Analysis of multiple prostate cancer genomics datasets found that MYC-amplified metastatic tumors yield significantly fewer adaptive immune receptor recombination reads, suggesting reduced immune infiltration that may predict poor response to immunotherapy. Published in Oncoscience.

Researchers at Arc Institute and Stanford traced memory loss in aging mice to Parabacteroides goldsteinii, a gut bacterium that produces metabolites triggering inflammation that silences vagus nerve signaling to the hippocampus. GLP-1 agonists and vagus nerve stimulation restored youthful cognition.

Stanford Medicine researchers traced age-related memory loss in mice to a specific gut bacterium whose metabolites inflame intestinal immune cells, silencing vagus nerve signals to the hippocampus. Reactivating the nerve restored cognitive performance to youthful levels.

A multi-center study in Nature found that newborns who develop severe E. coli infections have markedly lower levels of maternal antibodies against the bacterium. In mice, a commercially available probiotic given before pregnancy stimulated antibodies that protected pups from infection.

Children first exposed to H3N2 influenza develop cross-reactive antibodies that bind poorly to H1N1 and can interfere with more potent neutralizing responses. A single amino acid difference explains the failure. Published in Nature.

Dana-Farber/Boston Children's researchers mapped the spatial organization of aggressive childhood brain tumors, finding that cancer cells form distinct communities with specialized roles. Published in Nature, the work could guide targeted therapies for tumors that frequently recur after surgery.

Mass General Brigham researchers developed INSTALL, a method that wraps gene-sized DNA in mostly single-stranded circles that dodge immune detection. In mice, the approach safely inserted large genetic payloads into the liver while conventional double-stranded DNA triggered fatal immune reactions.

A chirp-like signal in the light curve of superluminous supernova SN 2024afav reveals Lense-Thirring precession around a newborn magnetar, confirming the long-theorized engine behind the universe's brightest stellar explosions. Published in Nature.

A new class of photonic devices uses microscopic structures that curl upward from a chip surface to project thousands of controllable laser beams into free space. Published in Nature, the platform could advance augmented reality displays, quantum computing, and miniaturized Lidar.

Superluminous supernova SN 2024afav displayed a never-before-seen chirp pattern in its light curve, produced by a wobbling accretion disk around a newborn magnetar. The finding, published in Nature, is the first direct evidence that magnetars power these ultra-bright stellar explosions.

Three organizations across two oceans are pooling coral breeding technologies, from two-part seeding devices to containerized fertilization systems, to create a standardized restoration toolkit that can be adapted to reefs anywhere.

A comprehensive review in Engineering details the optical, sensor, and processing bottlenecks that prevent vision systems from matching human perception in real driving conditions, and proposes quantum dot and neuromorphic computing solutions.

Using markerless motion capture, KU researchers found that proficient three-point shooters demonstrate greater lower-body flexion during the preparatory phase, not the release, and the findings are now being used in a Guinness World Record attempt.

An opinion paper warns that billions of people using the same handful of AI chatbots are losing stylistic individuality in writing and converging on narrower reasoning patterns, with potential consequences for collective problem-solving.

Mice with severe lung infections were more likely to develop lung cancer, and human data showed a 1.24-fold increase in lung cancer incidence after COVID hospitalization. Vaccination largely prevented the immune reprogramming that drives the risk.

Wildfire exposure and its socioeconomic consequences were associated with graded increases in psychological distress reaching well beyond the burn zone in Maui, with housing displacement and job loss driving much of the mental health burden.

Patients with type 2 diabetes and cancer that had spread to the brain showed significantly reduced all-cause mortality when taking GLP-1 receptor agonists, according to a cohort study published in JAMA Network Open.

Researchers built peptide-based crystalline solids that can reversibly switch between layered and honeycomb architectures in response to humidity changes, achieving the kind of structural adaptability previously seen only in biological molecules.

Two companion studies in Cell Genomics show that adult fruit fly neurons retain a molecular record of their developmental lineage and birth order, and that sex differences in the brain arise from selective survival of neurons born at different times.

Among 107,000 individuals studied at two medical centers, nearly all patients who carried both an APOL1 high-risk genotype and the protective M1 variant did not have APOL1 kidney disease, suggesting their condition has a different and potentially treatable cause.

The most comprehensive single-cell epigenetic atlas of brain aging reveals that the same cell type ages differently depending on where it sits in the brain, with non-neuronal cells showing the most pronounced changes in DNA methylation.

The Pew Charitable Trusts awarded fellowships to seven marine scientists in Australia, the US, Canada, Japan, and Thailand, funding work on genetic tracing of illegal fisheries, coral reef restoration, kelp forest mapping, and nanoplastic classification.

By disrupting a tRNA modification controlled by the KEOPS enzyme, researchers forced melanoma cells to produce misfolded proteins that triggered an innate immune response, converting immune-resistant tumors into targets for T cell attack.

The latest issue of Current Pharmaceutical Analysis is now available as fully open access on ScienceDirect, covering topics from advanced analytical characterization to drug formulation and emerging pharmaceutical science.

Using atomic force microscopy at sub-nanometer resolution, researchers directly observed three distinct types of motion within a single polymer chain at a solid surface, revealing non-equilibrium behavior that challenges conventional models of adhesion.