Media advisory: Brain cell injections may quiet epileptic seizures

NIH-supported study suggests cell therapy may be a viable approach

2013-05-06

(Press-News.org) More than two million people in the United States suffer from epilepsies, a group of neurological disorders caused by abnormal nerve cell firing in the brain which often produce debilitating seizures. Although anti-epileptic drugs and other therapies reduce seizures in about two-thirds of patients, the remaining one-third do not respond to any form of therapy and those who take drugs can experience harmful side effects. NIH funded researchers at the University of California at San Francisco used a mouse model of epilepsy to show that transplanting new born inhibitory nerve cells can quiet seizures. Inhibitory cells are one of two major nerve cell groups, the other being excitatory. Their results, published in Nature Neuroscience, show that injecting new inhibitory cells into the hippocampus in the brains of adult epileptic mice greatly reduced the occurrence of seizures and reversed some learning and memory problems associated with the disorder. Analysis of the mice brains suggested the new cells became fully incorporated into the brain regions where they were injected. The results support the idea that cell therapies may provide precise and novel ways to treat epilepsy and other neurological disorders.

### This study was supported by grants from NINDS (NS071785, NS077747) and a grant from the California Institute of Regenerative Medicine (#TR2-01749).

References: Hunt et al. "GABA progenitor grafted into the adult epileptic brain control seizures and abnormal behavior" Nature Neuroscience, May 5, 2013. DOI: 10.1038/nn.3392

For more information about Epilepsy, please visit:

http://www.ninds.nih.gov/epilepsy http://www.ninds.nih.gov/epilepsyweb/ NINDS is the nation's leading funder of research on the brain and nervous system. The NINDS mission is to reduce the burden of neurological disease – a burden borne by every age group, by every segment of society, by people all over the world.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov. END

ELSE PRESS RELEASES FROM THIS DATE:

Divide and define: Clues to understanding how stem cells produce different kinds of cells

2013-05-06

ANN ARBOR—The human body contains trillions of cells, all derived from a single cell, or zygote, made by the fusion of an egg and a sperm. That single cell contains all the genetic information needed to develop into a human, and passes identical copies of that information to each new cell as it divides into the many diverse types of cells that make up a complex organism like a human being. If each cell is genetically identical, however, how does it grow to be a skin, blood, nerve, bone or other type of cell? How do stem cells read the same genetic code but divide into ...

Scientists alarmed by rapid spread of Brown Streak Disease in cassava

2013-05-06

BELLAGIO, ITALY (6 MAY 2013)— Cassava experts are reporting new outbreaks and the increased spread of Cassava Brown Streak Disease or CBSD, warning that the rapidly proliferating plant virus could cause a 50 percent drop in production of a crop that provides a significant source of food and income for 300 million Africans. The "pandemic" of CBSD now underway is particularly worrisome because agriculture experts have been looking to the otherwise resilient cassava plant—which is also used to produce starch, flour, biofuel and even beer—as the perfect crop for helping to ...

A new cost-effective genome assembly process

2013-05-06

The U.S. Department of Energy Joint Genome Institute (DOE JGI) is among the world leaders in sequencing the genomes of microbes, focusing on their potential applications in the fields of bioenergy and environment. As a national user facility, the DOE JGI is also focused on developing tools that more cost-effectively enable the assembly and analysis of the sequence that it, as well as other genome centers, generates. Despite tremendous advances in cost reduction and throughput of DNA sequencing, significant challenges remain in the process of efficiently reconstructing ...

As climate changes, boreal forests to shift north and relinquish more carbon than expected

2013-05-06

It's difficult to imagine how a degree or two of warming will affect a location. Will it rain less? What will happen to the area's vegetation? New Berkeley Lab research offers a way to envision a warmer future. It maps how Earth's myriad climates—and the ecosystems that depend on them—will move from one area to another as global temperatures rise. The approach foresees big changes for one of the planet's great carbon sponges. Boreal forests will likely shift north at a steady clip this century. Along the way, the vegetation will relinquish more trapped carbon than most ...

More hurricanes for Hawaii?

2013-05-06

News of a hurricane threat sends our hearts racing, glues us to the Internet for updates, and makes us rush to the store to stock up on staples. Hawaii, fortunately, has been largely free from these violent storms in the recent past, only two having made landfall in more than 30 years. Now a study headed by a team of scientists at the International Pacific Research Center, University of Hawaii at Manoa, shows that Hawaii could see a two-to-three-fold increase in tropical cyclones by the last quarter of this century. The study, which appears in the May 5, 2013, online ...

NIH study provides clarity on supplements for protection against blinding eye disease

2013-05-06

Adding omega-3 fatty acids did not improve a combination of nutritional supplements commonly recommended for treating age-related macular degeneration (AMD), a major cause of vision loss among older Americans, according to a study from the National Institutes of Health (NIH). The plant-derived antioxidants lutein and zeaxanthin also had no overall effect on AMD when added to the combination; however, they were safer than the related antioxidant beta-carotene, according to the study published online today in the Journal of the American Medical Association. "Millions of ...

'Look but don't touch'

2013-05-06

Improving our understanding of the human brain, gathering insights into the origin of our universe through the detection of gravitational waves, or optimizing the precision of GPS systems- all are difficult challenges to master because they require the ability to visualize highly fragile elements, which can be terminally damaged by any attempt to observe them. Now, quantum physics has provided a solution. In an article published in Nature Photonics, researchers at the Institute of Photonic Sciences (ICFO) report the observation of a highly fragile and volatile body through ...

Organic vapors affect clouds leading to previously unidentified climate cooling

2013-05-06

University of Manchester scientists, writing in the journal Nature Geoscience, have shown that natural emissions and manmade pollutants can both have an unexpected cooling effect on the world's climate by making clouds brighter. Clouds are made of water droplets, condensed on to tiny particles suspended in the air. When the air is humid enough, the particles swell into cloud droplets. It has been known for some decades that the number of these particles and their size control how bright the clouds appear from the top, controlling the efficiency with which clouds scatter ...

Improving materials that convert heat to electricity and vice-versa

2013-05-06

ANN ARBOR---Thermoelectric materials can be used to turn waste heat into electricity or to provide refrigeration without any liquid coolants, and a research team from the University of Michigan has found a way to nearly double the efficiency of a particular class of them that's made with organic semiconductors. Organic semiconductors are carbon-rich compounds that are relatively cheap, abundant, lightweight and tough. But they haven't traditionally been considered candidate thermoelectric materials because they have been inefficient in carrying out the essential heat-to-electricity ...

Protein complex may play role in preventing many forms of cancer, Stanford study shows

2013-05-06

STANFORD, Calif. - Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers. The finding suggests that the proteins, which are members of a protein complex that affects how DNA is packaged in cells, work to suppress the development of tumors in many types of tissues. The broad reach of the effect of mutations in the complex, called BAF, rivals that of another well-known tumor suppressor called p53. It also furthers a growing notion that these so-called chromatin-regulatory complexes ...

Media advisory: Brain cell injections may quiet epileptic seizures

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: