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Bad bacteria can trigger painful gut contractions; new research shows how

Bad bacteria can trigger painful gut contractions; new research shows how
2024-12-17
Downloadable assets for media use: https://uoregon.canto.com/b/MSHJ8 EUGENE, Ore. — Dec. 18, 2024 — After a meal of questionable seafood or a few sips of contaminated water, bad bacteria can send your digestive tract into overdrive. Your intestines spasm and contract, efficiently expelling everything in the gut — poop and bacteria alike. A new study from the University of Oregon shows how one kind of bacteria, Vibrio cholerae, triggers those painful contractions by activating the immune system. The research also finds a more general explanation for how the gut rids itself of unwanted intruders, which could also help scientists ...

Partnership advances targeted therapies for blood cancers

Partnership advances targeted therapies for blood cancers
2024-12-17
Huntsman Cancer Institute at the University of Utah (the U) has joined other institutions in an innovative clinical trials program designed to match patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with a clinical trial specifically designed for the genetic signature of their disease. Sponsored by the National Cancer Institute (NCI), the myeloMATCH program aims to improve precision medicine, the use of therapies ...

How loss of urban trees affects education outcomes

How loss of urban trees affects education outcomes
2024-12-17
It’s well established that urban tree cover provides numerous environmental and psychological benefits to city dwellers. Urban trees may also bolster education outcomes and their loss could disproportionately affect students from low-income families, according to new research by University of Utah social scientists. Economics professor Alberto Garcia looked at changes in school attendance and standardized test scores at schools in the Chicago metropolitan region over the decade after a non-native ...

New virtual reality-tested system shows promise in aiding navigation of people with blindness or low vision

2024-12-17
A new study offers hope for people who are blind or have low vision (pBLV) through an innovative navigation system that was tested using virtual reality. The system, which combines vibrational and sound feedback, aims to help users navigate complex real-world environments more safely and effectively. The research from NYU Tandon School of Engineering, published in JMIR Rehabilitation and Assistive Technology, advances work from John-Ross Rizzo, Maurizio Porfiri and colleagues toward developing a first-of-its-kind ...

Brain cells remain healthy after a month on the International Space Station, but mature faster than brain cells on Earth

Brain cells remain healthy after a month on the International Space Station, but mature faster than brain cells on Earth
2024-12-17
LA JOLLA, CA—Microgravity is known to alter the muscles, bones, the immune system and cogni­tion, but little is known about its specific impact on the brain. To discover how brain cells respond to microgravity, Scripps Research scientists, in collaboration with the New York Stem Cell Foundation, sent tiny clumps of stem-cell derived brain cells called “organoids” to the International Space Station (ISS). Surprisingly, the organoids were still healthy when they returned from orbit a month later, but the cells had matured faster compared ...

NIH grant funds study of cerebral small vessel disease

NIH grant funds study of cerebral small vessel disease
2024-12-17
Researchers at Washington University School of Medicine in St. Louis have been awarded $7.5 million from the National Institutes of Health (NIH) to investigate a form of dementia caused by cerebral small vessel disease, the second-leading cause of dementia after Alzheimer’s disease. The grant funds the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center, which is a National Institute of Neurological Disorders and Stroke “Center Without Walls” initiative that will coordinate researchers at six sites across ...

Paranoia may be, in part, a visual problem

2024-12-17
New Haven, Conn. — Could complex beliefs like paranoia have roots in something as basic as vision? A new Yale study finds evidence that they might. When completing a visual perception task, in which participants had to identify whether one moving dot was chasing another moving dot, those with greater tendencies toward paranoid thinking (believing others intend them harm) and teleological thinking (ascribing excessive meaning and purpose to events) performed worse than their counterparts, the study found. Those individuals more often — and confidently — claimed one dot was chasing the other when it wasn’t. The findings, published Dec. 17 in ...

The high cost of carbon

The high cost of carbon
2024-12-17
The social cost of carbon — an important figure that global policymakers use to analyze the benefits of climate and energy policies — is too low, according to a study led by the University of California, Davis. The study, published today in the journal Proceedings of the National Academy of Sciences (PNAS), shows that current estimates for the social cost of carbon, or SCC, fail to adequately represent important channels by which climate change could affect human welfare. When included, the SCC increases to just over $280 per ton of CO2 emitted in 2020 — more than double the ...

This mysterious plant fossil belongs to a family that no longer exists

This mysterious plant fossil belongs to a family that no longer exists
2024-12-17
In 1969, fossilized leaves of the species Othniophyton elongatum — which translates to “alien plant” — were identified in eastern Utah. Initially, scientists theorized the extinct species may have belonged to the ginseng family (Araliaceae). However, a case once closed is now being revisited. New fossil specimens show that Othniophyton elongatum is even stranger than scientists first thought.  Steven Manchester, curator of paleobotany at the Florida Museum of Natural History, has studied 47-million-year-old fossils from Utah for several years. While visiting ...

Physicists ‘bootstrap’ validity of string theory

Physicists ‘bootstrap’ validity of string theory
2024-12-17
String theory, conceptualized more than 50 years ago as a framework to explain the formation of matter, remains elusive as a “provable” phenomenon. But a team of physicists has now taken a significant step forward in validating string theory by using an innovative mathematical method that points to its “inevitability.”  String theory posits that the most basic building blocks of nature are not particles, but, rather, one-dimensional vibrating strings that move at different frequencies ...

Parents’ childhood predicts future financial support for children’s education

2024-12-17
UNIVERSITY PARK, Pa. — Childhood circumstances, such as parental divorce or growing up poor, have been shown to influence health and other outcomes later in life. But does a person’s experiences in childhood also influence their future ability to provide financial support to their children? According to a new study from a researcher from Penn State, parents who endured difficult childhoods provided less financial support to their children’s education such as college tuition compared to parents who experienced few or no disadvantages. Regardless of current socioeconomic ...

SFU study sheds new light on what causes long-term disability after a stroke and offers new path toward possible treatment

2024-12-17
A recent study from Simon Fraser University researchers has revealed how an overlooked type of indirect brain damage contributes to ongoing disability after a stroke. The paper, published in Proceedings of the National Academy of Sciences, shows how the thalamus – a sort of central networking hub that regulates functions such as language, memory, attention and movement – is affected months or years after a person has experienced a stroke, even though it was not directly damaged itself. The findings may lead to new therapies that could reduce the burden of chronic stroke, which remains one of the leading causes of disability in the world. “Our ...

More calories – more consumption: Individuals with and without obesity both prefer high-calories food

More calories – more consumption: Individuals with and without obesity both prefer high-calories food
2024-12-17
Higher calorie foods were preferred among individuals with and without obesity despite similar taste and texture, according to a study published December 17th in the open-access journal PLOS Biology by Albino Oliveira-Maia from the Champalimaud Foundation, Portugal, and colleagues. Eating sends signals to the brain with information about a food’s energy content, which can influence food preferences irrespective of flavor. People with obesity often have impairments in areas of the brain where dopamine ...

Astrophysics: Mystery of the ‘missing’ binary stars solved

2024-12-17
An international team of researchers led by PD Dr Florian Peißker has found the first binary star in the immediate vicinity of the supermassive black hole Sgr A* (Sagittarius A star) at the centre of our galaxy. Although it is known that most stars in the universe do not form alone, so far there are only five confirmed binary stars at a greater distance from the black hole. None of the systems are so close. The researchers assume that the binary star system they found, named D9, will merge into a single star in the near future. The discovery was published in Nature Communications under the title ‘A binary ...

Peptide-guided nanoparticles deliver mRNA to neurons

Peptide-guided nanoparticles deliver mRNA to neurons
2024-12-17
Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s. In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino ...

Sexual dimorphism in thermotherapy responses in APP/PS1 mice

Sexual dimorphism in thermotherapy responses in APP/PS1 mice
2024-12-17
“Passive thermotherapy positively modulates multiple physiological parameters and represents a nonpharmacological approach for potential disease modifying treatment.” BUFFALO, NY- December 17, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 21 on November 29, 2024, entitled, “Thermotherapy has sexually dimorphic responses in APP/PS1 mice.” Researchers Samuel A. McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz, Caleigh A. Findley, ...

First ever binary star found near our galaxy’s supermassive black hole

First ever binary star found near our galaxy’s supermassive black hole
2024-12-17
An international team of researchers has detected a binary star orbiting close to Sagittarius A*, the supermassive black hole at the centre of our galaxy. It is the first time a stellar pair has been found in the vicinity of a supermassive black hole. The discovery, based on data collected by the European Southern Observatory’s Very Large Telescope (ESO’s VLT), helps us understand how stars survive in environments with extreme gravity, and could pave the way for the detection of planets close to Sagittarius A*. “Black holes are not as destructive as we thought,” says Florian Peißker, a researcher at the University of Cologne, Germany, and lead author of the ...

Training solar panels to dance with the wind

Training solar panels to dance with the wind
2024-12-17
WASHINGTON, Dec. 17, 2024 – Solar power is currently the fastest growing energy sector worldwide. Solar photovoltaic power plants convert sunlight into electricity and their vast potential for producing clean, renewable energy make solar power a cornerstone of the NetZero Emissions by 2050 initiative, which seeks to cut carbon dioxide emissions to zero by the year 2050. Wind has both positive and negative effects on solar power grids. It helps maintain solar panel performance by eliminating the buildup of dirt and dust, and ...

Tiny robots, big impact: Revolutionizing infertility treatment with magnetic microrobots

Tiny robots, big impact: Revolutionizing infertility treatment with magnetic microrobots
2024-12-17
WASHINGTON, Dec. 17, 2024 — Infertility affects an estimated 186 million people worldwide, with fallopian tube obstruction contributing to 11%-67% of female infertility cases. In AIP Advances, from AIP Publishing, researchers at the SIAT Magnetic Soft Microrobots Lab have developed an innovative solution using a magnetically driven robotic microscrew to treat fallopian tube blockages. “This new technology offers a potentially less invasive alternative to the traditional surgical methods currently used to clear tubal obstructions, which often involve ...

City of Hope scientists uncover protein that helps cancer cells dodge CAR T cell therapy

City of Hope scientists uncover protein that helps cancer cells dodge CAR T cell therapy
2024-12-17
LOS ANGELES — Scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, have collared a tricky culprit that helps cancer cells evade CAR T cell therapy. CAR T cell therapy harnesses the immune system to seek out and kill tumor cells. This treatment is used in certain types of leukemia and lymphoma — blood cancers. Some wily cancer cells, however, have learned how to hide from the immune system to avoid destruction. The study published today in the journal Cell could lead to more personalized therapies that ...

Discouraged zebrafish help reveal how ketamine works in the brain

Discouraged zebrafish help reveal how ketamine works in the brain
2024-12-17
The decades-old anesthetic ketamine could be a game changer for treating severe depression, but there are still many questions about how the drug works, including exactly how it affects the brain’s cells and circuits. To help answer these questions, researchers are turning to an unlikely animal: tiny, days-old zebrafish. The millimeters-long, translucent zebrafish may not get depressed exactly like humans do, but the fish do exhibit a “giving up” behavior: they stop swimming after they realize they aren’t getting anywhere – a passive behavior that scientists use to study ...

Daily physical activity, sports participation, and executive function in children

2024-12-17
About The Study: In this cohort study of Dutch children, early-life moderate to vigorous physical activity was not associated with executive function in middle childhood. Children participating in team sports at ages 10 to 11 consistently exhibited superior executive function compared with participants in individual sports. Corresponding Author: To contact the corresponding author, Lu Yang, MSc, email l.yang@umcg.nl. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.49879) Editor’s Note: Please see ...

Biased language in clinical handoffs may negatively impact patient care

2024-12-17
When doctors and nurses pass patient information from one shift to another — an exchange known as a “handoff” — the specific words they use behind closed doors matter more than they might realize. A new study published in JAMA Network Open shows that when clinicians hear a patient described with negatively biased language, they develop less empathy towards the patient and, in some cases, become less accurate in recalling the patient’s critical health details. Such shifts in perception may be subtle and unintentional in many cases, but as these hidden biases stack up, they can influence the care patients ultimately receive. “A lot is going on here ...

Young English speakers are most comfortable with digital health

2024-12-17
Study shows how language, education and age affect someone’s ability to engage with digital health tools. Digital health tools, such as patient portals, treatment apps and online appointment schedulers, are increasingly common. But not everyone is equally at home using them.  To find out how language, education and age may affect a person’s comfort in using digital tools, UC San Francisco researchers surveyed caregivers of hospitalized children at UCSF Benioff Children’s Hospitals. The researchers found that being a Spanish speaker, having less education, and being older all made people feel less comfortable with digital health ...

Study maps bed bugs’ genomes in unprecedented detail to find out why they just won’t die

Study maps bed bugs’ genomes in unprecedented detail to find out why they just won’t die
2024-12-17
Scientists mapped near-gap-free and near-error-free genomes of a susceptible bed bug strain and a superstrain around 20,000 times more insecticide-resistant, offering the broadest look yet at the full scope of their resistance mutations. Their findings were published in the journal Insects. Although there is no evidence that bed bugs transmit diseases to humans, their bites can cause itchy rashes and secondary skin infections. Widespread use of insecticides, including the now-banned DDT, nearly wiped out populations of these blood-sucking insects by the 1960s, making infestations ...
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