Contact Information:

Media Contact

ESC Press office
press@escardio.org

Twitter: escardio

http://www.escardio.org




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Peri-infarct pacing does not improve outcomes in patients with large myocardial infarction


2015-08-30
(Press-News.org) LONDON, UK - In patients with a large myocardical infarction (MI), pacing, with the left ventricular (LV) lead placed in the area of the lesion (peri-infarct) did not prevent further enlargement of the heart (remodeling), nor did it improve functional or clinical outcomes after 18 months, according to results of the Pacing Remodeling Prevention Therapy trial (PRomPT) trial.

In MI patients with large infarcts, medical therapy and rapid restoration of blood flow to the area is not always enough to prevent cardiac remodeling.

One reason for remodeling may be the response of the weakened area of the heart to a redistribution of stress and workload caused by the heart attack.

The principal objective of the PRomPT trial was to investigate whether pacing, which coordinates the heart's contractions and can reduce workload to the damaged area, might prevent post-MI remodeling if the LV lead is placed in the peri-infarct area of most damage.

The findings, presented as a Hot Line at ESC Congress 2015 and published simultaneously in the European Heart Journal (to be confirmed) likely signal a turning point in efforts to prevent post-MI remodeling, said the study's lead investigator, Gregg. W. Stone, MD.

"The results of this trial are sufficiently neutral such that future studies will most likely not explore peri-infarct LV pacing to improve outcomes for patients with large MI," noted Dr. Stone, from New York-Presbyterian Hospital/Columbia University Medical Center and Cardiovascular Research Foundation in New York.

The PRomPT trial was a prospective, multicenter, controlled study in which 126 patients with recent large MI were randomized to a non-pacing control group (n=45), or groups with either biventricular pacing (n=41), or LV peri-infarct pacing (n=40) as determined by 2D echocardiography.

A cardiac resynchronization therapy device (CRT-D) device with left and right ventricular leads was implanted in both pacing groups within 10 days of their MI. Subjects in the biventricular pacing group were paced from both LV and RV leads, while those in the LV pacing group were paced from the LV lead only.

No device was implanted in control group patients.

The study showed no significant difference between the pooled pacing groups and control group in the primary endpoint, which was change in LV end-diastolic volume (LVEDV) from baseline to 18 months.

LVEDV increased by 15.3 mL in the control group and 16.7 mL in the pacing groups during follow-up (p=0.92).

There were also no significant differences between the groups in the change in LVEDV or ejection fraction over time.

The neutral effects of pacing were also reflected in similar outcomes between groups in quality of life measures and exercise performance, as well as mortality and heart failure hospitalisation outcomes, noted Dr. Stone.

"Despite a sound hypothesis PromPT was unable to demonstrate a beneficial effect of pacing in patients with a large MI," he concluded. "Other strategies are desperately needed to improve the prognosis for these high-risk patients, and numerous pharmacologic and device-based approaches are being studied for this purpose."

INFORMATION:


ELSE PRESS RELEASES FROM THIS DATE:

Cyclosporine does not improve outcomes after PCI

2015-08-30
LONDON, UK - 30 August, 2015: The immunosuppressant drug cyclosporine did not improve clinical outcomes compared to placebo in patients receiving percutaneous coronary intervention (PCI) for the more severe form of heart attack known as ST-segment elevation myocardial infarction (STEMI). Results of the CIRCUS trial, presented today in a Hot Line session at ESC Congress 2015, and published simultaneously in the New England Journal of Medicine. showed that the drug, administered prior to PCI, had no impact on a composite of all-cause death, hospitalisation for - or worsening ...

Surprise cardiac finding predicts future risk

2015-08-30
LONDON, UK - In patients with chronic ischemic heart disease, a small left ventricle with thick walls, is the strongest predictor of morphologic remodelling, which is generally considered a first step towards heart failure, according to unexpected findings presented today at ESC Congress 2015. Results of the DOPPLER-CIP (which stands for "Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients") study were not expected and, if confirmed by other studies, "could completely change ...

How can we prevent suicide? Major study shows risk factors associated with depression

2015-08-30
A major multi-national study of suicides has identified the behaviour patterns which precede many suicide attempts. This may lead to changes in clinical practice in the care of patients affected with depression, as it shows the clinical factors which confer major risk of suicide attempts. The statistics for suicide are frightening. According to the WHO, more than 800,000 people commit suicide every year, with perhaps 20 times that number attempting suicide. Suicide is one of the leading causes of death in the young (in the UK for example, it is the leading cause of death ...

Scientists show how magnetic pulses change the brain in treatment for depressed patients

2015-08-30
A group of UK scientists have found a way of understanding how transcranial magnetic stimulation (TMS) can give relief to severely depressed patients. TMS is used as an alternative to Electro-Convulsive Therapy (ECT)*, but it is not known how it achieves its therapeutic effect. Understanding how it works may open the door to better, more targeted treatment for depression and other conditions. Transcranial magnetic stimulation works by applying a magnetic pulse to the frontal part of the brain of depressed patients. Like ECT, it seems to 'reset' the brain, but is easier ...

A single cocaine dose lowers perceptions of sadness and anger

2015-08-30
A single dose of cocaine can interfere with the ability to recognise negative emotions, according to new research presented at the ECNP conference in Amsterdam. In a placebo-controlled within subject study, researchers from the Netherlands and Germany took 24 students (aged 19 to 27) with light to moderate cocaine use, and gave them either 300mg of oral cocaine, or a placebo. After 1 to 2 hours, each participant was then subject to a series of biochemical tests, as well as the facial emotion recognition test to measure response to a series of basic emotions, such ...

Depression and extremes of blood pressure predict highest rates of harmful vascular events

2015-08-29
London, UK - 29 Aug 2015: Depressive symptoms and extremes of blood pressure predict the highest rates of harmful vascular events in patients with existing heart disease, diabetes or stroke, according to research presented at ESC Congress today by Dr Bhautesh Jani, clinical academic fellow in the Institute of Health and Wellbeing, University of Glasgow, UK.1 The study in more than 35 000 patients found that the risk of further stroke or heart attack, heart failure or dying due to heart disease at four years was 83% higher in depressed patients with high blood pressure ...

Prolonged television watchers have higher risk of fatal pulmonary embolism

2015-08-29
London, UK - 29 Aug 2015: Prolonged television watchers have a higher risk of fatal pulmonary embolism, a condition associated with long haul flights, reveals research presented at ESC Congress today by Mr Toru Shirakawa, public health research fellow in the Department of Social Medicine at Osaka University in Japan.1 The 18 year study in more than 86 000 people found that watching an average of five or more hours of television per day was associated with twice the risk of fatal pulmonary embolism as watching less than two and a half hours daily. "The association between ...

Midday naps associated with reduced blood pressure and fewer medications

2015-08-29
London, UK - 29 Aug 2015: Midday naps are associated with reduced blood pressure levels and prescription of fewer antihypertensive medications, according to research presented at ESC Congress today by Dr Manolis Kallistratos, a cardiologist at Asklepieion Voula General Hospital in Athens, Greece.1 "Although William Blake affirms that it is better to think in the morning, act at noon, eat in the evening and sleep at night, noon sleep seems to have beneficial effects," said Dr Kallistratos. "Two influential UK Prime Ministers were supporters of the midday nap. Winston Churchill ...

Coffee linked with increased cardiovascular risk in young adults with mild hypertension

2015-08-29
London, UK - 29 Aug 2015: Coffee drinking is associated with increased risk of cardiovascular events (mainly heart attacks) in young adults (18-45) with mild hypertension, according to research presented at ESC Congress today by Dr Lucio Mos, a cardiologist at Hospital of San Daniele del Friuli in Udine, Italy.1 The 12 year study in more than 1 200 patients found that heavy coffee drinkers had a four-fold increased risk while moderate drinkers tripled their risk. Future prediabetes attenuated the associations suggesting that the effect of coffee on cardiovascular events ...

Pollution and weather influence outcomes after heart attack

2015-08-29
London, UK - 29 Aug 2015: Pollution and weather influence outcomes after a heart attack, according to research presented at ESC Congress today by Ms Aneta Cislak, research fellow in the Silesian Centre for Heart Diseases, Medical University of Silesia in Zabrze, Poland.1 "Weather changes like rain or heat affect our daily activity and even our productivity at work," said Ms Cislak. "Since this influence is so noticeable we were interested to see if weather has any connection with cardiovascular diseases including acute coronary syndromes. Moreover, air pollution affects ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Peri-infarct pacing does not improve outcomes in patients with large myocardial infarction
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.