Real-world data from 7,938 patients show that stopping GLP-1 drugs leads to minimal average weight regain, with 45% of obesity patients continuing to lose weight or maintaining their loss at one year - largely because 47% restart medication or switch to alternatives.

The AMS has formally responded to NSF's request for feedback on restructuring NCAR, warning that dismantling the National Center for Atmospheric Research would undermine U.S. leadership in weather and climate science with severe consequences for public safety.

As Great Salt Lake has shrunk 70% since 1989, University of Utah scientists used electrical resistivity tomography to map the groundwater beneath 800 square miles of exposed playa, finding a surprisingly complex mosaic of fresh and saline water - and evidence of a rare convective instability.

A falls prevention clinic that added physiotherapist-led exercise to geriatrician care cut falls by 36% among high-risk older adults. The annual cost was $103,000 for the physiotherapist; the estimated healthcare savings were $956,288.

When participants were told others found an experience very painful, they rated the same low-intensity heat as more painful themselves. The effect persisted because of confirmation bias in learning - people favor evidence matching their expectations and discount the rest.

Black and Hispanic older adults showed higher tau levels in memory-related brain regions than white participants - even before amyloid plaque buildup. But the link between these proteins and memory decline varied across groups, suggesting Alzheimer's biomarkers may not apply equally to everyone.

Plants build leaves, stems, and flowers using strikingly similar developmental programs, yet shared regulatory DNA has been nearly impossible to find. A new computational tool called Conservatory reveals that core genetic instructions have persisted for 300 million years, hidden by constant genome reshuffling.

Mice fed a high-fat Western-style diet developed gut permeability that allowed live bacteria to travel through the vagus nerve into the brain - without entering the bloodstream. Similar low-level bacterial loads appeared in mouse models of Alzheimer's and Parkinson's disease.

Among 288,000 teens and young adults with both ADHD and substance use disorder, those receiving ADHD medication had fewer hospitalizations, overdoses, and suicidal thoughts, with a 30% lower five-year mortality risk. Yet stimulant prescriptions dropped 15-17% after a substance use diagnosis.

Contrary to longstanding assumption, ravens don't follow wolves to food. GPS tracking across Yellowstone shows the birds use spatial memory to revisit high-kill-density areas, flying over 150 km on direct paths to landscapes where wolves frequently hunt.

A 2.5-year GPS study in Yellowstone found ravens rarely follow wolves over long distances. Instead, they rely on spatial memory, returning to areas with historically high kill density from distances exceeding 150 kilometers.

By recording nearly every movement of African turquoise killifish across their entire lives, researchers built a machine learning model that estimates age and predicts lifespan from daily activity patterns alone - with long-lived fish showing distinct behaviors from just weeks old.

Contrary to previous assumptions, a new study finds that the needle-like lithium dendrites that grow in lithium (Li)-metal batteries are surprisingly strong and brittle, quite unlike soft bulk Li. According to the authors, understanding this brittle fracture behavior provides insights for suppressing dead Li formation and electrolyte cracking, enabling safer and more reliable Li-metal batteries. Li-metal anodes offer the highest specific capacity and the lowest electrochemical potential among all known anode materials, making them highly attractive for use in next-generation battery technologies. However, the use of Li-metal anodes poses significant safety challenges. During ...

By mapping the brains of seals and sea lions, researchers have uncovered specialized neural circuits that have evolved to support the control of complex vocal behavior and learning in the species. Humans are vocal learners, but they are not unique; some birds, bats and some marine mammals have demonstrated the ability to modify or acquire new vocalizations that fall outside of their inherited repertoire through experience or by mimicking novel sounds. Among marine mammals, pinnipeds, a group of mammals that includes seals (phocids) and sea lions (otariids), show clear behavioral evidence of different components of vocal flexibility, ranging from highly ...

By midlife, an animal’s everyday behaviors can signal how long it is likely to live.   That is the striking conclusion of a new study supported by the Knight Initiative for Brain Resilience at Stanford’s Wu Tsai Neurosciences Institute, in which researchers put scores of short-lived fish under continuous, lifelong surveillance to explore how behavior and aging are linked. Individual fish aged in markedly different ways, despite having similar genetics and living in a carefully controlled ...

ITHACA, N.Y. – A potted scarlet monkeyflower would die within a few days without water. But multiple natural populations of the species survived an extreme, four-year drought in California, and researchers now know why: The flowers were rescued by their own rapid evolution. In the study, under embargo until 2pm ET on March 12, 2026 in Science, researchers tracked scarlet monkeyflower populations in Oregon and California for more than a decade and found that the populations rapidly evolved in ...

For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it only appeared on the inside of cells, where it sent signals that fueled tumor growth and stayed hidden from the immune system.  But now researchers at UC San Francisco have discovered that the SRC enzyme also appears like a flag on the surface of bladder, colorectal, breast, pancreatic and probably many other tumor cells.  As cancer cells furiously divide, they produce a lot of garbage. In healthy cells, the trash gets broken down. But in tumors, the recycling ...

PHILADELPHIA – A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer developed. The research, published today in Science, was led by physician-scientists in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center. It’s the first time scientists have shown that a medical intervention could stop growth of pre-cancerous ...

How does a tiny cluster of cells become an embryo with a head, trunk, and tail? And how do thousands of genes coordinate this development? A new imaging method makes it possible to visualize the activity of thousands of genes simultaneously throughout the entire zebrafish embryo. Using this technology, a research team at the University of Basel, Switzerland, has created an atlas of all genes and cells involved in turning a cluster of cells into an embryo. The interplay between genes and cells during the development of a fertilized egg into an embryo is highly complex. Previous methods captured gene activity only in 2D slices, making whole-embryo visualization impossible and ...

The study is published online in Science. It is led by Eva González-Suárez, researcher at the Spanish National Cancer Research Centre.   The team has unexpectedly discovered that cells from the brain defence system play a role in the sexual maturation process. The link between them is RANK, a protein involved in mammary development.   The research has been carried out in animal models, but it has also found genetic mutations associated with a rare syndrome related to infertility in humans. The kick off signal for puberty begins in the brain. Specifically, in the hypothalamus, where ...

For the first time, scientists have observed how tiny metal "thorns" called dendrites sprout inside lithium-ion batteries, which can cause the batteries to short-circuit. Their findings, published Mar. 12 in the journal Science, shed light on previously unknown mechanical properties of lithium dendrites as they grow. Scientists have long studied lithium dendrites, but did not fully understand how these structures behave inside batteries. Dendrites form at the nanoscale; their growth is challenging to observe in the closed system of a working battery, but has been linked to battery decline and failure. The new study, an international ...

A recent study suggests that bacteria thrive more readily on untreated than treated wood surfaces. The finding has implications for hygiene in both homes and public spaces. A University of Helsinki study investigated bacterial adhesion, survival and transmission on untreated and treated wood surfaces under both laboratory and field conditions. The laboratory work focused on Staphylococcus epidermidis, a bacterium that forms part of the skin’s normal microbiota; and Pseudomonas aeruginosa, ...

(MEMPHIS, Tenn. – March 12, 2026) – St. Jude Children’s Research Hospital today announced the appointment of Carsten Bönnemann, MD, as a faculty member to lead and chair the hospital’s newly created Department of Genomic and Translational Neuroscience.    Bönnemann, who specializes in pediatric neuromuscular and neurogenetic disorders, comes to St. Jude from the National Institutes of Health, where he served as a physician-researcher and chief of the Neuromuscular and Neurogenetic Disorders of ...

To understand how professional networks contribute to persistent gender disparities in corporate leadership, researchers analyzed data from more than 19,000 corporate employees over 20 years. Publishing March 12 in the Cell Press journal Patterns, their results show that educational, employment, and social networks matter for both men and women, but women rely on more complex social networks to reach director-level positions than men. Women with professional ...

Mass General Brigham study results signal a call to do further research into the connection between vitamin D supplementation and long COVID In a large, randomized trial, researchers at Mass General Brigham have found that high-dose vitamin D3 did not reduce COVID-19 infection severity, but may impact long COVID outcomes. Results of the study are published in The Journal of Nutrition. “There’s been tremendous interest in whether vitamin D supplements can be of benefit in COVID, and this is one of the largest and most rigorous randomized trials on the subject,” said senior author JoAnn Manson, MD, DrPH, ...