Contact Information:

Media Contact

Melissa Osgood
mmo59@cornell.edu
607-255-2059

Twitter: cornell

http://pressoffice.cornell.edu




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Stiffer breast tissue in obese women promotes tumors


Stiffer breast tissue in obese women promotes tumors
2015-08-26
(Press-News.org) ITHACA, N.Y. - Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.

The study of mice and women shows obesity leads to a stiffening of a meshwork of material that surrounds fat cells in the breast, called the extracellular matrix, and these biomechanical changes create the right conditions for tumor growth. The findings suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser extracellular matrix. Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.

"We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening. But what these findings show is that there are also biophysical changes that are important," said Claudia Fischbach, associate professor of biomedical engineering and the paper's senior author. Bo Ri Seo, a graduate student in Fischbach's lab, is the paper's first author. The study is a collaboration between Cornell's Ithaca campus and researchers at Weill Cornell Medical College and includes Dr. Andrew Dannenberg, professor of medicine.

Fat tissue in obese women has more cells called myofibroblasts, compared with fat tissue in normal-weight women. Myofibroblasts are wound-healing cells that determine whether a scar will form. All cells secrete compounds to create an extracellular matrix, and they remodel and grab onto this meshwork to make tissue. But when myofibroblasts make an extracellular matrix, they pull together - the action needed to close a wound - stiffening the tissue.

But "these are cells in our body regardless of injury," said Fischbach. In obese women, there are more myofibroblasts than in lean women, which leads to scarring and stiffening without an injury in the extracellular matrix. Tumors also recruit more myofibroblasts than are found in healthy tissue, which also leads to stiffer extracellular matrix.

Many obese women get regular mammograms but signs of disease don't show up because detecting their dense extracellular matrix between the fat cells requires a finer-scale resolution. The findings "may inspire use of higher resolution imaging techniques to detect those changes," said Fischbach. "Right now, people don't look for stiffer extracellular matrices as a clinical biomarker."

During plastic or reconstructive surgery following mastectomy in breast cancer patients, doctors may inject adipose stromal cells from obese donors to regenerate tissue. "What our data suggests is that it is really important where these cells are being taken from," Fischbach said. "If you use these cells from an obese patient, they are very different and you may actually be driving malignancies if you implant them."

INFORMATION:

The study was funded by the National Institutes of Health, the National Science Foundation, the Breast Cancer Research Foundation and the Botwinick-Wolfensohn Foundation at WCMC.

Cornell University has television, ISDN and dedicated Skype/Google+ Hangout studios available for media interviews.


[Attachments] See images for this press release:
Stiffer breast tissue in obese women promotes tumors

ELSE PRESS RELEASES FROM THIS DATE:

New survey examines racial and ethnic differences in technology use by millennials

2015-08-26
A new study conducted by the Media Insight Project, a collaboration between the American Press Institute and The Associated Press-NORC Center for Public Affairs Research, found that while the similarities to the rest of their generation are numerous, there are some distinct differences in the way that Hispanic and African American Millennials use technology to access news and information. The source of their information is one area of difference: these young adults are more likely to use YouTube and Instagram for news than Millennials in general, though all groups rely ...

Neurodegenerative disease clogs nuclear pores

2015-08-26
Howard Hughes Medical Institute (HHMI) scientists have discovered how the most common genetic defect in amyotrophic lateral sclerosis kills nerve cells. Their study suggests that the pores that allow molecules into and out of a cell's nucleus get jammed, a finding that could speed the search for other genes that promote this fatal illness. In people who have amyotrophic lateral sclerosis (ALS), the motor neurons that operate the muscles deteriorate. Over time, the disease deprives patients of the ability to walk, swallow, and breathe, and they usually die within three ...

Antimatter catches a wave at SLAC

Antimatter catches a wave at SLAC
2015-08-26
A study led by researchers from the U.S. Department of Energy's (DOE) SLAC National Accelerator Laboratory and the University of California, Los Angeles has demonstrated a new, efficient way to accelerate positrons, the antimatter opposites of electrons. The method may help boost the energy and shrink the size of future linear particle colliders - powerful accelerators that could be used to unravel the properties of nature's fundamental building blocks. The scientists had previously shown that boosting the energy of charged particles by having them "surf" a wave of ionized ...

Capturing cancer

2015-08-26
They're among the most powerful tools for shedding new light on cancer growth and evolution, but mathematical models of the disease for years have faced an either/or stand off. Though models have been developed that capture the spatial aspects of tumors, those models typically don't study genetic changes. Non-spatial models, meanwhile, more accurately portray tumors' evolution, but not their three-dimensional structure. A collaboration between Harvard, Edinburgh, and Johns Hopkins Universities including Martin Nowak, Director of the Program for Evolutionary Dynamics ...

Methanotrophs: Could bacteria help protect our environment?

2015-08-26
New insight into methanotrophs, bacteria that can oxidise methane, may help us develop an array of biotechnological applications that exploit methane and protect our environment from this potent greenhouse gas. Publishing in Nature, scientists led by Newcastle University have provided new understanding of how methanotrophs are able to use large quantities of copper for methane oxidation. They have identified a new family of copper storage proteins called Csp that are present in a range of bacteria. These proteins store metal in a way that has not been seen previously ...

Scientists discover mechanism behind 'strange' earthquakes

2015-08-26
It's not a huge mystery why Los Angeles experiences earthquakes. The city sits near a boundary between two tectonic plates -- they shift, we shake. But what about places that aren't along tectonic plate boundaries? For example, seismicity on the North American plate occurs as far afield as southern Missouri, where earthquakes between 1811 and 1812 estimated at around magnitude 7 caused the Mississippi River to flow backward for hours. Until now, the cause of that seismicity has remained unclear. While earthquakes along tectonic plate boundaries are caused by motion ...

Pacific Northwest wildfires severe in intensity

Pacific Northwest wildfires severe in intensity
2015-08-26
The Pacific Northwest is abundantly dotted with wildfires in Washington, Oregon, Idaho and Montana. There are over 27 fires listed in the Inciweb database for the state of Washington. The largest active fire listed is the Okanogan Complex Fire which is currently at 256,567 acres and has 1,250 personnel working the fire. This fire began as a lightning strike on August 15, 2015. It is only 10% contained at present. Governor Inslee's request for a federal Emergency Declaration to provide additional resources to cover some of the costs related to multiple wildfires burning ...

Unusual use of blue pigment found in ancient mummy portraits

2015-08-26
Mostly untouched for 100 years, 15 Roman-era Egyptian mummy portraits and panel paintings were literally dusted off by scientists and art conservators from Northwestern University and the Phoebe A. Hearst Museum of Anthropology as they set out to investigate the materials the painters used nearly 2,000 years ago. What the researchers discovered surprised them, because it was hidden from the naked eye: the ancient artists used the pigment Egyptian blue as material for underdrawings and for modulating color -- a finding never before documented. Because blue has to be manufactured, ...

UCSF researchers control embryonic stem cells with light

2015-08-26
UC San Francisco researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue. The technique also revealed an internal timer within stem cells that lets them tune out extraneous biological noise but transform rapidly into mature cells when they detect a consistent, appropriate molecular signal, the authors report in a study published online August 26 in Cell Systems. "We've discovered a basic mechanism the cell uses ...

Wide-ranging networking boosts employee creativity

2015-08-26
Companies can promote creativity in employees by encouraging them to network beyond their immediate business networks, according to a new study by management experts at Rice University, Australian National University (ANU), Erasmus University Rotterdam, Monash University in Clayton, Australia, and the University of Los Andes in Bogota, Colombia. "Social networks can be important sources of information and insight that may spark employee creativity," the authors said. "The cross-fertilization of ideas depends not just on access to information and insights through one's ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Stiffer breast tissue in obese women promotes tumors
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.