The Icahn School of Medicine at Mount Sinai is pleased to announce it has received a three-year, $4.5 million grant from BD2: Breakthrough Discoveries for thriving with Bipolar Disorder to investigate the neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies. The team will be led by Ignacio Saez, PhD, Associate Professor of Neuroscience, Neurosurgery, Neurology at the Icahn School of Medicine and Director of the Human Neurophysiology Laboratory at Mount Sinai. Dr. Saez and his team are part of a select ...

Today, the Innovative Cancer Medicines (ICM) initiative announced the enrollment of the first Nigerian patient in a pioneering demonstration project to provide an immunotherapy drug used to treat cancer. The goal of the initiative is to develop an approach that explores sustainable and effective administration of innovative immuno-oncology therapies in low- and middle-income countries. The ICM initiative is a collaboration between the Clinton Health Access Initiative (CHAI) and the Parker Institute for Cancer Immunotherapy (PICI), along with Bristol Myers Squibb (BMS) and Roche, working ...

Learning about a topic by interacting with AI chatbots like ChatGPT rather than following links provided by web search can produce shallower knowledge. Advice given on the basis of this shallow knowledge tends to be sparser, less original, and less likely to be adopted by others. Shiri Melumad and Jin Ho Yun conducted seven experiments with thousands of online participants who were randomly assigned to learn about various topics, including how to plant a vegetable garden, how to lead a healthier lifestyle, or how to cope with financial scams, using either large language models (LLMs) or traditional Google web search links. Participants ...

October 28, 2025 — An international study led by the Azrieli Faculty of Medicine in the Galilee at Bar-Ilan University reveals that the COVID-19 pandemic has contributed to a diminishing public trust in childhood vaccines, resulting in declining vaccination rates and a resurgence of preventable, life-threatening diseases such as measles. The findings come amid one of the most severe measles outbreaks in Israel in decades, with thousands of infections and multiple child deaths reported nationwide. Published in the peer-reviewed journal Vaccine, the study surveyed 2,047 parents with children born both before and after the pandemic ...

Washington, D.C. – Today, BD², or Breakthrough Discoveries for thriving with Bipolar Disorder, announced its third round of Discovery Research grants, totaling nearly $18 million – expanding a comprehensive global effort to examine the key mechanisms of bipolar disorder.  Multidisciplinary teams of scientists and clinicians include leads from the Icahn School of Medicine at Mount Sinai, Mass General Brigham, Weill Cornell Medicine, and the University of Minnesota. These teams represent a unique cohort of successful Discovery Grantees, as they will all use neuromodulation to explore human neural circuitry in bipolar disorder. These teams will each ...

Every day, 17 Americans die while waiting for an organ transplant. Opt-out organ donation policies, which enroll everyone into post-mortem donation programs by default unless people choose to opt out, have been touted as a way to increase the supply of desperately needed organs. But opt-out organ donation policies may reduce living organ donations, leaving systems no better supplied with lifesaving organs. Pascal Güntürkün and colleagues analyzed epidemiological data from 24 countries between 2000–2023 and conducted four experimental ...

West Lafayette, Ind. – Frailty threatens older individuals because it increases their vulnerability to detrimental health outcomes, such as falling, longer hospitalization, or even shortened life expectancy.  New research exploring the linkage between frailty and mortality risk points to retaining gonad function as a potent strategy to fight late-life frailty. The study conducted by scientists at the Gerald P. Murphy Cancer Foundation’s Center for Exceptional Longevity Studies was published last week in the peer-reviewed scientific journal Scientific Reports. The ...

Brain scans from American football players reveal subtle differences in the brain’s outer grooves when compared to scans from otherwise healthy men who never played contact or collision sports, a new study shows. Its authors say the findings could potentially predict which people are more at risk of chronic traumatic encephalopathy (CTE). Like many neurodegenerative diseases, CTE is known to worsen over time, and it afflicts many who play contact and collision sports that involve repeated hits to the head. Popular contact sports include soccer and basketball, while common collision sports are ...

As populations continue to age, total hip replacement (THR) is becoming an increasingly common surgical procedure. Experts estimate that approximately one million THRs are performed each year worldwide. The surgery is often life-changing, as it can fully restore the function of the hip joint, reduce pain, and allow patients to walk and bear weight again. However, as with any major surgery, the procedure is not without risks, especially for older individuals with other health conditions.   A significant complication following THR is a femoral fracture—a break in the thigh bone near the artificial hip joint. This ...

Frailty is closely linked to adverse outcomes in older adults, particularly those with heart failure. Numerous epidemiologic studies show that frailty has important prognostic value in this population, underscoring the need for routine assessment. At the same time, the concept of frailty has expanded beyond the physical domain to include cognitive and other dimensions, making comprehensive evaluation increasingly complex and less feasible in everyday practice. The Clinical Frailty Scale (CFS) offers a practical alternative: a 9-point, bedside, visually assessed tool that can be completed in minutes. However, key questions remain—how closely ...

Aerospace industry has undergone tremendous developments over the last century, with materials science engineers playing a significant role in this transformation. It is well known that as the operating temperature of metallic materials increases, the speed of aircraft can be enhanced and fuel consumption can be reduced. Therefore, research on high-temperature materials has been directly linked to the improvement of aircraft performance and has been actively conducted worldwide since the 1940s. For more than 80 years, Ni-based alloys have been the primary materials used for high-temperature applications. To enable their use at even higher temperatures, ...

Fashion trend forecasting helps companies predict which clothes will be popular in upcoming seasons. Traditionally, this has relied on experts’ intuition, experience and creativity. More recently, big-data analysis has been incorporated, offering deeper insights into consumer behavior. However, such methods pose technical barriers and remain out of reach for fashion students or small brands. Recent developments in artificial intelligence (AI) can balance the scales. Large language models (LLMs) like ChatGPT have made big data analysis readily available to the public.  LLMs draw ...

Sinking land is quietly destabilizing urban infrastructure in India’s largest cities, putting thousands of buildings and millions of people at risk, according to Virginia Tech scientists. Groundwater overuse is a critical driver of the problem, said Susanna Werth, assistant professor of geosciences who co-authored the paper published Oct. 28 in Nature Sustainability. “When cities pump more water from aquifers than nature can replenish, the ground quite literally sinks,” Werth said. “Our study shows that this overexploitation ...

Key Messages In May 2023, devastating floods hit Emilia-Romagna, causing deaths, displacement, and estimated damages of €8.5 billion. Cul-de-sac effect: The CMCC research team described for the first time how a specific configuration of mountain topography and circulation patterns trapped moisture coming from the Adriatic, while a stationary cyclone fueled prolonged rains that lasted for several days over the same area, leading to extreme flooding. From the analysis of the Emilia-Romagna case, the ...

ITHACA, N.Y. – Astronomers have generated the first three-dimensional map of a planet orbiting another star, revealing an atmosphere with distinct temperature zones – one so scorching that it breaks down water vapor, a team co-led by a Cornell expert reports in new research. The temperature map of WASP-18b – a gas giant known as an “ultra-hot Jupiter,” located 400 light years from Earth – is the first applying a technique called 3D eclipse mapping, or spectroscopic eclipse mapping. The effort builds on a 2D model that members of the same team published in 2023, which demonstrated eclipse mapping’s potential ...

For the first time, a team of Inserm researchers from the Physics for Medicine Institute (Inserm/ESPCI Paris-PSL/CNRS) has succeeded in mapping the blood flow of an entire organ in animals (heart, kidney and liver) with great precision, in four dimensions: 3D + time. This new imaging technique, when applied to humans, could both improve our understanding of the circulatory system (veins, arteries, vessels and lymphatic system) and facilitate the diagnosis of certain blood circulation-related diseases. These results are published ...

Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body’s ability to fight infection, new research shows.  Scientists found that oxygen deprivation – known as hypoxia – changes the genetic material of immune cells called neutrophils, reducing their capacity to destroy harmful microbes.  The team discovered that low oxygen appears to leave a lasting mark on the bone marrow cells that produce neutrophils, meaning the impact can persist after oxygen ...

A new UCLA study reveals that breast milk from women living with HIV contains significantly lower levels of tryptophan, an essential amino acid likely important for infant immune function, growth, and brain development. This discovery may help explain why children born to women living with HIV experience higher rates of illness and developmental challenges, even when the children themselves are not infected with the virus. The study appears in Nature Communications. Why it matters Approximately 1.3 million children are born to women living with HIV annually worldwide. Even with effective antiretroviral therapy that prevents HIV transmission, these children who ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer treatment. But while they’ve delivered impressive results against certain blood cancers, they’ve struggled to make an impact in solid tumors, such as those in the breast, lung, and prostate. The tumor microenvironment is the problem A major problem is the tumor microenvironment (TME), which is a mix of cells and molecules ...

Photos: here SAN DIEGO (Oct. 28, 2025) – A new study published in the scientific journal Oikos reveals for the first time the critical role polar bears play as carrion providers for Arctic species. Researchers from University of Manitoba and San Diego Zoo Wildlife Alliance, alongside researchers from Environment and Climate Change Canada, and the University of Alberta, have estimated that polar bears leave behind approximately 7.6 million kilograms of their prey annually, creating a massive and vital food source for a wide network of arctic scavenger ...

Statement Highlights: Disruptions to circadian rhythms, the body’s internal clock, are strongly associated with increased risk of obesity, Type 2 diabetes, high blood pressure and cardiovascular disease. Factors such as rotating schedules or shift work, irregular sleep and meal times, or light exposure at night often cause these disruptions. Body clock disruptions impair metabolic regulation, blood pressure control and hormonal balance, contributing to disease progression. Optimizing circadian rhythms offers a promising preventive strategy for cardiometabolic health. Behavioral interventions to better regulate the body’s ...

In the 17th century, Francis Bacon described a simple experiment—scraping  and fracturing hard sugar in the dark to see sparks of light. This phenomenon is called mechanoluminescence (ML) or triboluminescence (TL), the process of materials emitting light under mechanical stimulation, like grinding or crushing. Usually, ML properties of luminescent compounds are observed in rigid crystalline systems, which limits their real-world applications. Now, researchers at the Okinawa Institute of Science and Technology (OIST) have found a way to generate ML ...

Proteins sourced from microorganisms are attracting attention for their potential in biomanufacturing a variety of products, including pharmaceuticals, industrial enzymes, and diagnostic antibodies. These proteins can also be used for converting resources into biofuels and bioplastics, which could serve as viable alternatives to petroleum-based fuels and products. Therefore, efficiently producing microbial proteins could make a significant contribution to sustainable manufacturing. Producing proteins from Escherichia coli (E. coli) has become popular due to its cost-effectiveness ...

The American Association for the Advancement of Science (AAAS) is pleased to announce its partnership with Sun Yat-sen University Cancer Center (SYSUCC) to publish Cancer Communications as a Science Partner Journal. Cancer Communications publishes basic, clinical, and translational cancer research. The journal welcomes submissions concerning clinical trials, epidemiology, molecular and cellular biology, and genetics. Professor Rui-Hua Xu will serve as Editor-in-Chief. “As a leading hub for cancer research, Sun Yat-sen University Cancer Center (SYSUCC) has long strived to bridge global oncology ...

MELBOURNE, Victoria, AUSTRALIA, 28 October 2025 -- A systematic review published today in Psychedelics by Mr. James Gattuso and colleagues at the Florey Institute of Neuroscience and Mental Health synthesizes clinical and preclinical evidence on psilocybin's effects on obsessive-compulsive behaviours, revealing consistent therapeutic potential across human patients and validated animal models. The comprehensive analysis examined 13 eligible studies identified through systematic database searches, including four clinical trials involving patients with obsessive-compulsive disorder and body dysmorphic disorder, alongside nine preclinical investigations using established behavioural paradigms. ...