Recognizing the sight of blood in urine, the most common first sign of bladder cancer, is often the impetus that leads people to a diagnosis. But for those with colorblindness, who usually have difficulty seeing red, that warning sign is more likely to go down the toilet unnoticed. Now a study by Stanford Medicine researchers and collaborators has found that missing this early sign can have serious health consequences. In an analysis of health records, they discovered that people with bladder cancer who ...

A new study by UCLA and Kaiser Permanente Northwest’s Center for Health Research demonstrates a health care approach matching treatment intensity to individual risk levels can significantly reduce self-harm and depression among at-risk adolescents and young adults while improving patient satisfaction with care. The randomized clinical trial, published in the Journal of the American Academy of Child & Adolescent Psychiatry, is the largest study to date evaluating a stratified stepped-care approach for reducing suicide risk in young Americans. Suicide ...

Scientists are invited to submit their latest research to a new special issue focusing on the intersection of artificial intelligence (AI) and biochar for sustainable land management. The special issue, titled "Artificial Intelligence in Biochar Ecological Applications: Advances for Soil Carbon and Sustainability in Agricultural, Forest, and Grassland Ecosystems," will be published in the journal Biochar. Agricultural land, forests, and grasslands cover most of the Earth's terrestrial surface, playing a central ...

Methane eating microbes could help turn a powerful greenhouse gas into everyday products like animal feed, green plastics, and cleaner fuels, according to a new scientific review of fast moving research on these unusual bacteria. The study highlights how methane consuming communities, known as methanotrophs, are emerging as biological “gatekeepers” that can both curb climate warming emissions and convert waste gases into valuable resources. “Our work shows that methanotrophs are ...

A team of scientists has shown that rice paddies in two of China’s most important grain producing regions release soil nitrogen in strikingly different ways, and that these differences can be predicted using fast, low cost laboratory tests. The findings could help farmers tailor fertilizer doses to local soils, avoiding waste while maintaining high yields. “Our work shows that farmers in different rice regions are not starting from the same nitrogen baseline in their soils, even when their yields look similar,” said lead author Siyuan Cai of the Institute of Soil Science, Chinese Academy ...

When firefighters respond to an emergency, the gear they wear to protect themselves can also create challenges that could jeopardize their performance and safety. Their gear is bulky, and it may not fit perfectly. Those challenges can include restricted movement, added weight and increased heat stress that raise the risk of injury and health problems down the road. Nearly 40% of the non-fatal injuries firefighters report involve their muscles and bones, and those injuries are often linked to the physical demands of the job and limitations that could be imposed by their personal protective equipment (PPE).  Dr. ...

Throwing another log into a crackling fireplace on a cold winter’s night might seem like a cozy, harmless tradition. But Northwestern University scientists have found residential wood burning is a major — yet often overlooked — contributor to winter air pollution across the United States. Although only 2% of U.S. homes rely on wood as their primary heating source, residential wood burning accounts for more than one-fifth of Americans’ wintertime exposure to outdoor fine particulate matter (PM2.5), the new study found.  These tiny airborne particles can penetrate deep into the lungs ...

Reston, VA (January 23, 2026)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes. Summaries of the newly published research articles are provided below. Targeting the Tumor Microenvironment with a New FAP Radiotracer Fibroblast activation ...

The abrupt ending of NIH support for fetal tissue research will undermine the development of new therapies for diseases that affect American families. Research with human fetal tissue (HFT) and HFT-derived cell lines has been integral to biomedical progress for nearly a century and has long been supported on a bipartisan basis under many U.S. administrations. This research has contributed to fundamental advances in understanding human development, infertility, infectious diseases, and chronic and neurodegenerative conditions. HFT-derived cell lines have played a critical role in the development of vaccines that have saved millions of lives worldwide. This research ...

Slippery, drippy goop makes Ralstonia bacteria devastating killers of plants, causing rapid wilting in tomato, potato and a wide range of other crops, according to new research. The work, published Jan. 22 in Proceedings of the National Academy of Sciences, comes from an unusual collaboration between plant pathologists and engineers at the University of California, Davis.  Ralstonia solanacearum can lurk in damp soils for years before infecting a plant, spreading rapidly through the water-carrying vessels (xylem). Infected plants wilt and die within days.  “My analogy is that they cause a heart attack for plants, because they clog up the vessels and ...

In a new study Indiana University researchers observed episodic memory in rats to a degree never documented before, suggesting that rats can serve as a model for complex cognitive processes often considered exclusively human. Unlike semantic memory, which involves isolated facts, episodic memory involves replaying events in the order and context in which they occurred. “The ability to replay a stream of episodic memories in context suggests that rats can serve as a model for complex cognitive processes,” said ...

  Open science at the center of global dialogue  Antimicrobial resistance: a “pandemic” killing more people than cancer by 2050 – Davos needs to talk about this   The science trust dividend: why data integrity matters   Before AI runs out of data, we need a new AGI paradigm  Frontiers Planet Prize: advancing planetary boundary science through interdisciplinary research  New AI platform building cities within planetary boundaries   UNESCO Science Decade: aligning global ...

Forests are central to climate mitigation, yet tracking how fast they grow over decades remains difficult. A new satellite-based approach reconstructs forest canopy height changes across southern China from the 1980s onward. The analysis reveals sustained forest growth, clear differences between plantation and secondary forests, and the dominant role of management in shaping forest structure. The results show that long-term forest development can be monitored consistently from space. Forest canopy height reflects tree growth, biomass accumulation, and carbon storage potential. While ...

New research into project management in software engineering shows that the most successful systems are not the ones that follow a fixed blueprint from the start, but those that evolve in response to real challenges as projects unfold. Hybrid delivery models are born out of practical necessity when teams face complex and competing demands in software projects, and they improve over time as those teams adapt to real-world pressures. The research offers reassurance that messiness and adjustment are not signs of failure, but normal features of working in complex environments. The paper, titled The Pragmatics of Hybridity: A Grounded Theory of Method Integration ...

An international task force of medical experts recently proposed major revisions to the way doctors measure treatment success for a common–and often severe–skin complication of stem cell transplantation. The National Institutes of Health (NIH) Consensus Project Task Force recently published a report of their refined approach in the journal, Transplantation and Cellular Therapy. CDI Faculty Member Rachel Rosenstein, M.D., Ph.D., co-authored the report. With her colleagues, she helped present ways to develop better response criteria for clinical trials evaluating impact of treatment on skin involvement in graft-versus-host ...

We knew we had something interesting with T3p, a single small RNA found in breast cancer but absent from normal tissue. After being described in 2018, this molecule took our team on a six-year journey to systematically map orphan non-coding RNAs (oncRNAs) across all major cancer types, understand which ones actually drive disease, and demonstrate their utility in monitoring patients through simple blood tests.  In a paper published today, we show how we went from mining cancer genome data to building machine learning classifiers, ...

About The Study: In this study, risks of severe neonatal morbidity or mortality increased with an increasing number of preexisting maternal chronic conditions. These findings suggest that women and adolescents with multiple chronic conditions may benefit from preconception counseling to optimize chronic disease management, monitoring in pregnancy for earlier identification of complications, and enhanced newborn supports. Corresponding Author: To contact the corresponding author, Hilary K. Brown, PhD, email hk.brown@utoronto.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.55558) Editor’s ...

About The Study: In this randomized clinical trial of older adults with diabetes, participants in the smart speaker group showed significant improvements in mental distress, quality of life, diabetes self-care, and glycemic control. These findings suggest that this easily implemented self-management intervention could enhance health outcomes in this population. Corresponding Author: To contact the corresponding author, Gabriela Heiden Telo, MD, PhD, email gabriela.telo@pucrs.br. To access the embargoed study: Visit our For The Media website ...

Liquid–liquid phase separation is a process in which a uniform solution separates into two coexisting liquid phases. In living cells, it governs the formation of membrane-less compartments that selectively concentrate molecules and regulate biochemical reactions. This phenomenon is also widely used in practical applications, including biomolecular separation and purification. A long-standing question in phase separation research is why specific molecules preferentially localize in one phase over the other. Conventional explanations have focused on polymer–polymer ...

Schizophrenia is a highly heterogeneous psychiatric disorder affecting ~1% of the global population, typically emerging in adolescence or early adulthood and characterized by hallucinations, delusions, disorganized thinking, and cognitive impairments; while its etiology remains elusive, genetic factors are widely recognized as fundamental, and GWAS have identified over 200 genome-wide significant loci.  White matter microstructure is essential for neural communication and is strongly heritable; diffusion tensor imaging (DTI) quantifies white matter integrity via FA, MD, and the three tensor eigenvalues (λ1–λ3), and widespread ...

A new study published in Big Earth Data provides a comprehensive evaluation of the accuracy of widely used satellite-based and reanalysis precipitation datasets, offering critical guidance for hydrological, climate, and environmental applications in Central Europe.  Citation Paluba, D., Bližňák, V., Müller, M., & Štych, P. (2025). Evaluation of ten satellite-based and reanalysis precipitation datasets on a daily basis for Czechia (2001–2021). Big Earth Data, 1–30. https://doi.org/10.1080/20964471.2025.2592444 Abstract This ...

Metastatic urothelial carcinoma has a poor prognosis: ~50% of muscle-invasive bladder cancer progresses to metastasis, and the 5-year survival for advanced/metastatic disease is <10%. Platinum-based chemotherapy was historically first-line, but its benefit is limited by renal insufficiency/poor tolerance and the lack of effective options after resistance. Immune checkpoint inhibitors have improved outcomes in a subset of patients and are supported by high tumor mutational burden and PD-L1 expression in bladder cancer; however, response ...

Investigational New Drug (IND) approval from the U.S. Food and Drug Administration (FDA) paves the way for ISM8969 clinical study in the United States. The Phase I clinical trial aims to evaluate safety, tolerability, and pharmacokinetics profiles. ISM8969 is a novel oral therapeutic candidate developed through Insilico’s Pharma.AI, with best-in-class potential, unique brain penetrant traits, and favorable druggability profiles demonstrated in preclinical studies. Insilico Medicine has entered into a co-development collaboration agreement with Hygtia Therapeutics, with both parties each holding 50% of ...

Hepatic steatosis is a core pathological feature of metabolic dysfunction-associated steatotic liver disease (MASLD). It not only drives disease progression to intrahepatic conditions such as cirrhosis but also elevates the incidence and mortality risk of cardiovascular diseases and extrahepatic malignancies. Importantly, hepatic steatosis is reversible in its early stages. Clinical practice guidelines recommend exercise intervention as the primary approach for treating the disease, and the concept of "exercise as medicine" is widely acknowledged. In recent years, researchers have mainly evaluated how different components of exercise prescriptions affect health ...

A new expert consensus made available online on 10 October 2025 and published in Volume 5, Issue 4 of the journal Intelligent Medicine on 1 November 2025, sets out a structured framework to assess large language models (LLMs) before they are introduced into clinical workflows. The guidance responds to the rapid uptake of artificial intelligence (AI) tools for diagnostic support, medical documentation, and patient communication, and the corresponding need for consistent evaluation of safety, effectiveness, and fairness. The consensus formalizes retrospective evaluation—testing ...