Mesonephric carcinoma and mesonephric-like adenocarcinoma of the female genital tract
2025-09-09
Mesonephric carcinoma (MC) is a rare cervical adenocarcinoma originating from mesonephric remnants, characterized by diverse architectural patterns and a distinct immunophenotype. A subset of adenocarcinomas in the endometrium and ovary with similar morphology but lacking association with mesonephric remnants is classified as mesonephric-like adenocarcinoma (MLA). This review synthesizes current knowledge on the clinicopathological and molecular features of MC and MLA, emphasizing their diagnostic challenges, differential diagnoses, and clinical behavior.
Mesonephric Remnants and Hyperplasia
Mesonephric remnants are vestiges of the Wolffian ducts, ...
Rural patients in the United States still face barriers to telehealth access
2025-09-09
(Toronto, September 9, 2025) Despite the promise of telehealth to bridge rural health care gaps, a new study published by JMIR Publications in the Journal of Medical Internet Research reveals that many rural-dwelling patients in the United States—especially those who are older, speak Spanish, or rely on public insurance—are still struggling to access virtual care.
The study, “Video and Telephone Telehealth Use and Web-Based Patient Portal Activation Among Rural-Dwelling Patients: Retrospective Medical Record Review and Policy Implications,” examined the telehealth usage patterns of over 9300 adults in rural California. Conducted by Meghan Rowe ...
Emphysema at CT lung screening increases death risk in asymptomatic adults
2025-09-09
OAK BROOK, Ill. – Emphysema detected on baseline low-dose chest CT (LDCT) in the lung cancer screening cohort of more than 9,000 asymptomatic adults was associated with death from all causes, chronic obstructive pulmonary disease (COPD), and cardiovascular disease within a 25-year follow-up period in a new study published today in Radiology, a journal of the Radiological Society of North America (RSNA).
Emphysema is a permanent and progressive lung disease in which air sacs in the lungs become damaged, making breathing difficult. It is primarily caused by long-term exposure to irritants like cigarette smoke and air pollution.
“Until now, ...
Brain iron on MRI predicts cognitive impairment, decline
2025-09-09
A special MRI technique that detects iron levels in different regions of the brain can predict the onset of mild cognitive impairment and cognitive decline in cognitively unimpaired older adults, potentially creating a pathway to earlier interventions, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA).
As the leading cause of dementia worldwide, Alzheimer’s disease is a growing public health crisis. The disease is characterized by the accumulation of abnormal ...
The ISSCR partners with Nuffield Council on Bioethics to compile global horizon scan on stem cell research
2025-09-09
The International Society for Stem Cell Research (ISSCR) today announced a new partnership with the Nuffield Council on Bioethics (NCOB) to conduct an ambitious international horizon scan focused on the future of stem cell science and its ethical implications. The initiative will help signal and inform updates to the ISSCR Guidelines for Stem Cell Research and Clinical Translation and guide the Society’s broader public policy agenda.
The ISSCR, the world’s largest and most influential independent organization dedicated to ...
Machine learning unveils COPD patient clusters and quality of life associations in China
2025-09-09
A recent study published in Engineering utilized machine learning to identify distinct clusters of chronic obstructive pulmonary disease (COPD) patients in China, highlighting how comorbidity profiles impact health-related quality of life (HRQoL). Conducted by researchers from the Chinese Academy of Medical Sciences & Peking Union Medical College, Heidelberg University, Stanford University, and other leading institutions, the study leverages data from the Chinese Enjoying Breathing Program to provide insights into the heterogeneity of COPD and its implications for targeted public health interventions.
COPD is a progressive respiratory disorder and a major global ...
No sign of toxic effects of inhaled anesthesia in young children
2025-09-09
CHICAGO – Preliminary findings from a new clinical trial show no adverse neurodevelopmental effects after brief inhaled anesthesia and surgery in infants and young children, reports the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).
A "balanced" strategy using a lower dose of the inhaled anesthetic sevoflurane did not lead to meaningful short-term differences in IQ or child behavior problems, according ...
CUNY SPH expands curriculum with concentration in sexual and reproductive justice and health
2025-09-09
New York, NY | Sept. 9, 2025: Beginning January 2026, the CUNY Graduate School of Public Health and Health Policy (CUNY SPH) will offer a new master of public health (MPH) concentration in sexual and reproductive justice and health (SRJH). Building on the school’s longstanding commitment to equity, the concentration expands and deepens opportunities for students to engage with sexual and reproductive health through a justice-centered, interdisciplinary lens.
As part of the Department of Community ...
High consumption of ultra-processed foods linked to systemic inflammation
2025-09-09
Ultra-processed foods (UPFs) are industrially altered products – like soda, snacks and processed meats – packed with additives and stripped of nutrients. Hundreds of new ingredients, previously unknown to the human body, now make up nearly 60% of the average adult’s diet and almost 70% of children’s diets in the United States.
These products reduce nutritional value, extend shelf life, and tend to increase how much people consume. In the U.S., UPFs account for about 60% of daily calorie ...
City of Hope launches transformative national clinical trials model to accelerate cancer research
2025-09-09
LOS ANGELES — City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S., launched an innovative national clinical trials model to expand access to emerging life-saving cancer treatments to more patients across the country. This model simplifies the opening of new trial locations and streamlines patient enrollment with the goal of accelerating the development of new cancer treatments and improving clinical care.
As the first academic center with a national clinical trial network and a large and diverse patient ...
Inside an academic scandal: a story of fraud and betrayal
2025-09-09
In 2012 Max Bazerman, along with four coauthors, published an influential paper showing that “signing first”—that is, promising to tell the truth before filling out a form—produced greater honesty than signing afterward. In 2021, academic sleuths revealed that two of the experiments in the paper were fraudulent, triggering what would become one of the most significant academic frauds of the twenty-first century.
In Inside an Academic Scandal, Bazerman tells the sobering story of how fraud in a published paper about inducing honesty upended countless academic careers, wreaked havoc in organizations ...
Innovative ultrasonic regeneration restores nano-phase change emulsions for low-temperature applications
2025-09-09
Phase change emulsions (NPCEs) have significant potential for energy storage and temperature regulation due to their high energy density and efficient heat transfer. However, in most conventional NPCEs, performance under low-temperature and shear conditions is often compromised, leading to droplet coalescence and instability. A team of scientists has developed a high-energy ultrasonic regeneration strategy that enables real-time restoration of NPCE performance without interrupting the operation cycle. Their work was published in the journal Industrial Chemistry & Materials on July 28.
“We aim to develop a robust emulsion system that can withstand ...
Targeted snow monitoring at hotspots outperforms basin-wide surveys in predicting water supply
2025-09-09
CORVALLIS, Ore. – Measuring mountain snowpack at strategically selected hotspots consistently outperforms broader basin-wide mapping in predicting water supply in the western United States, a new study found.
Researchers analyzed more than 20 years of snow estimates and streamflow data across 390 snow-fed basins in 11 western states to evaluate two potential strategies for expanded snow monitoring. This analysis revealed locations the researchers are calling hotspots — localized areas ...
Decades-old barrels of industrial waste still impacting ocean floor off Los Angeles
2025-09-09
In 2020, haunting images of corroded metal barrels in the deep ocean off Los Angeles leapt into the public consciousness. Initially linked to the toxic pesticide DDT, some barrels were encircled by ghostly halos in the sediment. It was unclear whether the barrels contained DDT waste, leaving the barrels’ contents and the eerie halos unexplained.
Now, new research from UC San Diego's Scripps Institution of Oceanography reveals that the barrels with halos contained caustic alkaline ...
Finalists announced for the 2025 Blavatnik National Awards for Young Scientists
2025-09-09
September 9, 2025 – New York – The Blavatnik Family Foundation and The New York Academy of Sciences today announced the Finalists for the 2025 Blavatnik National Awards for Young Scientists. The Awards recognize scientific advances made by researchers in the United States across the following disciplines: Life Sciences, Chemical Sciences, and Physical Sciences & Engineering.
Subra Suresh, ScD, Former Director of the National Science Foundation and current President of the Global Learning Council in Switzerland, will announce the three 2025 ...
Alkali waste dumped in the Pacific Ocean created alkalophilic ecosystems
2025-09-09
Barrels filled with industrial waste that were dumped in the sea near Los Angeles more than 50 years ago are creating new microbial ecosystems adapted to highly alkaline conditions. It has been estimated that hundreds of thousands of barrels of waste were dumped off the coast of California in the mid 20th century. Previous investigations suggested that the barrels once contained dichlorodiphenyltrichloroethane (DDT)—an insecticide known for its broad toxicity that was banned for agricultural use in 1972. ...
Bacterial ink to restore coral reefs
2025-09-09
A living ink containing bacteria attracts coral larvae and could help rebuild reefs. Corals are struggling with water pollution, as well as warming and acidification caused by climate change. One way to support coral reef persistence is to encourage coral recruitment onto the reef. Coral larvae are free-swimming animals that eventually settle onto a surface and transform into a polyp with a hard, durable body. Certain bacteria secrete chemical cues that stimulate settlement and metamorphosis. Settled polyps may then reproduce asexually, expanding the size of the reef. Daniel Wangpraseurt and colleagues created a living material that encourages coral larvae to attach ...
AI-based satellite count of migrating wildebeest
2025-09-09
An AI-powered satellite counting effort conducted over two years concludes that less than 600,000 wildebeest migrate across the Serengeti-Mara ecosystem each year—half of previous estimates from manned aircraft surveys. Lions, hyenas, crocodiles, and tourism professionals all rely on the annual migration of wildebeest (Connochaetes taurinus) which transit through Kenya and Tanzania as the herds follow the seasonal growth of grass. Prior estimates of the migratory wildebeest population that make the trek each year were reached by extrapolating counts from aerial photos in the south of the ecosystem. Isla Duporge and colleagues ...
Bee-sting inspired microneedles from Chung-Ang University could revolutionize drug delivery
2025-09-09
Neurological diseases affect millions worldwide, and the need for long-term patient-friendly treatments has never been greater. While needle-based injections are the standard for most therapies, regular drug injections can often be painful and inconvenient. Microneedles—which are tiny, micron-sized needle systems— have emerged as a promising alternative to conventional needles and offer a pain free way to deliver medicines. However, most existing microneedles are rigid and can cause discomfort during prolonged use and therefore limits their adoption in long-term use.
To overcome this, researchers from South Korea have designed a new microneedles system inspired by the ...
Pusan National University researchers reveal how uneven ocean warming is altering propagation of the Madden-Julian oscillation
2025-09-09
The Earth’s tropical regions drive some of the most powerful weather and climate variability globally. Among these, the Madden–Julian Oscillation (MJO) is a dominant intraseasonal climate signal, characterized by large clusters of clouds and rainfall that slowly move eastward across the warm tropical oceans. In doing so, the MJO shapes rainfall patterns, influences tropical cyclones, modulates monsoons, and even impacts weather far beyond the tropics. Understanding the factors that govern its ...
Mapping causality in neuronal activity: towards a better understanding of brain networks
2025-09-09
Understanding the brain’s functional architecture is a fundamental challenge in neuroscience. The connections between neurons ultimately dictate how information is processed, transmitted, stored, and retrieved, thus forming the basis of our cognitive functions. Scientists often study neuronal signaling by recording the brief electrical pulses they generate over time, often referred to as ‘spike trains.’
Because of their bursty and aperiodic nature, inferring causal relationships between spike trains recorded from different neurons remains ...
New research identifies IFITM3 as key driver of immunotherapy response in small cell lung cancer
2025-09-09
(Barcelona, Spain September 9, 2025 1 p.m. CEST / UTC +2) — New research presented identifies interferon-induced transmembrane protein 3 (IFITM3) as a critical regulator of immunotherapy sensitivity in small cell lung cancer (SCLC), offering a promising new avenue for overcoming resistance to PD-1/PD-L1 checkpoint blockade.
The research was presented at the International Association for the Study of Lung Cancer 2025 World Conference on Lung Cancer (WCLC).
SCLC tumors are typically characterized by low expression of major histocompatibility complex class I (MHC-I), which impairs ...
Scientists find curvy answer to harnessing “swarm intelligence”
2025-09-09
Birds flock in order to forage and move more efficiently. Fish school to avoid predators. And bees swarm to reproduce. Recent advances in artificial intelligence have sought to mimic these natural behaviors as a way to potentially improve search-and-rescue operations or to identify areas of wildfire spread over vast areas—largely through coordinated drone or robotic movements. However, developing a means to control and utilize this type of AI—or “swarm intelligence”—has proved challenging.
In a newly published paper, an international team of scientists describes a framework designed to advance swarm intelligence—by controlling flocking and ...
PALOMA-2 study: Subcutaneous amivantamab every 4 weeks plus lazertinib shows high response rate in EGFR-mutated NSCLC
2025-09-09
(Barcelona, Spain--September 9, 2025 at 11:30 AM CEST / UTC +2)— A new analysis from the PALOMA-2 study presented today shows that subcutaneous administration of amivantamab every four weeks (Q4W), in combination with daily oral lazertinib, yields a high objective response rate in patients with previously untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC).
The results were presented at the International Association for the Study of Lung Cancer at the 2025 World Conference on Lung Cancer (WCLC).
In the fully enrolled Cohort 5 of the PALOMA-2 trial, the Q4W dosing regimen was shown to maintain similar efficacy compared ...
First 3D real-time imaging of hydrogen’s effect on stainless steel defects opens the way to a safer hydrogen economy
2025-09-09
A study led by University of Oxford and Brookhaven National Laboratory researchers has uncovered how exposure to hydrogen atoms dynamically alters the internal structure of stainless steel.
The findings reveal that hydrogen allows internal defects in steel to move in ways not normally possible – which can lead to unexpected failure.
This discovery offers vital insights that could help make hydrogen fuel systems safer and more reliable, from aircraft and fusion reactors to pipelines and storage tanks.
The study has been published today (9 Sept) ...
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