Cancer ravages both body and mind. If you’ve ever lost loved ones to the disease, you might recognize the physical and emotional changes cancer patients often endure during their final months. They seem drained of strength and spirit. Even people who’ve maintained a positive outlook throughout their lives can enter a state of despair. New research published in Science suggests apathy and lack of motivation are symptoms of a condition called cancer cachexia. Cold Spring Harbor Laboratory ...

In the largest study of its kind to date, a team of international researchers has investigated how pharmaceutical pollution affects the behaviour and migration of Atlantic salmon. The study, led by the Swedish University of Agricultural Sciences, revealed that commonly detected environmental levels of clobazam – a medication often prescribed for sleep disorders – increased the river-to-sea migration success of juvenile salmon in the wild. The researchers also discovered that clobazam shortened the time it took for juvenile salmon to navigate through two hydropower dams along their migration route – obstacles that typically ...

In a groundbreaking study published in Science, a research team led by Prof. YE Jian from the Institute of Microbiology of the Chinese Academy of Sciences has identified the first mechanism of citrus resistance to citrus greening disease, or huanglongbing (HLB). Utilizing artificial intelligence (AI), the team has also developed antimicrobial peptides that offer a promising therapeutic approach to combat the disease. This discovery addresses a long-standing challenge in the agricultural community—the absence of naturally occurring HLB-resistant genes in citrus. Citrus ...

 Local climate can be used to predict the venom characteristics of a deadly snake that is widespread in India, helping clinicians to provide targeted therapies for snake bite victims, according to a study publishing April 10 in the open-access journal PLOS Neglected Tropical Diseases by Kartik Sunagar and colleagues at the Indian Institute of Science. Russell’s viper (Daboia russelii) is found across the Indian subcontinent and is responsible for over 40% of snake ...

The fatigue and lack of motivation that many cancer patients experience near the end of life have been seen as the unavoidable consequences of their declining physical health and extreme weight loss. But new research from Washington University School of Medicine in St. Louis challenges that long-held assumption, showing instead that these behavioral changes stem from specific inflammation-sensing neurons in the brain. In a study published April 11 in Science, the researchers report that they identified a direct connection between cancer-related inflammation ...

Researchers had been studying the green alga Chlamydomonas reinhardtii for decades without seeing evidence of an active virus within it — until a pair of Virginia Tech researchers waded into the conversation. Maria Paula Erazo-Garcia and Frank Aylward not only found a virus in the alga but discovered the largest one ever recorded with a latent infection cycle, meaning it goes dormant in the host before being reactivated to cause disease.    “We’ve known about latent infections for a long time,” said Aylward, associate professor in the Department of Biological Sciences. ...

The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T-cells, are activated and proliferate during a viral infection. Their findings revealed novel mechanisms: the immune system amplifies its defense cells in a far more targeted way than previously believed. T-Cells Proliferate and Specialize During the Immune Response T-cells are crucial defense cells in the immune system. To effectively ...

Bioinformaticians from Heinrich Heine University Düsseldorf (HHU) and the university in Linköping (Sweden) have established that the genes in bacterial genomes are arranged in a meaningful order. In the renowned scientific journal Science, they describe that the genes are arranged by function: If they become increasingly important at faster growth, they are located near the origin of DNA replication. Accordingly, their position influences how their activity changes with the growth rate. Are genes distributed randomly along the bacterial chromosome, as if scattered from a salt shaker? This opinion, which is held by a majority of researchers, has ...

Artificial intelligence (AI) is playing an increasingly pivotal role in revolutionizing the field of engineering, triggering a new era of technological and industrial evolution. A series of recent breakthroughs in areas like natural language processing, computer vision, and machine learning, with the Nobel Prize-winning work in artificial neural networks and protein structure prediction serving as prime examples, have effectively bridged the gap between the physical and digital worlds. The emergence of general AI technologies, especially large language models, has given rise ...

Bacteria play key roles in degrading organic matter, both in the soil and in aquatic ecosystems. While most bacteria digest large molecules externally, allowing other community members to share and scavenge, some bacteria selfishly take up entire molecules before digesting them internally. In a paper publishing April 10 in the Cell Press journal Cell Reports, researchers document “selfish polysaccharide uptake” in freshwater ecosystems for the first time. In Croatia’s Kozjak and Crniševo Lakes, they found that nutrient hoarding allows selfish species ...

A team led by Satoya Nakano and Kengo Tachihara at Nagoya University in Japan has revealed new insights into the motion of massive stars in the Small Magellanic Cloud (SMC), a small galaxy neighboring the Milky Way. Their findings suggest that the gravitational pull of the Large Magellanic Cloud (LMC), the SMC’s larger companion, may be tearing the smaller one apart. This discovery reveals a new pattern in the motion of these stars that could transform our understanding of galaxy evolution and interactions. The results were published ...

Researchers at McMaster University have identified six key factors in the first three years of life that influence the trajectory of obesity in South Asian children. The findings offer parents, primary care practitioners and policymakers new insights into addressing childhood obesity for a group of children who have a higher prevalence of abdominal fat and cardiometabolic risk factors, as well as a predisposition to diabetes. “We know that current measures of childhood obesity such as the body mass index (BMI) don’t work well for South Asians because of the so called ‘thin-fat’ phenotype: South Asian newborns are characterized as low birth weight, but proportionally ...

Only 9.5% of plastic materials produced globally in 2022 were manufactured from recycled materials. The findings, reported in Communications Earth & Environment, are part of a comprehensive analysis of the global plastics sector, which also reveals a large increase in the amount of plastic being disposed of by incineration and substantial regional differences in plastic consumption. Plastic production has increased from two million tonnes per year in 1950 to 400 million tonnes per year in 2022 and ...

About The Study: In this cross-sectional survey study, although overall influenza vaccination rates changed little from 2019 to 2022, they increased substantially for Black and Hispanic older adults, particularly those in rural areas, and decreased for some groups of white older adults. Determining the reasons for these divergent changes in influenza vaccination rates is a high priority for future research. Corresponding Author: To contact the corresponding author, Marc N. Elliott, PhD, email elliott@rand.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.4462) Editor’s ...

About The Study: In this cohort study of children and adolescents, associations between neighborhood characteristics and mental health evolved from childhood through adolescence. These findings suggest that targeted interventions in disadvantaged neighborhoods and strategies to protect young children from air pollution are essential. A comprehensive approach is recommended to incorporate air pollution, green space, and socioeconomic status not only in residential neighborhoods but also in other settings, such as schools. Corresponding Author: To contact the ...

Background and objectives Patients with acute liver failure (ALF) or acute-on-chronic liver failure (ACLF) are at high risk of bleeding with traditional artificial liver support systems. To address the bleeding risk in liver failure patients, the safety of regional mesylate anticoagulation (RMA) in centrifugation artificial liver support systems (cALSS) is proposed for study. Methods In this prospective single-arm study, ALF and ACLF patients were treated with cALSS using RMA. Coagulation function was monitored, and the predictors of mesylate dose were analyzed ...

April 10, 2025, ONTARIO — A yearlong campaign from the Ontario Institute for Cancer Research (OICR) is celebrating the profound difference cancer research is making in the lives of Ontarians. Cancer Research Changed My Life showcases the people behind research discoveries, bringing their personal stories to life through videos and first-person testimonials. As the province’s cancer research institute, OICR brings together a community of scientists, cancer patients, clinicians and everyday Ontarians to solve cancer ...

Washington, April 10, 2025—The American Educational Research Association (AERA) has announced the winners of its 2025 awards for excellence in education research. “We are pleased to present the 2025 awards to this commendable and exemplary group of education scholars and champions,” said AERA Executive Director Felice J. Levine. “They have contributed tremendously to education research, across all career stages and fields, and continue to make a difference in the lives of students and educators.” AERA will honor the recipients at the Awards Ceremony Luncheon at the 2025 Annual Meeting in Denver on ...

A recent study published in Engineering presents a novel approach to predict Salmonella antimicrobial resistance, a growing concern for public health. The research, led by Le Zhang from Sichuan University, combines large language models (LLMs) and quantum computing to develop a predictive platform. Salmonella is a common foodborne pathogen. The overuse of antimicrobials and genetic mutations have led to the rise of antimicrobial-resistant Salmonella strains, making it crucial to predict resistance accurately for effective treatment. However, traditional methods like bacterial antimicrobial susceptibility tests (ASTs) are inefficient, ...

A study has resulted in the transplantation of 384 m² of Posidonia oceanica seagrass on the scale of an industrial project as part of maritime works in Monaco. This success challenges the idea that these ecosystems are "non-transplantable". This unprecedented experiment, conducted over a period of eight years, opens up new prospects for the preservation of seagrass meadows threatened by coastal urbanisation. As part of the construction project for the "Mareterra" district in Monaco, the marine works involved the destruction of several hectares of Posidonia oceanica meadows, an underwater plant essential to the Mediterranean ...

Everyone wants good quality healthcare, but what exactly is quality and how do you measure it? Is it to do with the waiting time for home care services? Or how many nursing home residents have had medical supervision in the past year? Or whether the medication lists have been checked recently? “These are important aspects that are all worth monitoring. The problem is that quality cannot be easily reduced to a quantifiable value,”said Randi Olsson Haave, an assistant professor and PhD research fellow at the Norwegian University of Science ...

Beijing (China) and Berlin (Germany) April 10, 2025 - Tsinghua University Press (TUP), the leading university press in China, and ResearchGate, the professional network for researchers, has announced an expansion of its Journal Home partnership, which was the first of its kind with a Chinese publisher last year. This expansion more than doubles TUP’s coverage, now including 11 open access titles. Since 1980, TUP has maintained a strong presence in China’s higher education, science, and technology sectors. The expanded partnership will increase the visibility of 10,000+ research articles, spanning nano research, AI, computing, ...

Background Therapy-related B-lymphoblastic leukemia (B-ALL) following treatment for multiple myeloma is a rare occurrence. Despite its rarity and the lack of recognition by the World Health Organization as a distinct disease entity, previous publications indicate its possible emergence following myeloma treatment. Case presentation The patient is a 65-year-old gentleman with a history of IgG kappa multiple myeloma, status post multiple lines of therapy. The patient presented with a fever, and a complete blood count showed cytopenia. Bone marrow morphologic evaluation revealed numerous blasts. ...

Helicobacter pylori (H. pylori) is a widespread bacterial infection associated with gastritis, peptic ulcers, and gastric cancer. While conventional antibiotic-based treatments have been the gold standard for eradication, their efficacy has been steadily declining due to the alarming rise in antibiotic resistance. This has spurred interest in alternative therapies, one of which is fecal microbiota transplantation (FMT). FMT is a novel therapeutic approach that involves transferring microbiota from a healthy donor to a patient’s ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent. Due to overlapping morphological, clinical, and immunophenotypic characteristics, distinguishing these disorders from related entities such as T-prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL), Sézary syndrome (SS), and aggressive NK-cell leukemia (ANKL) presents a significant diagnostic challenge. This review integrates recent molecular insights and updates from the WHO 5th edition ...