MINNEAPOLIS / ST. PAUL (08/25/2025) — For the first time, a research team at the University of Minnesota Twin Cities demonstrated a groundbreaking process that combines 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery.  The study was recently published in Advanced Healthcare Materials, a peer-reviewed scientific journal. According to the National Spinal Cord Injury Statistical Center, more than 300,000 people in the United States suffer from spinal cord injuries, yet there is no way to completely reverse the damage and paralysis from the injury. A major challenge is the death of nerve cells ...

DARIEN, IL - The American Academy of Sleep Medicine has developed and validated a patient-reported outcome tool for use in a clinical setting to monitor treatment response and longitudinal symptom progression in adults who have obstructive sleep apnea. Results show that the “Patient-reported Longitudinal Assessment Tool for OSA” demonstrates strong internal consistency and test-retest reliability, and it exhibits robust construct validity through moderate-to-strong correlations with established measures. Scores from the PLATO questionnaire also discriminate between sleep apnea severity levels ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, where hydrogen atoms are replaced by various chemical groups, are naturally produced by plants, fungi, and even the human body. Due to their properties, indoles have gained attention as a backbone for synthesizing a wide variety of drugs. Since 2015, the U.S. Food and Drug Administration has approved 14 indole drugs to treat conditions, such as migraines, infections, and hypertension. Chemists have developed many ...

Maybe you shouldn’t always listen to your gut. Researchers at the Fralin Biomedical Research Institute at VTC recently studied flavor-nutrient learning — how people come to prefer certain food based on how it makes them feel. Flavor-nutrient learning is one factor that influences eating habits and may impact body weight. “We have to learn what we are going to eat, and one factor that’s less well studied is post-ingestive signals — our gut talking to our brain, teaching ...

Four and a half billion years ago Jupiter rapidly grew to its massive size. Its powerful gravitational pull disrupted the orbits of small rocky and icy bodies similar to modern asteroids and comets, called planetesimals. This caused them to smash into each other at such high speeds that the rocks and dust they contained melted on impact and created floating molten rock droplets, or chondrules, that we find preserved in meteorites today.   Now, researchers at Nagoya University in Japan and the Italian National Institute for Astrophysics (INAF) have for the first time determined how these droplets formed and accurately dated the formation of Jupiter based on their ...

A research team from the University of Basel, Switzerland, has developed a new molecule modeled on plant photosynthesis: under the influence of light, it stores two positive and two negative charges at the same time. The aim is to convert sunlight into carbon-neutral fuels. Plants use the energy of sunlight to convert CO2 into energy-rich sugar molecules. This process is called photosynthesis and is the foundation of virtually all life: animals and humans can “burn” the carbohydrates produced in this way again and use the energy stored within them. This once more produces carbon dioxide, closing the cycle. This model could also be the key to environmentally ...

With today’s advanced microscopes, scientists can capture videos of entire embryos developing in real time. But there’s a catch: turning those breathtaking images into clean, accurate trajectories of each cell's journey as it finds its proper place in a developing organism is incredibly hard. The difficulty comes from cells moving, dividing, and sometimes vanishing altogether as they form the tissues and organs that will comprise a functioning adult animal. Using the cells’ nuclei as landmarks, ...

A research team at Kyoto University has discovered STAG3-cohesin, a new mitotic cohesin complex that helps establish the unique DNA architecture of spermaotogonial stem cells (SSCs), the stem cells that give rise to sperm. This "DNA organizer" is crucial for sperm production in mice: without STAG3, SSCs cannot differentiate properly, leading to a fertility problem. In humans, the researchers found that STAG3 is highly expressed in immune B cells and in B-cell lymphomas (a type of blood cancer), and blocking it slowed the growth of these cells. This discovery might open the door to new strategies for treating ...

Researchers found dietary changes may help improve cognitive health and stave off dementia A new study led by investigators from Mass General Brigham, Harvard T.H. Chan School of Public Health, and the Broad Institute of MIT and Harvard suggests that a Mediterranean-style diet may help reduce dementia risk. The study, published in Nature Medicine, found that people at the highest genetic risk for Alzheimer's disease benefited more from following a Mediterranean-style diet, showing a greater reduction in dementia risk compared to those at lower genetic risk. "One reason we wanted to study the Mediterranean diet is because it is the only dietary pattern that has ...

The new research titled "Interstadial diversity of East Asian summer monsoon linked to changes of the Northern Westerlies", published in Nature Communications at 10 am, August 25, 2025 (London time) (https://www.doi.org/10.1038/s41467-025-63057-2) and led by scientists from Xi’an Jiaotong University in China the British Antarctic Survey and international collaborators, shows that isotopic signatures of the EASM during DO events are not uniform but rather reflect diverse changes in response to subtle variations of the Westerlies’ position. “Our isotope-enabled climate model successfully replicates the spatial heterogeneity seen in proxy records, ...

New research indicates that many patients with advanced cancer report receiving treatment focusing on longevity over comfort, even when their goal is the opposite. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Treatment of serious illnesses generally aims to optimize longevity and quality of life, but in some cases, these goals are at odds with each other. Therefore, clinicians must strive to understand each individual’s objectives so that patients do not receive burdensome treatments that go against their wishes. “When treating advanced cancer, the goal is to help patients live ...

Genetic testing of IVF-created embryos could help more women over 35 have a baby in less time, a clinical trial by researchers from King’s College London, King’s College Hospital, and King’s Fertility has found. Published today in the Journal of Clinical Medicine, this is the first randomised controlled trial worldwide to focus exclusively on women aged 35–42, a group at higher risk of producing embryos with chromosomal abnormalities. The trial looked at the use of Preimplantation genetic testing for aneuploidy (PGT-A) to check embryos ...

COLUMBUS, Ohio – Having a hard time bending over to put your shoes on? Experiencing pain in the knees, groin, thigh or back? A new survey by The Ohio State University Wexner Medical Center reveals many people don’t realize these symptoms can mean there’s a problem in the hip. The survey of 1,004 people in the United States shows 72% are not aware that knee pain can actually be a sign of a hip problem. Similarly, 69% miss groin pain and 66% miss thigh pain as rooted in the hip. “Patients will be referred to me for knee pain,” explained Matthew Beal, MD, an orthopedic surgeon at Ohio State Wexner Medical Center. “When I examine the patient, ...

Tobacco smoking is the number one cause of preventable disease and death in Canada; it is highly addictive and hard to stop. Recognizing these challenges, a new guideline from the Canadian Task Force on Preventive Health Care provides a menu of effective options to help people quit smoking, with behavioural and medication options and a natural health product that can be tailored and combined for personal choice. The guideline is published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.241584. “Quitting ...

Dr. Dong-Soo Han's research team at the Korea Institute of Science and Technology (KIST) Semiconductor Technology Research Center, in collaboration with the research teams of Prof. Jung-Il Hong at DGIST and Prof. Kyung-Hwan Kim at Yonsei University, has developed a device principle that can utilize "spin loss," which was previously thought of as a simple loss, as a new power source for magnetic control. Spintronics is a technology that utilizes the "spin" property of electrons to store and control information, and it is being recognized as a key foundation for next-generation information processing technologies such as ultra-low-power ...

A recent review of the Canadian Task Force on Preventive Health Care underscores the need for expert bodies to produce evidence-based guidance and that Canada should ensure a renewed task force is adequately funded and supported, argues a commentary in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.251038. Dr. Vivek Goel, President and Vice-Chancellor of the University of Waterloo and author of the commentary, chaired the External Expert Review panel that reviewed the task force’s structure, ...

Children residing in “very low-opportunity” neighborhoods are up to 20 times more likely to be hospitalized for gun injuries than those living in the most advantaged areas, reports a new multi-state study published in Pediatrics. The study also found that most hospitalizations for gun injuries among children under 18 are the result of unintentional shootings — incidents caused by mishandling or accidental discharge of a gun. “The fewer opportunities a child has in their neighborhood, the greater their odds of ending up in the hospital with a firearm injury,” said co-author Dr. Mehul Raval, Head of Pediatric ...

Study analyzed nearly 7,000 pediatric gun injuries and mapped odds by ZIP code Kids in ‘low-opportunity’ neighborhoods far more likely to be shot than those in ‘high-opportunity’ areas ‘High-opportunity’ kids are far less likely to be shot, but twice as likely to die when it happens Authors stress urgent need for safe storage and firearm safety education CHICAGO --- Children residing in “very low-opportunity” neighborhoods are up to 20 times more likely to be hospitalized ...

The first study of its kind to compare cardiovascular risk in type 1 diabetes (T1D) and type 2 diabetes (T2D) in both men and women shows that younger men with T2D have worse mortality and cardiovascular disease (CVD) outcomes than those with T1D, whereas for women of all ages, almost all outcomes are worse for T1D than for T2D. The study is by Dr Vagia Patsoukaki, Uppsala University, Uppsala, Sweden, and colleagues and is presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September). CVD is the leading cause of death and morbidity worldwide and individuals with ...

Osaka, Japan – Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task. Now, in an article published in Light: Science & Applications, researchers from The University of Osaka, together with collaborating institutions, have unveiled a cryo-optical microscopy technique that take a high-resolution, quantitatively accurate snapshot at a precisely selected timepoint in dynamic ...

A line of engineering research seeks to develop computers that can tackle a class of challenges called combinatorial optimization problems. These are common in real-world applications such as arranging telecommunications, scheduling, and travel routing to maximize efficiency. Unfortunately, today’s technologies run into limits for how much processing power can be packed into a computer chip, while training artificial-intelligence models demands tremendous amounts of energy. Researchers at UCLA and UC Riverside have demonstrated a new approach that overcomes these ...

  Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men. While early-stage disease can be effectively managed, advanced forms—particularly metastatic castration-resistant prostate cancer (mCRPC)—pose significant therapeutic hurdles. A growing body of evidence highlights the pivotal role of SOX transcription factors, with SOX2 emerging as a central driver in tumor growth, spread, and resistance to therapy.   SOX2 is intricately linked to the fate of cancer stem/progenitor cells, influencing processes ...

  The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark achievements of the Human Genome Project (HGP), scientists have increasingly focused on deciphering the non-coding regions of the human genome, which comprise approximately 98% of the genetic material. These regions, long overlooked due to their non-protein-coding nature, are now known to harbor ...

  The identification of Chitinase-3-like protein 1 (CHI3L1) as a crucial biomarker in liver disease is revolutionizing how clinicians approach the diagnosis, monitoring, and treatment of various liver conditions. As a member of the glycoside hydrolase family 18, CHI3L1 is recognized for its unique ability to bind to ligands and influence multiple pathophysiological processes, despite lacking enzymatic activity. This distinctive protein plays a key role in mediating cell proliferation, inflammation, fibrosis, and carcinogenesis.   Liver diseases, including hepatitis-related fibrosis, non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease ...

Reston, VA (August 22, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes. Summaries of the newly published research articles are provided below. Mapping Tiny Lifetimes ...