A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis. The clinical trial evaluated the safety and efficacy of an innovative CAR-T cell immunotherapy that is specifically designed to attack cancerous T cells. Participants in the trial had been diagnosed with rare cancers — T cell acute lymphoblastic leukemia or T cell lymphoblastic lymphoma — and had run out of treatment options after standard therapy proved ineffective for them. With the new immunotherapy, most of ...

A research team funded by the National Institutes of Health (NIH) has identified a diagnostic aid that has the potential to accurately predict the recurrence of diabetic foot ulcers that appear to be fully healed. By measuring the skin’s barrier function through a process known as trans-epidermal water loss, or TEWL, scientists were able to determine which wounds were more likely to reopen. TEWL measurements are a major factor in burn care, where deep layers of the skin are often damaged. The findings suggest that full restoration of skin ...

Complaint lines such as New York City’s 311 let people report quality-of-life problems in their building or neighborhood, from excessive noise to illegal parking. But resident-generated data typically suffer from reporting bias, with some neighborhoods and addresses calling attention to problems at lower rates than others. A team of New York University researchers has developed an automated modeling tool to help the New York City government estimate 311 under-reporting by building, neighborhood, and subpopulation. In a new study, published today [May 30] in Annals of Applied Statistics, the researchers describe a method that, using machine learning, can estimate the potential ...

May 30, 2025 — A proposed classification system appears highly accurate in evaluating nasal deformities in infants with cleft lip and/or palate (CLP), reports a study in the May/June issue of The Journal of Craniofacial Surgery. The journal is published in the Lippincott portfolio by Wolters Kluwer. "This new tool offers a reliable and practice tool for categorizing the severity of nasal deformities in CLP patients," comments lead author Martha Mejia, DDS, of Nicklaus Children's Health System, Miami. "With ongoing evaluation, it may promote more consistent diagnosis, individualized treatment planning, and standardized approaches ...

Background and objectives This study investigates upper gastrointestinal tract (UGIT) involvement in patients with ulcerative colitis (UC), a condition traditionally considered limited to the colon. Although extra-colonic manifestations of UC are well recognized, UGIT issues have received less attention. This research aimed to document the clinical, endoscopic, and histopathological UGIT findings in adults with UC and assess their association with disease severity and extent. Methods This descriptive cross-sectional study was conducted at Ain Shams University over one year. A total of 78 UC patients underwent comprehensive clinical evaluations, including assessments ...

  Approximately 8 to 12% of patients with colorectal cancer have BRAF mutations  Treatment with the triplet combination of drugs – encorafenib, cetuximab and chemotherapy – helped patients live longer and kept cancer from progressing   The Food and Drug Administration granted accelerated approval for this new combination in Dec. 2024   Median overall survival was 30.3 months with the triplet therapy, compared to 15.1 months with standard treatment  ABSTRACT: ...

Once organizations achieve their profitability and market performance targets, they often focus on additional goals. However, these goals do not always align and can sometimes conflict. For example, prioritizing shareholder returns may come at the expense of investments in social causes. This raises a critical question: How do companies decide where to allocate their surplus resources and which goals to prioritize? A study published online in the Journal of Business Ethics on May 9, 2025, examines this question by turning the spotlight on the boardroom. A research team consisting of Professor Toru Yoshikawa from the School of Social Sciences, Waseda University, ...

Autism spectrum disorders are associated with difficulties in social communication, long attributed to individual socio-cognitive deficits. As a consequence of this perspective, stigma and pressure to conform to neurotypical social norms often lead to mental health challenges among autistic individuals. Emerging theories suggest that communication difficulties may rather arise from mismatches in perspectives between autistic and non-autistic partners. Addressing this mismatch collaboratively could transform the understanding of autism and improve communication outcomes. Social behavior also varies significantly across cultures. ...

Resistance to disease should mean a longer life, but researchers have found that a mutant protein that helps a plant fight mildew might make it age sooner. The Osaka Metropolitan University research team of Graduate School of Agriculture student Tomoko Matsumoto and Professor Noriko Inada and Graduate School of Science Professor Koichi Kobayashi discovered that thale cress (Arabidopsis thaliana) plants with the mutant Actin Depolymerizing Factor protein turn yellow sooner over time and in dark conditions compared to wild-type thale cress. “ADFs are involved not only in leaf aging ...

AURORA, Colo. (May 30, 2024) –  Children exposed to gestational diabetes in utero with a specific variation of a common gene are at a higher risk of becoming overweight or obese during childhood, according to a new study by researchers at the University of Colorado Anschutz Medical Campus. The study was published today in the journal Diabetes Care. Scientists have long known that exposure to gestational diabetes is a strong predictor for both childhood obesity and diabetes. “But it’s not infallible,” said the study’s lead author Kylie Harrall, ...

Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing complex biological samples. Compared to its diagnostic predecessors, LUCAS creates 500-fold stronger and 8-fold longer-lasting bioluminescence signals, overcoming longstanding challenges faced by point-of-care diagnostics. Their study published today in Nature Biomedical Engineering. “Developing effective ...

As the digital world demands greater data storage and faster access times, magnetic memory technologies have emerged as a promising frontier. However, conventional magnetic memory devices have an inherent limitation: They use electric currents to generate the magnetic fields necessary to reverse their stored magnetization, leading to energy losses in the form of heat. This inefficiency has pushed researchers to explore approaches that could further reduce power consumption in magnetic memories while maintaining or even enhancing their performance. Multiferroic materials, ...

This compelling book sheds light on one of the most defining yet often overlooked forces in Japanese society: dōchō atusryoku (conformity pressure). Far beyond a matter of individual psychology, this book argues that conformity acts as an important force in shaping politics, governance, and the legal system in Japan. It is a force that binds people together, enforces unspoken rules, and even fills the gaps where laws or clear leadership are absent. At the heart of this analysis is the concept of “sekken”—the collective social ...

The water we use every day is purified in wastewater treatment plants and discharged into rivers, and in recent years, the reuse of treated water for domestic and industrial use has been expanding to solve the water shortage problem. The purification process removes various harmful substances, including phosphorus, which causes green algae, and disinfects microorganisms such as total coliform. Phosphorus is an essential component of domestic and industrial waste, including fertilizers, detergents, and animal manure, but when it remains in the water, it causes algae blooms in rivers and lakes. A research team led by Dr. Jae-Woo Choi and Dr. Kyungjin Cho of the Center ...

New research finds that self-employed women have fewer risk factors for cardiovascular disease (CVD) compared to non-self-employed women, suggesting that the work environment may play a role in the development of risk factors that can lead to heart attacks. While the findings also showed some positive associations between health outcomes and self-employment among white men, the researchers found women had the most favorable CVD risk profile associated with being self-employed, possibly because they are more likely than men to experience stress and time demands related to balancing responsibilities across work and home.   Self-employed men ...

   Journals from BMJ Group Press Release: Embargoed 23:30 hours UK (BST) time Thursday 29 May 2025 Please click on links for full articles and contact authors direct for further comment - details can be found under Notes for Editors. Please remember to credit the relevant journal - this assures your audience it is from a reputable source. Headlines: US general military service may lower, rather than heighten, depression risk Around 1 in 7 US adults who smoke may have some degree of disability BMJ MILITARY HEALTH Externally ...

A new study has found that depression is linked to an increased risk of dementia in both mid and later life.   The new research, which is published in eClinicalMedicine, was led by Jacob Brain and Maha Alshahrani from the Institute of Mental Health and School of Medicine at the University of Nottingham, University of Adelaide and the Dementia Centre of Excellence at Curtin University in Australia.   Mr Brain said: "Our study shows that depression is linked to an increased risk of dementia in both midlife ...

A new study published in The Lancet Child & Adolescent Health journal suggests that parental or caregiver intuition may outperform some traditional early warning systems in identifying children at risk of deterioration. The new analysis found that caregiver concern for worsening condition of paediatric patients was strongly associated with critical illness in pediatric patients admitted to the hospital, even after accounting for abnormal vital signs (abnormal heart rate or abnormal respiratory rate). In high-income countries critical illness in children is rare, and often ...

Around 1 in 7 of US adults who currently smoke may have some degree of disability, suggests the first study of its kind published online in the journal Tobacco Control. And the prevalence of disability and/or some degree of functional difficulty is twice as high among those who continue to puff away as it is among those who have never smoked, the data analysis indicates. All in all, the figures suggest that 40% of the estimated 25 million adults who currently smoke experience some level of functional difficulty, ...

In 2024, Brazil celebrated the 20th anniversary of the Bolsa Família Programme (BFP), one of the world’s largest conditional cash transfer initiatives. A new study published in The Lancet Public Health shows that the BFP has prevented more than 8.2 million hospitalisations and 713,083 deaths in Brazil between 2004 and 2019. In addition, it is estimated that an additional 683,721 deaths could be prevented if the programme's coverage is expanded by 2030. These programmes provide cash transfers to low-income families, often with school-age children, provided they meet certain conditions, such as ensuring school attendance and up-to-date vaccinations. ...

Open water swimming can be strangely claustrophobic. Immerse your face in cloudy water and your view might dwindle to a few centimetres. Yet, harbour seals (Phoca vitulina) manage to negotiate the turbid coastal waters in which they reside with ease, detecting their surroundings through various senses, including their dextrous whiskers. But Frederike Hanke from University of Rostock, Germany, wondered whether the resourceful creatures may also to use their vision to determine which direction they are manoeuvring in, despite the opaque view. ‘We wanted to know whether harbour seals can determine their heading from ...

VIDEO AVAILABLE HERE MIAMI, FLORIDA (MAY 29, 2025) – A new four-drug combination is highly effective and safe in patients with newly diagnosed multiple myeloma, according to data presented at the annual meeting of the American Society of Clinical Oncology, held May 30 through June 3 in Chicago. The data emerged from the ADVANCE clinical trial led by Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine.    The randomized, multi-center trial tests the effects of adding the targeted drug daratumumab to the standard three-part therapy regimen, called KRd (carfilzomib, lenalidomide and dexamethasone). “This ...

VIDEO AVAILABLE HERE MIAMI, FLORIDA (May 29, 2025) – A new study led by experts at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, is the first to look at trends over time in alcohol-linked cancer mortality across the United States. The findings, titled “Escalating Impact of Alcohol-Related Cancer Mortality in the U.S.: A call for action,” will be presented May 31 at ASCO 2025, the annual meeting of the American Society of Clinical Oncology in Chicago. Earlier this year, the former U.S. ...

As climate change fuels more frequent and severe heat waves, governments worldwide have adopted Heat-Health Action Plans (HHAPs) to prevent illness and death from heat stroke, heart attacks, and other unwanted physical and mental health outcomes. Yet a new study by researchers at Columbia University Mailman School of Public Health reveals a critical gap in these plans: while most acknowledge mental health risks, such as heightened anxiety, depression, and suicide, few propose concrete interventions to protect vulnerable populations. According to one estimate, exposure to heatwaves globally has doubled ...

In an important contribution from the social sciences, Rice University anthropologists Cymene Howe and Dominic Boyer examine the societal consequences of global glacier loss in a commentary published today in Science. Their article appears alongside new research that estimates that more than three-quarters of the world’s glacier mass could disappear by the end of the century under current climate policies. While the study projects the physical outcomes of glacial melt, Howe and Boyer highlight the social impacts and human ...