Nearly 40% of patients diagnosed with type 2 diabetes imperil their health by stopping their medication within the first year, UVA Health diabetes experts note in a new paper highlighting a growing array of treatment options. The pragmatic new paper urges doctors to consider not just traditional diabetes medicines but emerging alternatives that patients may be more likely to stick with long-term. “Prescribing a medication or making lifestyle recommendations that a patient is not willing or able to follow for any reason is not likely to lead to improvements ...

“This work provides new opportunities for the development of the next generation of ChE inhibitors that specifically target AChE and BChE associated with AD pathology.” BUFFALO, NY — April 1, 2025 — A new research paper was published in Aging (Aging-US) on March 29, 2025, as the cover of Volume 17, Issue 3, titled “Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer’s disease.” In this study, a research team from Dalhousie University, led by Sultan Darvesh, discovered that certain anti-aging ...

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. The research suggests the role of CD11c-positive microglia—immune cells in the brain crucial for myelination—during infant brain development. The results, published in Communications Biology, suggest new strategies to mitigate the long-term neurodevelopmental effects of maternal inflammation.  Inflammation during pregnancy occurs when the mother’s immune system becomes activated during pregnancy, typically due to an infection, autoimmune response, or environmental factors. ...

North America’s smallest falcon, the American Kestrel (Falco sparverius), has declined across the continent since the 1970s, yet the causes continue to stump raptor biologists. A new study published in the Journal of Raptor Research adds a piece to the puzzle with the discovery that in the Northeast, where declines are most alarming, fledglings demonstrate a relatively high survival rate. This paper, titled “Juvenile and Adult Survival Estimates of American Kestrels Throughout the Full Annual Cycle in Eastern North America,” is the first of its kind. No other study has assessed winter survival ...

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat “triple negative” breast cancer subtype, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to new dietary and pharmaceutical strategies against breast and other cancers. In the study, published March 14 in Science, the researchers found that linoleic acid can activate a major growth pathway in tumor cells by binding to a protein called FABP5. Comparing breast cancer subtypes, the team observed that this growth pathway activation ...

As of the end of 2023, nearly 40 million people worldwide were living with HIV, including approximately 1.2 million in the United States. In the same year, about 630,000 people globally died from AIDS-related illnesses. Although this is a significant decline from previous years, AIDS-related deaths remain a critical global health challenge. While antiretroviral therapy (ART) has improved the life expectancy of people with AIDS, a lack of effective diagnostics and disease management tools has hindered its global implementation. Only 59% of those in need have access to treatment, and about one in four people living with HIV are unaware of their status. Additionally, ...

Cardiac deaths increase significantly during compound heatwaves—heatwaves where temperatures are elevated both during the day and overnight—according to a new study in JACC, the flagship journal of the American College of Cardiology. The study also found that some types of heart disease are more sensitive to heatwaves than others and that different types of heatwaves may impact heart health in distinct, nonlinear ways. The research highlights the special risks of compound heatwaves ...

DALLAS, April 1, 2025 — A New York City-based physician scientist who explores ways to improve health by looking at the ways in which cells and molecules impact disease and an epidemiologist from Baltimore who has devoted her career to identifying ways to improve screening, diagnosis and patient care for people with diabetes are the most recent American Heart Association Merit Award recipients. Over the next five years, each researcher will receive a total of $1 million in funding from the Association, a global force changing the future of health for all. The American Heart Association’s Merit Award is one of ...

A study of the use of AI by a Russian-backed propaganda outlet shows how AI allows propagandists to increase their production capacity without any loss in persuasive power. In December 2023, journalists at the BBC and Clemson University’s Media Forensics Hub published an investigation revealing that the site DCWeekly.org was a Russian propaganda outlet, part of a broader network disseminating pro-Kremlin and anti-Ukrainian narratives. Morgan Wack and colleagues found that prior to September 20, 2023, much of the content on the site was simply lifted from other right-leaning outlets. After that date, however, the stories were generally rewritten by AI, allowing the site to use a broader ...

Polysiloxane materials, such as polydimethylsiloxane (PDMS)-based elastomers, exhibit a self-healing capability by the introduction of silanolate (Si–O–) groups. This ability stems from their dynamic siloxane (Si–O–Si) bonds, which can break and reform to repair damage. Their self-healing properties could make them valuable in applications like protective coatings for use in various fields, such as optics, electronics, and aerospace. To improve the properties of PDMS-based materials, they have been combined with inorganic fillers such as nanoparticles or nanosheets. Generally, the introduction of nanosheets into polymers leads to the formation of ...

New York, NY – April 1, 2025-  A study published today in the American Journal of Gastroenterology reveals significant disparities in healthcare utilization among racial and ethnic groups with inflammatory bowel disease (IBD) in the United States. The research, funded by the Centers for Disease Control and Prevention (CDC), led by investigators from the University of Pennsylvania, the University of North Carolina at Chapel Hill, and the Crohn's & Colitis Foundation provides crucial insights into the challenges faced by underrepresented communities ...

DALLAS, April 1, 2025 — Sedentary behavior has become a national health crisis, with 1 in 4 U.S. adults sitting for more than eight hours a day, increasing their risk for heart disease, stroke, and mental health challenges, according to the Centers for Disease Control and Prevention. To help people move more, the American Heart Association, a global force changing the future of health of all, invites communities nationwide to walk together on Wednesday, April 2. Adopting healthier routines doesn’t have to be intimidating or overwhelming according to Eduardo Sanchez MD, MPH, FAHA, the ...

A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumours in chicken eggs and analyzing their proteins. The team, led by researchers from the University of British Columbia and BC Children’s Hospital Research Institute, is the first in Canada to combine these two techniques to identify and test a drug for a young patient's tumour in time for their treatment. Their success in finding a new drug for the patient, described today in EMBO Molecular Medicine, shows how the study of proteins, known as proteomics, ...

Eye tracking plays a critical role in the latest virtual and augmented reality headsets and is an important technology in the entertainment industry, scientific research, medical and behavioral sciences, automotive driving assistance and industrial engineering. Tracking the movements of the human eye with high accuracy, however, is a daunting challenge. Researchers at the University of Arizona Wyant College of Optical Sciences have now demonstrated an innovative approach that could revolutionize eye-tracking ...

It’s (going to be) electric. But how soon? How quickly our society can maximize the benefit of electrification hinges on finding cheaper, higher performance batteries — a reality closer to hand through new research from Virginia Tech. A team of chemists led by Feng Lin and Louis Madsen found a way to see into battery interfaces, which are tight, tricky spots buried deep inside the cell. The research findings were published on April 1 in the journal Nature Nanotechnology. “There are major, longstanding challenges at the interfaces,” ...

April 1, 2025   AMHERST, Mass. – While the threat that microplastics pose to human and ecological health has been richly documented and is well known, nanoplastics, which are smaller than one micrometer (1/50th the thickness of an average human hair), are far more reactive, far more mobile and vastly more capable of crossing biological membranes. Yet, because they are so tiny and so mobile, researchers don’t yet have an accurate understanding of just how toxic these particles are. The first step to understanding the toxicology of nanoplastics is to build a reliable, ...

Mpox has the potential to become a significant global health threat if taken too lightly, according to scientists at the University of Surrey.  In a letter published in Nature Medicine, researchers highlight how mpox – traditionally spread from animals to humans – is now showing clear signs of sustained human-to-human transmission.  Mpox is a viral infection caused by a virus that belongs to the same family as smallpox. The virus can cause a painful rash, fever, and swollen glands and, in some cases, lead to more serious illness. Mpox usually spreads through ...

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment’s effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH). The findings, published April 1, 2025 in Nature Medicine, offer hope that this therapy could be used to treat a variety of solid tumors, which has so far eluded researchers developing cell-based ...

Real estate is precious. Some creatures defend territories extending over several kilometres, but when Jayne Yack (Carleton University, Canada) encountered miniature newborn warty birch caterpillars (Falcaria bilineata) she wondered if she might have discovered one of the world’s smallest, and youngest, territorial critters. ‘We had noticed that tiny warty birch caterpillars produced vibrations’, says Yack, who first encountered the feisty little creatures in 2008. She also noticed that the tiny caterpillars – 1 to 2 mm long – reside in solitude on birch leaves, making her speculate whether they ...

A new study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, has found that children exposed to higher levels of air pollution in early and mid childhood have weaker connections between key brain regions. The findings, published in Environment International, highlight the potential impact of early exposure to air pollution on brain development. The research showed reduced functional connectivity within and between certain cortical and subcortical brain networks. These networks are systems of interconnected brain structures that work together to perform different cognitive functions, such as thinking, perceiving and controlling ...

LOS ANGELES — Researchers with City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center in Los Angeles ranked among the nation’s top 5 cancer centers by U.S. News & World Report, and MSK have created a tool that uses machine learning to assess a non-Hodgkin lymphoma (NHL) patient’s likely response to chimeric antigen receptor (CAR) T cell therapy before starting the treatment, according to study results published today in Nature Medicine. CAR T cell therapy ...

New projections by the UNSW Institute for Climate Risk & Response (ICRR) reveal a 4°C rise in global temperatures would cut world GDP by around 40% by 2100 – a stark increase from previous estimates of around 11%.  The recently-published analysis fixes an oversight in the current economic model underpinning global climate policy, toppling previous carbon benchmarks.  The results support limiting global warming to 1.7 °C, which is in line with significantly faster decarbonisation goals like the Paris Agreement, and far lower than the 2.7°C supported ...

While the Middle Paleolithic period is viewed as a dynamic time in European and African history, it is commonly considered a static period in East Asia. New research from the University of Washington challenges that perception. Researchers discovered a complete Quina technological system — a method for making a set of tools — in the Longtan site in southwest China, which has been dated to about 50,000 to 60,000 years ago. Quina technology was found in Europe decades ago but has never before been found in East Asia. The team published its findings March ...

Whales and dolphins sleep by turning off one half of their brains at a time; scientists discover more about the genes and pathways that enable this phenomenon.  #### Article URL: https://plos.io/4c9g5gm Article Title: Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation Author Countries: China Funding: This work was supported by the National Key Research and Development (R&D) Program of China (grant no. 2022YFF1301600) to G.Y. & S.X., the Key Project ...

Life emerged on Earth some 3.8 billion years ago. The “primordial soup theory” proposes that chemicals floating in pools of water, in the presence of sunlight and electrical discharge, spontaneously formed organic molecules. These building blocks of life underwent chemical reactions, likely driven by RNA, eventually leading to the formation of single cells. But what sparked single cells to assemble into more complex, multicellular life forms? Nature Physics published a new insight about a possible driver of this key step in evolution — the fluid ...