Contact Information:

Media Contact

Kim Polacek
Kim.Polacek@Moffitt.org
813-745-7408

Twitter: MoffittNews

http://www.moffitt.usf.edu




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Moffitt makes important steps toward developing a blood test to catch pancreatic cancer early

A blood test that measures a set of molecular markers called microRNAs could someday help identify and characterize precursor lesions that can progress to pancreatic cancer


2015-08-28
(Press-News.org) TAMPA, Fla. - Pancreatic cancer is the fourth most common cause of cancer-related death in the United States and has a 5-year survival rate of only 6 percent, which is the lowest rate of all types of cancer according to the American Cancer Society. This low survival rate is partially attributed to the difficulty in detecting pancreatic cancer at an early stage. According to a new 'proof of principle' study published in Aug. 27 issue of Cancer Prevention Research, Moffitt Cancer Center researchers hope to improve pancreatic cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant pancreatic lesions called intraductal papillary mucinous neoplasms (IPMNs).

"One promising strategy to reduce the number of people affected by pancreatic cancer is to identify and treat premalignant pancreatic lesions," said first author Jennifer Permuth-Wey, Ph.D., M.S., assistant member in the Departments of Cancer Epidemiology and Gastrointestinal Oncology at Moffitt. "IPMNs are established precursor lesions to pancreatic cancer that account for approximately half of all asymptomatic pancreatic cysts incidentally detected by computerized tomography (CT) scans or magnetic resonance imaging (MRI) in the U.S. each year."

IPMNs can be characterized as either low- or high-risk for the development of pancreatic cancer; however, the only way to accurately characterize the severity of IPMNs is by their surgical removal that is in itself associated with a risk of complications, such as long-term diabetes and death. Alternatively, not removing the IPMN(s) could lead to a missed opportunity to prevent high-risk lesions from developing into invasive pancreatic cancer.

Moffitt researchers want to develop a fast, cost-effective blood test that can accurately differentiate low-risk IPMNs that can be monitored from high-risk IPMNs that need to be surgically removed by studying microRNAs (miRNAs), a class of small molecules that regulate key genes involved in the development and progression of cancer. "Using new digital technology, we compared the expression patterns of miRNAs in the blood and discovered a set of 30 miRNAs that differentiated between IPMN patients and healthy volunteers. We also identified five miRNAs that could distinguish between high-risk IPMNs and low-risk IPMNs," said senior author Mokenge Malafa, M.D, F.A.C.S., department chair and program leader for Moffitt's Gastrointestinal Oncology Program. "We are excited about our preliminary findings, but much more research is needed before such a blood test could be made available in the clinical setting."

"The hope is that in the not-so-distant future a miRNA-based blood test can be used in conjunction with imaging features and other factors to aid the medical team in accurately predicting disease severity of IPMNs and other pancreatic cysts at the time of diagnosis or follow-up so that more informed personalized medical management decisions can be made," explained Permuth-Wey.

The authors believe that the incorporation of such a blood test into routine clinical practice could provide a prime opportunity for intervention during the pre-cancerous phase before the development of pancreatic malignancy.

Through funding from the State of Florida and the newly established Florida Academic Cancer Center Alliance, Moffitt researchers plan to further their research on IPMNs by partnering with researchers from the University of Florida Health Cancer Center and the University of Miami/Sylvester Comprehensive Cancer Center. This new partnership, called the Florida Pancreas Collaborative, represents the first state-wide multi-cancer center collaboration dedicated to conducting research on IPMNs with the ultimate goal of promoting the prevention and early detection of pancreatic cancer. "Considering that Florida ranks second in the number of pancreatic cancer deaths that occur each year and the fact that pancreatic cancer is projected to surpass breast, prostate, and colorectal cancer and become the second leading cause of cancer deaths by 2030, we are thrilled that our state is committed to investing in pancreatic cancer research now," said Permuth-Wey.

"Early detection and screening are the most effective ways for 'at-risk' individuals to minimize the potential for developing pancreatic cancer," said Malafa. Screening and diagnostic procedures for pancreatic cysts and other gastrointestinal conditions can be performed at Moffitt's state-of-the-art endoscopy clinic.

INFORMATION:

This research was made possible by patients who were treated at Moffitt and generously donated blood and tissue samples to the Total Cancer Care® Program and was supported in part by grants from the American Cancer Society (93-032-16) and the National Cancer Institute.

About Moffitt Cancer Center Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt's excellence in research, its contributions to clinical trials, prevention and cancer control. Moffitt is the top-ranked cancer hospital in Florida and has been listed in U.S. News & World Report as one of the "Best Hospitals" for cancer care since 1999. With more than 4,600 team members, Moffitt has an economic impact in the state of $1.9 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, Twitter and YouTube.


ELSE PRESS RELEASES FROM THIS DATE:

Staying safe in sandy beaches

2015-08-28
Beach sand contains all kinds of microorganisms, including those that can harm human health. Yet current guidelines are focused exclusively on monitoring the levels of microbes in the water. Now, an international panel of scientists is recommending monitoring the sand at recreational beaches, to minimize health risks for beachgoers. Their advice is based on the general consensus reached during the international conference "Trends in Environmental Microbiology and Public Health," held in Lisbon Portugal in September 2014. "Beach sands accumulate contaminants and people ...

New embryo image processing technology could assist in IVF implantation success rates

2015-08-28
A collaboration between biologists and engineers at Monash University has led to the development of a new non-invasive image processing technique to visualise embryo formation. Researchers were able to see, for the first time, the movement of all of the cells in living mammalian embryos as they develop under the microscope. This breakthrough has important implications for IVF (in vitro fertilisation) treatments and pre-implantation genetic diagnosis (PGD). In the future, this approach could help with embryo selection before the embryo is implanted back into the uterus to ...

Neurobiology: Light-activated learning

2015-08-28
A German-French team has developed a light-sensitive switch that regulates a protein implicated in the neurobiology of synaptic plasticity. The agent promises to shed new light on the phenomenology of learning, memory and neurodegeneration. Learning is made possible by the fact that the functional connections between nerve cells in the brain are subject to constant remodeling. As a result of activation-dependent modification of these links ('synaptic plasticity'), circuits that are repeatedly stimulated "learn" to transmit signals ever more efficiently. This process is ...

Lack of folic acid enrichment in Europe causes mortality among fetuses

2015-08-28
This news release is available in German. A new international study shows that 5,000 foetuses in Europe annually are affected by spina bifida and other severe defects on the central nervous system. Seventy per cent of these pregnancies are terminated, while increased mortality and serious diseases affect the children who are born. At least half of the cases can be avoided by adding folic acid to staple foods as is already being done in seventy non-European countries. A lack of folic acid enrichment in Europe is the cause of several thousand cases of foaetal abnormalities ...

The alien within: Fetal cells influence maternal health during pregnancy (and long after)

The alien within: Fetal cells influence maternal health during pregnancy (and long after)
2015-08-28
Parents go to great lengths to ensure the health and well-being of their developing offspring. The favor, however, may not always be returned. Dramatic research has shown that during pregnancy, cells of the fetus often migrate through the placenta, taking up residence in many areas of the mother's body, where their influence may benefit or undermine maternal health. The presence of fetal cells in maternal tissue is known as fetal microchimerism. The term alludes to the chimeras of ancient Greek myth--composite creatures built from different animal parts, like the goat-lion-serpent ...

Future climate models greatly affected by fungi and bacteria

2015-08-28
When a plant dies, its leaves and branches fall to the ground. Decomposition of soil organic matter is then mainly carried out by fungi and bacteria, which convert dead plant materials into carbon dioxide and mineral nutrients. Until now, scientists have thought that high quality organic materials, such as leaves that are rich in soluble sugars, are mainly decomposed by bacteria. Lower quality materials, such as cellulose and lignin that are found in wood, are mainly broken down by fungi. Previous research has also shown that organic material that is broken down by ...

Physics meets biology to defeat aging

2015-08-28
The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging Prof. Robert J. Shmookler Reis (current world record holder in life extension for model animals - 10 fold for nematodes) has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks. The work has just been published as "Stability analysis of a model gene network links aging, stress resistance, and negligible senescence" in Scientific Reports ...

New technique could enable design of hybrid glasses and revolutionize gas storage

2015-08-28
A new method of manufacturing glass could lead to the production of 'designer glasses' with applications in advanced photonics, whilst also facilitating industrial scale carbon capture and storage. An international team of researchers, writing today in the journal Nature Communications, report how they have managed to use a relatively new family of sponge-like porous materials to develop new hybrid glasses. The work revolves around a family of compounds called metal-organic frameworks (MOFs), which are cage-like structures consisting of metal ions, linked by organic bonds. ...

Researchers use brain scans to predict response to antipsychotic medications

2015-08-28
MANHASSET, NY - Investigators at The Feinstein Institute for Medical Research have discovered that brain scans can be used to predict patients' response to antipsychotic drug treatment. The findings are published online in the latest issue of The American Journal of Psychiatry. Psychotic disorders, such as schizophrenia and bipolar disorder, are characterized by delusions, hallucinations, and disorganized thoughts and behavior. They are estimated to occur in up to three percent of the population and are a leading cause for disability worldwide. Psychotic episodes are ...

The Lancet Psychiatry: Goth teens could be more vulnerable to depression and self-harm

2015-08-28
Young people who identify with the goth subculture might be at increased risk of depression and self-harm, according to new research published in The Lancet Psychiatry journal. The findings show that teenagers who identified very strongly with being a goth at age 15 were three times more likely to be clinically depressed and were five times more likely to self-harm at age 18 than young people who did not identify with the goth subculture. "Our study does not show that being a goth causes depression or self-harm, but rather that some young goths are more vulnerable to ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Moffitt makes important steps toward developing a blood test to catch pancreatic cancer early
A blood test that measures a set of molecular markers called microRNAs could someday help identify and characterize precursor lesions that can progress to pancreatic cancer
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.