Contact Information:

Media Contact

ESC Press office
press@escardio.org

Twitter: escardio

http://www.escardio.org




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Recruitment of leukocytes is a hallmark of stent thrombosis


2015-08-31
(Press-News.org) London, UK - 30 Aug 2015: Recruitment of leukocytes is a hallmark of stent thrombosis, according to results from the PRESTIGE study presented today at ESC Congress1 and published in European Heart Journal.2 The findings suggest that immune cell mediated thrombotic processes may be a realistic target for novel therapies to prevent stent thrombosis.

"Stent thrombosis (ST) is a life-threatening complication of percutaneous coronary intervention and recent large scale clinical registries reported an incidence of up to 0.4-0.6% per year," said principal investigator Professor Steffen Massberg, director of the Department of Cardiology at the Ludwig-Maximilians University (LMU) Munich, Germany. "The majority of ST patients present with acute myocardial infarction and rates of mortality following presentation are as high as 20-40%."

He continued: "The incidence of ST is highest within the first 30 days after stenting, however, patients treated with drug-eluting stents (DES) - the dominant devices used in contemporary practice - have been shown to be at higher risk of late ST. Clinical practice guidelines therefore recommend a more prolonged duration of dual antiplatelet therapy after stenting with DES as compared to after bare metal stents."

The PREvention of late Stent Thrombosis by an Interdisciplinary Global European effort (PRESTIGE) consortium was established to investigate the mechanisms triggering stent thrombosis across Europe. As part of this study, thrombus specimens retrieved from catheter thrombectomy were systematically collected and analysed in a central core laboratory at the German Heart Centre in Munich, Germany. The main findings from the histopathological evaluation of thrombus specimens from these patients are presented today by Dr Julia Riegger, a cardiologist at the Department of Cardiology at the LMU in Munich.

Dr Riegger said: "Although some pathological processes associated with ST have been identified, the triggering mechanisms remain incompletely understood, and the influence of factors such as timing of ST after the procedure, stent type or polymer coating is poorly characterised. In particular, the potential role of immune cells and related extracellular components has not been elucidated in detail."

The PRESTIGE substudy presented during ESC Congress included patients with ST and undergoing thrombus aspiration at nine centres in Europe between 2010 and 2014. Thrombus specimens were analysed histologically at a core laboratory. Overall 253 thrombus specimens were analysed. Of these, 79 (31.2%) were from patients presenting with early ST and 174 (68.8%) from late ST, while 79 (31.2%) were from bare metal stents, 166 (65.6%) from DES and 8 (3.2%) from stents of unknown type.

The investigators found that the thrombus specimens had heterogeneous morphology with platelet-rich thrombus and fibrin/fibrinogen fragments being most abundant. Leukocyte infiltrations were hallmarks of both early and late ST with neutrophils representing the most prominent subset. Neutrophils were found in similar amounts in early and late ST. "It is important to note that leukocyte counts were significantly higher compared with a control group of patients with thrombus aspiration in spontaneous myocardial infarction," said Professor Massberg.

Neutrophil extracellular traps (NETs), which are prothrombotic extracellular DNA released by neutrophils, were observed in 23% of samples. Eosinophils were present in all stent types, with higher numbers in patients with late ST in sirolimus-eluting and everolimus-eluting stents. "The presence of NETs supports their pathophysiological relevance in ST, while eosinophil recruitment suggests an allergic component to the process of ST," said Professor Massberg.

He concluded: "Our results suggest that immune cell mediated thrombotic processes may be a realistic target for novel therapies to prevent ST. Inhibition of triggers, such as extracellular nucleic acids activating the contact phase, may not only result in efficient anticoagulation in the setting of ST but might also yield less therapy-associated bleeding. Future studies should evaluate whether inhibition of immune cell-driven thrombotic pathways are effective and safe in clinical practice."

INFORMATION:


ELSE PRESS RELEASES FROM THIS DATE:

Tail as old as time -- researchers trace ankylosaur's tail evolution

Tail as old as time -- researchers trace ankylosaurs tail evolution
2015-08-31
How did the ankylosaur get its tail club? According to research from North Carolina State University and the North Carolina Museum of Natural Sciences that traces the evolution of the ankylosaur's distinctive tail, the handle arrived first on the scene, and the knot at the end of the tail followed. The typical ankylosaur had a wide armored body and a flexible tail. But one group of ankylosaurs - ankylosaurids - also had a tail club that could have served as a useful weapon. These "weaponized" ankylosaurids lived about 66 million years ago, during the Cretaceous period. ...

Cardiologists fail to identify basic and advanced murmurs

2015-08-31
LONDON (Aug. 31, 2015) -- Cardiologists failed to identify more than half of basic and about 35 percent of advanced pre-recorded murmurs, but skills improved after a 90 minute training session, according to research presented today at the European Society of Cardiology Congress 2015. Recent breakthroughs in the transcatheter treatment of aortic and mitral valve disorders provide new therapies for patients, but physicians must be able to detect valve problems in a timely manner for patients to see the full benefit of these advances, said Michael Barrett, MD, the lead ...

Gene associated with sudden cardiac death identified by ICD monitoring

2015-08-31
London, UK - 31 Aug 2015: A gene associated with sudden cardiac death in the general population has been identified using implantable cardioverter defibrillator (ICD) monitoring in research presented for the first time at ESC Congress today.1 The research included patients from the DISCOVERY trial and Oregon-SUDS and discovered that a polymorphism in the GNAS gene predicted ventricular tachyarrhythmias and sudden cardiac death. "This is the first time a gene has been identified using ICD monitoring and then confirmed to be associated with sudden cardiac death in the general ...

ELIXA trial shows CV safety of lixisenatide

2015-08-31
LONDON, UK - 30 August, 2015: In patients with type 2 diabetes and acute coronary syndrome, the glucose-lowering medication lixisenatide did not increase or decrease the rate of cardiovascular (CV) events compared to placebo, according to results of the Evaluation of Lixisenatide in Acute Coronary Syndrome (ELIXA) trial. The study, presented today at ESC Congress 2015, "demonstrates the cardiovascular safety of lixisenatide", reported Eldrin F. Lewis, MD, MPH, a member of the ELIXA trial's executive committee, a physician in the Cardiovascular Medicine Division at Brigham ...

New TECOS analysis adds heart failure data for sitagliptin

2015-08-31
LONDON, UK - 30 August, 2015: Patients with type-2 diabetes and cardiovascular disease can safely take the antihyperglycemic drug sitagliptin without an increased risk of cardiovascular complications - even if they have a history of heart failure - a new analysis of the TECOS (Trial Evaluating Cardiovascular Outcomes with Sitagliptin) study shows. The findings, presented today at ESC Congress 2015, "provide reassurance to patients and prescribers about the cardiovascular safety of sitagliptin" - a dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin - according to Paul ...

Depressed patients have more frequent chest pain even in the absence of coronary artery disease

2015-08-31
London, UK - 31 Aug 2015: Depressed patients have more frequent chest pain even in the absence of coronary artery disease, according to results from the Emory Cardiovascular Biobank presented at ESC Congress today by Dr Salim Hayek, a cardiologist at Emory University School of Medicine in Atlanta, Georgia, US.1 The findings suggest that pain and depression may share a common neurochemical pathway. "Depression is a common and well recognised risk factor for the development of heart disease," said Dr Hayek. "Patients with known heart disease and depression tend to experience ...

Retrieval of larger thrombi associated with improved neurological recovery after stroke

2015-08-31
London, UK - 31 Aug 2015: Retrieval of larger thrombi during intra arterial treatment (IAT) is associated with improved neurological recovery after acute ischaemic stroke, according to a sub study of the MR CLEAN trial presented at ESC Congress today by Dr Anouchska Autar, PhD candidate at the Erasmus Medical Centre in Rotterdam, the Netherlands.1 "Acute ischaemic strokes occur when a blood clot, also called a thrombus, embolises to the brain where it restricts the flow of blood," said Dr Autar. "MR CLEAN was the first trial to show the benefit of IAT to remove blood ...

Use of ozone-tolerant cultivars can enhance India's food security

2015-08-31
India's bread basket, the Indo-Gangetic Plains (IGP), have been classified as a "hot spot" for air pollution. A recent study from the University of Eastern highlights the current status of ozone research in the IGP region, which is agriculturally important and densely populated. To study adverse effects of ozone, field experiments were conducted with local crop cultivars of mustard (Brassica campestris L.) and rice (Oryza sativa L.), and various growth, physiological (gas-exchange), biochemical and yield parameters were studied throughout the growing season. Ethylenediurea ...

Volcanic eruptions: Properties of magma influence forecasts

2015-08-31
Many volcanoes are located in densely settled areas. Every time one of these becomes active, large populations are put at risk. Hence, one of the primary goals of the current generation of volcanologists is to develop tools that can accurately predict when volcanoes will erupt. In the case of an impending eruption, these tools are of key importance to those charged with making decisions about what action to take and when. "However, the tools available for predicting eruptions are still in their infancy. We can't always successfully predict an eruption as we lack an understanding ...

MACC1 gene is an independent prognostic biomarker for survival in Klatskin tumor patients

2015-08-31
Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer. If MACC1 expression is low, the patients have a good chance that surgery will prolong survival. By contrast, if the gene is ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Recruitment of leukocytes is a hallmark of stent thrombosis
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.