A randomized trial found that continuing GLP-1/GIP agonists before upper endoscopy increased clinically significant residual gastric volume, but a clear-liquid diet the day before may mitigate the risk regardless of medication use.

A 140-patient NIH-supported trial found that weekly injectable extended-release buprenorphine produced significantly higher rates of illicit opioid abstinence during pregnancy than daily sublingual buprenorphine, with fewer serious adverse events and comparable neonatal outcomes.

Insilica's ToxIndex platform uses AI agents to orchestrate over 600 toxicology models and a 60-billion-triple knowledge graph, producing traceable risk assessments that could reshape how chemicals and drugs are evaluated for safety.

A new polygenic risk score built from 20 metabolic traits and multi-ancestry genetic data predicts type 2 diabetes, obesity, and downstream complications better than existing models, identifying people twice as likely to need GLP-1 drugs or bariatric surgery.

A Guilin University team created lead-free tungsten bronze ceramics that achieve 7.93 J/cm3 energy density at 94.25% efficiency with ultrafast 1.56-microsecond discharge times, maintaining performance across a 30-180 degrees C temperature range.

Researchers used machine learning to screen 660,000 candidate compositions and identified a BaTiO3-based high-entropy ceramic that achieves an energy storage density of 10.8 J per cubic cm with 86% efficiency - a result enabled by its unusual position between two types of ferroelectric behavior.

A review in Future Integrative Medicine examines clinical evidence for traditional Chinese medicine as an add-on treatment for febrile neutropenia, a dangerous chemotherapy complication with 9.5% mortality that current standard care cannot always manage.

Researchers at Kunming University developed tantalate high-entropy ceramic coatings that endured 614 thermal shock cycles at 1500 degrees C and 12,830 fatigue cycles at 1150 degrees C while keeping a stable crystal structure - outperforming current YSZ coatings limited to 1200 degrees C.

JMIR Publications has appointed Dr. Sara Simblett, a clinical academic specializing in digital health innovation and patient engagement, as the new editor in chief of JMIR Neurotechnology.

SwRI received a US Air Force Academy contract to develop and characterize eddy current inspection methods that can detect cracks in aircraft bolt holes through installed bushings, eliminating the risk of damage from removal.

When researchers fed 719 scientific hypotheses to ChatGPT ten times each, the AI answered correctly 76-80% of the time overall but was only 60% better than random chance, and gave contradictory answers to identical prompts in many cases.

Obesity among US high school students rose from 13.7% to 15.9% between 2013 and 2023, while the proportion attempting weight loss fell from 47.7% to 44.5%, according to CDC survey data analyzed by Florida Atlantic University researchers.

The largest study of its kind in livestock maps where gene promoters and enhancers sit in the sheep genome, offering breeders tools to select for beneficial traits while avoiding unintended harm to other tissues.

Despite growing recognition that elevated Lp(a) is an independent cardiovascular risk factor, a new study shows that clinicians seldom initiate lipid-lowering therapy after detecting high levels - even when results suggest increased danger.

Researchers at Jeonbuk National University developed a clustering-based machine learning framework that trains one model per group of hydrologically similar stations, enabling accurate water level forecasts even where historical records are sparse.

Simulations from six global models show that aggressive climate mitigation (1.5C target) could put 56 million more people at risk of hunger by 2050 through higher food prices. But the same policies reduce ozone pollution, boosting crop yields enough to offset about 15% of that increase - with 56% of benefits concentrated in Sub-Saharan Africa and India.

Oxford-led research identifies L 98-59 d as a potential new class of exoplanet - one sustaining a permanent magma ocean that stores massive sulfur reserves and maintains a thick, hydrogen-sulfide-rich atmosphere. Published in Nature Astronomy, the finding suggests planetary diversity may be greater than current models allow.

University of Edinburgh scientists engineered E. coli bacteria to convert PET plastic waste into L-DOPA, a frontline Parkinson's disease medication. Published in Nature Sustainability, the process breaks PET into terephthalic acid, which bacteria then transform through a series of biological reactions into the drug.

The Alliance for Clinical Trials in Oncology is launching a phase III trial testing whether adding vorasidenib, a brain-penetrant IDH inhibitor, to standard temozolomide chemotherapy after radiation improves progression-free survival in newly diagnosed grade 3 IDH-mutant astrocytoma. The study aims to enroll 400 patients.

The NIH-funded Baby CHAMP trial compared three intensive therapies for infants with unilateral cerebral palsy: two forms of constraint-induced movement therapy and bimanual training. All three produced significant, lasting improvements in hand function, with gains continuing six months after treatment ended. No approach proved superior.

A University of Michigan national poll of 1,780 parents found that over half witnessed unsafe driving by their teen or young adult, yet 96% rated their child as an average or better driver. Only one in four took corrective action, despite one in three worrying their child could cause a crash.

Researchers mapped cellular mechanisms behind fibrosis in Crohn's Disease, finding that endothelial cells cluster around immune aggregates in the submucosa and signal fibroblasts to overproduce collagen. Published in The Journal of Pathology, the work identifies potential therapeutic targets for a complication that currently requires surgery.

Researchers at Osaka Metropolitan University used lipocalin-type prostaglandin D synthase (L-PGDS) as a novel carrier for Paclitaxel, improving the drug's solubility 3,600-fold and achieving sustained antitumor effects in a mouse breast cancer model even after treatment stopped.

Researchers at Doshisha University developed DUPGT-CDR, a deep learning framework that separately processes positive and negative user ratings to improve recommendations for new-platform users. Tested on Amazon review data, it reduced prediction errors by up to 20.9% compared to existing cross-domain methods.

A study of 1.1 million Ontario births found that extending monitoring for severe maternal morbidity from labor and delivery to the full period from conception through six weeks postpartum captured over 40% more cases. Sixteen percent occurred prenatally and 29% postpartum - periods largely invisible to current Canadian surveillance.