PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Retrieval of larger thrombi associated with improved neurological recovery after stroke

2015-08-31
(Press-News.org) London, UK - 31 Aug 2015: Retrieval of larger thrombi during intra arterial treatment (IAT) is associated with improved neurological recovery after acute ischaemic stroke, according to a sub study of the MR CLEAN trial presented at ESC Congress today by Dr Anouchska Autar, PhD candidate at the Erasmus Medical Centre in Rotterdam, the Netherlands.1

"Acute ischaemic strokes occur when a blood clot, also called a thrombus, embolises to the brain where it restricts the flow of blood," said Dr Autar. "MR CLEAN was the first trial to show the benefit of IAT to remove blood clots within six hours after a stroke.2 IAT, which was given against a background of standard care including intravenous tissue plasminogen activator3 if indicated, led to better restoration of blood flow and improved functional outcome when compared to no IAT."

Thrombi retrieved during the MR CLEAN trial were collected for the current sub study to investigate the relationship between the macroscopic appearance of thrombi retrieved during IAT, cause of stroke, and clinical outcome. Measures of macroscopic appearance included length, width, area and numbers of particles the thrombus had broken into. Neurological recovery was assessed using the National Institutes of Health Stroke Severity Scale (NIHSS).

The study included 35 collections of thrombi from 35 patients who had undergone IAT after an acute ischaemic stroke. Most of the patients had a severe stroke, of which 49% were of cardiac origin and 20% were due to atherosclerosis.

The researchers found that patients whose stroke was caused by atherosclerosis had significantly longer and larger thrombi (p=0.0035 and p=0.045, respectively) than those with stroke from other causes. "This could be because patients with atherosclerosis have more diseased arteries and this may influence thrombus size," said Dr Autar.

They also found that patients from whom longer and wider thrombi were retrieved had significantly improved neurological recovery at discharge after IAT compared to those with smaller thrombi (p=0.03 and p=0.04, respectively). "This finding is particularly important because it indicates that the larger the pieces that you retrieve, the better this is for your patient," said Dr Autar.

Interestingly, an increased number of particles retrieved during IAT showed a trend towards a worse neurological recovery at discharge, although the association was not significant (p=0.079). Dr Autar said: "Together, this suggests that some emboli are more likely to disintegrate and the smaller particles may embolise and obstruct the microvasculature of the brain, leading to incomplete recovery."

She concluded: "Our study shows that retrieval of larger thrombi during IAT is associated with improved neurological recovery at discharge in patients with acute ischaemic stroke. The findings indicate that a simple parameter such as thrombus size might influence the decision to give or refrain from additional thrombolysis. This needs to be verified of course in larger trials."

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Use of ozone-tolerant cultivars can enhance India's food security

2015-08-31
India's bread basket, the Indo-Gangetic Plains (IGP), have been classified as a "hot spot" for air pollution. A recent study from the University of Eastern highlights the current status of ozone research in the IGP region, which is agriculturally important and densely populated. To study adverse effects of ozone, field experiments were conducted with local crop cultivars of mustard (Brassica campestris L.) and rice (Oryza sativa L.), and various growth, physiological (gas-exchange), biochemical and yield parameters were studied throughout the growing season. Ethylenediurea ...

Volcanic eruptions: Properties of magma influence forecasts

2015-08-31
Many volcanoes are located in densely settled areas. Every time one of these becomes active, large populations are put at risk. Hence, one of the primary goals of the current generation of volcanologists is to develop tools that can accurately predict when volcanoes will erupt. In the case of an impending eruption, these tools are of key importance to those charged with making decisions about what action to take and when. "However, the tools available for predicting eruptions are still in their infancy. We can't always successfully predict an eruption as we lack an understanding ...

MACC1 gene is an independent prognostic biomarker for survival in Klatskin tumor patients

2015-08-31
Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer. If MACC1 expression is low, the patients have a good chance that surgery will prolong survival. By contrast, if the gene is ...

Better outcomes achieved with ESC guideline adherent antithrombotic management

2015-08-31
London, UK - 30 Aug 2015: Patients with atrial fibrillation who receive antithrombotic management according to ESC guidelines have better outcomes than those who do not, according to one year follow up results from the ESC's EORP-AF Pilot General Registry presented today at ESC Congress 20151 and published online in Europace. 2 "This is the first study to show better outcomes using the 2012 ESC guidelines on atrial fibrillation," said principal investigator Professor Gregory YH Lip, from the University of Birmingham, UK and Aalborg University, Denmark.3 "This is novel ...

Respiratory infection associated with increased death after acute myocardial infarction

2015-08-31
London, UK - 31 Aug 2015: Respiratory infection is associated with a four-fold increased risk of in-hospital cardiovascular mortality after acute myocardial infarction (AMI), according to research presented at ESC Congress today by Dr Catarina Quina-Rodrigues, a cardiologist at Hospital de Braga in Portugal.1 The findings highlight the importance of diagnostic alertness for respiratory infections in AMI patients so that therapeutic measures can be promptly taken. "Cardiovascular disease remains the leading cause of death in Europe and around the world," said Dr Quina-Rodrigues. ...

Young women with diabetes have 6-fold risk of heart attack

2015-08-31
London, UK - 31 Aug 2015: Women aged 45 years and under with diabetes have a six-fold risk of heart attack, according to research presented at ESC Congress today.1 The study in more than 7 000 women also found that young women who had a heart attack (myocardial infarction, MI) were more likely to be smokers than older women with MI. "Cardiovascular diseases (CVDs) affect mainly the elderly, but for many years an increase in incidence has been observed in young people as well, regardless of gender," said Professor Hanna Szwed, last author and head of the 2nd Department ...

University of Toronto biologists identify mechanisms of embryonic wound repair

University of Toronto biologists identify mechanisms of embryonic wound repair
2015-08-31
TORONTO, ON - It's like something out of a science-fiction movie - time-lapse photography showing how wounds in embryos of fruit flies heal themselves. The images are not only real; they shed light on ways to improve wound recovery in humans. Researchers at the University of Toronto (U of T) and the Hospital for Sick Children have found that the process of endocytosis - how cells "eat" by absorbing molecules - drives rapid embryonic healing. "Endocytosis removes the junctions between wounded and non-wounded cells, to allow the non-wounded cells to move and stretch over ...

Close friendships in adolescence predict health in adulthood

2015-08-31
Teens are often warned to beware the undue influence of peer pressure, but new research suggests that following the pack in adolescence may have some unexpected benefits for physical health in early adulthood. The study was published in Psychological Science, a journal of the Association for Psychological Science. Psychological scientists Joseph P. Allen, Bert N. Uchino, and Christopher A. Hafen found that physical health in adulthood could be predicted based on the quality of close friendships in adolescence. In addition, efforts to conform to peer norms were actually ...

Knee and hip replacements may be bad for the heart

2015-08-31
Contrary to recent reports, Boston-based researchers found that osteoarthritis patients who had total knee or hip joint replacement surgery, known as arthroplasty, were at increased risk of heart attack (myocardial infarction) in the early post-operative period. However, findings published in Arthritis & Rheumatology, a journal of the American College of Rheumatology (ACR), indicate that long-term risk of heart attack did not persist, while the risk for venous thromboembolism--blood clot in veins and lungs--remained years after the procedure. Osteoarthritis is the most ...

Gene regulating severity of tissue damage caused by rheumatoid arthritis identified

Gene regulating severity of tissue damage caused by rheumatoid arthritis identified
2015-08-31
Scientists have identified a new protein (C5orf30) which regulates the severity of tissue damage caused by rheumatoid arthritis (RA), an autoimmune disease that causes inflammation, pain, stiffness and damage to the joints of the feet, hips, knees, and hands. Following the discovery published in the scientific journal PNAS, rheumatoid arthritis patients most likely to suffer the severest effects of the condition can now be identified early and fast-tracked to the more aggressive treatments available. Although there is no cure for RA, new effective drugs are increasingly ...

LAST 30 PRESS RELEASES:

First performance standards published to measure the effectiveness of lifestyle medicine treatments

To keep volunteers, connect them

Suppressing boredom at work hurts future productivity, study shows

Older brain cells linger unexpectedly before their death

Clear shift in arterial diseases in diabetes

Celebrating half a century of pioneering excellence: EBMT marks its 50th anniversary

Ancient DNA reveals the appearance of a 6th century Chinese emperor

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

Familial Alzheimer’s disease transferred via bone marrow transplant in mice

Perspectives of oncologists on the ethical implications of using AI for cancer care

Industry payments to US physicians by specialty and product type

Andrew E. Place, MD, PhD appointed as Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Vice President, Pediatric Chief Medical Officer

COVID-19 antibody discovery could explain long COVID

Wild plants face viral surprise

Storing electrons from hydrogen for clean chemical reactions

Unlocking how to use mRNA to target Alzheimer’s disease

Kessler Foundation secures $770,000 in grants to advance leading-edge spinal cord research

Going ‘back to the future’ to forecast the fate of a dead Florida coral reef

How extratropical ocean-atmosphere interactions can contribute to the variability of jet streams in the Northern Hemisphere

MSK Research Highlights, March 28, 2024

USDA, Nueta Hidatsa Sahnish College collaborate to support Indigenous Seed Sovereignty

For younger women, mental health now may predict heart health later

Missed opportunity: AEDs near cardiac arrests rarely used by bystanders

Eggs may not be bad for your heart after all

Alcohol raises heart disease risk, particularly among women

TTUHSC announces new center for nursing research

Adding just enough fuel to the fire

Impact of synbiotic supplements on the gut microbiome and overall health of penguins

Promising advances in organosilica membranes for separating organic liquid mixtures

Cell phone video technology unveils new method for analyzing walking and gait

[Press-News.org] Retrieval of larger thrombi associated with improved neurological recovery after stroke