Contact Information:

Media Contact

Luise Dirscherl
presse@lmu.de
49-089-218-03423

http://www.uni-muenchen.de




Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości.

PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION
RSS - Press News Release
Add Press Release

Alzheimer's disease -- Overlooked for 30 years: A new kid on the block


2015-08-31
(Press-News.org) Alzheimer's disease is associated with the appearance of characteristic neurotoxic protein aggregates in various regions in the brain. Chemical analysis of these insoluble deposits reveals that they are made up of a family of short protein fragments, referred to as beta-amyloid peptides, which are derived from a precursor protein called APP by the sequential action of two enzymes. An international team of researchers led by Christian Haass (Professor of Metabolic Biochemistry at LMU and Speaker for the German Center for Neurodegenerative Diseases in Munich) and Dr. Michael Willem (LMU) has now made a discovery which extends this picture of the pathogenesis of Alzheimer's disease, and has potentially far-reaching implications for our understanding of the condition: "A second mode of APP cleavage exists, which involves a previously unknown cleavage and generates an alternative peptide," says Christian Haass.

Its discoverers refer to the newly characterized protein fragment by the Greek letter eta, christening it 'amyloid-η'. "The processing pathway that produces it has been overlooked for 30 years. This is because investigators including myself have focused their attention on elucidating the origins of the beta-amyloid and on attempts to cure Alzheimer's by inhibiting production of this peptide," Haass explains. The paper that describes the generation of amyloid-η appears in the new issue of the journal "Nature".

A previously unknown interaction

In collaboration with neurobiologist Dr. Hélène Marie based at the IPMC-CNRS in Valbonne (France) and with the local colleagues from the Technical University of Munich (TUM) in the Synergy Excellence Cluster (Professor Arthur Konnerth and Dr. Marc Aurel Busche), the LMU researchers have also studied the effects of the eta-amyloid on nerve-cell function in the brain. Beta-amyloid is known to make nerve cells hyperactive, and now it turns out that the eta-amyloid antagonizes this effect. "So here we have two small peptides snipped from the same precursor protein, which have opposite effects on neuronal activity, and whose actions must normally be carefully balanced," Haass explains.

These findings have immediate implications for ongoing clinical trials in humans, all of which are targeted to beta-amyloid. One of the trials, for instance, is designed to ascertain whether or not pharmacological inhibition of beta-secretase, the proteolytic enzyme that initiates the release of the toxic beta-amyloid from APP, can reduce memory loss in patients with Alzheimer's. Haass, Willem and colleagues confirmed that blocking the action of the beta-secretase does indeed reduce levels of beta-amyloid. However, this is accompanied by a massive increase in the amount of eta-amyloid generated. "This could result in attenuation of neuronal activity and might therefore compromise brain function," says Haass. He therefore suggests that investigators need to be on the look-out for any signs of unanticipated side-effects in the current clinical trials.

INFORMATION:

(Nature 2015)


ELSE PRESS RELEASES FROM THIS DATE:

Mayo researchers examine risk factors/patient outcomes associated with colorectal cancer

2015-08-31
ROCHESTER, Minn. -- About 20 percent of colorectal cancer patients have cancers that have spread (metastasized) beyond the colon at the time of their diagnosis. The liver is the most common site for these metastases. The approach to treating primary tumors within the colon and metastatic tumors in the liver continues to evolve; however, it typically involves chemotherapy plus surgical removal (resection) of both types of tumors. However, experts continue to debate whether surgical resection of primary tumors and metastatic tumors should be performed at the same time (synchronously) ...

As wind-turbine farms expand, research shows they could offer diminishing returns

2015-08-31
LAWRENCE -- Renewable wind energy is experiencing a boom, with more wind turbines popping up across landscapes in the U.S. and abroad. Indeed, wind energy accounted for 3.3 percent of electricity generation in the United States in 2011, according to the U.S. Energy Information Administration. Globally, that number was 2.9 percent for the same year. But as wind turbines proliferate, researchers at the University of Kansas are looking at how these forests of turbines affect the wind itself. What happens to the wind when a larger number of wind turbines removes more and ...

NASA sees a weakening Hurricane Ignacio moving parallel to Hawaiian Islands

NASA sees a weakening Hurricane Ignacio moving parallel to Hawaiian Islands
2015-08-31
NASA's Aqua satellite passed over Hurricane Ignacio and viewed the storm in infrared light, providing valuable temperature data. Aqua saw a weaker Ignacio moving parallel to the Hawaiian Islands. The Atmospheric Infrared Sounder or AIRS instrument aboard Aqua gathers infrared data that shows temperatures. That AIRS data was made into a false-colored infrared image from August 30 at 22:47 UTC (6:47 p.m. EDT) and showed high, cold, strong thunderstorms surrounded the center of Hurricane Ignacio. AIRS imagery also showed a thick band of thunderstorms spiraling into the ...

Northwestern researchers find predictor of child vocabulary

2015-08-31
Researchers link babies' performance on cognitive tasks to later learning progress Study underscores importance of talking to your baby well before they can talk back Findings may eventually contribute to reducing "vocabulary gap" EVANSTON, Ill. --- At 12 months old, your infant's ability to group objects according to the names associated with them -- as opposed to their appearance alone -- offers a glimpse into how his or her vocabulary will develop by the time they are 18 months, Northwestern University researchers have found. The research, by Brock Ferguson, ...

A technique designed to predict how much energy waves will be bringing

2015-08-31
This news release is available in Spanish. Marine energy has a great future potential according to the experts, but there is still a long way to go before it can be used on a large scale. Despite the problem of intermittency, wave energy has an advantage over wind energy, for example: it is easier to predict optimum swell than some suitable gusts of wind. That is why knowing how much energy the waves will be bringing within a few hours is as important as having available efficient prototypes to make use of wave power. If this information is known, the energy produced ...

Television viewing linked to higher injury risk in hostile people

2015-08-31
PITTSBURGH, Aug. 31, 2015 -- People with hostile personality traits who watch more television than their peers may be at a greater risk for injury, potentially because they are more susceptible to the influence of television on violence and risk-taking behaviors, a University of Pittsburgh Graduate School of Public Health analysis discovered. The research, published online in the International Journal of Injury Control and Safety Promotion, suggests that a reduction in television viewing and content rating systems geared not just to age, but also personality traits, ...

Lizards can stomach island living

Lizards can stomach island living
2015-08-31
Life on an island isn't always easy. To make the most of the little there is to eat on many Greek islands, the digestive system of Balkan green lizards has evolved considerably compared to family members on the mainland. Surprisingly, many of these insect-eating lizards even have special valves that help to digest plants. These are some of the findings¹ from a study led by Konstantinos Sagonas of the National and Kapodistrian University of Athens in Greece, published in Springer's journal The Science of Nature². Reptiles can adjust their digestive system and ...

Watching more TV as a young adult predicts obesity

2015-08-31
PITTSBURGH, Aug. 31, 2015 -- The more hours young adults spend watching television each day, the greater the likelihood that they'll have a higher body mass index and bigger waist circumference, a 15-year analysis by the University of Pittsburgh Graduate School of Public Health revealed. The association did not hold in later years, indicating that young adulthood is an important time to intervene and promote less television viewing, according to the research published online in the journal SAGE Open. "We were quite surprised to find that television viewing was associated ...

NCI awards SPORE grant to multiple myeloma research team from Mayo Clinic Cancer Center

2015-08-31
ROCHESTER Minn. -- A team of Mayo Clinic Cancer Center scientists has been awarded a Specialized Program of Research Excellence (SPORE) grant in multiple myeloma from the National Cancer Institute. The Mayo Clinic Cancer Center is one of only three cancer centers to receive a SPORE grant for multiple myeloma cancer research. MULTIMEDIA ALERT: Video and audio are available for download on the Mayo Clinic News Network. "With project leaders from Mayo campuses in Arizona, Rochester and Florida, our SPORE team will study the genetic basis for myeloma, develop novel viral ...

NASA sees Tropical Storm Erika dissipate near eastern Cuba

NASA sees Tropical Storm Erika dissipate near eastern Cuba
2015-08-31
Satellite data from NOAA's GOES-East satellite was made into an animation that showed the demise of former Tropical Storm Erika as it neared eastern Cuba early on August 29. At NASA's Goddard Space Flight Center in Greenbelt, Maryland, NASA/NOAA's GOES Project compiled three days' worth of imagery from NOAA's GOES-East satellite that showed the movement and changes in former Tropical Storm Erika from August 27 to August 29. The animation showed Erika move through the Leeward Islands and into the Eastern Caribbean Sea, as its center passed just south of Puerto Rico, then ...

LAST 30 PRESS RELEASES:

How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[Press-News.org] Alzheimer's disease -- Overlooked for 30 years: A new kid on the block
Press-News.org is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.