Preclinical study identifies Rb1 deficiency as key therapeutic vulnerability in a subset of breast cancers resistant to standard CDK4/6 inhibitors Drugs that may exploit this vulnerability are already in clinical trials Rb1-deficient cancers represent nearly 40% of triple-negative and estrogen receptor–positive tumors, which together account for roughly 20% of all breast cancers Rb1 status could also serve as an important predictive biomarker for other treatment strategies HOUSTON, DECEMBER 24, 2025 ― A new study published today in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center details a ...

Artificial intelligence (AI) is rapidly advancing across modern healthcare, yet its role in pediatric surgery remains limited and ethically complex. This study reveals that although surgeons recognize AI’s potential to enhance diagnostic precision, streamline planning, and support clinical decision-making, its practical use is still rare and mostly academic. Pediatric surgeons expressed strong concerns about accountability in the event of AI-related harm, the difficulty of obtaining informed consent for children, the risk of data privacy ...

Prescription stimulants, such as Ritalin and Adderall, are widely used to treat attention deficit hyperactivity disorder (ADHD), including in children. In the U.S., about 3.5 million kids ages 3 to 17 take an ADHD medication, a number that has increased as more children have been diagnosed with the neurodevelopmental disorder. Stimulant medications have long been thought to treat ADHD by acting upon regions of the brain that control attention, but a new study by researchers at Washington University School of Medicine in St. Louis casts doubt on that thinking. Led by Benjamin Kay, MD, PhD, an assistant professor of neurology, and Nico U. Dosenbach, ...

Scientists at HSE University have found that current AI models, including ChatGPT and Claude, tend to overestimate the rationality of their human opponents—whether first-year undergraduate students or experienced scientists—in strategic thinking games, such as the Keynesian beauty contest. While these models attempt to predict human behaviour, they often end up playing 'too smart' and losing because they assume a higher level of logic in people than is actually present. The study has been published in the Journal of Economic Behavior & Organization. In the 1930s, British economist John Maynard Keynes developed the theoretical ...

An international team, including researchers from HSE University, has created the first comprehensive map of quadruplexes—unstable DNA structures involved in gene regulation. For the first time, scientists have shown that these structures function in pairs: one is located in a DNA region that initiates gene transcription, while the other lies in a nearby region that enhances this process. In healthy tissues, quadruplexes regulate tissue-specific genes, whereas in cancerous tissues they influence genes responsible for cell growth and division. These findings may contribute to the development of new anticancer drugs that target quadruplexes. The study has been published in Nucleic ...

Researchers have developed experimental drugs that encourage the mitochondria in our cells to work a little harder and burn more calories. The findings could open the door to new treatments for obesity and improve metabolic health. Obesity is a global epidemic and a risk factor for many diseases, including diabetes and cancer. Current obesity drugs require injections and can cause side effects, so a safe way to boost weight loss could deliver significant public health benefits. The study, led by Associate Professor Tristan Rawling from the University of Technology Sydney (UTS), has just been published ...

Researchers at Osaka Metropolitan University have discovered a practical way to detect and fix common labeling errors in large radiographic collections. By automatically verifying body-part, projection, and rotation tags, their research improves deep-learning models used for routine clinical tasks and research projects. Deep-learning models using chest radiography have made remarkable progress in recent years, evolving to accomplish tasks that are challenging for humans such as estimating cardiac and respiratory function. However, AIs are only as good as the images ...

Even a low daily intake of alcohol—-just 9 g or around one standard drink—is linked to a 50% heightened risk of mouth (buccal mucosa) cancer in India, with the greatest risk associated with locally brewed alcohol, finds a large comparative study, published online in the open access journal BMJ Global Health.   And when combined with chewing tobacco, it likely accounts for 62% of all such cases in India, the findings suggest.   Mouth cancer is the second most common malignancy in India, with an estimated 143,759 new cases and 79,979 deaths every year. Rates ...

Members of the American Meteorological Society (AMS), the professional society for weather, water, and climate sciences and services, have elected Richard (Rick) Spinrad to the position of AMS president-elect for 2026, as well as electing five new council members.  Spinrad, an oceanographer, formerly served as U.S. Under Secretary of Commerce for Oceans and Atmosphere and the 11th administrator of the National Oceanic and Atmospheric Administration (NOAA). He will be inducted as president-elect on Sunday, 25 January, 2026, during the AMS’s 106th Annual Meeting in Houston, Texas.  The five newly elected AMS Council Members are Marilyn Averill, Julie Demuth, Jordan Gerth, ...

As countries around the world grapple with the challenge of achieving net-zero emissions, a newly released online webinar recording is drawing attention to one of the most promising and underappreciated climate solutions: biomass-based carbon capture. The full recording of the international seminar, held online on December 17, 2025, is now freely available on YouTube, offering researchers, policymakers, and the public an accessible deep dive into how nature’s carbon cycle can be harnessed for large-scale climate mitigation. The webinar, ...

  Invisible pollutants at the nanoscale are quietly entering bodies and ecosystems, yet standard toxicology tools still treat living organisms like a black box. A new perspective article in the journal New Contaminants describes how cutting edge bioimaging is turning that black box into a transparent map, revealing where these particles go and how they may harm health. Lighting up hidden nano pollution Emerging nanoscale contaminants such as engineered nanomaterials and nanoplastics are now found in water, soil, food and even the air we breathe, but their tiny size and complex behavior make them hard to track with traditional methods. Conventional ...

EMBARGOED FOR RELEASE UNTIL 4:00 P.M. ET, TUESDAY, DECEMBER 23, 2025 MINNEAPOLIS — A new study published on December 23, 2025, in Neurology®, the medical journal of the American Academy of Neurology, looks at how age may affect recovery for people with spinal cord injuries. “With population growth and improvements in medicine, the number of people diagnosed with spinal cord injury is increasing and the average age at the time of injury is rising,” said study author Chiara Pavese, MD, PhD, of the University of Pavia in Pavia, ...

A team led by investigators at Mass General Brigham and Dana-Farber Cancer Institute has developed and validated an artificial intelligence (AI)–based noninvasive tool that can predict the likelihood that a patient’s oropharyngeal cancer—a type of head and neck cancer that develops in the throat—will spread, thereby signaling which patients should receive aggressive treatment. The research is published in Journal of Clinical Oncology. “Our tool may help identify which patients should receive multiple interventions or would be ideal candidates for clinical trials of intensive strategies such ...

RIVERSIDE, Calif. -- A study led by biomedical scientists at the University of California, Riverside, has shown for the first time that a father’s exposure to microplastics (MPs) can trigger metabolic dysfunctions in his offspring. The research, conducted using mouse models, highlights a previously unknown pathway through which environmental pollutants impact the health of future generations. While MPs have already been detected in human reproductive systems, the study, published in the Journal of the Endocrine Society, is the first to bridge the gap between paternal ...

“The insights gained from this study not only validate OVCAR3 as a representative model for HGSOC, but also provide a foundation for developing targeted therapeutic strategies.” BUFFALO, NY — December 23, 2025 — A new research paper was published in Volume 12 of Oncoscience on October 14, 2025, titled “Bridging clinical insight and laboratory model in high-grade serous ovarian carcinoma (HGSOC) using DNA sequencing-based profiling of TP53.” In this study, Faisal Iqbal from the University ...

FAIRFAX, VA (Dec. 23, 2025)—Registration is open for the Society of Interventional Radiology (SIR) 2026 Annual Scientific Meeting. Join top interventional radiologists to shape the future of the specialty, April 11–15, 2026, at the Metro Toronto Convention Centre in Toronto, Ontario, Canada. More than just a conference, SIR’s Annual Scientific Meeting is a gathering place for a vibrant, inclusive community of more than 4,000 IR professionals—from those in training to seasoned experts. The scientific program ...

The International Society for Stem Cell Research (ISSCR) today announced the 10 most downloaded papers of 2025 from Stem Cell Reports, its peer-reviewed, open-access journal. Together, these highly read articles reflect the extraordinary scientific range of the field – from foundational mechanisms of pluripotency and differentiation to translational advances in regenerative medicine, disease modeling, and bioethics – and underscore the journal’s role as a trusted platform for impactful stem cell science. Engineered Proxies and the Illusion of De-Extinction A timely and widely discussed perspective examining recent claims of “de-extinction,” using dire ...

FOR IMMEDIATE RELEASE Oxford-led study estimates NHS spends around 3% of its primary and secondary care budget on the health impacts of heat and cold in England Analysis of 4.37 million patient records in England finds resources asymmetrically impacted by winter cold and summer heat, with about 64% linked to common cold days while very hot days drive sharp same-day demand surges A new University of Oxford-led study, published in The Lancet Planetary Health, is the first to link daily temperature data to health-care use and costs across primary and secondary care in England. Using ...

Since his postdoctoral days at MIT, Hang Yu, associate professor of materials science and engineering, has been wrestling with the challenge of creating a shape-memory ceramic that can be manufactured at scale without breaking. Now, in tandem with Ph.D. student Donnie Erb '15, M.S. '18 and postdoctoral researcher Nikhil Gotawala, he’s had a breakthrough. Yu’s team has used an advanced manufacturing technique called additive friction stir deposition to embed functional ceramic particles into metal. The result? A strong, defect-free material that can phase-shift under stress to dissipate energy and, unlike normally brittle ceramics, can be 3D-printed in ...

As cities grow and natural habitats shrink, urban wildlife must adapt to rapidly changing environments. A new study published in Insect Science shows that the guts of urban-dwelling wild bees contain detailed microbial signatures that reflect both bee health and the quality of the surrounding environment, offering a powerful new tool for monitoring ecological well-being in cities. Researchers at Xi’an Jiaotong-Liverpool University (XJTLU) used metagenomic sequencing of the solitary mason bee Osmia excavata to analyze dietary pollen, gut bacteria and viruses, ...

Older adults who live in economically disadvantaged neighborhoods spend significantly fewer days at home in the year after a fall-related hip fracture than those living in more affluent areas, according to a large national study published today in JAMA Network Open. The study analyzed Medicare data from more than 52,000 older adults who experienced a hip fracture. Researchers found that people living in the most disadvantaged neighborhoods spent about 23 fewer days at home during the year after their injury compared with those in the least disadvantaged areas after considering individual factors such as age or chronic illnesses.  “Neighborhood ...

About The Study: Commercial autonomous vehicle (AV) availability and adoption are underway and could impact national road traffic injuries. In this simulation study, potential injury reductions in the U.S. were forecasted using several scenarios based on real-world data. The results of this study suggest that AV adoption may reduce expected injuries; however, predicted confidence intervals remain broad for the baseline injury forecast, and none of the scenarios reduced expected injuries outside of these bounds.  Corresponding Author: To contact the corresponding author, Avery B. Nathens, MD, MPH, PhD, email avery.nathens@sunnybrook.ca. To access the embargoed study: Visit our For The ...

About The Study: In this serial cross-sectional study of nationally representative administrative data from 2016 to 2022, the rate of alcohol-related hospitalizations was stable while mortality, length of stay, and health care costs all increased. Preventive efforts are needed to improve outcomes and reduce health care spending by reducing population-level alcohol consumption and engaging patients in alcohol use disorder treatment before progression to alcohol-related hospitalizations. Corresponding Author: To contact the corresponding author, Eden Y. Bernstein, MD, MPH, email eden.bernstein@cuanschutz.edu. To access the embargoed ...

About The Study: In this prespecified exploratory analysis of the SELECT randomized clinical trial, the trial cohort had a high rate of hospital admissions. Treatment with once-weekly semaglutide was associated with significant reductions in hospital admissions and overall time spent in hospital, extending its benefits beyond cardiovascular risk reduction. Corresponding Author: To contact the corresponding author, Stephen J. Nicholls, MD, email stephen.nicholls@monash.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamacardio.2025.4824) Editor’s ...

Key points: A system which replicates the womb lining (endometrium) with high biological fidelity has been developed by researchers at the Babraham Institute and used to listen in to the communication that happens between the embryo and endometrium at the crucial stage of development when the embryo implants. Using donated endometrial tissue to seed the model, the approach provides the most advanced culture system for understanding how early-stage human embryos implant into the endometrium to establish ...