About The Study: This situational analysis of cross-sectional WHO STEPS surveys of cardiovascular health (CVH) status region identified actionable factors of the CVH status across 22 countries in the WHO African Region. This information is crucial for guiding policy efforts in cardiovascular disease prevention in countries of the WHO African Region. Corresponding Author: To contact the corresponding author, Jean-Philippe Empana, MD, PhD, email jean-philippe.empana@inserm.fr. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please see the article for additional information, including ...

A major new analysis from REBOOT (Treatment with Beta-blockers after Myocardial Infarction without Reduced Ejection Fraction) clinical trial, an international study coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), published at the European Heart Journal has revealed important sex-specific differences in the effects of beta-blockers following heart attacks, raising questions about long-standing treatment practices. REBOOT, presented in a Hotline session of the ESC congress in Madrid, ...

Madrid, August 30, 2025. An international clinical trial coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with the Mario Negri Institute for Pharmacological Research in Milan, has found that beta-blockers—drugs commonly prescribed for a range of cardiac conditions—offer no clinical benefit for patients who have had an uncomplicated myocardial infarction (i.e., without deterioration of the heart function after the event). The findings—published in two articles in The New England Journal of Medicine and The Lancet and presented today during a “Hot Line” ...

About The Study: Randomization systolic blood pressure (SBP) was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit. Early SBP may help identify patients most likely to gain a net benefit from microaxial flow pump treatment. Findings are hypothesis generating. Corresponding Author: To contact the corresponding author, Astrid Duus Mikkelsen, MD, email astrid.duus.mikkelsen@reigonh.dk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ Editor’s Note: Please see the article for additional information, including ...

Beta blockers—drugs commonly prescribed for a range of cardiac conditions, including heart attacks—provide no clinical benefit for patients who have had an uncomplicated myocardial infarction with preserved heart function. Beta blockers have been the standard treatment for these patients for 40 years. This is a breakthrough discovery from the “REBOOT Trial” with senior investigator Valentin Fuster, MD, PhD, President of Mount Sinai Fuster Heart Hospital and General Director of Spain’s Centro Nacional de Investigaciones Cardiovasculares ...

Glaciers across High Mountain Asia are losing more than 22 gigatons of ice per year—the equivalent to nearly 9 million Olympic swimming pools, according to research from the University of Utah and Virginia Tech. The impact of a warming climate on glacial loss is undisputed—this new study provides the first evidence that seasonal shifts in rainfall and snowfall patterns, particularly of the South Asian monsoons, are also exacerbating glacier melting across the region. “These findings highlight that glaciers dominated by the South Asian monsoons, such as the Central Himalaya, ...

LA JOLLA (August 29, 2025)—A plant’s number one priority is to grow—a feat that demands sunlight, nutrients, and water. If just one of these three inputs is missing, like water in a drought, growth halts. You might then think that at the end of that drought, the plant would jump right back into growing. Instead, its priorities shift. Salk plant biologists used advanced single-cell and spatial transcriptomic techniques to look closely at how a small, flowering plant called Arabidopsis thaliana recovers after drought. They discovered that immunity became the plant’s number one priority during this ...

The stereotypical employee may be at a desk in front of a computer screen working a nine-to-five, but for many employees, the work day is filled with manual labor, hazardous environments and late-night shifts. Your local garbage collector, for example, is someone with a job that society might consider “dirty,” both literally and socially. Scott Dust, PhD, professor in the management department at the University of Cincinnati Carl H. Lindner College of Business, worked with doctoral candidates Sodiq Babatunde and Ben Fagan to analyze the impact of stress and ...

Picture this: You’re stuck in traffic on a summer afternoon, checking the weather app on your phone as dark storm clouds roll in. You might think about power outages or possible flooding, but you probably don’t think about how every lightning bolt that flashes across the sky also emits a gas, nitrogen oxide (NO), that is also emitted in the exhaust from your car’s engine. Yet, that’s exactly what occurs during a thunderstorm. For the first time, scientists from the University of Maryland were able to detect lightning and its impact on air quality using high-frequency ...

Hormonal birth control is a fact of life for millions of women. In the U.S. alone, more than 60 million women of reproductive age have used contraceptives according to the Centers for Disease Control and Prevention, most often to prevent pregnancy but also to manage conditions such as endometriosis, polycystic ovary syndrome and irregular cycles. And as many women will attest, these drugs can affect more than the body. Mood changes, weight fluctuations and emotional ups and downs are common stories women ...

The Philippines, like other tropical countries, is known more for its balmy climate than for hailstorms. But a new Philippine study—the first of its kind—has found that the country’s hottest days are, in fact, more likely to produce hail. Hailstorms are so few and far between in the Philippines that, even in an age of pervasive social media updates, they are still met with amazement and astonishment. “Most people are surprised when hail happens because it is relatively rare in the Philippines,” ...

The European Society of Cardiology (ESC) has selected Roxana Mehran, MD, Director of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Wiener Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai, as a winner of the organization’s top honor. Dr. Mehran was presented with the “ESC Gold Medal” during a special ceremony at the ESC Congress in Madrid on Friday, August 29. The ESC Gold Medal recognizes exceptional scientists for their contributions to cardiovascular ...

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive. Despite the severity of the condition, there are currently no drugs available that improve kidney function. A research group led by Tohoku University Graduate School of Medicine’s Professor Takaaki Abe has found a remarkable solution to treat patients with CKD by co-opting a drug typically used for constipation. This is the first time that this drug (lubiprostone) was shown to prevent the decline of renal function in patients with ...

Throughout human history, there have been many instances where two populations came into contact – especially in the past few thousand years because of large-scale migrations as a consequence of conquests, colonialization, and, more recently, globalization. During these encounters, not only did populations exchange genetic material, but also cultural elements. When populations interact, they may borrow technologies, beliefs, practices, and also, crucially, aspects of language. With this, sounds, words or grammatical patterns can be exchanged ...

With control of Congress and a check on the Trump administration at issue in the 2026 midterm elections, the upcoming election cycle may again see claims of voter fraud. But warning voters beforehand that there may be false claims about the election, and providing them with information on election security measures through "prebunking," can increase confidence in the results and decrease beliefs in voter fraud, according to a new study published in Science Advances. "Prebunking is effective because it provides people with novel facts about how elections are ...

Carbon dioxide levels in the atmosphere vary naturally between ice ages and interglacial periods. A new study by researchers at the University of Gothenburg shows that an unexpectedly large proportion of carbon dioxide emissions after the ice age may have come from thawing permafrost. For a long time, it was the shifts between ice ages and interglacial periods that determined how much carbon dioxide was in the atmosphere. During ice ages, CO2 levels fell, only to rise by around 100 ppm (parts per million) during interglacial ...

Few of us ever think about what happens beneath our feet when we walk through a field of wheat or clover. We see the stalks, leaves, and flowers, but in practice we have no direct access to the roots. Roots, however, are central. They anchor plants in the soil, supply them with water and nutrients, and contribute to carbon storage in the ground. But because roots are hidden, researchers have for decades struggled to measure how much biomass lies below and how it is distributed among species. “We have always known that roots are important, but we have lacked a precise tool to measure them. It’s a bit like studying marine ecosystems without ever being able to dive ...

BIRMINGHAM, Ala. – Retinitis pigmentosa retinal degeneration is caused by a family of hereditary mutations in nearly 100 genes that slowly lead to blindness over years or decades. One of those genes encodes the enzyme DHDDS, part of the pathway that glycosylates proteins in higher cells. Retinitis pigmentosa from DHDDS mutations is called RP59. This is a recessive genetic disease, meaning mutations must be present on both copies of the DHDDS gene to cause disease. To better understand and potentially treat RP59, Steven Pittler, Ph.D., and colleagues at the University of Alabama at Birmingham have created novel mouse models with mutations in the mouse gene for DHDDS. Their first model, ...

Some might say it looks like a finger. Others might see a worm. Scientists in the field often liken it to an antenna. The technical name is primary cilium. This slender, microscopic appendage juts out from the surface of most cells in the human body — and yet for many years, it was completely missing from textbook illustrations. Scientists began paying more attention to primary cilia around 2003. That’s when a scientist at Memorial Sloan Kettering Cancer Center (MSK), the late Kathryn Anderson, PhD, discovered that primary cilia play a hugely ...

The microscopic alliance between algae and bacteria offers rare, step-by-step snapshots of how bacteria lose genes and adapt to increasing host dependence. This is shown by a new study led by researchers from Stockholm University, in collaboration with the Swedish University of Agricultural Sciences and Linnaeus University, published in Current Biology.  In some of the most nutrient-poor waters of our oceans, tiny partnerships are hard at work keeping life going. These partnerships, called symbioses, are between microscopic algae known as diatoms and a specific bacteria called cyanobacteria that can take nitrogen ...

An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialised immune cells. The discovery, published in Immunity, could pave the way for more precise and personalised cancer immunotherapies. About the study: basic research // peer-reviewed // in vitro // in vivo // mice // The team has taken an important step toward harnessing the immune system to fight cancer. Their work describes how they identified a genetic toolkit that programs two powerful subtypes of dendritic cells – key sentinels of the immune system. Dendritic cells are a diverse group of immune cells that act as the body’s ...

“Together, these findings confirm that proteostasis inhibition can slow RMS growth and suggest that targeting compensatory network components might yield synergistic outcomes.” BUFFALO, NY – August 29, 2025 – A new research paper was published in Volume 16 of Oncotarget on August 29, 2025, titled “In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.” In this study led by first author Kristen Kwong and corresponding author Amit J. Sabnis from the Department of Pediatrics, Division of Oncology, ...

The Hertz Foundation, a nonprofit dedicated to advancing American scientific and technological leadership, today announced that the application for the 2026 Hertz Fellowship is now open. The Hertz Fellowship is one of the most competitive and coveted awards for doctoral students in applied sciences, engineering and mathematics. Hertz Fellows receive up to five years of funding, giving them freedom from the traditional constraints of graduate training and the independence needed to pursue groundbreaking research. They also gain lifelong professional support, including mentoring, events and networking opportunities. Hertz Fellows join ...

The gut contains the largest collection of immune cells in the body. New research at the Buck Institute shows that some of those immune cells travel along the brain/gut axis in a mouse model of Alzheimer’s disease (AD) providing a potential new therapeutic pathway for the memory-robbing malady. The research, published in the August29, 2025 issue of Cell Reports, also shows that feeding the mice a high fiber diet reduces AD-related frailty, including tremor. “This paper brings the gut immune system to the forefront of neurodegenerative disease pathology,” says ...

Young children with attention deficit/hyperactivity disorder often receive medication just after being diagnosed, which contravenes treatment guidelines endorsed by the American Academy of Pediatrics, a Stanford Medicine-led study has found. The finding, which will be published Aug. 29 in JAMA Network Open, highlights a gap in medical care for 4- and 5-year-olds with ADHD. Treatment guidelines recommend that these young children and their families try six months of behavior therapy before starting ADHD medication. But pediatricians ...