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Making lighter work of calculating fluid and heat flow

2025-12-13
Tokyo, Japan – Scientists from Tokyo Metropolitan University have re-engineered the popular Lattice-Boltzmann Method (LBM) for simulating the flow of fluids and heat, making it lighter and more stable than the state-of-the-art. By formulating the algorithm with a few extra inputs, they successfully got around the need to store certain data, some of which span the millions of points over which a simulation is run. Their findings might overcome a key bottleneck in LBM: memory usage.   From rocket fuel and drainpipes to the inner workings of organisms, simulations of fluids ...

Normalizing blood sugar can halve heart attack risk

2025-12-13
For the first time, an international analysis has shown that when people with prediabetes bring their blood glucose back into the normal range through lifestyle changes, their risk of heart attack, heart failure, and premature death is cut in half. These findings could revolutionize prevention and establish a new, measurable target for clinical guidelines. Among others, researchers from University Hospital Tübingen, Helmholtz Munich, and the German Center for Diabetes Research (DZD) took part in the study.  Millions of people in Germany live with elevated blood glucose levels without knowing ...

Lowering blood sugar cuts heart attack risk in people with prediabetes

2025-12-13
Lowering blood sugar levels halves the likelihood of serious heart problems in people with prediabetes.  According to King’s College London research, published today in The Lancet Diabetes & Endocrinology, bringing blood glucose back to normal levels – effectively reversing prediabetes – cuts the risk of death from heart disease or hospital admission for heart failure by more than 50%.   This finding is especially important in light of recent research showing that lifestyle changes alone - including ...

Study links genetic variants to risk of blinding eye disease in premature infants

2025-12-12
OKLAHOMA CITY – A new study from the University of Oklahoma suggests that small genetic differences in two proteins – previously known for their role in premature infants’ lungs – may also influence how their eyes develop, potentially affecting the risk of retinopathy of prematurity (ROP). ROP is a serious eye disease that affects premature infants, whose retinas – the light-sensitive tissue at the back of the eye – are still developing when they are born. In some babies, the blood vessels in the retina grow abnormally, which can lead to vision problems or even blindness. ROP is the leading ...

Non-opioid ‘pain sponge’ therapy halts cartilage degeneration and relieves chronic pain

2025-12-12
SereNeuro Therapeutics, a preclinical biotechnology company developing non-opioid pain therapies, unveiled new data today on a novel approach to chronic pain management and joint tissue preservation. The data highlights SN101, a first-in-class induced pluripotent stem cell (iPSC)-derived therapy. SN101 utilizes mature iPSC-derived peripheral pain-sensing neurons (nociceptors) to treat chronic osteoarthritis joint pain. The data highlights a scientific approach that challenges traditional pain management logic. “Our approach utilizes high-purity, iPSC-derived nociceptors (SN101) that effectively function as a sponge for pain factors. By injecting SN101 ...

AI can pick up cultural values by mimicking how kids learn

2025-12-12
Artificial intelligence systems absorb values from their training data. The trouble is that values differ across cultures. So an AI system trained on data from the entire internet won’t work equally well for people from different cultures. But a new University of Washington study suggests that AI could learn cultural values by observing human behavior. Researchers had AI systems observe people from two cultural groups playing a video game. On average, participants in one group behaved more altruistically. ...

China’s ecological redlines offer fast track to 30 x 30 global conservation goal

2025-12-12
A new commentary in Environmental and Biogeochemical Processes proposes a practical pathway for countries to meet the global goal of protecting 30 percent of land and sea by 2030, known as the 30 × 30 target, by rethinking how existing ecological policies are counted and governed. Focusing on China, the authors argue that the country’s Ecological Protection Redline policy offers a ready model for turning ambitious maps into real conservation outcomes while balancing development needs. Turning redlines into real protection China’s Ecological Protection Redline system has legally identified about 32 percent of the ...

Invisible indoor threats: emerging household contaminants and their growing risks to human health

2025-12-12
Indoor dust, air and everyday products are exposing people to a growing mix of “new contaminants” inside homes, schools and workplaces, according to a new perspective published in the journal New Contaminants. The authors warn that these emerging chemicals may quietly increase the risk of heart disease, cancer and developmental problems while remaining largely unregulated and poorly monitored indoors. Hidden pollution indoors People now spend about 90 percent of their time indoors, yet most pollution research and standards still focus on outdoor air. The paper highlights that ...

Adding antibody treatment to chemo boosts outcomes for children with rare cancer

2025-12-12
Children with a rare form of cancer called neuroblastoma which hasn’t responded to initial treatment or that has relapsed may benefit from adding antibody treatment to usual chemotherapy, according to new results from a clinical trial.   The results of the BEACON phase 2 trial carried out by an international consortium of researchers, coordinated by the University of Birmingham’s Cancer Research UK Clinical Trials Unit. Published in the Journal of Clinical Oncology found that among children who have a high risk form cancer called neuroblastoma, using a monoclonal antibody treatment called dinutuximab beta ...

Germline pathogenic variants among women without a history of breast cancer

2025-12-12
About The Study: In this secondary analysis of the WISDOM trial, a randomized clinical trial that enrolled women without breast cancer ages 40 to 74, criteria-independent genetic testing in a pragmatic trial identified a substantial number of women with clinically actionable results, many of whom would not have qualified for genetic testing under current guidelines. These findings support broader access to genetic testing as part of personalized breast cancer risk assessment. Corresponding Author: To contact the corresponding author, Lisa Madlensky, ...

Tanning beds triple melanoma risk, potentially causing broad DNA damage

2025-12-12
Study analyzed thousands of medical records to compare melanoma rates in tanning bed users vs. non-users, and sequenced 182 skin biopsies from tanning bed users and controls Tanning bed users carried double the mutation burden of controls In users, mutations appeared even in body areas that don’t get much sun exposure CHICAGO ---Tanning bed use is tied to almost a threefold increase in melanoma risk, and for the first time, scientists have shown how these devices cause melanoma-linked DNA damage across nearly the entire skin surface, reports a new study led by Northwestern Medicine and University of California, San ...

Unique bond identified as key to viral infection speed

2025-12-12
UNIVERSITY PARK, Pa. — Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State reveals a deliberate imbalance in their shape that helps them infect their hosts.  The finding, the researchers say, not only illuminates a fundamental viral strategy but also opens doors for antiviral drug design and molecular delivery technologies critical for vaccines, cancer therapies, medication development and ...

Indoor tanning makes youthful skin much older on a genetic level

2025-12-12
Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age.   The study, which was led by UC San Francisco and Northwestern University, appears Dec. 12 in Science Advances.   “We found that tanning bed users in their 30s and 40s had even more mutations than people in the general population who were in their 70s and ...

Mouse model sheds new light on the causes and potential solutions to human GI problems linked to muscular dystrophy

2025-12-12
Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract. Although around 80% of people with DM1 experience GI problems that greatly reduce their quality of life, including difficulty swallowing, delayed stomach emptying, constipation and severe conditions like intestinal obstruction, the underlying causes remain understudied. To shed light onto the causes and potential solutions to ...

The Journal of Nuclear Medicine ahead-of-print tip sheet: December 12, 2025

2025-12-12
Reston, VA (December 12, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes. Summaries of the newly published research articles are provided below. Tracking Kidney Cancer Spread with a New Targeted Imaging Tool This study explored whether two biomarkers—CD70 ...

Smarter tools for peering into the microscopic world

2025-12-12
The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and the planet’s ecosystems. Yet even with modern DNA sequencing, figuring out what these microbes are and how they are related to one another remains extremely difficult. In a pair of new studies, researchers at Arizona State University introduce powerful tools that make this work easier, more accurate and far more scalable. One tool improves how scientists build microbial family trees. The other provides a software foundation used worldwide to analyze ...

Applications open for funding to conduct research in the Kinsey Institute archives

2025-12-12
The Kinsey Institute invites applications for two competitive research awards that provide in-person access to the Institute’s internationally renowned Library & Special Collections at Indiana University Bloomington. These awards support original scholarship drawing on one of the world’s most significant archives on sexuality, relationships, gender, and human behavior—spanning manuscripts, publications, fine art, photography, ephemera, and scientific data across disciplines including biology, medicine, psychology, anthropology, ...

Global measure underestimates the severity of food insecurity

2025-12-12
(Santa Barbara, Calif.) — Before you can address a problem, you need to understand its scope. That’s why the United Nations developed the Integrated Food Security Phase Classification System. Aid organizations rely on analyses from this global partnership, which monitors and classifies the severity of food insecurity to help target assistance where and when it is most needed. These analyses are multifaceted and complex — often taking place in regions where data is scarce and conditions are deteriorating — and stakeholders tend to assume ...

Child survivors of critical illness are missing out on timely follow up care

2025-12-12
When the unthinkable happens and a child is left critically ill or injured, the miracle workers in pediatric intensive care units around the country work tirelessly to save their lives. Yet, after discharge from the hospital, many of these children could be missing out on vital follow up care, finds a study from Michigan Medicine. “There aren't specific guidelines in terms of whether or when a child should follow up with their primary care physician or pediatrician after a stay in the PICU,” ...

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

2025-12-12
About The Study: In a randomized clinical trial, researchers found risk-based breast cancer screening was as safe as annual screening for detecting advanced cancers but did not reduce breast biopsy rates. Corresponding author Laura J. Esserman, MD, MBA, of the University of California, San Francisco, will present the study at the San Antonio Breast Cancer Symposium. Corresponding Author: To interview Dr. Esserman, contact UCSF Senior Public Information Representative Elizabeth Fernandez by ...

University of Toronto launches Electric Vehicle Innovation Ontario to accelerate advanced EV technologies and build Canada’s innovation advantage

2025-12-12
Toronto, Ontario - The University of Toronto today announced the launch of Electric Vehicle Innovation Ontario (EVIO), a new industry–academic partnership that will accelerate the development and commercialization of next-generation electric vehicle (EV) and mobility technologies. Led by the University of Toronto, in collaboration with seven other southern Ontario universities, EVIO will embed 37 highly skilled graduate researchers directly inside 20 Ontario EV and mobility companies. The researchers will work on real-world challenges in battery chemistry, charging reliability, power electronics, mobility software, cold-weather ...

Early relapse predicts poor outcomes in aggressive blood cancer

2025-12-12
Mature nodal T-cell lymphoma is a type of rare and aggressive blood cancer. Limited data make it difficult to identify high-risk patients or tailor treatment strategies, so most patients receive similar care despite differences in disease characteristics and outcomes. A new study led by investigators from PETAL Consortium at the Mass General Brigham Cancer Institute found that among patients who achieved a complete remission after initial chemotherapy treatment, survival was worse for those whose disease relapsed within 12 months of initial treatment, suggesting that alternative strategies are needed to benefit these patients. The results are published in Blood. “The study suggests ...

American College of Lifestyle Medicine applauds two CMS models aligned with lifestyle medicine practice and reimbursement

2025-12-12
The American College of Lifestyle Medicine (ACLM) applauds two new Centers for Medicare and Medicaid Services (CMS) models that could significantly reshape the landscape for lifestyle medicine practice and reimbursement. The first model, The Make America Healthy Again: Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence (MAHA ELEVATE) for Original Medicare, was announced Thursday, December 11, 2025. The model will provide approximately $100 million to fund three-year cooperative agreements for up to 30 proposals that promote ...

Clinical trial finds cannabis use not a barrier to quitting nicotine vaping

2025-12-12
Adolescent and young adult nicotine vaping has become an urgent public health concern, as 2024 marked the first year that nicotine vaping was the most initiated drug. Though vaping is the most common way young people use nicotine, few treatments exist to help those trying to quit. What’s more, a 2022 Drug Alcohol Dependence study reported around half of young people who vape nicotine also use cannabis, though the impact of this dual substance use on treatment outcomes remains unclear. A new clinical trial by investigators from Mass General Brigham found varenicline—a ...

Supplemental nutrition assistance program policies and food insecurity

2025-12-12
About The Study: In this cross-sectional study, adoption of state-level policies associated with higher Supplemental Nutrition Assistance Program (SNAP) participation was also associated with lower county-level food insecurity rates. Policies that lower barriers to SNAP participation may help address rising food insecurity rates observed in 2022 and 2023. Corresponding Author: To contact the corresponding author, Sameed Ahmed M. Khatana, MD, MPH, email sameed.khatana@pennmedicine.upenn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2025.5597) Editor’s ...
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