Contact Information:

Media Contact

Jacqui Bealing
press@sussex.ac.uk
44-127-367-8888

http://www.sussex.ac.uk




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Alzheimer's culprit causes memory loss even before brain degeneration

A brain protein believed to be a key component in the progress of dementia can cause memory loss in healthy brains even before physical signs of degeneration appear according to new University of Sussex research


2015-05-29
(Press-News.org) The study, published May 29 in the open access Nature Publishing Group journal Scientific Reports, reveals a direct link between the main culprit of Alzheimer's disease and memory loss.

Alzheimer's disease is characterized by the formation of amyloid plaques in the brain tissue. These amyloid plaques are made up of an insoluble protein, 'Amyloid-beta' (Abeta), which forms small structures called 'oligomers' that are important in the disease progression.

Although these proteins are known to be involved in Alzheimer's, little is understood about how they lead to memory loss.

Sussex Neuroscience researchers investigated how Abeta affected healthy brains of pond snails (Lymnaea stagnalis) by observing the effect of administering the protein following a food-reward training task.

The results showed that snails treated with Abeta had significantly impaired memories 24 hours later when tested with the food task, even though their brain tissue showed no sign of damage.

Lead author on the study Lenzie Ford said this demonstrated that Abeta alone is enough to lead to the symptoms of memory loss that are well known in Alzheimer's disease.

She said, 'what we observed was that snail brains remained apparently healthy even after the application of the protein. There was no loss of brain tissue, no signs of cell death, no changes in the normal behaviour of the animals, and yet memory was lost.

'This shows that Alzheimer's amyloid proteins don't just affect memory by killing neurons of the brain, they seem to be targeting specific molecular pathways necessary for memories to be preserved.'

Professor George Kemenes, a Sussex neuroscientist who pioneered a thorough understanding of the molecular mechanisms of learning and memory in the pond snail's nervous system, said, 'because we understand the memory pathways so well, the simple snail brain has provided the ideal model system to enable us to link the loss of established memory to pure Abeta'.

The work will provide a platform for a more thorough investigation of the mechanisms and effects on memory pathways that lead to this memory loss.

Professor Serpell, a senior author on the study and co-director of the University of Sussex's Dementia Research Group, said, 'It is absolutely essential that we understand how Alzheimer's disease develops in order to find specific targets for therapeutics to combat this disease.'

INFORMATION:

Notes for editors:

'Effects of Aß exposure on long-term associative memory and its neuronal mechanisms in a defined neuronal network' Ford, L., Crossley, M., Williams, T., Thorpe, J.R., Serpell, L.C., Kemenes, G. Sci. Rep. 5, 10614; doi: 10.1038/srep10614 (2015). Article: http://www.nature.com/srep/2015/150529/srep10614/full/srep10614.html.

Jacqui Bealing and James Hakner
press@sussex.ac.uk
44-127-367-8888


ELSE PRESS RELEASES FROM THIS DATE:

New 'designer carbon' from Stanford boosts battery performance

New designer carbon from Stanford boosts battery performance
2015-05-29
Stanford University scientists have created a new carbon material that significantly boosts the performance of energy-storage technologies. Their results are featured on the cover of the journal ACS Central Science. "We have developed a 'designer carbon' that is both versatile and controllable," said Zhenan Bao, the senior author of the study and a professor of chemical engineering at Stanford. "Our study shows that this material has exceptional energy-storage capacity, enabling unprecedented performance in lithium-sulfur batteries and supercapacitors." According to ...

Experts on aging: UN Sustainable Development Goals discriminatory, ageist

2015-05-29
One of the main health targets proposed by the UN Sustainable Development Goals (SDG) is to reduce by one-third premature mortality from non-communicable diseases such as cancer, stroke and dementia. The goals for 2016-2030 define premature mortality as deaths occurring among people aged 69 years old or younger. The proposed SDG target sends an unambiguous statement to UN member states that health provision for younger groups must be prioritised at the expense of people aged 70 or more, according to the international group of signatories of the letter published in The ...

Prosthetic hands with a sense of touch? Breakthroughs in providing 'sensory feedback' from artificial limbs

2015-05-29
May 29, 2015 - Researchers are exploring new approaches to designing prosthetic hands capable of providing "sensory feedback." Advances toward developing prostheses with a sense of touch are presented in a special topic article in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). Emerging sensory feedback techniques will provide some sensation and enable more natural, intuitive use of hand prostheses, according to the review by ASPS Member Surgeon Paul S. Cederna, MD, of University ...

Migraine surgery for teens -- good results in initial experience

2015-05-29
May 29, 2015 - As in adults, migraine surgery is effective for selected adolescent patients with severe migraine headaches that don't respond to standard treatments, reports a study in the June issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). ASPS Member Surgeon Bahman Guyuron, MD, Emeritus professor of plastic surgery at Case School of Medicine, Cleveland, and colleagues report good outcomes in an initial experience with migraine surgery in younger patients. They write, "Our data demonstrate ...

Altered pain processing in patients with cognitive impairment

2015-05-29
May 29, 2015 - People with dementia and other forms of cognitive impairment (CI) have altered responses to pain, with many conditions associated with increased pain sensitivity, concludes a research review in PAIN®, the official publication of the International Association for the Study of Pain. The journal is published by Wolters Kluwer. The available evidence questions the previous notion that people with CI have reduced pain sensitivity to pain. Rather, "It appears that those with widespread brain atrophy or neural degeneration...all show increased pain responses ...

CWRU social work researchers create easier, accurate way to analyze TSCC trauma results

2015-05-29
The 54-question Trauma Symptoms Checklist for Children (TSCC) has been used for decades to test how trauma affects youth in hopes of developing the best treatment and support possible. But interpreting the results can be labor intensive and difficult because the work is done manually and involves a complex matrix from which to draw conclusions. Now, a Case Western Reserve University social work research team, led by Fredrick Butcher, PhD, a research associate at the Semi J. and Ruth W. Begun Center for Violence Prevention Research and Education, has proposed and tested ...

Study: Race influences warfarin dose

2015-05-29
(WASHINGTON, May 29, 2015) - A new report demonstrates that clinical and genetic factors affecting dose requirements for warfarin vary by race. The study, published online today in Blood, the Journal of the American Society of Hematology (ASH), proposes race-specific equations to help clinicians better calculate warfarin dosage. Warfarin is the most widely used blood thinning medication, or anticoagulant, prescribed to prevent stroke and to treat blood clots. Determining the optimal warfarin dose to prevent clots while avoiding dangerous bleeding is difficult. To ensure ...

'Green chemistry' to quantify the components of cosmetics

2015-05-29
Cosmetics is an important industry worldwide and has attained high levels of sophistication. There are over 10,000 components that can be used to make cosmetics; so it is essential to monitor these components to guarantee consumer safety. Regulation 1223/2009 approved by the European Union in 2009 established a list of components that guarantee consumer safety as well as certain conditions for using these components, such as maximum concentration and what type of products they can be used in. In his Ph.D. thesis, the researcher Josu López of the Department of Applied ...

Finding loopholes in the genome

2015-05-29
Singapore -- Scientists from A*STAR's Bioinformatics Institute (BII) have developed an analytical model and computational tool to rapidly and accurately predict the occurrence and locations of R-loop Forming Sequences (RLFSs) in any genome or artificial nucleic acid sequences. R-loops, which are three-stranded RNA and DNA hybrid structures, can be crucial to many normal biological processes and have also been associated with triggering mutations, DNA breaks and diseases. These hybrid structures provide intriguing possibilities for use as novel targets for diagnostics and ...

UH Case Medical Center experts to present data at 51st ASCO Annual Meeting

2015-05-29
CLEVELAND: Researchers from University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine will present data from several new studies, including a study evaluating a potential novel combination treatment for cancer patients with advanced solid tumors and a first-of-its-kind analysis of gene mutations in small cell lung cancer (SCLC), at the 51st American Society for Clinical Oncology (ASCO) Annual Meeting in Chicago. Jennifer Eads, MD, oncologist at UH Seidman Cancer Center, will present data from a Phase 1 clinical ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Alzheimer's culprit causes memory loss even before brain degeneration
A brain protein believed to be a key component in the progress of dementia can cause memory loss in healthy brains even before physical signs of degeneration appear according to new University of Sussex research
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.