Macrophage immune cells need constant reminders to retain memories of prior infections
Researchers from the University of California, Los Angeles, have discovered that immune cells known as macrophages remain poised to fight repeat infections due to the persistent presence of signaling molecules left behind during previous infections. The study, to be published February 18 in the Journal of Experimental Medicine (JEM), provides surprising new details about how the body’s innate immune system retains memories of previous immune threats, and suggests new ways to reduce the activity of misprogrammed macrophages that contribute to ...