Embargoed for release until 5:00 p.m. ET on Monday 26 May 2025    Follow @Annalsofim on X, Facebook, Instagram, threads, and Linkedin         Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing ...

How does a bird learn its birdsong? Tomoko Fujii and Masashi Tanaka, from Waseda University, explored what drives a zebra finch to approach and imitate other zebra finches to learn its birdsong in a new JNeurosci paper.  The researchers explored song learning in young male zebra finches as they interacted with “tutor” adults that already knew their birdsongs. Young zebra finches preferably approached tutors that sang longer but less frequently. Fujii and Tanaka next probed the role of a brain region traditionally linked to emotions in mammals (the amygdala) in this song-learning process. To examine the ...

Background and objectives Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer. Although studies identified adenocarcinoma-like driver mutations in LSCC using next-generation sequencing (NGS), the disease is challenging to treat due to the limited number of detectable mutations for targeted drug therapy. This study aimed to evaluate the mutation profiles of LSCC detected by NGS to assess the relationships between different driver mutations and clinicopathological parameters. Methods NGS ...

FRANKFURT. Otodus megalodon was the largest predatory fish in Earth’s history: Measuring up to 24 meters, it was longer than a truck with a trailer and weighed almost twice as much. Embedded in its jaws were triangular teeth the size of a hand, and its bite had the force of an industrial hydraulic press. It swam through the world’s oceans between 20 and 3 million years ago, frequently on the hunt for prey to satisfy a calorie demand as vast as its size: According to estimates, it required around 100,000 kilocalories per day. Science widely assumed that megalodon’s main calorie intake was in the form of ...

Toronto, ON – Climate change and extreme weather events are threatening the sexual and reproductive health (SRH) of young adolescents in Kenya, according to a new study published earlier this month in BMJ Global Health. The study reveals that food, water, and sanitation insecurities are placing young adolescents aged 10-14, especially girls, at increased risk of school dropout, transactional sex, gender-based violence, and early pregnancy. “Climate change isn’t just an environmental issue, it’s an urgent public health ...

Males are more than four times more likely to receive an autism diagnosis than females. But a new study by researchers at UC San Diego School of Medicine has found no clinical differences in autistic traits between the sexes in toddlers when they are first diagnosed with autism. The study was published in Nature Human Behavior on May 26, 2025. The findings have potential implications for early diagnosis and intervention for autistic children. Between 2002 and 2022, the researchers assessed more than 2,500 male and female toddlers between 12 and 48 months of age. Of these toddlers, 1,500 were ...

Africa's predominantly rainfed agricultural sector is highly vulnerable to erratic rainfall and the impacts of climate change. Despite having significant irrigation potential, only a small fraction of Africa’s arable land is currently equipped for irrigation. A new policy brief by the United Nations University Institute for Water, Environment and Health (UNU-INWEH) - Implementing the IDAWM Framework to Enhance Agricultural Water Management in the African Union – developed in collaboration with Centre on Climate Change & Planetary Health of London School of Hygiene and Tropical Medicine, International ...

A new guideline to diagnose and treat hypertension is aimed at helping primary care clinicians, including family physicians, nurses, nurse practitioners, and pharmacists, manage the disease. The new guideline, the first of 2 from Hypertension Canada, is published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.241770, and will be republished with permission in Canadian Family Physician and Canadian Pharmacists Journal, with a summary in Canadian Nurse. Hypertension is the most common modifiable risk factor for heart disease and death, affecting about 1 in 4 adults in Canada. Canada has been a ...

Milan, Italy: A new, rapid testing method will greatly help the diagnosis of rare diseases in babies and children, according to research to be presented to the annual conference of the European Society of Human Genetics today (Monday). While rare genetic diseases are uncommon, as their name suggests, there are more than 7,000 types of disease caused by mutations in more than 5,000 known genes, affecting approximately 300 million individuals worldwide. Currently about half of all patients with a suspected rare disease remain undiagnosed and existing testing methods for undiagnosed conditions are typically slow, ...

Milan, Italy: Neuropathy, a disorder in which damage to nerves can impair sensation and movement, has many causes, including infection1. Now, researchers from the UK have identified distinct genetic changes in a newly-discovered neuropathy and believe that their work will provide insights into the causal mechanism and why some previously healthy people develop neuropathies after infection whereas others do not. Dr Rob Harkness, a postdoctoral research Fellow at the University of Manchester, Manchester, UK, will tell the annual ...

In recent years, the concept of "rewilding" has risen to prominence in the conservation community, but to date, most efforts have been concentrated on large protected areas far from cities—and consequently, far from urban areas suffering pronounced biodiversity losses. In a recently published BioScience article, Patrick Finnerty (University of Sydney) and colleagues make the case for "urban rewilding" as a vital approach for addressing biodiversity losses, focusing on the rapidly expanding cities that are soon expected to be home to ...

A gene that regulates the development of roots in vascular plants is also involved in the organ development of liverworts — land plants so old they don’t even have proper roots. The Kobe University discovery highlights the fundamental evolutionary dynamic of co-opting, evolving a mechanism first and adopting it for a different purpose later. When scientists discover that a gene is necessary for the development of a trait, they are quick to ask since when this gene has been involved in this and how the evolution of the gene has ...

The murder of George Floyd could have been avoided if police had responded to the concerns of bystanders reveals research led by Lancaster University. George Floyd was murdered by Minneapolis police officer Derek Chauvin on May 25 2020. For the first time, psychologists have analysed 12 videos recorded on the body-worn cameras of the attending officers, the smartphones of bystanders and local CCTV cameras from 19:55 until 20:42 (CST) on the date of his death. Their research published in American Psychologist examines the range of verbal and physical ...

Researchers at the School of Engineering of the Hong Kong University of Science and Technology (HKUST) have developed a novel elastic alloy called Ti₇₈Nb₂₂, which achieves remarkable efficiency for solid-state heat pumping and exhibits a reversible temperature change (ΔT) ability that is 20 times greater than that of conventional metals when stretched or compressed, offering a promising green alternative to traditional vapor-compression heating and cooling technologies. Nearly half of the world’s energy is consumed for heating, including district heating in the building sector and process heating in various industrial sectors. Currently, global heat ...

Children born before 37 weeks of gestation have a considerably increased risk of dying before they reach the age of five. Predicting the risk of preterm birth (PTB) and hence implementing preventive strategies is complicated by the heterogeneity of the condition, the many unknown mechanisms involved, and the lack of reliable predictive tools. Now, however, researchers have been able to show that blood cell-free RNA (cfRNA) signatures can predict PTB over four months before delivery date, the annual conference of the European Society of Human Genetics will hear ...

Lorundrostat, a novel therapy which blocks the production of aldosterone from the adrenal glands, demonstrated clinically meaningful and sustained reductions in blood pressure in 1,083 patients with uncontrolled or resistant hypertension, according to the results of a phase 3 trial announced today.  LONDON, UK – 24 May 2025 – The data from the Launch-HTN trial, announced at the 34th European Meeting on Hypertension and Cardiovascular Protection, show that lorundrostat, an aldosterone synthase inhibitor, is ...

A case in which a sperm donor was later found to be carrying a cancer-causing pathogenic variant in his gametes has highlighted the problems of regulating gamete donation at European and international level, the annual conference of the European Society of Human Genetics will hear today (Saturday). Dr Edwige Kasper, a specialist in genetic predisposition to cancer at the Rouen University Hospital, Rouen, France, will say that the lack of cross-border regulation in Europe can result in the multiple use of gametes in  families and risks inbreeding and the  abnormal  dissemination of inherited diseases. Towards ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) now derived universal rules to enable the de novo design of optimal enzymes. As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme. First, the interface of both enzyme and molecule should be located at their respective smaller end. This way, a strong coupling between both of them ...

Jonathan Ajo-Franklin, a leading mind in applied geophysics and Trustee Professor of Earth, Environmental and Planetary Sciences at Rice University, has been awarded the 2025 Reginald Fessenden Award by the Society of Exploration Geophysicists. The honor recognizes a “specific technical contribution to exploration geophysics” that represents a major scientific or conceptual advancement — a distinction that places Ajo-Franklin among the most influential innovators in the field. Ajo-Franklin is internationally recognized for ...

Q: How would you summarize your study for a lay audience? Our study investigated the role of astrocytes, an abundant cell type in the brain, in regulating an immune response against glioblastoma (GBM)—a highly aggressive brain cancer. We found a subset of astrocytes that limits the immune response and can be targeted with therapeutics.   Q: What question were you investigating? GBM is a brain cancer that has remained untreatable for decades. Immunotherapies that have worked in other cancers are ineffective in GBM, potentially due to the local suppression of immune responses in the tumor microenvironment. Astrocytes are abundant ...

HOUSTON – (May 23, 2025) – More than ten years ago, researchers at Rice University led by materials scientist Boris Yakobson predicted that boron atoms would cling too tightly to copper to form borophene, a flexible, metallic two-dimensional material with potential across electronics, energy and catalysis. Now, new research shows that prediction holds up, but not in the way anyone expected. Unlike systems such as graphene on copper, where atoms may diffuse into the substrate without forming a distinct alloy, the ...

Flowers grow stems, leaves and petals in a perfect pattern again and again. A new Cornell study shows that even in this precise, patterned formation in plants, gene activity inside individual cells is far more chaotic than it appears from the outside. This finding has important implications for plant engineering, where scientists design artificial gene switches to control growth or behavior. Understanding how plants manage genetic “noise” could also inform research in other fields, from synthetic ...

Q: How would you summarize your study for a lay audience?  Given the rise in brain-based conditions and the growing development and investment in neurotechnologies to target them, it is important to understand how the public views these interventions and whether they would be willing to use them. To explore this, we conducted a survey of over 1,000 U.S. adults to examine perceptions of four neurotechnologies designed to treat severe mood, memory, or motor symptoms.  Q: What question were you investigating?   One of the goals of the recently created Neurotech Justice Accelerator at Mass General Brigham (NJAM), a Dana Center for Neuroscience & Society, is to better ...

NEW ORLEANS, May 23, 2025 – When children are dropped off at a school or day care for the first time, there can be a lot of feelings and sometimes meltdowns caused by being separated from parents, meeting new people, and hearing new noises. Could the architecture of the room help to soothe at least some of the children’s concerns? “Classrooms without any sound absorption are the majority in Japan,” said Ikuri Matsuoka, a master’s student at Kumamoto University in Japan. “My motivation was to make people aware of the importance of acoustics in classrooms because in Japan, there are no standards ...

Eight times more American young adults now take medication to protect them from HIV than a decade ago, a new study finds. But even with this positive news about increasing use of pre-exposure prophylaxis or PrEP, the study also suggests that health care providers and public health agencies could do more to promote consistent use of these medications. The new study, done by a team at the University of Michigan Medical School, uses national pharmacy data to look at prescriptions for oral PrEP from 2016 to 2023 among people ages 18 to 25. It’s published in the Journal of General Internal Medicine. At the start of the study period, 26 of every 100,000 U.S. young ...