PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Swiss researchers evaluate fetal progenitor tenocytes for repairing tendon injuries

Tendon regeneration may be possible for injuries to Achilles tendons, rotator cuffs, wrists, elbows

2015-08-20
(Press-News.org) Putnam Valley, NY. (Aug. 20, 2015) - Tendon injuries, especially those acquired while engaging in sports, are not easily healed due to the fibrous nature of tendon tissues which transmit forces from muscle to bone and protect surrounding tissues against tension and compression. Tendon injuries to wrists, knees, elbows and rotator cuffs, often from over use when playing golf or tennis, are increasingly common for both professional and amateur athletes ("weekend warriors") alike.

Previous studies in which human fetal progenitor tenocyte (hFPT) transplantation stimulated regeneration of tendons and expedited the healing process served as the impetus for a recent study conducted by a team of Swiss researchers who characterized hFPTs and evaluated their therapeutic potential.

Their study will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited early e-pub at: http://ingentaconnect.com/content/cog/ct/pre-prints/content-CT-1447_Grognuz_et_al

"Tendon healing is always a long process," said study co-author Dr. Lee Ann Laurent-Applegate of the University Hospital of Lausanne's Department of Musculoskeletal Medicine, Switzerland. "The healing process is not perfect and the natural structure is often never attained again. The scar tissue and adhesions remain and can lead to decreased mobility and rupture."

The researchers noted that because of poor healing outcomes, new strategies in regenerative therapy are needed.

Their study reviewed previous laboratory and clinical studies in which fetal progenitor cells were used. One such study found positive results when children suffering from burns were treated with biological bandages comprised of fetal skin progenitor cells.

The current study involved developing the optimal culturing and storage procedures for hFPTs so that they can be used for tendon regeneration.

"In order for this procedure to become a viable treatment option, it is crucial to be in accordance with laws and regulations," wrote the researchers. "Tissues and cells for clinical use are stringently regulated in most countries worldwide. In the present study, the tissue was obtained as an organ donation which is registered with Swissmedic (Swiss Agency for Therapeutic Products) in a Federal Transplantation Program and its use was in accordance with the Law for Transplantation RS810.21 of Switzerland and its related directives on research with human subjects."

According to the researchers, their co-culture model demonstrated that hFPTs could stimulate adult tenocytes and that an increase in their activity could potentially accelerate the regenerative process. In addition, previous studies have indicated that transplanted hFTPs could potentially provide healing without scars with the absence of fibrotic tissue. An in vivo study to show safety and efficacy would be the next step to bring this cell therapy closer to the clinic, they concluded.

"The ability of hFPTs to stimulate the activity of adult tenocytes is of importance as it could lead to a more rapid healing process," said the authors. "The in vivo model chosen for further evaluation should also allow researchers to determine whether rapid regenerative healing without scarring could be attained, while assuring safety and that no immune reaction would be elicited by these particular banked fetal progenitor tenocytes."

"The data from this study propose that not only do fetal tenocytes proliferate more rapidly than their adult counterpart, but they are also able to induce increased metabolic activity in mature cells," said Dr. Maria Carolina de Oliveira Rodrigues of the University of São Paulo, Brazil and section editor for Cell Transplantation. "In addition, it was shown that hFPTs maintained their phenotype even under osteogenic and adipogenic culture conditions-a tribute to their stability. While the study elucidates characteristics germane to the use of these cells for therapeutic purposes, in vivo studies are imperative for assessment of safety and efficacy, while also addressing potential ethical concerns."

INFORMATION:

Contact: Prof. Lee Ann Laurent-Applegate, University Hospital of Lausanne, Service of Plastic, Reconstructive and Hand Surgery Regenerative Unit, EPCR/Croissettes 22, CH-1066 Epalinges, Switzerland

Email: Lee.Laurent-Applegate@chuv.ch
Ph: +41 21 314 35 10
Fax: + 41 21 887 84 14 Citation: Grognuz, A; Scaletta, C.; Farron, A.; Raffoul, W.; Applegate, L. A. Human Fetal Progenitor Tenocytes for Regenerative Medicine. Cell Transplant. Appeared or available on-line: June 24, 2015. The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD or Samantha Portis, MS, at celltransplantation@gmail.com

News release by Florida Science Communications http://www.sciencescribe.net



ELSE PRESS RELEASES FROM THIS DATE:

Memorial Sloan Kettering Cancer Center researchers publish landmark 'basket study'

2015-08-20
Researchers from Memorial Sloan Kettering Cancer Center (MSK) have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients' tumors rather than where their cancer originated. Published in the New England Journal of Medicine, the early phase II study, led by MSK Physician-in-Chief and Chief Medical Officer José Baselga, MD, PhD, looked at the effect of vemurafenib (Zelboraf®) in multiple nonmelanoma BRAFV600-mutated cancers in 122 patients from 23 ...

Report shows uninsured Texans are twice as likely to delay seeking primary care, mental health care

2015-08-20
HOUSTON - (Aug. 20, 2015) - Texans without health insurance are twice as likely to skip seeking primary and mental health care because of cost. That's one of the findings of a new survey released today by Rice University's Baker Institute for Public Policy and the Episcopal Health Foundation. The report found that in the past year 32 percent of uninsured adult Texans said they had skipped primary care due to costs, compared with 16 percent of adults who have health insurance. When it comes to mental health care or counseling, 12 percent of uninsured Texans said they had ...

NASA's CloudSat slices into Super Typhoon Atsani

NASAs CloudSat slices into Super Typhoon Atsani
2015-08-20
NASA's CloudSat Satellite passed over Super Typhoon Atsani as it moved through the western North Pacific Ocean. CloudSat looked at the super typhoon from the side, revealing heavy rainfall in a sloping eyewall. Typhoon Atsani strengthened into a super typhoon on August 19, 2015 at 0000 UTC. CloudSat flew over Atsani at 03:27 UTC, shortly after it became a super typhoon when maximum sustained winds were near 130 knots (150 mph). Atsani was equivalent to a category 4 strength hurricane. CloudSat's cloud profiling radar (CPR), passed just to the west of Super Typhoon Atsani's ...

Electrospray solves longstanding problem in Langmuir-Blodgett assembly

2015-08-20
In the 1930s, Irving Langmuir and his colleague Katharine Blodgett were working long days in the General Electric Company's research laboratory. Together, they discovered that by spreading molecules with volatile organic solvents on the surface of water, they could create a one-molecule-thick film and use it as an anti-reflective coating for glass. Later named Langmuir-Blodgett assembly, this thin-film fabrication technique became popular for creating molecule or nanoparticle monolayers and is commonly used until this day. Since Langmuir-Blodgett assembly was first reported ...

PET imaging detects fast-growing prostate cancer

2015-08-20
Reston, Va. (August 20, 2015) - A molecular imaging biomarker is able to detect fast-growing primary prostate cancer and distinguish it from benign prostate lesions, addressing an unmet clinical need. The new research, published in the July 2015 issue of The Journal of Nuclear Medicine, is significant for patients with suspected prostate cancer that has not been confirmed by standard biopsy. "We were able to demonstrate in our research that PSMA PET imaging was more specific than MR imaging for detection of clinically significant high-grade prostate cancer lesions, and ...

Study finds causal connection between genotypes and years of education achieved

2015-08-20
WASHINGTON, D.C., August 20 -- A first-of-its-kind, nationally representative study of siblings supports previously published research on unrelated individuals that links specific genotypes to educational attainment among adults in their mid-20s to early 30s. The research, published today in AERA Open, a peer-reviewed journal of the American Educational Research Association, found that, within families, an adolescent with a higher "polygenic score"--which summarizes previously identified genome-wide associations for educational attainment--than her or his sibling tended ...

Extracorporeal life support is 'bridge-to-life' for patients with sudden onset cardiogenic shock

2015-08-20
Summary: The ideal management strategy for primary cardiogenic shock is a matter of debate. After some early discouraging experiences, the use of extracorporeal life support for patients with cardiogenic shock is having a resurgence. A report from researchers in Padua, Italy finds that patients who have an acute onset of cardiogenic shock, for example following a heart attack, and are placed on extracorporeal life support, fare better than those who have a chronic cardiac pathology. In an accompanying editorial, Dr. Vivek Rao of the University of Toronto puts the findings ...

Virginia Tech researchers discover potential biomarker for pre-diabetes

2015-08-20
Virginia Tech researchers have identified a biomarker in pre-diabetic individuals that could help prevent them from developing Type II diabetes. Publishing in Clinical Epigenetics, the researchers discovered that pre-diabetic people who were considered to be insulin resistant -- unable to respond to the hormone insulin effectively -- also had altered mitochondrial DNA. Researchers made the connection by analyzing blood samples taken from 40 participants enrolled in the diaBEAT-it program, a long-term study run by multiple researchers in the Fralin Translational Obesity ...

Harvard's Wyss Institute improves its sepsis therapeutic device

2015-08-20
(BOSTON) - Last year, a Wyss Institute team of scientists described the development of a new device to treat sepsis that works by mimicking our spleen. It cleanses pathogens and toxins from blood circulating through a dialysis-like circuit. Now, the Wyss Institute team has developed an improved device that synergizes with conventional antibiotic therapies and that has been streamlined to better position it for near-term translation to the clinic. The improved design is described in the October volume 67 of Biomaterials. Sepsis is a common and frequently fatal medical ...

Home births save money, are safe, UBC study finds

2015-08-20
Having a baby at home can save thousands of dollars over a hospital birth and is just as safe for low-risk births, according to a new UBC study. Researchers with UBC's School of Population and Public Health and the Child and Family Research Institute looked at all planned home births attended by registered midwives in B.C. between 2001 and 2004. They compared them to planned hospital births attended by registered midwives or physicians in which the mothers met the criteria for home birth. For the first 28 days postpartum, they found planned home births saved an average ...

LAST 30 PRESS RELEASES:

Q&A: How to train AI when you don't have enough data

Wayne State University researchers uncover potential treatment targets for Zika virus-related eye abnormalities

Discovering Van Gogh in the wild: scientists unveil a new gecko species

Small birds spice up the already diverse diet of spotted hyenas in Namibia

Imaging detects transient “hypoxic pockets” in the mouse brain

Dissolved organic matter could be used to track and improve the health of freshwaters

Indoor air quality standards in public buildings would boost health and economy, say international experts

Positive associations between premenstrual disorders and perinatal depression

New imaging method illuminates oxygen's journey in the brain

Researchers discover key gene for toxic alkaloid in barley

New approach to monitoring freshwater quality can identify sources of pollution, and predict their effects

Bidirectional link between premenstrual disorders and perinatal depression

Cell division quality control ‘stopwatch’ uncovered

Vaccine protects cattle from bovine tuberculosis, may eliminate disease

Andrew Siemion to receive the SETI Institute’s 2024 Drake Award

New study shows how the Crimean-Congo hemorrhagic fever virus enters our cells

Neoadjuvant chemotherapy proves effective for locally advanced penile squamous cell carcinoma

Study flips treatment paradigm in bilateral Wilms tumor, shows resistance to chemotherapy may point toward favorable outcomes

Doctors received approximately $12.1 billion from drug and device makers between 2013-2022

Discovery suggests new strategy against follicular lymphoma

Making the future too bright: how wishful thinking can point us in the wrong direction

Ochsner Health named to Newsweek’s America’s Greatest Workplaces 2024 for Job Starters

Three-year study of young stars with NASA’s Hubble enters new chapter

North Carolina takes the lead in PFAs research with Collaboratory’s $3 million investment to expand the state’s research capacity

Is it the school, or the students?

Exploring the relationship between HIV pre-exposure prophylaxis and the incidence of chlamydia, gonorrhea and syphilis – findings from Denmark

Music: Song lyrics have become simpler and more repetitive since 1980

Environment: More than half of Colorado River’s water used to irrigate crops

When inequality is more than “skin-deep”: Social status leaves traces in the epigenome of spotted hyenas in Tanzania

Study explores the future of at-home cancer treatment

[Press-News.org] Swiss researchers evaluate fetal progenitor tenocytes for repairing tendon injuries
Tendon regeneration may be possible for injuries to Achilles tendons, rotator cuffs, wrists, elbows