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A new blood-based epigenetic clock for aging focuses on intrinsic capacity

2025-06-04
A team of international researchers has developed a new biological age “clock” that estimates how well someone is aging, not just how “old” they or their various organs might be. The IC Clock, which is described in a study in Nature Aging, measures intrinsic capacity (IC), the sum of six key functions that determine healthy aging: mobility, cognition, mental health, vision, hearing and nutrition/vitality. “Maintaining function during the aging process is what matters to older adults. Function should inform medical care instead of focusing on getting patients to some disease-free state,” said senior ...

Creating ice layer by layer: the secret mechanisms of ice formation revealed

2025-06-04
Tokyo, Japan – Water is everywhere and comes in many forms: snow, sleet, hail, hoarfrost… However, despite water being so commonplace, scientists still do not fully understand the predominant physical process that occurs when water transforms from liquid to solid. Now, in an article recently published in the Journal of Colloid and Interface Science, researchers from the Institute of Industrial Science, The University of Tokyo, have carried out a series of molecular-scale simulations to uncover why ice forms ...

Life from oceans to savannas explained with one single rule

2025-06-04
A simple rule that seems to govern how life is organised on Earth is described in a new study published today (Wednesday, 4 June) in Nature Ecology & Evolution. The research team led, by Umeå University and involving the University of Reading, believe this rule helps explain why species are spread the way they are across the planet. The discovery will help to understand life on Earth – including how ecosystems respond to global environmental changes. The rule is simple: in every region on Earth, most species cluster together in small 'hotspot' areas, then gradually spread outward with fewer and fewer species able to survive farther away from these ...

From mixed to matched: new marker pinpoints therapeutically relevant stem cell–derived islets

2025-06-04
Over 500 million people worldwide suffer from diabetes—a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer’s disease. At the heart of this condition lies the dysfunction of pancreatic islets, the mini-organs called organoids responsible for regulating blood sugar, in both autoimmune type 1 diabetes and stress-induced type 2 diabetes. Replacing these damaged islets with lab-grown, functional islets represents a promising therapeutic strategy. However, the lack of reliable markers to identify truly functional, stem cell–derived islets has hindered the consistent production needed for clinical application. In ...

A giant planet around a tiny star: A discovery that challenges planet formation theories

2025-06-04
The host star, TOI-6894, is a red dwarf with only 20% the mass of the Sun, typical of the most common stars in our galaxy. Until now, such low-mass stars were not thought capable of forming or retaining giant planets. But as published today in Nature Astronomy, the unmistakable signature of a giant planet — TOI-6894b — has been detected in orbit around this tiny star. This exceptional system was first identified in data from NASA’s Transiting Exoplanet Survey Satellite (TESS), as part of a large search for giant planets around small stars, led by Dr. Edward Bryant from UCL’s ...

One single rule helps explain life from ocean depths to open savannas

2025-06-04
A new study published in Nature Ecology & Evolution has found a simple rule that seems to govern how life is organised on Earth. The researchers believe this rule helps explain why species are spread the way they are across the planet. The discovery will help to understand life on Earth – including how ecosystems respond to global environmental changes. At first glance, Earth seems like a collection of wildly different worlds. Each region has its own species and environmental conditions. Yet, beneath this variety, ...

Can early exposure to dogs lessen genetic susceptibility to eczema?

2025-06-04
New research published in Allergy indicates that certain environmental exposures may affect a child’s risk of developing atopic eczema, a condition characterized by dry, itchy, and inflamed skin. In other words, although some people may be genetically predisposed to eczema, certain environmental factors may increase or decrease that risk. For the study, investigators analyzed data from 16 European studies to test for interactions between the 24 most significant eczema-associated genetic variants and 18 early-life environmental factors. They applied their findings to an additional 10 studies and used lab modelling tests to assess their results. The ...

Are stress and resilience factors among gender and sexual minority adolescents related to sleep health?

2025-06-04
New research in the Journal of Adolescence found that among LGBTQ+ adolescents in the United States, those who experienced more violence because of their identity or more bullying because of their gender expression had more trouble falling asleep, whereas those who experienced more familial warmth had less trouble falling asleep. Gender-based victimization, family rejection, absence of a gender-sexuality alliance, and not having a trusted adult at school were also related to trouble falling asleep for cisgender sexual minority youth (who identify with the gender they were assigned at birth but who are not heterosexual). For gender minority youth, being able to use the restroom that matched ...

How does a common plant pathogen affect urban trees, and how should it be managed?

2025-06-04
Trees are important to the environmental health of cities through their capacity to improve air quality, provide cooling via shade and transpiration, and foster natural beauty. New research in Plant-Environment Interactions reveals how the widespread plant pathogen Phytophthora affects urban trees, specifically Common Lime trees. Using numerous tree sensors, investigators found that infected trees exhibited reduced water use and stem growth compared with healthy trees, but some still managed to maintain ...

Which seeds are best to include in annual flowering seed mixes to attract insect pollinators?

2025-06-04
Annual flowering seed mixes are often grown in gardens and parks, but the flowers included may not be the most pollinator-friendly. New research in Plants, People, Planet reveals plant species that have the potential to attract a diversity of pollinators. Investigators surveyed 447 scientific papers on plant-insect interactions and conducted field trials of commercially available seed mixes to see which plants pollinators visited the most, focusing on bees and hoverflies. These analyses and tests were used to develop two novel experimental seed mixes that were assessed for insect visitation and ...

How useful are states’ adolescent social media laws?

2025-06-04
Bills related to adolescent social media regulation have been adopted in more than half of all U.S. states. Research in The Milbank Quarterly finds that these state policies—such as school cell phone bans and anti-cyberbullying laws—have significant limitations. The study identifies research priorities that will help inform more effective interventions. Because definitive evidence around the potential impacts of social media may take years to emerge, and because the absence of regulation may result in avoidable harm to the public, ...

Evidence to support state policies regulating teen use of social media is limited, study finds

2025-06-04
Evidence supporting policies that restrict social media use like school cell phone bans and anti-cyberbullying laws has significant limitations according to a new study at Columbia University Mailman School of Public Health.  The findings are published in the latest issue of the Milbank Quarterly. More than 50 bills related to adolescent social media regulation have been adopted or enacted in more than half of all U.S. states, with legislators often citing concerns about mental health, harmful content, and ...

Pet dogs could combat genetic eczema risk in children

2025-06-04
Having a dog at home could help to prevent eczema in children who are genetically prone to the condition, a study suggests. Children with a change in their DNA that increases their chance of developing eczema were less likely to have the condition if they were exposed to a dog in early life, researchers say. The findings provide new insights into what could cause eczema in children and how environmental factors may influence genetic risk, experts say. The study did not look at the effect of dog exposure in the treatment of existing eczema, and experts caution that introducing a dog may make ...

A threesome that hatches potato parasites

2025-06-04
Potatoes produce a molecule that is converted by microbes and causes potato parasites to hatch. The Kobe University discovery of this three-way relationship not only adds a new perspective to how plants interact with their environment, it also opens an avenue for developing countermeasures against the parasite. The potato cyst nematode is a root parasite in plants like potatoes and tomatoes that can cause large-scale yield loss if left untreated. Their eggs can survive in the soil for up to 20 years and hatch when they detect certain molecules, called “hatching factors,” secreted by the roots of their target species. Kobe University phytochemistry scientist MIZUTANI ...

Young people discover the technologies shaping their future in the World Economic Forum and Frontiers for Young Minds collection

2025-06-04
Today's breakthroughs – from interactive smart surfaces to genetically engineered animal organs – that are emerging from laboratories now will be day-to-day realities for tomorrow’s adults and leaders. In this new collection, the next generation takes a driver’s seat in understanding and communicating the technologies that will transform our world. A new collection from the open-access science journal for kids Frontiers in Young Minds (FYM), published in collaboration with the World Economic Forum, gives curious young people a front-row seat to the innovations that could define their future – and invites them to take active control, ensuring their young ...

Real-time 3D visualization reveals potent antibacterial and antibiofilm activity against superbacteria

2025-06-04
A research group in Korea has discovered a novel natural antimicrobial peptide, ‘Hirunipin-2,’ from the salivary glands of the medicinal leech (Hirudo nipponia) using cutting-edge imaging technology, demonstrating that the material has high potential as a new therapeutic effective against superbacteria. This discovery underscores the significant potential of combining natural resources with advanced imaging technologies to address the global challenge of antibiotic-resistant infections. Dr. ...

Abnormal uterine bleeding and insulin resistance are on the rise: Is there a connection?

2025-06-04
CLEVELAND, Ohio (June 4, 2025)—Insulin resistance is becoming more common because of a combination of lifestyle factors, genetics, and medical conditions. A lot of those same risk factors play a role in abnormal uterine bleeding. A new study sets out to prove the connection between the two as a means to better predict abnormal uterine bleeding. Results of the study are published online today in Menopause, the journal of The Menopause Society. Abnormal uterine bleeding has become more common, with approximately 30% of women of reproductive age experiencing it. More than $34 billion in healthcare ...

Eye wear breakthrough: MXene-coated lenses for safer and smarter wearables

2025-06-04
With recent advancements in technology, the Internet of Things and wireless devices are in high demand. However, these innovations also raise concerns about prolonged exposure to electromagnetic radiation (EMR), which may pose potential risks to eye health. MXenes, a class of two-dimensional transition metal carbides/nitrides, have shown promise in shielding against EMR. However, their poor adhesion and susceptibility to oxidation have limited their applications. In a recent breakthrough, researchers led by Professor Takeo Miyake from the Graduate School of Information Production and Systems, Waseda University, Japan, ...

‘AI scientist’ suggests combinations of widely available non-cancer drugs can kill cancer cells

2025-06-04
An ‘AI scientist’, working in collaboration with human scientists, has found that combinations of cheap and safe drugs – used to treat conditions such as high cholesterol and alcohol dependence – could also be effective at treating cancer, a promising new approach to drug discovery. The research team, led by the University of Cambridge, used the GPT-4 large language model (LLM) to identify hidden patterns buried in the mountains of scientific literature to identify potential new cancer drugs. To test their approach, the researchers prompted GPT-4 to identify potential new drug combinations that could have a significant impact on a breast cancer ...

Phage therapy at a turning point: Global experts converge in Berlin to shape the future of antimicrobial medicine

2025-06-03
As antibiotic resistance reaches critical levels worldwide, the 8th World Congress on Targeting Phage Therapy (June 10–11, 2025) returns to Berlin, bringing together over 75 international speakers and contributors from 27 countries. The congress offers the most comprehensive scientific and clinical update on phage therapy—a once-overlooked solution now at the forefront of next-generation medicine. Phage Therapy 2025 covers the full translational pipeline: from phage–bacteria interactions and biofilm disruption to regulatory frameworks, GMP manufacturing, and ...

Low calorie diets linked to heightened risk of depressive symptoms

2025-06-03
Following a low calorie diet is linked to a heightened risk of depressive symptoms, finds research published in the open access journal, BMJ Nutrition Prevention & Health. Men and those who are overweight may be especially vulnerable to the effects of restrictive eating, the findings suggest. A ‘healthy’ diet rich in minimally processed foods, fresh fruits and vegetables, whole grains, nuts, seeds, lean proteins and fish, is generally associated with a lower risk of depression, while an ‘unhealthy’ diet, dominated by ultra-processed foods, refined carbs, saturated fats, processed ...

Bronchiolitis, monoclonal antibody halves hospitalizations of children younger than six months old

2025-06-03
A single dose of the long-acting antibody nirsevimab developed to prevent respiratory syncytial virus infections (The drug has been approved at the European level to protect infants in their first season of exposure to the virus) to infants can halve hospitalisations for bronchiolitis. It is the result of a study involving the Università Cattolica del Sacro Cuore, Rome campus - Fondazione Policlinico Universitario Agostino Gemelli IRCCS, co-ordinated by Universitat Politècnica de Catalunya (UPC), Catalonia, Children's Emergency Department, Leicester Royal Infirmary and University of Edinburgh, ...

Mum’s obesity linked to child’s heightened hospital admission risk for infection

2025-06-03
Children born to mothers who are very obese with a BMI of 35 or higher are at heightened risk of being admitted to hospital for an infection, finds a long term study published in the open access journal BMJ Medicine. The findings highlight the importance of maintaining a healthy body weight before and after the pregnancy, say the researchers. On current trends, the global prevalence of maternal obesity is projected to reach nearly 1 in 4 (23%) by 2030, point out the researchers. This is of particular concern, given that obesity is characterised by a state of chronic inflammation, which increases the risk of a disordered immune ...

Millions of new solar system objects to be found and ‘filmed in technicolor’ – studies predict

2025-06-03
A group of astronomers from across the globe, including a team from the University of Washington and led by Queen’s University Belfast, have revealed new research showing that millions of new solar system objects will be detected by a brand-new facility, which is expected to come online later this year.   The NSF–DOE Vera C. Rubin Observatory is set to revolutionize our knowledge of the solar system’s “small bodies” — asteroids, comets and other minor planets.  The Rubin Observatory, ...

Pitt study has upended decades-old assumptions about brain plasticity

2025-06-03
A new study from Pitt researchers challenges a decades-old assumption in neuroscience by showing that the brain uses distinct transmission sites — not a shared site — to achieve different types of plasticity. The findings, published in Science Advances, offer a deeper understanding of how the brain balances stability with flexibility, a process essential for learning, memory and mental health. Neurons communicate through a process called synaptic transmission, where one neuron releases chemical messengers called neurotransmitters ...
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