MULTIMEDIA ALERT: Video and audio of Dr. Croome is available for download on the Mayo Clinic News Network. "Our program has one of the largest experiences in the world with liver transplants using donations after cardiac death," says the study's lead investigator, transplant surgeon Kristopher P. Croome, M.D. "We now know that these organs effectively offer new life for patients with liver cancer."

"I believe this study firmly and finally answers the question as to whether liver donations after cardiac death are as viable for patients with liver cancer as livers from donors who die from brain death," he says. "They are."

Using organs after cardiac death for liver transplants could increase the number of transplants performed by 10 percent to 15 percent nationwide, Dr. Croome says. "One reason why the wait time for liver transplant is short at Mayo Clinic in Florida is that we efficiently and successfully use both types of donated livers. But nationwide, over the last decade, the transplant list and the number of liver cancer patients are increasing."

Some studies, including both human and animal, have suggested that donations after cardiac death have inferior results in patients with liver cancer because the liver has suffered some damage due to loss of oxygen during organ recovery.

For the purposes of transplantations, a person who dies from a heart attack is not considered for donation. Instead, cardiac death is controlled in a patient who will donate organs. "This can occur, for example, in a patient who has had a bad brain injury and will not recover. In this controlled setting, with the purpose of donating organs, a patient is taken off life support, and will pass into death. Then after a short time period, the organs will be recovered and donated," says Dr. Croome.

"Some ischemia -- lack of oxygen -- will occur in the organs during this procedure. The concern has been that these livers may not be healthy enough to fight off development of new cancer," he says. "There may be circulating tumor cells in a patient whose cancerous liver is removed at the time of transplant, so the question had been whether these livers donated from cardiac death donors are as healthy and resilient as those obtained after brain death."

Donations after brain death occur in patients with absence of brain activity, but whose heart and other organs are still active. Due to absence of brain activity, which is an irreversible condition, these patients are considered legally dead.

Between 2003 and 2012, the team from the Department of Transplantation at Mayo Clinic in Florida transplanted 1,633 livers using donor brain death organs and 241 livers obtained from donors after cardiac death.

In this study, the investigators identified 397 liver cancer patients who received a new liver -- 340 patients who received a liver after brain death and 57 patients whose organ was donated after cardiac death. They found no difference in liver cancer recurrence between the two groups -- liver cancer recurred in about 12 percent of patients in both groups.

"The gap between patients who need a new liver and the number of organs available has been widening, but the use of donations after cardiac death could potentially alleviate some of the organ shortage," Dr. Croome says.

INFORMATION:

Co-authors are from the Department of Transplantation, Mayo Clinic in Florida: David D. Lee, M.D.; Justin M. Burns, M.D.; Kaitlyn Musto; Diego Paz; Justin H. Nguyen, M.D.; Dana K. Perry, M.D.; Denise M. Harnois, D.O.; and senior author C. Burcin Taner, M.D.

About Mayo Clinic

Mayo Clinic is a nonprofit organization committed to medical research and education, and providing expert, whole-person care to everyone who needs healing. For more information, visit mayoclinic.com or newsnetwork.mayoclinic.org.

MEDIA CONTACT:

Paul Scotti, Mayo Clinic Public Affairs, 904-953-0199, scotti.paul@mayo.edu END


ELSE PRESS RELEASES FROM THIS DATE:

Large urban hospitals disadvantaged by medicare/medicaid patient satisfaction rating system

2015-05-19
(New York, May 19, 2015) -- The largest urban health systems, which serve as safety nets for large patient populations with lower socioeconomic status and greater likelihood to speak English as a second language, do worse on government patient satisfaction scores than smaller, non-urban hospitals likely to serve white customers with higher education levels, according to a new study by Mount Sinai researchers published this month in the Journal of Hospital Medicine. Patient satisfaction scores, in part due to the Affordable Care Act of 2010, are a key part of the formula ...

Cancer drugs may hold key to treating Down syndrome and other brain disorders

2015-05-19
ANN ARBOR--A class of FDA-approved cancer drugs may be able to prevent problems with brain cell development associated with disorders including Down syndrome and Fragile X syndrome, researchers at the University of Michigan Life Sciences Institute have found. The researchers' proof-of-concept study using fruit fly models of brain dysfunction was published today in the journal eLife. They show that giving the leukemia drugs nilotinib or bafetinib to fly larvae with the equivalent of Fragile X prevented the wild overgrowth of neuron endings associated with the disorder. ...

Specialist care prevents acute confusion in older patients after surgery

2015-05-19
For the patient, surgery involves extreme physical stress, and in older patients especially this can lead to disorders of consciousness or cognition. The acute confusional state known as delirium, however, can often be prevented by specialist nursing care after the operation, as Torsten Kratz and co-authors show in an original article in the current issue of Deutsches Ärzteblatt International (Dtsch Arztebl Int 2015; 112: 289-96). In their study delirium liaison nurses were employed to help care for surgical patients aged 70 years and over. In every patient, the risk ...

Developmental psychology: Sharing doesn't hurt

2015-05-19
Preschoolers already recognize what it feels like to be left out when goodies are being shared. In a new study, Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich show that 3-year-olds can anticipate negative feelings in others, and adjust their own behavior in response. Why are we willing to share with others what we could just as well keep for ourselves? Willingness to allot a portion of a coveted resource to someone else is a behavioral pattern that can throw light on the origins and development of prosocial modes of response during childhood. In a new ...

Differences in tumor cell metabolism affect growth, invasion and response, says Moffitt researchers

2015-05-19
TAMPA, Fla. -- Cells within a tumor are not the same; they may have different genetic mutations and different characteristics during growth and throughout treatment. These differences make treating tumors extremely difficult and often lead to tumor recurrence dominated by more aggressive tumor cells. Moffitt Cancer Center researchers are using mathematical modeling to characterize these differences within a tumor and hope that the results of their latest study will lead to better therapeutic treatments. "Many tumors exhibit different metabolic behaviors compared to normal ...

Persistent nightmares in childhood could be linked to psychotic experiences in later life

2015-05-19
Researchers at the University of Warwick have found a significant link between the presence of persistent nightmares in childhood and psychotic experiences in later adolescence. In a new paper published in the British Journal of Psychiatry, a team based at the Division of Mental Health and Wellbeing at Warwick Medical School at the University of Warwick found that persistent childhood nightmares both at an early age (between 2 and 9) and at age 12 were significantly associated with new incidences of suspected or definite psychotic experiences at age 18. The University ...

Horizontal gene transfer in E. coli

2015-05-19
Escherichia coli O104 is an emergent disease-causing bacterium various strains of which are becoming increasingly well known and troublesome. The pathogen causes bloody diarrhea as well as and potentially fatal kidney damage, hemolytic uremic syndrome. Infection is usually through inadvertent ingestion of contaminated and incompletely cooked food or other materials, such as animals feces. Escherichia coli is a so-called gram negative bacterium, commonly found in the intestine of humans and other mammals. Entero-hemorrhagic strains including O157, O26, O103 and O111 and ...

Bodyguards for precious seeds

Bodyguards for precious seeds
2015-05-19
The fungi (Rhizoctonia solani) is stealthy blight, becoming visible only shortly before the harvest infesting beets or corn at their roots. The fungal rot begins early in the season, working its way from the inside out, and only becoming visible in the fall, destroying the possibility of a harvest. Year after year crop failures due to attacks by pests and pathogens are reported in the media despite their being treated with pesticides. Crop failure is further exacerbated by pesticide treatments which cause the death of insects such as bees through neonicotinoids. "There ...

Griffon vultures are exposed to high concentrations of lead in their diets

Griffon vultures are exposed to high concentrations of lead in their diets
2015-05-19
Because of their position on the food chain and their dietary habits, Griffon vultures from the Iberian Peninsula are exposed to accumulation of heavy metals in their tissues. A study benefiting from the participation of the Autonomous University of Barcelona reveals that, due to their diets, wild populations of Griffon vultures in Catalonia show the presence of a high amount of lead, which affects their immune systems and reproductive function. The population of wild birds is subject to the dangers resulting from the presence of toxic elements in the environment. Even ...

International Clinical Trials Day: Investigating the benefits of 'sticky sperm' for IVF

2015-05-19
Scientists from the University of Leeds are investigating whether a molecule usually found in moisturisers and skin creams could improve IVF success rates in the UK. Embryologists running a clinical trial at the University are investigating whether hyaluronic acid, normally found in beauty products which are designed to maintain elasticity in the skin and keep hair and joints hydrated, helps sperm stick to the human egg when it is released from the ovary. The hyaluronic acid method relies on picking only mature and fertile sperm that stick to a specially coated plate ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Livers donated after cardiac death are safe to use in liver cancer patients
On a transplant list, Mayo Clinic study finds
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.