Contact Information:

Media Contact

Vincent Lamontagne

Twitter: HeartInstitute

Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości. - Press Release Distribution
RSS - Press News Release
Add Press Release

Canadian Researchers answer important scientific debate connected to heart disease

( Ottawa - September 8, 2015 - Researchers from the University of Ottawa Heart Institute (UOHI), together with the teams of Dr. Martin Farrell at Oxford University, and Dr. Sekar Kathiresan at the Broad Institute, have found the answer to an ongoing debate in the cardiovascular scientific world. Dr. Ruth McPherson and Dr. Majid Nikpay, researchers at the UOHI's Ruddy Canadian Cardiovascular Genetics Centre, report that the genetic basis of heart disease is largely derived from the cumulative effect of multiple common genetic variants, rather than from a few rare variants with large effects.

The study, published today in the eminent Nature Genetics, used the data from the 1000 Genomes project in order to obtain information on close to 10 million genetic variants (called SNPs). The analysis involved 60,000 heart disease patients, 120,000 healthy individuals, from a total of 48 studies around the world. Not only is the number of genetic variants much greater than the approximately 1 million previously studied, this is the first time that researchers have been able to study the link of rare genetic variants present in as few as 1 in 1000 people at risk of heart disease.

"Our analysis provides a comprehensive survey of the fine genetic architecture of coronary artery disease (CAD), showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size rather than just a few rare variants with large effects," say the authors of this important study.

Dr. Majid Nikpay, post-doctoral fellow at the Ottawa Heart Institute, also used an alternative statistical method of analysis to find two new risk markers that have an effect only if an individual has inherited two copies of the "bad gene", that is one from each parent. In addition to discovering a total of 10 new risk markers, by using other statistical approaches, this research team has produced a list of 202 genetic variants in 129 gene regions that together explain approximately 23% of the heritability of coronary heart disease as compared to only 11% reported in previous studies.

"Many of these genetic variants are likely to exert their effects on the walls of arteries, making them more susceptible to the common heart disease risk factors such as cigarette smoking, diabetes and cholesterol," added Dr Ruth McPherson, Director of the Ruddy Canadian Cardiovascular Genetics Centre at the University of Ottawa Heart Institute.

A number of preventative strategies target the vessel wall (control of blood pressure and smoking cessation), but the large majority of existing drug treatments for lowering CAD risk operate through manipulation of circulating lipid levels and few directly target vessel wall processes. Detailed investigation of new aspects of vessel wall biology that are implicated by genetic association but have not previously been explored in atherosclerosis may provide new insights into the complex etiology of disease and, hence, identify new targets.


Media Contact
Vincent Lamontagne
Director, Corporate Communications
University of Ottawa Heart Institute
613-899-6760 (cell)


Children overcoming adversity

Making a plan can be the difference in overcoming a difficult childhood, while just thinking about those difficulties can drag down the child. A set of four new studies from researchers at USC and Southwest University in China suggest, contrary to prior belief, children in difficult situations need to do more than dream of a happier and successful future self: They need a strategy for becoming that person. Two of the studies found eighth graders performed better in school if they had strategies for becoming their future selves, as well as several options for becoming ...

Pitt researcher lands the cover of Developmental Cell by uncovering an evolutionary secret

PITTSBURGH--How did the elephant get its trunk? Or the turtle its shell? How, in general, did the seemingly infinite diversity of complex animal forms on our planet arise? The scientific pursuit of how such "evolutionary novelties" come about is one of the big mysteries that biologists are trying to tease apart. The University of Pittsburgh's Mark Rebeiz and colleagues provide some answers in a paper published today in the journal Developmental Cell. Even in the most complex organisms, the genetic repertoire is limited. If creatures don't evolve by acquiring new genes, ...

Teens are not always irrational

DURHAM, N.C. -- Teenagers are irrational and make bad decisions. Or do they? A new Duke study finds that adolescents ages 10 to 16 can be more analytical in their economic choices than many slightly older young adults. Published online in the October-December issue of Cognitive Development, the study suggests not only that society should give adolescents more credit for rationality but also that parents should help children hone their cost-benefit analysis skills in making real-life decisions. "The new results point to the idea that we should not think of adolescents ...

Increased detection of low-risk tumors driving up thyroid cancer rates, Mayo study finds

ROCHESTER, Minn. -- Low-risk cancers that do not have any symptoms and presumably will not cause problems in the future are responsible for the rapid increase in the number of new cases of thyroid cancer diagnosed over the past decade, according to a Mayo Clinic study published in the journal Thyroid. According to the study authors, nearly one-third of these recent cases were diagnosed when clinicians used high-tech imaging even when no symptoms of thyroid disease were present. "We are spotting more cancers, but they are cancers that are not likely to cause harm," says ...

Light shed on the underside of the 'cocktail effect' of endocrine disruptors

This news release is available in French. Chemical substances that are safe for humans when taken in isolation can become harmful when they are combined. Three research teams bringing together researchers from Inserm and CNRS in Montpellier have elucidated in vitro a molecular mechanism that could contribute to the phenomenon known as the "cocktail effect." This study is published in the journal Nature Communications. Every day we are exposed to many exogenous compounds such as environmental pollutants, drugs or substances in our diet. Some of these molecules, known ...

Untangling the mechanics of knots

Got rope? Then try this experiment: Cross both ends, left over right, then bring the left end under and out, as if tying a pair of shoelaces. If you repeat this sequence, you get what's called a "granny" knot. If, instead, you cross both ends again, this time right over left, you've created a sturdier "reef" knot. The configuration, or "topology," of a knot determines its stiffness. For example, a granny knot is much easier to undo, as its configuration of twists creates weaker forces within the knot, compared with a reef knot. For centuries, sailors have observed such ...

Changing behavior through synaptic engineering

WORCESTER, MA -- Researchers at the University of Massachusetts Medical School are the first to show that it's possible to reverse the behavior of an animal by flipping a switch in neuronal communication. The research, published in PLOS Biology, provides a new approach for studying the neural circuits that govern behavior and has important implications for how scientists think about neural connectomes. New technologies have fueled the quest to map all the neural connections in the brain to understand how these networks processes information and control behavior. The human ...

Did grandmas make people pair up?

Did grandmas make people pair up?
SALT LAKE CITY, Sept. 7, 2015 - If you are in a special relationship with another person, thank grandma - not just yours, but all grandmothers since humans evolved. University of Utah anthropologist Kristen Hawkes is known for the "grandmother hypothesis," which credits prehistoric grandmothering for our long human lifespan. Now, Hawkes has used computer simulations to link grandmothering and longevity to a surplus of older fertile men and, in turn, to the male tendency to guard a female mate from the competition and form a "pair bond" with her instead of mating with ...

Silicon nanoparticle is a new candidate for an ultrafast all-optical transistor

Silicon nanoparticle is a new candidate for an ultrafast all-optical transistor
Physicists from the Department of Nanophotonics and Metamaterials at ITMO University have experimentally demonstrated the feasibility of designing an optical analog of a transistor based on a single silicon nanoparticle. Because transistors are some of the most fundamental components of computing circuits, the results of the study have crucial importance for the development of optical computers, where transistors must be very small and ultrafast at the same time. The study was published in the scientific journal Nano Letters. The performance of modern computers, which ...

PolyU develops novel efficient and low-cost semitransparent solar cells

PolyU develops novel efficient and low-cost semitransparent solar cells
Developing transparent or semitransparent solar cells with high efficiency and low cost to replace the existing opaque and expensive silicon-based solar panels has become increasingly important due to the increasing demands of the building integrated photovoltaics (BIPVs) systems. The Department of Applied Physics of The Hong Kong Polytechnic University (PolyU) has successfully developed efficient and low-cost semitransparent perovskite solar cells with graphene electrodes. The power conversion efficiencies (PCEs) of this novel invention are around 12% when they are illuminated ...


How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[] Canadian Researchers answer important scientific debate connected to heart disease is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.