PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

rcssci: Simplifying complex data relationships with enhanced visual clarity

2025-07-18
(Press-News.org)

The recent release of the rcssci R package represents a significant advancement in the way researchers visualize and analyze complex relationships between continuous variables and their outcomes. The package introduces an innovative methodology for creating more refined and aesthetically pleasing Restricted Cubic Spline (RCS) plots, offering four distinct styles for enhanced data interpretation. These improvements not only increase the statistical clarity of the results but also provide a more user-friendly interface for researchers working across various types of regression models.

“We’ve seen a need in the research community for a more intuitive and visually sophisticated way to represent RCS data,” said Dr. Zhiqiang Nie, lead researcher behind the package. “With rcssci, we’ve taken an existing tool and refined it to make these complex relationships more accessible, visually appealing, and easier to interpret.”

One of the standout features of the rcssci package is its ability to automatically generate four different types of RCS plots based on the data input, including Cox, logistic, linear, and quasi-Poisson regression models. Each plot includes dynamic reference lines and morphologically optimized cut-off points, providing not just statistical insight but also a clear visual representation of non-linear trends.

The package’s flexibility is evident in its handling of the number of knots used in the spline fitting process. By allowing users to adjust the number of knots from 3 to 5, the tool can adapt to different data sets and provide more accurate models of non-linear relationships. The results can be tailored to identify U-shaped or L-shaped associations, or even stratified analyses based on subgroup variables.

"This package is a game-changer for anyone working with RCS data," Dr. Hongbin Xu added. "It not only addresses the limitations of previous packages but also empowers researchers to explore and present their data with greater precision."

In practical terms, rcssci helps researchers visualize trends in healthcare data, such as the relationship between blood pressure and health risks. By improving the visual clarity of these relationships, rcssci enables a deeper understanding of how continuous variables interact with health outcomes, which could lead to more accurate models for predicting disease risk.

With its robust analytical capabilities and elegant design, rcssci is poised to become an essential tool in the research community, improving both the clarity and the impact of data analysis.

END



ELSE PRESS RELEASES FROM THIS DATE:

Why some ecosystems collapse suddenly—and others don’t

2025-07-18
A new study published in the journal One Earth reveals that the way ecosystems collapse—abruptly or gradually—may depend on internal complexity, much like how magnetic materials behave under stress. The study, led by Professor John Dearing at the University of Southampton with colleagues from Rothamsted Research, Bangor University, and Edinburgh University, challenges the prevailing assumption that climate tipping points always happen suddenly. Instead, it shows that some large-scale Earth systems may be experiencing gradual ...

One-third of U.S. public schools screen students for mental health issues

2025-07-18
Nearly one-third of the nation’s K-12 U.S. public schools mandate mental health screening for students, with most offering in-person treatment or referral to a community mental health professional if a student is identified as having depression or anxiety, according to a new study.   About 40% of principals surveyed said it was very hard or somewhat hard to ensure that students receive appropriate care, while 38% said it was easy or very easy to find adequate care for students. The findings are published in the journal JAMA Network ...

GLP-1 RA use and survival among older adults with cancer and type 2 diabetes

2025-07-18
About The Study: In older patients with cancer and type 2 diabetes, glucagon-like peptide-1 receptor agonist (GLP-1RA) use was associated with lower all-cause mortality compared with dipeptidyl peptidase-4 inhibitor (DPP4i) use, with no significant difference relative to sodium-glucose cotransporter-2 inhibitor. The survival benefit over DPP4i persisted across age, sex, non-Hispanic white race, obesity status, and several cancer types (colorectal, lung, and breast).  Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.21887) Editor’s ...

Trends in physician exit from fee-for-service Medicare

2025-07-18
About The Study: Over time, physician exit from traditional Medicare has increased. This result is consistent with earlier findings, but exits remained high even after the pandemic, which likely accelerated some physicians’ exit. The findings may reflect multiple factors, including the greater burden of new communication methods (e.g., portal messages) and demands for clinical documentation. Corresponding Author: To contact the corresponding author, Hannah T. Neprash, PhD, email hneprash@umn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2025.2267) Editor’s ...

Systematic investigation of tumor microenvironment and antitumor immunity with IOBR

2025-07-18
Over the past decade, the advent of immune checkpoint blockade (ICB) therapy has transformed cancer treatment. Unlike conventional cytotoxic and targeted therapies, immunotherapy leverages both the innate and adaptive immune systems to target and eradicate tumors within the tumor microenvironment (TME). The TME is a highly organized ecosystem shaped by the intricate interactions between its diverse cellular and non-cellular components, which include tumor cells, immune cells, microbiota, endothelial cells, fibroblasts, and the extracellular matrix. Consequently, gaining a thorough ...

Common feature between forest fires and neural networks reveals the universal framework underneath

2025-07-18
Researchers from the University of Tokyo in collaboration with Aisin Corporation have demonstrated that universal scaling laws, which describe how the properties of a system change with size and scale, apply to deep neural networks that exhibit absorbing phase transition behavior, a phenomenon typically observed in physical systems. The discovery not only provides a framework describing deep neural networks but also helps predict their trainability or generalizability. The findings were published in the journal Physical Review Research. In recent years, it seems no matter where we look, we come across artificial intelligence ...

New R package revolutionizes gene set enrichment analysis visualization for biomedical research

2025-07-18
Scientists at China Pharmaceutical University have launched GseaVis, a groundbreaking R package designed to transform how researchers visualize and interpret Gene Set Enrichment Analysis (GSEA) results in biomedical research. Gene Set Enrichment Analysis is a powerful computational method widely used to determine whether predefined sets of genes show statistically significant differences between biological states, such as healthy versus diseased conditions. However, effective visualization of GSEA results ...

Benign uterine tumor resembling cancer highlights diagnostic challenges

2025-07-18
“This case highlights that lipoleiomyomas can present many years after attaining menopause.” BUFFALO, NY — July 18, 2025 — A new case report was published in Volume 12 of Oncoscience on July 2, 2025, titled “Navigating diagnostic complexity: A case report on uterine lipoleiomyoma, unveiling its benign nature amidst characteristics resembling liposarcoma.” In this report, Seetu Palo, first corresponding author Mishu Mangla and colleagues from the All India Institute of Medical Sciences describe a rare case where a benign uterine tumor closely resembles a malignant tumor in an elderly patient. ...

Diagnostic performance of ATR-FTIR spectroscopy in discriminating normal breast tissue and breast tumors

2025-07-18
Background and objectives Histopathology is the gold standard in cancer diagnosis. However, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy has shown diagnostic potential in other settings. Therefore, this study aimed to investigate the sensitivity and specificity of the ATR-FTIR spectroscopy in evaluating breast lesions. Methods This study was conducted on formalin-fixed, paraffin-embedded biopsy blocks received at Ladoke Akintola University of Technology Teaching Hospital between ...

Recent advancements in the treatment of age-related macular degeneration

2025-07-18
Age-related macular degeneration (AMD) remains a leading cause of vision loss globally, with significant advancements in treatment options for both dry and wet AMD. As highlighted by Huang and colleagues, "Current therapies for dry AMD have limited effectiveness in halting the progression of geographic atrophy (GA), underscoring the need for innovative approaches". One of the most notable breakthroughs is the FDA approval of pegcetacoplan and avacincaptad pegol, targeting the complement system to slow GA progression. Pegcetacoplan, a C3 inhibitor, reduced GA lesion growth by 19–22% ...

LAST 30 PRESS RELEASES:

How and when could AI be used in emergency medicine?

Report yields roadmap for Americans to age with health, wealth, and social equity

Pain research reveals new detail of how synapses strengthen

Hidden process behind 2025 Santorini earthquakes uncovered

Giant impactor Theia formed in the inner Solar System

Rebalancing lung repair with immune damage is key to surviving severe influenza

2025 Santorini seismic unrest triggered by “pumping” magma flow

Toxic gut bacteria may drive ulcerative colitis by killing protective immune cells

Rethinking where language comes from

Subverting plasmids to combat antibiotic resistance

Theia and Earth were neighbors

Calcium “waves” shape flies’ eyes

Scientists uncover new on-switch for pain signaling pathway that could lead to safer treatment and relief

Modeling of electrostatic and contact interaction between low-velocity lunar dust and spacecraft

Building a sustainable metals infrastructure: NIST report highlights key strategies

Discovering America’s ‘epilepsy belt’: First-of-its-kind national study reveals US regions with high epilepsy rates among older adults

Texting helps UCSF reach more patients with needed care

Working together to combat the spread of antibiotic resistance

Developing dehydration and other age-related conditions following major surgery linked to dramatically worse outcomes for older adults

Aged blood vessel cells drive metabolic diseases

This moss survived 9 months directly exposed to the elements of space

UC San Diego researchers develop new tool to predict how bacteria influence health

Prediction of optic disc edema progression during spaceflight

Age-based screening for lung cancer surveillance in the US

Study reveals long-term associations of strangulation-related brain injury from intimate partner violence

Monsoon storms will bring heavier rains but become weaker

New therapeutic strategies show promise against a hard-to-treat prostate cancer

Inflammatory biomarkers in ischemic stroke: mechanisms, clinical applications, and future directions

Grants to UC San Diego will boost roadway safety for Native American youth and pedestrians

Announcing the 2025 Mcknight Brain Research Foundation Innovator Awards in Cognitive Aging and Memory Loss: Leah Acker, MD, Ph.D., of Duke University and Erin Gibson, Ph.D., of the Stanford School of

[Press-News.org] rcssci: Simplifying complex data relationships with enhanced visual clarity