The tumor microenvironment (TME) represents a highly complex system that encompasses cellular components (such as cancer cells, stromal cells, and immune cells) and non-cellular components (such as blood vessels and signaling molecules)[1-3]. These diverse components engage in complex interactions with tumor cells and undergo dynamic changes during tumor progression. Specifically, intratumoral microbial metabolites play an important role on the TME. The metabolic products of these microorganisms encompass a range of bioactive molecules, including lactate, amino acids, short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide, and inosine. These metabolites, ...

About The Study: Transparency of evidence supporting Food and Drug Administration (FDA) authorization of artificial intelligence (AI)- and machine learning -based devices for Alzheimer disease and related dementias was limited, precluding effective evaluation of training and validation dataset representativeness. Disease status (i.e., dementia type and distribution), age, and sex were reported for fewer than half of devices, while race and ethnicity data were rarely disclosed, raising uncertainty about real-world generalizability and clinical accuracy in intended populations.  Corresponding Author: To contact the corresponding ...

About 80% of people have the fungus Candida albicans in their gut. Although most of the time it persists unnoticed for years causing no health problems, C. albicans can turn into a dangerous microbe that causes serious diseases in many organs, including the urinary tract, lungs and brain. Understanding how this fungus colonizes the gut is key to preventing it from becoming harmful. Working with a mouse model, researchers at Baylor College of Medicine and international collaborators have discovered unexpected factors that help C. albicans ...

Recent climate-related crises — from severe storms and flooding to extreme heat — have raised new questions about how local governments communicate the risk of these crises and what they are doing to keep their citizens safe. To better understand what this communication looks like at local level, and the factors that may be shaping it, researchers from Drexel University analyzed climate resilience planning information available on the public-facing websites of 24 coastal communities in New Jersey that are contending with the effects of sea level rise. Their report, recently published in the Journal of Extreme Events, ...

A new technology that harnesses AI to analyze mammograms and improve the accuracy of predicting a woman’s personalized five-year risk of developing breast cancer has received Breakthrough Device designation from the Food and Drug Administration (FDA). Developed by researchers at Washington University School of Medicine in St. Louis, the software has been licensed to Prognosia Inc., a WashU startup company. The system analyzes mammograms to produce a risk score estimating the likelihood that a woman will develop breast cancer over the next five years. The technology is ...

True or false? “It is safe to take an over-the-counter medicine to help you sleep, even if you are drunk on alcohol.” “Driving while high on THC (cannabis) is safe.” “Using psychedelics is safe for everyone.” None of those statements is true. But young men who take a passive approach to news and information—consuming whatever flows over their social media transoms—were likely to believe them in a national survey conducted by Washington State ...

The University of Copenhagen is excited to announce Zuber Lawler as a Sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online. “Zuber Lawler demonstrates meticulous attention to detail with a client-first mentality… They offer personalized care from highly intelligent and creative counsel… ...

Decades ago, archaeologists discovered a sticky substance in a copper jar in an ancient Greek shrine. And until recently, the identity of the residue was still murky — is it a mixture of fats, oils and beeswax or something else? Researchers publishing in the Journal of the American Chemical Society have reanalyzed samples of the residue using modern analytical techniques and determined that it’s likely the remains of ancient honey — a conclusion previous analyses rejected. Honey was an important substance in the ancient world, sometimes left in shrines as offerings ...

The COVID-19 pandemic has placed enormous pressure on healthcare systems and economies around the world, with particularly severe impacts on vulnerable groups like residents of long-term care facilities (LTCFs). One key lesson from the pandemic is that early detection and treatment can lower hospitalization and death rates while also cutting medical costs. Wastewater surveillance at treatment plants (WSTPs) has emerged as a low-cost and innovative method to detect outbreaks early. Many developed countries have adopted this approach, ...

The University of Copenhagen is excited to announce Deep Origin as the latest tier 3 sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online. Deep Origin is building hybrid mechanistic, physics and AI-based models that help researchers design, test, and filter therapeutics in silico – particularly for challenging disease areas such as aging. ...

Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism which helps the cells repair DNA damage and survive the crowded environments of the human body. The findings help explain how cancer cells survive complex mechanical gauntlets like crawling through a tumour microenvironment, sliding into porous blood vessels or enduring the battering of the bloodstream. The discovery of the ...

A huge flood triggered by the rapid draining of a lake beneath the Greenland ice sheet occurred with such force that it fractured the ice above and burst out across its surface. This phenomenon, observed for the first time in Greenland and detailed in research published today in the journal Nature Geoscience, sheds new light on the destructive potential of meltwater stored beneath the ice sheet. It reveals how, under extreme conditions, water flooding underneath the ice can force its way upwards through the ice and escape at the ice sheet surface. This phenomenon is not considered by numerical models ...

The cerebral cortex processes sensory information via a complex network of neural connections. How are these signals modulated to refine perception? A team from the University of Geneva (UNIGE) has identified a mechanism by which certain thalamic projections target neurons and modify their excitability. This work, published in Nature Communications, reveals a previously unknown form of communication between two regions of the brain, the thalamus and the somatosensory cortex. It could explain why the same sensory stimulus does not always elicit the same sensation ...

Bethesda, MD (July 29, 2025) — A new international study confirmed a significant post-pandemic rise in disorders of gut-brain interaction, including irritable bowel syndrome (IBS) and functional dyspepsia, according to the paper published in Clinical Gastroenterology and Hepatology. Building on prior research, investigators used Rome Foundation diagnostic tools to analyze nationally representative samples from both 2017 and 2023 — offering the first direct, population-level comparison of disorders of gut-brain interaction prevalence before and after the COVID-19 pandemic. Key findings: Overall disorders of gut-brain ...

Studying plant vegetative reproduction is key to increasing crop yield and for bioengineering. Kobe University research is making progress on studying the genetic regulation of the process in liverworts, which are ideal model plants and even a candidate for space crops. Potatoes are tubers, ginger is a rhizome, and both are forms of vegetative plant reproduction, in which plants create structures from which genetically identical individuals can emerge. This mode of reproduction is very important for agriculture and horticulture, but there is very little research on the underlying genetic mechanism. Kobe University ...

Walking is well known to have significant health benefits, but few people achieve the daily recommended steps. Fortunately, mobile health (mHealth) applications have emerged as promising tools to promote physical activity. These apps track user activities on mobile devices to deliver health and wellness services. However, the effectiveness of these apps in increasing daily walking behavior remains underexplored, partly due to variations in their incentive structures. Dr. Haruka Kato, Junior Associate Professor at Osaka Metropolitan University, investigated the impact of incentive design on walking behavior using a local mHealth application called ...

Changmin Sung, a principal researcher at the Doping Control Center at the Korea Institute of Science and Technology (KIST), announced that he and his collaborators at the Department of Biomedical Engineering at Korea University have developed a high-throughput multiplexed gene and cell doping analysis (HiMDA) based on gene scissors (CRISPR-Cas). Unethical doping practices to enhance athletic performance is becoming more sophisticated with the use of advanced technology, and gene and cell doping - the ...

Philadelphia, July 30, 2025 – Despite widespread public health efforts, the dangerous myth of "prevention of tongue swallowing" continues to persist during cardiopulmonary resuscitation (CPR). New research in the Canadian Journal of Cardiology, published by Elsevier, exposes the mainstream and social media’s detrimental role in perpetuating this misconception, which often leads to critical delays in proper CPR for collapsed athletes. Concern about “tongue swallowing” leads resuscitators to waste valuable time trying ...

Female pilots may outperform their male counterparts in high-pressure flight situations, according to a new study led by University of Waterloo researchers.   The findings challenge traditional assumptions in aviation and suggest that women pilots may have unique strengths that could be better recognized in pilot training and evaluation systems.  “These findings are exciting because they push us to rethink how we evaluate pilots,” said Naila Ayala, lead author of the study and postdoctoral fellow ...

Hydrogen peroxide (H₂O₂) is an essential eco-friendly oxidant, but its conventional anthraquinone-based production is energy-intensive and generates hazardous waste. Photocatalysis offers a sustainable, solar-driven alternative. Organic polymer photocatalysts, notably covalent organic frameworks (COFs), have gained attention due to their tunable structures, earth-abundant elements, and visible-light responsiveness. Although recent advances (e.g., polarity-optimized, fluorinated, or sulfone-containing COFs) have improved H₂O₂ yields and extended stability to 336 hours, long-term durability remains limited. Most systems exhibit reaction times of less than 200 hours ...

Two decades-long catalytic journey has borne industrial fruit—greener, cleaner, and smarter. Fischer–Tropsch synthesis (FTS) and heterogeneous hydroformylation are two cornerstone processes in modern chemical manufacturing. They convert syngas (a mixture of CO and H₂, typically derived from coal or biomass) into hydrocarbons and oxygenates that underpin fuel, plastics, and pharmaceutical industries. Yet for over a century, challenges in selectivity, catalyst longevity, and process integration have limited their broader industrial deployment—until now. In a newly published account in Chinese Journal of ...

□ The research team led by Senior Researchers Yoonhee Lee from the Division of Biomedical Technology and Gyogwon Koo from the Division of Intelligent Robot at DGIST (under President Kunwoo Lee) has developed a technology that distinguishes lung cancer gene mutations solely by measuring the “stiffness” of exosomes—tiny particles released from cancer cells in the bloodstream—using atomic force microscopy (AFM). Their study enables rapid and precise analysis of individual exosomes and is expected to advance into a new liquid biopsy-based diagnostic technique for lung cancer.   □ Non-small cell lung cancer (NSCLC) is the most common type ...

When Black and Latino youth aspire toward careers in science and technology, their confidence in exploring career possibilities and how they think society views their ethnic-racial group can play a crucial role in whether their dreams take root. Such is a finding of a study by UC Riverside associate professor of psychology Aerika Brittian Loyd, UCR doctoral candidate Tate LeBlanc, and co-authors published in the Journal for STEM Education Research. Middle and high school students who voiced higher expectations of success in exploring different career paths — along with perceptions that their racial ...

The presence of humans and human infrastructure in U.S. national parks has lasting effects on the behaviours of the large animals that call them home, according to a new study. “Wildlife all around the world fear people and avoid areas of high human activity, but it was surprising to see that this holds true even in more remote protected areas,” said Dr. Kaitlyn Gaynor, a zoologist at the University of British Columbia and lead author of the paper published today in the Proceedings of the Royal Society B. Researchers tracked 229 animals from 10 species across 14 national parks and protected areas using GPS collar data from 2019 to 2020, ...

In a discovery that deepens our understanding of animal social bonds, a study led by University of Oxford researchers in collaboration with the University of Leeds has demonstrated that wild great tits exhibit clear behaviours signalling ‘divorce’ long before the breeding season. The findings, published today (30 July) in Proceedings of the Royal Society B, provide valuable new insights into how animals navigate complex social decisions. provide valuable new insights into how animals navigate complex social decisions. For monogamous birds that only bond with one partner at a time, ...