STANFORD, California, USA, 10 June 2025 – In a compelling Genomic Press Interview published today in Brain Medicine, Sophia Shi, PhD, unveils her pioneering research that fundamentally changes our understanding of brain aging and opens revolutionary therapeutic pathways for Alzheimer's disease and related neurodegenerative conditions. Uncovering the Brain's Hidden Shield Dr. Shi's groundbreaking work focuses on the glycocalyx, a complex "forest" of sugar molecules coating blood-brain barrier endothelial cells. Her research, recently published in Nature, ...

MILAN, Italy, 10 June 2025 -- In a revealing Genomic Press Interview published today in Brain Medicine, Sara Poletti, PhD, senior researcher at IRCCS Ospedale San Raffaele Milan, illuminates the profound connections between childhood adversity and lifelong vulnerability to psychiatric disorders through persistent neuroinflammation pathways and alterations in brain structure. Bridging Psychology and Neurobiology Dr. Poletti's groundbreaking research has transformed understanding of how early life experiences become biologically embedded, creating lasting changes in brain structure and immune function. As ...

NEW YORK, New York, USA, 10 June 2025 -- In a comprehensive Genomic Press Interview published today in Brain Medicine, John M. Oldham, MD, MS, one of psychiatry's most influential architects of personality disorder theory, traces his remarkable journey from frontier medicine roots in Oklahoma to revolutionizing how mental health professionals understand and diagnose personality pathology. Transforming Diagnostic Paradigms Dr. Oldham's contributions have fundamentally reshaped personality disorder classification, moving the field from rigid diagnostic categories toward a more nuanced dimensional system. As former President of both ...

The stem cell-based embryo model (SCBEM) takes advantage of the flexibility of pluripotent stem cells (non-reproductive cells that can give rise to many different types of cells) to resemble that of embryos. While this model has helped to advance research in diseases and develop therapies or treatments, it has also sparked international debate on what regulations should be placed on this type of experimentation. Researchers reviewed what countries are doing to regulate SCBEM and proposed what regulation should look like for this field of stem cell research to ...

When volcanoes are preparing to erupt, scientists rely on typical signs to warn people living nearby: deformation of the ground and earthquakes, caused by underground chambers filling up with magma and volcanic gas. But some volcanoes, called ‘stealthy’ volcanoes, don’t give obvious warning signs. Now scientists studying Veniaminof, Alaska, have developed a model which could explain and predict stealthy eruptions.  “Despite major advances in monitoring, some volcanoes erupt with little ...

Whether it's electric vehicles, drones, or spacecraft, a common technical challenge for future transportation is lightweighting. Reducing the weight of a vehicle not only reduces energy consumption, but also increases battery efficiency and increases range. This is considered a key technology that is directly linked to sustainability, as it improves the performance of the system as a whole and thus contributes to reducing carbon emissions. Electric motors in particular are an essential component of most electric mobility vehicles, and coils account for a large ...

Understanding how genes behave within their native tissue environment is unlocking new frontiers in medical science. A recent review highlights how spatial transcriptomics—a technique that visualizes gene activity in situ—is reshaping the study of bones, muscles, and connective tissues. By linking gene expression patterns to their precise spatial locations, researchers can now explore how cellular environments influence development, disease, and healing. This new approach offers unprecedented resolution in musculoskeletal research, enabling ...

Opening any new North Sea oil and gas fields is incompatible with achieving the Paris Climate Agreement goals of limiting warming to 1.5°C or holding warming to “well below 2°C” relative to preindustrial levels, finds a new report published by UCL academics. Researchers behind the study, based at the UCL Energy Institute, UCL Department of Political Science and UCL Policy Lab, are now calling on the UK Government to stop licensing new oil and gas exploration, and refuse development consent for already-licensed ...

A series of digital tests, carried out via a smartphone app, could enhance the detection of disease progression in Huntington’s disease and improve the efficiency of clinical trials, finds research led by scientists at University College London (UCL) and Roche. The research, published in Brain, highlights how digitising tests designed to measure the progression of motor symptoms in people with Huntington’s disease can provide a sensitive and reliable way to track changes in the function of patients. Once participants have completed five simple tests of movement control, including assessment of balance, finger tapping and ...

Patients with womb cancer are not being tested for a genetic condition that increases their chance of developing further cancers, a study has found. Despite NHS guidance, less than half of those eligible received a blood test for Lynch syndrome, an inherited condition that leaves individuals more susceptible to womb and bowel cancer. Diagnosis of Lynch syndrome is important as it enables patients to take action to reduce their cancer risk, improving outcomes and reducing NHS costs, experts say. Lynch syndrome affects one in 300 people, but as little ...

About The Study: The findings of this cross-sectional study suggest substantial cost shifting in veterans’ surgical care from Medicare Advantage to Veterans Health Administration among high-veteran Medicare Advantage plans, underscoring the urgent need for policy reforms to improve the efficiency of veterans’ care. Corresponding Author: To contact the corresponding author, Jose F. Figueroa, MD, MPH, email jfigueroa@hsph.harvard.edu. To access the embargoed study: Visit our For The Media ...

A new multi-university study co-authored by Texas A&M University’s Dr. Shrihari Sridhar and alumnus Dr. Muzeeb Shaik of Indiana University reveals that fatal school shootings have far-reaching consequences beyond the immediate tragedy, altering daily life and disrupting economies in affected communities for months. The research, published in the Journal of Marketing Research, provides the first large-scale empirical evidence that fatal school shootings are linked to a measurable decline in consumer activity, especially in public spaces like grocery stores and restaurants. The study found that in the months following a fatal school shooting, grocery spending declines ...

APA 2025, the annual convention of the American Psychological Association, will be held Aug. 7-9 at the Colorado Convention Center in Denver. The meeting will feature hundreds of sessions – including main stage events, keynote lectures, symposia and posters – and will have a limited virtual component. Media registration is now open and complimentary for credentialed reporters. Sessions will cover such topics as: Potential for psychedelic drugs for clinical therapy and fighting addiction Systems-level strategies for addressing the youth mental health crisis The role of artificial intelligence in shaping the future of work, education and autonomous technologies The ...

Embargoed for release until 5:00 p.m. ET on Monday 9 June 2025    Follow @Annalsofim on X, Facebook, Instagram, threads, and LinkedIn         Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.    ----------------------------       1. ...

Some queens don’t rule nonstop. A new study from the University of California, Riverside shows that even bumble bee queens, the sole founders of their colonies, take regular breaks from reproduction—likely to avoid burning out before their first workers arrive. In the early stages of colony building, bumblebee queens shoulder the entire workload. They forage for food, incubate their developing brood by heating them with their wing muscles, maintain the nest, and lay eggs. It’s a high-stakes balancing act: without the queen, ...

University of Michigan researchers have helped develop a method to take carbon dioxide, an industrial waste product that pollutes the atmosphere and turn it into something useful: precursors to make cement.   U-M chemist Charles McCrory and his research group, along with Jesús Velázquez's lab at the University of California, Davis and Anastassia Alexandrova's lab at the University of California, Los Angeles, have developed a method to capture carbon dioxide and turn it into metal oxalates, which then can be used as precursors for ...

Between 12–15 May 2025, the SELINA partners, including scientists, decision-makers, and ecosystem service experts, gathered in Ponta Delgada, Azores for the 5th SELINA thematic Workshop, hosted at the University of the Azores. The event brought together approximately 80 in-person attendees and 10 online participants, marking the first in-person SELINA Consortium meeting in nearly a year, a timely and welcome opportunity to reconnect and refocus the project’s collaborative efforts. The central theme of the ...

BIRMINGHAM, Ala. – Cocaine, a drug of abuse, activates just a portion — 10 to 20 percent — of the neurons in the brain’s nucleus accumbens, a critical region linked to motivation and addiction. Though small in numbers, this activated neuronal population strongly controls drug-related behavior through downstream changes in gene expression, nerve synapses, neural circuitry and neural function that lead to behavioral change, including addiction. In a study published in Science Advances, University of Alabama at Birmingham researchers led by Kasey Brida and Jeremy Day, Ph.D., report that the secreted glycoprotein reelin is a marker for those nucleus accumbens neurons ...

Creatine, the supplement popular with athletes for its ability to help build strength and power, is increasingly being recognized for its broad health benefits. The compound’s usefulness extends well beyond the gym, according to Dr. Richard Kreider, professor and director of the Exercise & Sport Nutrition Lab at Texas A&M University. Kreider has spent more than 30 years investigating the effects of creatine, a naturally occurring compound stored in the muscle that combines with phosphate to form creatine phosphate, which ...

Coordinated behaviors like swarming – from ant colonies to schools of fish – are found everywhere in nature. Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have given a nod to nature with a next-generation robot system that’s capable of movement, exploration, transport and cooperation. A study in Science Advances describing the new soft robotic system was co-led by L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics, Physics, and Organismic and Evolutionary Biology ...

Age-related macular degeneration (AMD) is a major cause of blindness, especially in older adults. A key feature of early AMD is the formation of drusen, clumps of debris made of lipids and proteins that collect between two layers at the back of the eye — the retinal pigment epithelium (RPE) and Bruch’s membrane (BrM). These drusen are not just signs of the disease; they actively contribute to vision loss by damaging the retina above them. Scientists suspect that lipoproteins — fat-protein complexes like high density lipoprotein (HDL) — play a big role in forming drusen. However, it wasn’t clear why these lipoproteins get stuck in BrM in the first place. This ...

University of Connecticut professor of anthropology Dimitris Xygalatas is a scientist and self-declared rational thinker. But he’s also a lifelong soccer fan, and he fully admits that when his Greek home team finally won their league in 2019, he cried tears of joy. “Not what you might call a rational organism’s behavior,” he jokes. But his reaction is in keeping with his latest study, to be published online Monday, June 9, in the Proceedings of the National Academy of Sciences, which shows that the intense feelings of joy, ...

Northwestern University biophysicists have developed a new computational tool for identifying the gene combinations underlying complex illnesses like diabetes, cancer and asthma. Unlike single-gene disorders, these conditions are influenced by a network of multiple genes working together. But the sheer number of possible gene combinations is huge, making it incredibly difficult for researchers to pinpoint the specific ones that cause disease. Using a generative artificial intelligence (AI) model, the new method amplifies limited gene expression data, enabling ...

As solar energy becomes more affordable and widespread, farmland has emerged as a prime location for large-scale solar development. But with this expansion comes a persistent question: Do nearby property values suffer when solar farms move in? In a new paper published in the Proceedings of the National Academy of Sciences, researchers in Virginia Tech’s Department of Agricultural and Applied Economics in the College of Agriculture and Life Sciences looked at millions of property sales and thousands of commercial solar sites to shed some light on one of the mostly commonly cited downsides of large-scale solar adoption.  “As the ...

ANN ARBOR, Michigan — A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer – and offers a potential pathway for new treatments.   High-grade serous carcinoma, the most common type of ovarian cancer, usually begins in the fallopian tube, before spreading to the ovaries and other pelvic organs. The cancer is typically discovered at an advanced stage and becomes resistant to current chemotherapies. Its underlying genetics are complex, with multiple genetic alterations and instabilities. One of the genes involved is CDK12.   In this new study, published in the Proceedings ...