Contact Information:

Media Contact

Aleea Khan

Twitter: ASMnewsroom

Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości. - Press Release Distribution
RSS - Press News Release
Add Press Release

Following maternal transmission, group B strep mutates to sicken infants

( Washington, DC - August 18, 2015 - Group B streptococcus, a mostly benign inhabitant of healthy adults, is one of the world's leading causes of neonatal sepsis and meningitis. A team of French investigators has now shown that such cases might occur when the microbe mutates within the infant following transmission from the mother. The research appeared August 17 in the Journal of Bacteriology, a publication of the American Society for Microbiology.

In the study, the investigators compared for the first time samples of group B streptococcus (GBS) from pairs of infected newborns and their mothers. They found that in five out of the 19 sampled newborns, mutations with a potential role in promoting virulence had occurred in GBS.

"The mechanism that encourages these virulence mutations is unknown at present," said Claire Poyart, MD, PHD, Director of the Barriers and Pathogens team at INSERM and the Centre National de Reference des Streptococques, Paris. However, she suggested that the virulence mutations take hold in neonates after their first few days of life, as their immunological defenses develop, applying selective pressure on any group B streptococcus strains that have a fitness advantage.

Some of the virulence-promoting mutations occurred in a gene that can prevent expression of certain group B streptococcus genes, such that when the former malfunctions, virulence genes are expressed copiously. Another virulence-promoting mutation occurred in the promoter for a highly immunogenic surface protein. By contrast, this mutation caused a reduction in the expression of the affected gene, which the authors suggest might help the mutated strain evade the host's immune response.

However, these genomic changes were found only in a few cases, as in most of the mother-infant pairs analyzed, group B streptococcus were genetically identical. "In most cases, GBS is just naturally virulent in neonates," said Philippe Glaser, PhD, group leader, Bacterial Genomes and Evolution, at the Institut Pasteur, Paris.

Group B streptococcus is one of the leading causes of neonatal sepsis and meningitis worldwide. It is a benign inhabitant of the gastrointestinal tract and the genitourinary tract of an estimated 10-30 percent of humans, and a significant cause of disease in the elderly and in immunocompromised adults. The leading cause of early onset GBS infections in infants is thought to be aspiration of GBS-contaminated amniotic or vaginal fluid, leading to pneumonia or sepsis. Later onset cases, which develop after 2-3 weeks, may result in meningitis. A higher number of early onset pairs were studied in this work, but a greater proportion of late onset strains were found to be genetically different.

"There is an urgent need for better therapeutic interventions against neonatal GBS infections," said Poyart.


The full study can be found at

The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.


New internet routing method allows users to avoid sending data through undesired countries

Censorship is one of the greatest threats to open communication on the Internet. Information may be censored by a user's country of residence or the information's desired destination. But recent studies show that censorship by countries through which the data travels along its route is also a danger. Now, computer scientists at the University of Maryland have developed a method for providing concrete proof to Internet users that their information did not cross through certain geographic areas. The new system offers advantages over existing systems: it is immediately deployable ...

Pregnant mothers influence fetal growth through genetics rather than maternal height

Transmitted genes, rather than growth limitations caused by actual differences in maternal height, are the key means by which a mother's height influences her baby's birth weight and length, according to a new study published this week in PLOS Medicine. The report from Ge Zhang and Louis Muglia of Cincinnati Children's Hospital Medical Center and the March of Dimes Prematurity Research Center Ohio Collaborative and colleagues does, however, suggest that maternal height can directly mediate duration of gestation. Compared to tall mothers, short mothers tend to deliver ...

Shorter women have shorter pregnancies

WHITE PLAINS, N.Y., Aug. 18, 2015 - Shorter mothers have shorter pregnancies, smaller babies, and higher risk for a preterm birth. New research has found that a mother's height directly influences her risk for preterm birth. Investigators at the March of Dimes Prematurity Research Center Ohio Collaborative looked at 3,485 Nordic women and their babies, and found that maternal height, which is determined by genetic factors, helped shape the fetal environment, influencing the length of pregnancy and frequency of prematurity. In contrast, birth length and birth weight ...

Hot chilli may unlock a new treatment for obesity

University of Adelaide researchers have discovered a high-fat diet may impair important receptors located in the stomach that signal fullness. Published today* in the journal PLOS ONE, researchers from the University's Centre for Nutrition and Gastrointestinal Diseases (based at the South Australian Health and Medical Research Institute) investigated the association between hot chilli pepper receptors (TRPV1) in the stomach and the feeling of fullness, in laboratory studies. "The stomach stretches when it is full, which activates nerves in the stomach to tell the ...

The Tree of Life may be a bush

New species evolve whenever a lineage splits off into several. Because of this, the kinship between species is often described in terms of a 'tree of life', where every branch constitutes a species. Now, researchers at Uppsala University have found that evolution is more complex than this model would have it, and that the tree is actually more akin to a bush. Less than a year ago, a consortium of some hundred researchers reported that the relationship between all major bird clades had been mapped out by analysing the complete genome of around 50 bird species. This included ...

Complete resection of high-grade brain cancer yields better survival in children -- especially girls

August 18, 2015 - For children with aggressive brain cancers called high-grade gliomas (HGG), the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer. In addition to showing better survival with gross total resection (GTR) for children with HGG, the results suggest that this survival benefit is greater in girls compared to boys with HGG. The study provides "compelling evidence ...

Women choose contraception based on relationships not just pregnancy desires

Women's contraceptive choices are more often driven by current relationships and sexual activity than by long-term pregnancy intentions, according to Penn State College of Medicine researchers. Cynthia H. Chuang, associate professor of medicine and public health sciences and Carol S. Weisman, Distinguished Professor of Public Health Sciences and Obstetrics and Gynecology and colleagues surveyed nearly 1,000 women in Pennsylvania, all with private health insurance covering prescription contraception, on their contraception use -- including prescription and over-the-counter ...

Cell phones help track of flu on campus

DURHAM, N.C. -- New methods for analyzing personal health and lifestyle data captured through wearable devices or smartphone apps can help identify college students at risk of catching the flu, say researchers at Duke University and the University of North Carolina-Chapel Hill. With help from a mobile app that monitors who students interact with and when, epidemiologist Allison Aiello of UNC and statistician Katherine Heller of Duke have developed a model that enables them to predict the spread of influenza from one person to the next over time. Unlike most infection ...

Engineers identify how to keep surfaces dry underwater

Imagine staying dry underwater for months. Now Northwestern University engineers have examined a wide variety of surfaces that can do just that -- and, better yet, they know why. The research team is the first to identify the ideal "roughness" needed in the texture of a surface to keep it dry for a long period of time when submerged in water. The valleys in the surface roughness typically need to be less than one micron in width, the researchers found. That's really small -- less than one millionth of a meter -- but these nanoscopic valleys have macroscopic impact. Understanding ...

UC Davis team finds early inflammatory response paralyzes T cells

(SACRAMENTO, Calif.) -- In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders. This mechanism may act as a firewall, shutting down the immune response before it gets out of hand. However, from a clinical standpoint, this discovery could lead to more effective cancer immunotherapies, better drugs for autoimmune conditions and new ways to ...


How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[] Following maternal transmission, group B strep mutates to sicken infants is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.