Researchers have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule that helps certain cancer cells survive. Using advanced “RIBOTAC” technology, their compound finds TERRA inside cells and breaks it down without harming healthy molecules. This discovery could pave the way for a new generation of RNA-based cancer treatments, targeting the disease at its genetic roots rather than just its symptoms.   Scientists at the Hebrew University of Jerusalem have developed a new kind of drug ...

Titanium (Ti) is a promising metal for biomedical implant applications owing to lightweight, superior corrosion resistance and biocompatibility. Unfortunately, Ti is besieged by poor wear resistance owing to inferior plastic shear-resistance and strain-hardening capacity, thus causing premature failure upon joint friction. And conventional strengthening methods inevitably compromise the inherent biocompatibility and safety of pure titanium, which poses a sizable challenge in the manufacturing of wear-resistant Ti orthopedic implants. As described by the Archard law, wear resistance ...

Forget gears and motors. The next generation of robots may run on living muscle. Scientists are now fusing biological tissue with engineered structures to create "biohybrid robots"—machines that flex, contract, and move using the same power source we do: cells. The potential could be striking. Imagine tiny robots swimming through your bloodstream to deliver drugs, engineered tissues that help heal damaged organs, or living systems that model diseases more faithfully than any computer. But so far, most of these robots are fragile lab prototypes, more science experiment than practical tool. A new review in the International Journal of Extreme Manufacturing maps out how to get ...

Our fat cells, called adipocytes, do more than just store extra weight. They play a key role in managing the body’s energy. Adipocytes accumulate fat in the form of lipid droplets that the body can use when needed—for example, during fasting periods between meals. To do this, the body uses the HSL protein like a kind of switch. When energy is lacking, HSL is activated by hormones such as adrenaline and releases fat to fuel various organs. In the absence of HSL, one might assume that the energy tap is shut off and that fat would inevitably accumulate. Paradoxically, however, studies in mice and in patients with mutations in the HSL gene show that this does ...

Up to 60% of congenital and early-onset hearing loss is caused by genetic mutations in an inherited gene, and gene therapy has recently emerged as a potential treatment option. To provide a standardized framework for conducting safe, high-quality clinical trials, a group of international experts has put together guidelines on the administration of gene therapy for hereditary hearing loss. Publishing in the Cell Press journal Med on October 23, the guidelines highlight the need for patient-centered care and respect for the diversity of perspectives within the hearing loss community.  “Cochlear gene therapy ...

Coffee beans harvested from the faeces of the Asian palm civet (Paradoxurus hermaphroditus) may have higher levels of fats and other key flavour-enhancing compounds than traditionally harvested beans. The results, published in Scientific Reports, may help explain why this type of coffee is so prized. Civet coffee, also known as kopi luwak, is one of the most expensive types of coffee in the world, and can sell for more than US $1,000 per kilogram of beans. The beans are harvested from the faecal matter of civets — usually Asian palm civets ...

About The Study: In this cohort study, glucagon-like peptide-1 receptor agonist (GLP-1RA) use was associated with reduced risk of developing nonexudative age-related macular degeneration (AMD) but was not associated with progression to exudative AMD among individuals with nonexudative AMD. These findings may inform future randomized trials evaluating the ocular effects of GLP-1RAs in nondiabetic populations.  Corresponding Author: To contact the corresponding author, Benjamin K. Young, MD, MS, email youngbe@ohsu.edu. To access ...

About The Study: In this large cohort study, prenatal exposure to specific fine particulate matter (PM2.5) components and postnatal ozone (O3) exposure were associated with autism spectrum disorder risk. The second and third trimesters may represent sensitive exposure windows. These findings support further research on air pollution’s role in autism spectrum disorder etiology.  Corresponding Author: To contact the corresponding author, Eric Lavigne, PhD, email eric.lavigne@hc-sc.gc.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.38882) Editor’s ...

About The Study: In this cohort study, night light exposure was a significant risk factor for developing cardiovascular diseases among adults older than 40 years. These findings suggest that, in addition to current preventive measures, avoiding light at night may be a useful strategy for reducing risks of cardiovascular diseases.  Corresponding Author: To contact the corresponding author, Daniel P. Windred, PhD, email daniel.windred@flinders.edu.au. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.39031) Editor’s ...

A new study led by Flinders University has found that being exposed to bright light at night can significantly increase the chances of developing serious heart problems, including heart attacks, strokes and heart failure. Published in JAMA Network Open, the research is the largest study of its kind to explore how personal light exposure affects heart health using data from nearly 89,000 people in the UK. Using wrist-worn sensors, researchers from FHMRI Sleep Health tracked over 13 million hours of light exposure and followed participants for up to 9.5 years. The study found that people who were exposed to the brightest light at night were much more likely to develop ...

“These results indicate that PAI-1 is partly involved in aging-related sarcopenia and osteopenia in female mice, although the corresponding mechanisms remain unknown.” BUFFALO, NY — October 23, 2025 — A new research paper was published in Volume 17, Issue 9 of Aging-US on September 11, 2025, titled “Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice.” In this study led by first author Takashi Ohira and corresponding author Hiroshi Kaji from Kindai University Faculty of Medicine, researchers found that female mice lacking the gene for plasminogen ...

Few actions in nature inspire more fear and fascination than snake bites. And the venomous reptiles have to move fast to sink their fangs into their prey before their victim flinches, which may be as little as 60 ms when hunting rodents. Until recently, video technology was not sufficiently sophisticated to capture the deathly manoeuvres in high definition, but recent improvements have made this possible, so Alistair Evans and Silke Cleuren from Monash University, Australia, decided to get to the heart of how venomous viper, ...

A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists. The King’s College London discovery, published today, could provide new treatment options for some of the most aggressive forms of breast cancer. This may be particularly important for patients whose cancers no longer respond to existing therapies, as well as those with triple-negative breast cancer – a subtype which lacks the receptors which are common drug targets, where treatment choices remain very limited. The team designed an antibody that not only attacks the tumour cells directly, but also harnesses the body’s own immune ...

UNIVERSITY PARK, Pa. — The discovery of a possible “super-Earth” less than 20 light-years from our own planet is offering scientists new hope in the hunt for other worlds that could harbor life, according to an international team including researchers from Penn State. They dubbed the exoplanet, named GJ 251 c, a “super-Earth” as data suggest it is almost four times as massive as the Earth, and likely to be rocky planet. "We look for these types of planets because they are our best chance at finding life elsewhere,” said Suvrath Mahadevan, the Verne M. Willaman Professor of Astronomy at Penn State and co-author ...

This study was led by Jinxiao Hou, Dr. Xiaolin Hou, and Dr. Yanyun Wang from the Institute of Earth Environment, Chinese Academy of Sciences. The northern offshore region of the South China Sea hosts one of the highest densities of nuclear power plants along China’s coastline. By systematically collecting seawater samples throughout this area and applying the laboratory’s well-established ultra-trace analytical techniques for ¹²⁹I and ¹²⁷I, the team measured the concentration levels and spatial distributions of both isotopes. By integrating observed ¹²⁹I/¹²⁷I atomic ...

Interventions designed to reduce loneliness can be effective, but do not yet offer a complete solution to what is becoming a worldwide public health problem, according to research published by the American Psychological Association.   “Loneliness is now widely acknowledged as a serious public health concern linked to depression, anxiety, cardiovascular disease and even early mortality,” said lead author Mathias Lasgaard, PhD, of the Central Denmark Region and University of Southern Denmark. “Our findings provide strong evidence that interventions can make a difference, though their overall impact remains modest. Loneliness does not have a one-size-fits-all ...

WASHINGTON (Oct. 23, 2025) — A new study estimates that nearly one in five urinary tract infections in Southern California may be caused by E. coli strains transmitted through contaminated meat – and pose a hidden foodborne risk to millions of people not just in California but across the US. The research, published in mBio, also found that people living in low-income neighborhoods are at the greatest risk. “Urinary tract infections have long been considered a personal health issue, but our findings suggest that they are also a food safety problem,” said Lance B. Price, senior author of the ...

A study from the College of Engineering and Computer Science and the Sensing Institute (I-SENSE) at Florida Atlantic University reveals that foot-mounted wearable sensors and a 3D depth camera can accurately measure how people walk – even in busy clinical environments – offering a powerful and more accessible alternative to traditional gait assessment tools. Gait, the pattern of how a person walks, is an increasingly important marker of overall health, used in detecting fall risk, monitoring rehabilitation, and identifying ...

Quantum computers are computers that are much faster at performing some important types of computational tasks than many of today's machines. Sounds perfect, right? But for now, the building blocks that perform the calculations in the quantum computer, so-called quantum bits or "qubits", are too unstable to make quantum processors that are large enough to be really useful. "Quantum computers are completely dependent on qubits remaining stable in order to perform the special calculations they are designed for," says Jacob Benestad, who recently ...

LOS ANGELES — Liver disease is usually caused by one of three factors: alcohol consumption, fat buildup in the liver linked to obesity, diabetes and high cholesterol, or hepatitis B and C.   Now, a new study published in Liver International from Keck Medicine of USC reveals that tetrachloroethylene (PCE), a chemical used in dry cleaning and found in consumer products such as adhesives for arts and crafts, spot cleaners and stainless steel polish, may also be harmful to the liver.  Exposure to PCE was shown to triple the risk ...

DALLAS, Oct. 23, 2025 — Zainab Mahmoud, M.D., M.Sc., an assistant professor of medicine at Washington University School of Medicine in St. Louis, and Zhao Zhang, Ph.D., an assistant professor at the University of Texas (UT) Southwestern Medical Center in Dallas, will receive the inaugural Jack Sarver Prize in Clinical Science and Jack Sarver Prize in Basic Science, respectively, at the American Heart Association’ Scientific Sessions 2025. The meeting, to be held Nov. 7-10, 2025, in New Orleans, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular ...

Miami (October 23, 2025) – The Bronchiectasis and NTM Association announced today that two abstracts using Bronchiectasis and NTM Research Registry data were presented at CHEST 2025, held October 19-22, 2025, in Chicago. The abstracts are: “The Relationship Between Baseline Severity of Bronchiectasis and Incident Non-Tuberculous Mycobacterial Infection: findings from the U.S. Bronchiectasis and NTM Research Registry,” which examined whether increased bronchiectasis severity was associated with an increased risk of NTM ...

CLEVELAND—For decades, scientists have thought they understood the biochemical machinery that causes asthma—inflammation in the lungs that constricts airways and makes it hard to breathe. Molecules called “leukotrienes”—chemicals that get released from white blood cells when something irritates your airways or you inhale an allergen—were labeled the culprits. Medications have been developed to block the molecular cascade they initiate that leads to difficulty breathing. But ...

Nursing education is not only about clinical skills. It also shapes the values, attitudes, and sense of responsibility of those who provide care. In Japan, most nursing programs follow government-prescribed curricula that emphasize qualifications, leaving limited space for universities to articulate their own missions. Catholic universities, however, stand apart. Their nursing faculties embed spiritual and ethical perspectives, placing compassion, dignity, and service at the heart of the profession.   A study led by Professor Naoko Tsukamoto with Ms. Aya Watanabe, Ms. Yoko Takiguchi, and Ms. Yukiko Katagiri from Sophia University’s ...

Chronic kidney disease (CKD) is a progressive condition in which the kidneys gradually lose their ability to filter waste from the blood. It is a common health concern that affects an estimated 8–16% of the global population, particularly among older adults. CKD can arise from various causes, including glomerulonephritis, a group of diseases that damage the glomeruli, the tiny filtering units within the kidneys.   Now, researchers from Chiba University have identified a molecule called C-C chemokine ligand 5 (CCL5) as a key player in ...