Inhibiting the sonic hedgehog (Shh) pathway strongly perturbs feather development in chickens by restricting feather bud outgrowth, invagination and branching, according to a study published March 20th, in the open-access journal PLOS Biology by Rory Cooper and Michel Milinkovitch from the University of Geneva, Switzerland. Avian feathers are intricate appendages whose forms vary substantially across species and body areas, and between juvenile and adult stages. Understanding both the developmental and evolutionary mechanisms underpinning this morphological diversity has long fascinated biologists. The morphological intricacies ...

Fruit fly mutants that have severe sleep deficits perform better at olfactory learning and memory tasks, according to a study published March 20th in the open-access journal PLOS Biology by Sheng Huang and Stephan Sigrist from Freie Universität Berlin, Germany, and colleagues. The paradox of enhanced memory despite sleep loss could be explained by protein kinase A (PKA) signaling in the mushroom body of the fly brain.  Sleep is a dynamic process conserved from invertebrates to mammals and humans. Although sleep is thought to serve many purposes, it is often studied for its restorative roles, which ...

Marine mammals may have a secret weapon to survive long dives – an ability to directly sense their own circulating blood-oxygen levels that most mammals lack – allowing them to stay submerged longer and resurface before hypoxia leads to drowning, researchers report. Air-breathing marine mammals have developed a range of physiological adaptations to survive in aquatic environments, including thermoregulation to endure the pressures of the deep. However, one of the most critical evolutionary challenges for diving mammals is avoiding drowning. Despite adaptations for larger oxygen storage and tolerance to low oxygen levels, these animals still risk drowning if they ...

Challenging assumptions about infant memory, a novel functional magnetic resonance imaging (fMRI) study shows that babies as young as 12 months old can encode memories, researchers report. The findings suggest that infantile amnesia – the inability to remember our first few years of life – is more likely caused by memory retrieval failures rather than an inability to form memories in the first place. Despite infancy being a period of rapid learning, memories from this time do not persist into later childhood or adulthood. In ...

Rising mountains do more than reshape the landscape – they also drive evolutionary change, according to a new study. By simulating millions of years of tectonic uplift, researchers have uncovered a link between mountain building and biodiversity, shedding light on how Earth’s dynamic topography shapes biodiversity over deep time. Mountain ranges are widely recognized as global hotspots of terrestrial biodiversity yet only cover a relatively small proportion of the Earth’s surface, suggesting a strong connection between topographic evolution and species diversity. Mountainous terrain can promote speciation by isolating populations, ...

Challenging long-held assumptions about global terrestrial carbon storage, a new study finds that the majority of carbon dioxide (CO2) absorbed by ecosystems has been locked away in dead plant material, soils, and sediments, rather than living biomass, researchers report. These new insights, which suggest that terrestrial carbon stocks are more resilient and stable than previously appreciated, are crucial for shaping future climate mitigation strategies and optimizing carbon sequestration efforts. Recent studies have shown that terrestrial carbon stocks are increasing, offsetting ...

Feathers are among the most complex cutaneous appendages in the animal kingdom. While their evolutionary origin has been widely debated, paleontological discoveries and developmental biology studies suggest that feathers evolved from simple structures known as proto-feathers. These primitive structures, composed of a single tubular filament, emerged around 200 million years ago in certain dinosaurs. Paleontologists continue to discuss the possibility of their even earlier presence in the common ancestor of dinosaurs and pterosaurs (the first flying vertebrates with membranous wings) around 240 million years ago.   Proto-feathers are ...

Though we learn so much during our first years of life, we can’t, as adults, remember specific events from that time. Researchers have long believed we don’t hold onto these experiences because the part of the brain responsible for saving memories — the hippocampus — is still developing well into adolescence and just can’t encode memories in our earliest years. But new Yale research finds evidence that’s not the case. In a study, Yale researchers showed infants ...

Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, researchers at the University of Basel, Switzerland, have now gained insight into the architecture of mitochondria at unprecedented resolution. They discovered that the proteins responsible for energy generation assemble into large “supercomplexes”, which play a crucial role in providing the cell’s energy. Most living organisms on our planet-whether plants, animals, or ...

Recent studies have shown that carbon stocks in terrestrial ecosystems are increasing, mitigating around 30% of the CO2 emissions linked to human activities. The overall value of carbon sinks on the earth's surface is fairly well known—as it can be deduced from the planet's total carbon balance anthropogenic emissions, the accumulation of carbon in the atmosphere and the ocean sinks—yet, researchers know very little about carbon distribution between the various terrestrial pools: living vegetation—mainly forests—and nonliving carbon pools—soil organic matter, sediments at the bottom of lakes and rivers, wetlands, ...

WASHINGTON — The American Geophysical Union and the U.S. Academic Alliance for the IPCC today open calls for U.S. researchers to self-nominate as experts, authors and review editors for the Intergovernmental Panel on Climate Change Seventh Assessment Report through a new application portal. The IPCC nomination period opened in early March and will close in mid-April. USAA-IPCC is a newly established network of U.S. academic institutions registered as observers with the IPCC. Both observer organizations and governments may nominate experts for ...

Scientists at the University of Leicester have captured the first detailed “molecular movie” showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying their genetic material. The groundbreaking discovery, published in the prestigious journal Nature, could have far-reaching implications, helping us to understand how certain viruses and cancers replicate.  Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature’s DNA unzipping machine) in the process of unwinding DNA. DNA helicases are essential during DNA replication because ...

The protein (Exportin-1) is often found in high levels in patients with leukemia, other cancers Protein was previously known to move materials out of a cell’s nucleus New findings suggest protein may also stimulate transcription, which if hijacked, could contribute to abnormal cell division (cancer) Future anti-cancer therapies that target Exportin-1’s role in transcription may be less toxic or more effective than current therapies EVANSTON, Ill. --- Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell nuclei of all flora and fauna. In addition to exporting ...

Plasmonic modulators are tiny components that convert electrical signals into optical signals in order to transport them through optical fibres. A modulator of this kind had never managed to transmit data with a frequency of over a terahertz (over a trillion oscillations per second). Now, researchers from the group led by Jürg Leuthold, Professor of Photonics and Communications at ETH Zurich, have succeeded in doing just that. Previous modulators could only convert frequencies up to 100 or 200 gigahertz ...

Many U.S. police departments face a serious recruiting and staffing crisis, which has spurred a re-examination of recruitment methods. In a new study, researchers drew on the field of intergroup communication to analyze how police are portrayed in recruitment materials to determine whether humanizing efforts make a difference. The study found that presenting officers in human terms boosted participants’ interest in policing as a career. The study was conducted by researchers at the University of California Santa Barbara (UCSB), Texas State University (TXST), ...

A new AI weather prediction system, Aardvark Weather, can deliver accurate forecasts tens of times faster and using thousands of times less computing power than current AI and physics-based forecasting systems, according to research published today (Thursday 20 March) in Nature.  Aardvark has been developed by researchers from the University of Cambridge supported by the Alan Turing Institute, Microsoft Research and the European Centre for Medium Range Weather Forecasting, providing a blueprint for a completely new approach to weather forecasting with the potential to transform current practices.  The ...

As young children have an increased risk of developing tuberculosis (TB) disease during the first year after infection, childhood TB serves as an indicator of ongoing transmission within a community.  In 2023, 1,689 children and young adolescents below the age of 15 years were diagnosed with tuberculosis in the European Union/European Economic Area (EU/EEA) countries. This particular age group usually represents a relatively small proportion among the overall reported TB cases in the region, with a range from 3.4% in 2021 for example to 6.4% in 2016. However, the data for children and young ...

COLUMBUS, Ohio – Americans have long believed that sports are one area in society that offers kids from all backgrounds the chance to succeed to the best of their abilities.   But new research suggests that this belief is largely a myth, and that success in high school and college athletics often is influenced by race and gender, as well as socioeconomic status, including family wealth and education.   “We often think about sports as level playing fields that reward people who earn their success, but that’s not the whole ...

According to a predictive model developed by a CNRS researcher1 and his European colleagues, the microalgae present in peat bogs could offset up to 14% of future CO2 emissions, thanks to their photosynthetic activity2. This conclusion was reached by basing the work on in situ experiments and the various predictive scenarios established by the IPCC. It is the first model to quantify the potential compensation of future CO2 emissions by peatlands on a global scale. This result lifts the veil on a currently ambiguous section of the terrestrial carbon cycle3 and its alterations by anthropogenic climate change. The associated study is published in Nature Climate Change. Representing ...

CAMBRIDGE, MA – The ability to generate high-quality images quickly is crucial for producing realistic simulated environments that can be used to train self-driving cars to avoid unpredictable hazards, making them safer on real streets. But the generative AI techniques increasingly being used to produce such images have drawbacks. One popular type of model, called a diffusion model, can create stunningly realistic images but is too slow and computationally intensive for many applications. On the other hand, the autoregressive models that power LLMs like ChatGPT are much faster, but they ...

Researchers at University of California San Diego School of Medicine, in collaboration with the Prevencasa free clinic in Tijuana, Mexico, have confirmed the presence of xylazine in the illicit drug supply at the U.S.-Mexico border. While xylazine remains less common in the Western U.S., border cities serve as key trafficking hubs and may have higher rates of emerging substances. The findings, published on March 20, 2025 in the Journal of Addiction Medicine, highlight the urgent need for public health intervention. “Xylazine is a veterinary anesthetic that is not approved for human use and is increasingly detected alongside illicit fentanyl in parts of the United States ...

Lithium-6 is essential for producing nuclear fusion fuel, but isolating it from the much more common isotope, lithium-7, usually requires liquid mercury, which is extremely toxic. Now, researchers have developed a mercury-free method to isolate lithium-6 that is as effective as the conventional method. The new method is presented March 20 in the Cell Press journal Chem. “This is a step towards addressing a major roadblock to nuclear energy,” says chemist and senior author Sarbajit Banerjee of ETH Zürich and Texas A&M University. “Lithium-6 is a critical material for the renaissance of nuclear energy, ...

Adverse genetic mutations can cause harm and are due to various circumstances. “Jumping genes” are one cause of mutations, but cells try and combat them with a specialized RNA called piRNA. For the first time, researchers from the University of Tokyo and their collaborators have identified how the sites responsible for piRNA production evolve effective behaviors against jumping genes. This research could lead to downstream diagnostic or therapeutic applications. The word mutation can mean different things in different situations. ...

About The Study: In this cohort study of patients with ovarian cancer, American Indian and Black patients were 23% less likely to have an elevated cancer antigen (CA)-125 level at diagnosis. Current CA-125 thresholds may miss racially and ethnically diverse patients with ovarian cancer. International guidelines use CA-125 thresholds to recommend which patients with pelvic masses should undergo evaluation by gynecologic oncologists for ovarian cancer. However, CA-125 thresholds were developed from white populations. Work is needed to develop inclusive CA-125 thresholds and ...

About The Study: In this study, lifestyle changes after the pandemic were associated with an increase in the prevalence and severity of child astigmatisms, likely associated with changes in the developing cornea. The potential impact of higher degrees of astigmatism may warrant dedicated efforts to elucidate the relationship between environmental and/or lifestyle factors, as well as the pathophysiology of astigmatism. Corresponding Authors: To contact the corresponding authors, email Jason C. Yam, MD (yamcheuksing@cuhk.edu.hk) and Li ...