THE ORIGINAL COLLECTION · SINCE 2010

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Medicine

More than 200 metabolic enzymes sit directly on DNA, and cancer types each have their own pattern

Researchers at the Centre for Genomic Regulation found that over 200 metabolic enzymes bind directly to chromatin in human cells, with distinct patterns across cancer types. Breast cancer cells harbor oxidative phosphorylation enzymes in their nuclei that lung cancer cells lack, hinting at disease-specific metabolic strategies that could explain differences in treatment response.

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Medicine

A gut-restricted drug protects the liver after bowel surgery in mice

Researchers at Washington University School of Medicine synthesized a gut-restricted liver X receptor agonist that prevented liver fibrosis and improved nutrient absorption in mice after small bowel resection. The compound, WUSTL0717, acts only in the intestines, avoiding the side effects that derailed earlier drugs in this class.

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Science

Ceramic water filter achieves 99.8% dye removal at tap-water pressure

Scientists at the Korea Institute of Materials Science created a ceramic membrane that filters dye-contaminated wastewater at just 2 bar of pressure while letting salt ions pass through. The key innovations: a mutual doping technique that reduces sintering temperature by 300 degrees and a surface so smooth it prevents the microcracks that typically degrade membrane performance.

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