PHILADELPHIA – A topical cream activated the skin’s immune defenses and suppressed tumor growth in two preclinical models of cutaneous squamous cell carcinoma (cSCC), one of the most common cancers in the world, according to a study published today in the Journal of Clinical Investigation. Developed by researchers at the Perelman School of Medicine at the University of Pennsylvania, the cream works by blocking LSD1, an enzyme that suppresses immune‑activating pathways in the skin. “What’s ...

The Stanley Family Foundation has renewed its commitment to psychiatric research at the Broad Institute, bringing its total investment to more than $1 billion. This funding, including their newest commitment of $280 million to the Stanley Center for Psychiatric Research, is opening up new paths to urgently needed therapies for schizophrenia and bipolar disorder.  For decades, scientists have struggled to understand the biological causes of psychiatric disorders as patients continue to face both stigma ...

Thursday, March 12, 2026, CLEVELAND: As the use of injectable GLP-1 drugs continues to rise, questions persist about what happens after patients stop taking them in real-world settings. A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing semaglutide and tirzepatide, on average, does not lead to significant weight regain in clinical practice, as many patients later restart the original medication or try an alternative obesity treatment. In one of the largest real-world studies to date ...

The American Meteorological Society, the United States professional society for weather, water, and climate, has submitted an official response to the National Science Foundation’s Dear Colleague Letter requesting information and feedback about restructuring science and observing facilities associated with the National Center for Atmospheric Research, which the Trump Administration has proposed to “dismantle.” The comment deadline is 13 March. The response outlines numerous ways that NCAR plays a central role in atmospheric and related sciences across the U.S. ...

Thanks to upstream diversions and climate change, Utah’s Great Salt Lake has shrunk by 70% since 1989, exposing about 800 square miles of playa and mudflats—along with numerous curiosities. While a potential environmental catastrophe, the lake’s dewatering presents numerous research opportunities for University of Utah geoscientists, including several who are looking to characterize the extent, characteristics, chemistry and flow of a mysterious, mostly freshwater aquifer under the playa. In a pair of studies coming out this year, a team led by geophysicist Mike Thorne deployed electrical resistivity tomography, or ERT, lines in 30 locations ...

Falls are one of the leading causes of injury and hospitalization among older adults, placing significant strain on individuals, families and the health-care system. And new research by UBC Okanagan’s Dr. Jennifer Davis shows that money spent to prevent additional falls and avoid significant injuries among older adults at high risk of future falls yields a strong return on the dollar. Dr. Davis is a Tier 2 Canada Research Chair in Applied Health Economics and an associate professor in UBCO’s Faculty of ...

Imagine waiting in line for a shot when someone who just got one tells you it was really painful. Could hearing that make the shot hurt more? According to a new Dartmouth study, what others say about an experience can shape how it actually feels. The findings, published in the Proceedings of the National Academy of Sciences, show that social information can influence how people experience negative events from physical pain to watching others in pain and performing mentally demanding tasks. "Our results suggest that ...

A team of researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC has identified important differences in how early Alzheimer’s disease-related brain changes appear across racial and ethnic groups, underscoring the need for more inclusive approaches to studying and diagnosing the disease. Their findings are now available in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. In a large, ...

A deep genetic mystery has baffled plant scientists for decades. Although leaves, stems, and flowers develop in strikingly similar ways across many plant species, scientists have struggled to identify the shared DNA instructions that guide their formation. A new study now uncovers this hidden regulatory code and shows that its core has been conserved for 300 million years of plant evolution. Remarkably, these ancient DNA sequences were hidden in plain sight but were obscured by the constant reshuffling and duplication of plant genomes. By uncovering this deep-time blueprint, the research reshapes our understanding of plant evolution, showing how core regulatory logic ...

With more than 100 million neurons in the digestive tract, the gut is commonly known as the “second brain” in numerous cultures, including ancient Greece, Japan, China and India, linking digestion with physical and mental well-being. Now, a new study from Emory University explains the gut-brain connection, indicating that live bacteria from the gut can directly enter the brain, with potential implications for neurological health. Published in PLOS Biology in March, this study, performed using mouse models, establishes that ...

HERSHEY, Pa. — Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, affecting 12%–13% of adolescents in the United States, according to some studies. The pattern of inattention, hyperactivity and impulsivity can interfere with daily life, raising problems at home, work or school. At the same time, individuals diagnosed with ADHD are at a higher risk of developing substance use disorder. But treating the combination of these two conditions can be complicated. A team, led by researchers from Penn State College of Medicine, identified a treatment gap among adolescents and young adults diagnosed with both ADHD and substance use disorder. In ...

Stark black against an open sky, common ravens are often spotted soaring above wolves in Yellowstone National Park. Researchers assumed that the notorious scavengers were following the wolves to get their scraps, but new research reveals a twist: Ravens don’t follow wolves, they remember common hunting grounds and regularly check back for fresh meat. When food is easy to find, animals save energy by memorizing the path to retrieving it. Because scavengers rely on other animals to eat, their meals are less predictable. Some scavengers contend with this insecurity by tailing predators, ...

New findings challenge the long-held idea that scavengers seeking food routinely follow predators to find it. Studying common raven, gray wolf, and cougar in Yellowstone National Park, researchers found that ravens rarely trail predators over long distances; instead, they rely on spatial memory to return to places where kills have occurred before. Scavenger species that rely on the kills of predators face the challenge of finding food that is patchily distributed, unpredictable, and often ephemeral because many animals compete for it. A widely accepted hypothesis suggests that scavengers solve this problem by adjusting their movements to follow large carnivores to their kills. Although scavengers ...

By tracking nearly every movement of a tiny fish’s life from adolescence to death, a new study reveals a hidden behavioral blueprint of aging – one that can predict a fish’s age or how long an individual will live. This is possible based on behavioral patterns visible early in life, researchers report. Aging in vertebrates unfolds over long and complex timescales and is influenced by a myriad of factors. Behavior provides a powerful window into an animal’s internal state and has been shown to reflect the aging process in several species, including humans. However, the ability to continuously ...

Contrary to previous assumptions, a new study finds that the needle-like lithium dendrites that grow in lithium (Li)-metal batteries are surprisingly strong and brittle, quite unlike soft bulk Li. According to the authors, understanding this brittle fracture behavior provides insights for suppressing dead Li formation and electrolyte cracking, enabling safer and more reliable Li-metal batteries. Li-metal anodes offer the highest specific capacity and the lowest electrochemical potential among all known anode materials, making them highly attractive for use in next-generation battery technologies. However, the use of Li-metal anodes poses significant safety challenges. During ...

By mapping the brains of seals and sea lions, researchers have uncovered specialized neural circuits that have evolved to support the control of complex vocal behavior and learning in the species. Humans are vocal learners, but they are not unique; some birds, bats and some marine mammals have demonstrated the ability to modify or acquire new vocalizations that fall outside of their inherited repertoire through experience or by mimicking novel sounds. Among marine mammals, pinnipeds, a group of mammals that includes seals (phocids) and sea lions (otariids), show clear behavioral evidence of different components of vocal flexibility, ranging from highly ...

By midlife, an animal’s everyday behaviors can signal how long it is likely to live.   That is the striking conclusion of a new study supported by the Knight Initiative for Brain Resilience at Stanford’s Wu Tsai Neurosciences Institute, in which researchers put scores of short-lived fish under continuous, lifelong surveillance to explore how behavior and aging are linked. Individual fish aged in markedly different ways, despite having similar genetics and living in a carefully controlled ...

ITHACA, N.Y. – A potted scarlet monkeyflower would die within a few days without water. But multiple natural populations of the species survived an extreme, four-year drought in California, and researchers now know why: The flowers were rescued by their own rapid evolution. In the study, under embargo until 2pm ET on March 12, 2026 in Science, researchers tracked scarlet monkeyflower populations in Oregon and California for more than a decade and found that the populations rapidly evolved in ...

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.  But now researchers at UC San Francisco have discovered that the SRC enzyme also appears like a flag on the surface of bladder, colorectal, breast, pancreatic and probably many other tumor cells.  As cancer cells furiously divide, they produce a lot of garbage. In healthy cells, the trash gets broken down. But in tumors, the recycling ...

PHILADELPHIA – A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer developed. The research, published today in Science, was led by physician-scientists in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center. It’s the first time scientists have shown that a medical intervention could stop growth of pre-cancerous ...

How does a tiny cluster of cells become an embryo with a head, trunk, and tail? And how do thousands of genes coordinate this development? A new imaging method makes it possible to visualize the activity of thousands of genes simultaneously throughout the entire zebrafish embryo. Using this technology, a research team at the University of Basel, Switzerland, has created an atlas of all genes and cells involved in turning a cluster of cells into an embryo. The interplay between genes and cells during the development of a fertilized egg into an embryo is highly complex. Previous methods captured gene activity only in 2D slices, making whole-embryo visualization impossible and ...

The study is published online in Science. It is led by Eva González-Suárez, researcher at the Spanish National Cancer Research Centre.   The team has unexpectedly discovered that cells from the brain defence system play a role in the sexual maturation process. The link between them is RANK, a protein involved in mammary development.   The research has been carried out in animal models, but it has also found genetic mutations associated with a rare syndrome related to infertility in humans. The kick off signal for puberty begins in the brain. Specifically, in the hypothalamus, where ...

For the first time, scientists have observed how tiny metal "thorns" called dendrites sprout inside lithium-ion batteries, which can cause the batteries to short-circuit. Their findings, published Mar. 12 in the journal Science, shed light on previously unknown mechanical properties of lithium dendrites as they grow. Scientists have long studied lithium dendrites, but did not fully understand how these structures behave inside batteries. Dendrites form at the nanoscale; their growth is challenging to observe in the closed system of a working battery, but has been linked to battery decline and failure. The new study, an international ...

A recent study suggests that bacteria thrive more readily on untreated than treated wood surfaces. The finding has implications for hygiene in both homes and public spaces. A University of Helsinki study investigated bacterial adhesion, survival and transmission on untreated and treated wood surfaces under both laboratory and field conditions. The laboratory work focused on Staphylococcus epidermidis, a bacterium that forms part of the skin’s normal microbiota; and Pseudomonas aeruginosa, ...

(MEMPHIS, Tenn. – March 12, 2026) – St. Jude Children’s Research Hospital today announced the appointment of Carsten Bönnemann, MD, as a faculty member to lead and chair the hospital’s newly created Department of Genomic and Translational Neuroscience.    Bönnemann, who specializes in pediatric neuromuscular and neurogenetic disorders, comes to St. Jude from the National Institutes of Health, where he served as a physician-researcher and chief of the Neuromuscular and Neurogenetic Disorders of ...