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Radiation therapy after surgery safely reduces pelvic relapse risk from locally advanced, muscle-invasive bladder cancer

2025-09-29
SAN FRANCISCO, September 29, 2025 — Radiation therapy could be an underused tool to reduce pelvic relapse risk for patients with locally advanced, muscle-invasive bladder cancer, according to results of a new phase III randomized trial. In the study, moderate doses of radiation therapy after bladder removal surgery sharply cut the rates of cancer returning in the pelvis without adding serious side effects. Findings of the Bladder Adjuvant RadioTherapy (BART) trial conducted at centers across India will be presented today at the American Society ...

Intensity modulated radiotherapy matches proton beam therapy for head and neck cancer

2025-09-29
Intensity-modulated radiotherapy is as good as proton beam therapy for treating people with head and neck cancer, according to the results of a Cancer Research UK-funded clinical trial. The TORPEdO trial funded by Cancer Research UK and The Taylor Family Foundation, led by The Christie NHS Foundation Trust and sponsored by the Institute of Cancer Research, London, compared two forms of highly targeted radiotherapy for head and neck cancer – proton beam therapy (PBT) and intensity-modulated radiotherapy (IMRT). Presented at the American Society of Radiation Oncology (ASTRO) Annual Meeting in San Francisco, California, the initial results of ...

Simultaneous synthesis of all 21 types of tRNA in vitro

2025-09-29
Collaborative research by the University of Tokyo and RIKEN Center for Biosystems Dynamics Research has led to the development of a new method for simultaneously synthesizing all transfer RNA (tRNA) required for protein synthesis in a reconstituted translation system in vitro. Currently, humans rely on living organisms (bacteria, yeast, plants, and animals) for the production of pharmaceuticals and food. However, living organisms are susceptible to environmental changes, breeding improvements require time, and ...

Renshaw receives funding for VISR 3.0: Learning management system development and implementation

2025-09-29
Keith Renshaw, Senior Associate Provost for Undergraduate Education, Office of the Provost, received funding for: “VISR 3.0: Learning Management System Development and Implementation.” This project aims to train employees within a wide variety of agencies in a) identifying service members, veterans, and family members; b) screening for suicide risk; and c) providing appropriate referrals and/or interventions as needed. VISR was first piloted in 2020, with good success. From 2022-2023, Renshaw led a follow-up project dubbed “VISR 2.0” focused on evaluating VISR’s broader impact and identifying ways to increase the scale of the program. Results ...

Yang receives funding for welfare and poverty mapping project

2025-09-29
Yang Receives Funding For Welfare & Poverty Mapping Project Ruixin Yang, Associate Professor, Geography Geoinformation Science, College of Science, received funding for: “Welfare and Poverty Mapping with Satellite-Derived Data, Spatial Analysis and Machine Learning Application.” The objective of this consultancy is to provide technical and advisory support in: processing satellite imagery and geospatial datasets; designing and implementing machine learning models for spatial analysis; and supporting ...

New BBRF webinar to explore biological factors underlying suicide risk

2025-09-29
Suicide is a leading cause of death in the United States. The Brain & Behavior Research Foundation (BBRF) will host a free webinar on Tuesday, October 14, 2025, at 2:00 pm ET, examining the biological factors that contribute to suicide risk and what can be done to strengthen prevention efforts. The event will be hosted by Jeffrey Borenstein, M.D., President & CEO of BBRF and host of the Emmy® nominated television series Healthy Minds. Featured speaker, Steven Lamontagne, Ph.D., a postdoctoral fellow in the Experimental Therapeutics and Pathophysiology Branch at the National Institute of Mental Health (NIMH), will ...

From shortage to success: How MUSC anesthesia team navigated IV fluid crisis

2025-09-29
As we approach the first anniversary of flooding from Hurricane Helene that devastated parts of North Carolina, the anesthesia department from the Medical University of South Carolina is sharing how it responded to one effect of that flooding: the disruption of the IV fluid supply chain. “The culture in anesthesia is to be prepared for everything,” said Carlee A. Clark, M.D., lead author of the MUSC study published in A&A Practice. The journal is for doctors working in anesthesia and pain medicine, focusing on short, peer-reviewed articles on innovative treatments and solutions.  The anesthesia team was prepared for an IV fluid supply shortage. Previous publications ...

Forget numbers: your PIN could consist of a shimmy and a shake

2025-09-29
In the near future, you may not need to touch a keypad to select a tip or pay for large purchases. All it may take is a swipe, tap or other quick gesture. Hygienic tips The innovation utilizes near-field communication (NFC), the short-range wireless technology embedded in smartphones, payment cards and terminals, passports and key fobs. UBC computer scientists say it could help prevent the spread of germs through touchpads, speed up transactions, and improve accessibility for users unable to press buttons. Researchers debuted ...

Walking shapes how people process sound

2025-09-29
Does walking influence how people process sensory information, like sounds, from the environment? In a new JNeurosci paper, researchers led by Liyu Cao, from Zhejiang University, and Barbara Händel, from University of Würzburg, explored whether walking direction influences how people process sounds.  Thirty volunteers walked in an eight-shaped path as they listened to a continuous stream of sound with changing intensities while researchers collected recordings of brain activity. People had stronger neural responses to sound while walking as opposed to standing or walking in place. These responses changed to the same degree as manipulations to sound intensity. ...

How EU’s data protection regulation affected news and media websites

2025-09-29
In May 2018, the European Union (EU) implemented the General Data Protection Regulation (GDPR), a major component of EU privacy law. Privacy regulations like the GDPR have long been criticized by the online advertising industry as harmful to the digital economy. Critics argue that stricter privacy laws reduce online tracking, disrupt targeted advertising, and, as a result, weaken the ability of publishers and content creators to generate revenue and maintain free, high-quality content for users. But since its implementation, little attention has been directed to understanding the regulation’s ...

Dr. Amar Kishan honored with Steven A. Leibel Memorial Award

2025-09-29
Dr. Amar Kishan, professor and executive vice chair of radiation oncology at the David Geffen School of Medicine at UCLA and co-director of the cancer molecular imaging, nanotechnology and theranostics program at the UCLA Health Jonsson Comprehensive Cancer Center, has been named the recipient of the 2025 Steven A. Leibel Memorial Award, one of the most distinguished honors in radiation oncology.  Presented by the American Society for Radiation Oncology (ASTRO) and the American Board of Radiology (ABR) Foundation, the award recognizes outstanding principal investigators within the first decade of their careers following board certification. Kishan was selected for ...

Europe's oldest blue pigment found in Germany

2025-09-29
At the Final Palaeolithic site of Mühlheim-Dietesheim, Germany, archaeologists from Aarhus University found traces of a blue residue on a stone artifact dating back around 13,000 years. Using a suite of cutting-edge scientific analyses, they confirmed the traces were from the vivid blue mineral pigment azurite, previously unseen in Europe’s Palaeolithic art.  “This challenges what we thought we knew about Palaeolithic pigment use”, sais Dr. Izzy Wisher, the lead author of the study.  Until now, scholars believed Palaeolithic artists predominantly used red and black pigments – practically no other colours ...

New study links genetic variation to chemotherapy-related liver damage in patients with colorectal cancer liver metastases

2025-09-29
ROCHESTER, Minn. — A new international study led by Mayo Clinic researchers has identified a genetic factor that may explain why some patients with colorectal cancer that has spread to the liver experience more severe liver damage after chemotherapy. For patients with colorectal liver metastases, surgery offers the best chance of long-term survival. To improve outcomes, many patients receive chemotherapy before surgery. While this approach can shrink tumors to make them more operable, one potential side effect is injury to the liver. Until now, it hasn't been clear why certain patients' livers are more ...

Daydreaming can lead to epiphanies, greater career purpose, WashU research finds

2025-09-29
The legendary tale of the business leader who had an epiphany that fundamentally changed his or her professional journey — turning hobbies, small observations or frustrations into billion-dollar ideas — is well known. Julia Child writing her first cookbook at 50 and becoming a famous chef; Sara Blakely channeling frustration with undergarments to develop Spanx; Jeff Bezos leaving a successful Wall Street investment career to get in on the booming growth of the internet … the list goes on. Epiphanies — sudden realizations that transform how people see ...

High pollen count: The last straw effect on suicide risk

2025-09-29
Images Beyond the sneezing and itchy eyes, high pollen seasons are now linked to a significant increase in suicide risk.   A new University of Michigan study found a 7.4% jump in deaths, suggesting the physical discomfort of allergies may trigger a deeper, more dangerous despair, an overlooked factor in suicide prevention.   The study indicates that allergies' physiological effects, such as poor sleep and mental distress, may contribute to this increased risk.   "A small shock could have a big effect ...

Physicists tighten the net on elusive dark matter

2025-09-29
Determining the nature of dark matter, the invisible substance that makes up most of the mass in our universe, is one of the greatest puzzles in physics. New results from the world’s most sensitive dark matter detector, LUX-ZEPLIN (LZ), have narrowed down the possibilities for one of the leading dark matter candidates: weakly interacting massive particles (WIMPs). “While we always hope to discover a new particle, it is important for particle physics that we are able to set bounds on what the dark matter might actually be,” said UC Santa Barbara experimental ...

Laboratory breakthrough recreating star formation mechanism wins prestigious John Dawson Award

2025-09-29
Groundbreaking scientific findings on how swirling matter can form stars, planets and supermassive black holes earned a team of scientists from the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) and Princeton University the 2025 John Dawson Award for Excellence in Plasma Physics Research from the American Physical Society (APS). The winning team includes Fatima Ebrahimi, Erik Gilson, Hantao Ji and Yin Wang, as well as Princeton University’s Jeremy ...

New one-hour, low-cost HPV test could transform cervical cancer screening in Africa and beyond

2025-09-29
A team of researchers led by Rice University, in collaboration with colleagues in Mozambique and The University of Texas MD Anderson Cancer Center, has developed a simple, affordable human papillomavirus (HPV) test that delivers results in less than an hour with no specialized laboratory required. The breakthrough could provide an option for women in low-resource settings to be screened and treated for cervical cancer in a single clinic visit, a step that global health experts say could save countless lives. The research was recently published in Nature Communications. Cervical cancer is considered easily preventable, yet ...

Ontology 2.0 deepens LOINC®-SNOMED collaboration, speeds global lab interoperability

2025-09-29
INDIANAPOLIS, US and LONDON, UK – Regenstrief Institute and SNOMED International have released LOINC® Ontology 2.0, the next version of The LOINC Ontology: A LOINC and SNOMED CT Interoperability Solution and a significant advance in their ongoing collaboration to streamline the exchange and use of health data worldwide. This version expands the Ontology with approximately 6,000 additional concepts, with more than 2,500 new “Orderable Grouper” concepts that provide practical, higher-level groupings for laboratory orders. By introducing this organization, ...

Cornell launches initiative to unravel the science of menopause

2025-09-29
ITHACA, N.Y. -- Two centuries ago, few women lived long enough to reach menopause. Today, it marks a major inflection point in women’s health, yet remains poorly understood. Cornell researchers aim to change that. Drawing on cutting-edge technology and interdisciplinary expertise, researchers are launching Menopause Health Engineering, a new initiative uniting faculty from Cornell’s Ithaca campus and Weill Cornell Medicine, to uncover how menopause shapes health and disease, and to develop urgently needed treatment ...

Reform of federal drug discount program should target misaligned incentives

2025-09-29
The dramatic growth of a key federal drug discount program has fueled debate about whether it is helping low-income patients as intended or primarily benefiting healthcare providers. Congress created the 340B Drug Pricing Program over 30 years ago to help hospitals and clinics that serve high levels of uninsured patients purchase outpatient drugs from manufacturers at significantly discounted prices. However, the law does not require participating providers to pass on discounts to patients or dedicate program funds to safety-net care. A new white paper from the USC Schaeffer Center for Health Policy & Economics traces how major eligibility expansions and distorted program incentives ...

Variation in US commercial health plan coverage restrictions for cell and gene therapies

2025-09-29
About The Study: For Food and Drug Administration (FDA)-approved cell and gene therapies, commercial health plans commonly imposed coverage requirements beyond FDA-approved product labeling. These restrictions were often aligned with pivotal trial criteria, suggesting that plan coverage aligns with stronger supporting evidence. Corresponding Author: To contact the corresponding author, James D. Chambers, PhD, email james.chambers@tuftsmedicine.org. To access the embargoed study: Visit our For The Media website at this ...

Motivational and mobile-based support improved child passenger safety behaviors, clinical trial finds

2025-09-29
Parents improved use of appropriate child car seats after remote motivational counseling and mobile-based support, according to the results from a randomized clinical trial published in JAMA Network Open. The intervention included tailored web content, periodic text messages and personalized feedback on photos parents submitted every four to six weeks showing how their child usually travels in a car. “Parents and children might resist using the recommended car seat or booster seat, even though it’s the law, due to inconvenience or beliefs that their child is safe enough riding ...

Population-level effectiveness and herd protection 17 years after HPV vaccine introduction

2025-09-29
About The Study: In this study, population-level effectiveness and herd protection were robust 17 years after human papillomavirus (HPV) vaccine introduction, even in sexually experienced adolescent girls and young women at relatively high risk for HPV who may not have received the full vaccination series.  Corresponding Author: To contact the corresponding author, Jessica Kahn, MD, MPH, email jessica.kahn@einsteinmed.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2025.3568) Editor’s Note: Please see the article for additional ...

Modeling the health impact of discontinuing COVID-19 vaccination during pregnancy in the US

2025-09-29
About The Study: This decision analytical model study estimates that COVID-19 vaccination (primarily annual COVID-19 vaccination) during pregnancy will likely continue to yield meaningful public health benefits in the U.S., especially to reduce COVID-19 hospitalizations in infants. COVID-19 vaccination during pregnancy has been shown to be safe. While there is global variation in policy recommending COVID-19 vaccination during pregnancy, the U.S. has a high risk of severe COVID-19 in newborns, underscoring relevance of maternal COVID-19 vaccination.  Corresponding ...
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