Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day. Knowing local time helps our bodies to regulate essential processes, including when to sleep and wake, when to eat and what temperature to maintain, among many other important functions. But a deadly interloper is keeping time the same ...

About The Study: The results of this study suggest that the BNT162b2 XBB vaccine (Pfizer-BioNTech) provided protection against COVID-19–associated hospitalization and emergency department or urgent care visits among children 5 to 17 years of age during the 2023-2024 season with estimated vaccine effectiveness point estimates ranging from 63% to 73%.  Corresponding Author: To contact the corresponding author, Sara Y. Tartof, PhD, MPH, email Sara.Y.Tartof@kp.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.49944) Editor’s ...

About The Study: From 2008-2020, teachers reported an increase in emotional/mental health and suicide prevention in schools, along with related teacher training. However, they reported a decrease in substance use prevention, particularly among middle schools, and no change in teacher training. Substance use during early adolescence is associated with risk for long-term addiction, and middle schools may be underused for prevention.  Corresponding Author: To contact the corresponding author, Chloe Gao, BHSc, email chloe.gao@childrens.harvard.edu. To ...

Genetic variants that determine the shape of your teeth – including a gene inherited from Neanderthals – have been identified by a team co-led by UCL researchers. In a new paper published in Current Biology, scientists found substantial tooth differences between ethnicities, potentially due in part to a gene inherited from Neanderthals that was only found in study participants of European origin. Co-lead author Dr Kaustubh Adhikari (UCL Genetics, Evolution & Environment and The Open University) said: “Teeth ...

Whether they’re lifelong buddies or recently connected, close to home or miles away, a new poll shows the key role that friends play in the lives and wellbeing of adults aged 50 and older. But it also reveals some challenges for those who have physical health or mental health issues – suggesting it may be important for them connect with existing friends or make new friends. In all, 90% of people aged 50 and older say they have at least one close friend, and 75% say they have enough close friends, ...

Excessive screen use by preschool-age children can lead to reduced sleep quality, exacerbating problems such as poor attention, hyperactivity and unstable mood, a new study suggests. Peer-reviewed findings published in Early Child Development and Care show how screen time is “significantly” correlated with increased hyperactive attention problems and emotional symptoms, and with decreased sleep quality. Additionally, the research – carried out by experts in China and Canada – demonstrates how sleep quality is also extensively correlated with decreased hyperactive attention problems, emotional symptoms and peer problems. The findings ...

Sweetpotatoes are an agricultural powerhouse that feeds millions globally. However, their complex genetics make it challenging for breeders to understand and improve traits like yield, disease resistance, and nutritional content. A new study reveals insights into the significance of leveraging “allele dosages” in sweetpotato breeding practices. “Sweetpotatoes are hexaploid, meaning they have six copies of each chromosome, unlike diploid crops like tomato or rice, which have two," explained Zhangjun Fei, a professor at the Boyce Thompson Institute and one of the study's lead authors. “This genetic ...

Dan M. Frangopol, the inaugural Fazlur R. Khan Endowed Chair of Structural Engineering and Architecture at Lehigh University, has co-authored a new book on probabilistic structural performance assessments. System Reliability, Risk, Longevity, Sustainability and Optimal Decision-Making: Emphasis on Marine Structures (available April 11, 2025) offers a comprehensive framework for analyzing and predicting the time-dependent performance of deteriorating structures. The book emphasizes marine infrastructure, addressing system reliability, risk, longevity, sustainability, and optimal decision-making processes. It is a valuable resource for students, engineers, researchers, decision-makers, ...

DILI is broadly categorized into intrinsic and idiosyncratic types. Intrinsic hepatotoxins, such as APAP, cause dose-dependent injury, while idiosyncratic DILI involves complex immune and metabolic interactions that remain poorly understood. Mechanistic studies of intrinsic hepatotoxins have revealed oxidative stress and mitochondrial dysfunction as key contributors to injury. Historically, LPO and iron-catalyzed free radical generation were central to understanding DILI, but the focus shifted toward apoptosis in the late 20th century. The discovery of ferroptosis—a regulated form of cell death characterized ...

CLEVELAND - A recent study conducted at University Hospitals Connor Whole Health has evaluated a Reiki program designed for outpatients with cancer and receiving infusion treatments at two University Hospitals infusion centers. The study, entitled “Evaluation of a Reiki Volunteer Program within Two Cancer Infusion Centers,” was recently published in the Journal of Pain and Symptom Management, a peer-reviewed journal that serves as an interdisciplinary audience of professionals. This retrospective review, conducted between March 2022 and February 2024, evaluated the effects of Reiki on outpatients receiving infusion treatments such as chemotherapy. During Reiki sessions, a ...

WHAT: A large study found that greater exposure to long-term air pollution was linked with increased risks for blood clots that can occur in deep veins, which, if untreated, can block blood flow and cause serious complications, even death.   These findings came from a longitudinal study funded by the National Institutes of Health (NIH) that included 6,651 U.S. adults who were followed for an average of 17 years between 2000 and 2018. Participants lived in or near one of six major metropolitan areas: New York, Baltimore, Chicago, Los Angeles, Minneapolis, and Winston-Salem, North Carolina. Throughout the study, 248 adults, 3.7% of the study sample, developed blood clots ...

The National Academy of Inventors (NAI) is proud to announce the recipients of the inaugural Prince Mohammad bin Fahd University (PMU)-National Academy of Inventors International Patent Award. This year’s recipients will be honored at a special ceremony on December 12th, 2024 at PMU’s campus in Al-Khobar, Kingdom of Saudi Arabia. The PMU-NAI International Patent Award was created to recognize and honor distinguished scientists, research institutions, research centers, and universities across the globe for their outstanding patents and inventions that create positive societal ...

OAK BROOK, Ill. – Using just one inhalation lung CT scan, a deep learning model can accurately diagnose and stage chronic obstructive pulmonary disease (COPD), according to a study published today in Radiology: Cardiothoracic Imaging, a journal of the Radiological Society of North America (RSNA). COPD is a group of progressive lung diseases that impair a person’s ability to breathe. Symptoms typically involve shortness of breath and fatigue. There currently is no cure for COPD, and it is the third leading cause of death worldwide, according to the World Health Organization. A ...

Alliance Foundation Trials, LLC (AFT) and Pfizer Inc. today announced results from the phase III PATINA trial demonstrating that the addition of palbociclib (IBRANCE®) to current standard-of-care first-line maintenance therapy (following induction chemotherapy) resulted in statistically significant and clinically meaningful improvement in progression-free survival (PFS) by investigator assessment in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-positive (HER2+) metastatic ...

SAN ANTONIO – Patients with low-risk ductal carcinoma in situ (DCIS) who underwent active monitoring reported comparable physical, emotional, and psychological outcomes to patients who received upfront treatment, according to results from the COMET clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. The results of this study were simultaneously published in JAMA Oncology. “Active monitoring” is a strategy in which patients are monitored closely, with surgery reserved for those patients who ...

SAN ANTONIO – For patients with “good-risk” ductal carcinoma in situ (DCIS) who underwent breast- conserving surgery and did not receive radiotherapy, tamoxifen significantly decreased the risk of recurrence in the same breast, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. “Good-risk” DCIS was defined as grade 1 or 2, 2.5 cm or smaller, and having clear surgical margins of 3 mm or greater. Current guidelines from the National Comprehensive Cancer Network (NCCN) advise that patients who undergo breast-conserving surgery after a diagnosis ...

SAN ANTONIO – Among patients with hormone receptor (HR)-positive, HER2-negative, low-risk ductal carcinoma in situ (DCIS), those who underwent active monitoring had similar two-year invasive ipsilateral breast cancer recurrence rates as those who underwent guideline-concordant treatment, according to results from the COMET clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. The results of this study were simultaneously published in JAMA. “Active monitoring” is a strategy in which patients are monitored closely, with surgery reserved for those patients who develop cancer. A steady increase ...

SAN ANTONIO – Patients with intermediate-risk breast cancer had similar rates of 10-year overall survival whether or not they underwent chest wall irradiation (CWI) after mastectomy, according to results from the BIG 2-04 MRC SUPREMO clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024. “While post-mastectomy CWI is the standard of care for most patients with early-stage breast cancer who have four or more positive axillary lymph nodes, its role in patients with fewer positive lymph nodes or node-negative disease remains controversial,” ...

About The Study: Women with low-risk ductal carcinoma in situ randomized to active monitoring did not have a higher rate of invasive cancer in the same breast at 2 years compared with those randomized to guideline-concordant care.  Corresponding Author: To contact the corresponding author, E. Shelley Hwang, MD, MPH, email shelley.hwang@duke.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.26698) Editor’s Note: Please ...

About The Study: In this prespecified secondary analysis of the Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) prospective randomized trial, the overall lived experience of women randomized to undergo active monitoring for low-risk ductal carcinoma in situ was similar to that of women randomized to guideline-concordant care during the 2 years following diagnosis.  Corresponding Author: To contact the corresponding author, Ann H. Partridge, MD, MPH, email ann_partridge@dfci.harvard.edu. To access the embargoed study: Visit our For The Media website ...

Not only are they the smallest among us, premature children also face health and life challenges that make them the most vulnerable. Generally speaking, they have a slightly higher risk of mortality due to illness. It is now apparent that they also have a higher risk of unexpected death from so-called external causes: road traffic accidents, substance abuse and suicide. This has been revealed in a major Nordic study led by Professor Kari Risnes from the Faculty of Medicine and Health Sciences at the Norwegian University of Science and Technology (NTNU). The researchers have analyzed birth data and causes of death for nearly 37,000 individuals aged between 15 ...

Petrovax announced today the positive results from “Long-CoV-III-21,” a randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of bovhyaluronidase azoximer in adult patients with pulmonary sequelae of COVID-19. Bovhyaluronidase azoximer, marketed under the brand name Longidaza, is a polymer-conjugated hyaluronidase with an extended half-life. The study drug and placebo were administered for 71 days, with an observation period extending to Day 180. Longidaza demonstrated a statistically significant 62% reduction in the proportion of patients with exertional desaturation ...

Mosasaurs are extinct marine lizards, spectacular examples of which were first discovered in 1766 near Maastricht in the Netherlands, fueling the rise of the field of vertebrate palaeontology (the study of fossil remains of animals with backbones). Palaeontologist Michael Polcyn presented the most comprehensive study to date on the early evolution and ecology of these extinct marine reptiles. On 16 December, Polcyn will receive his PhD from Utrecht University for his research into the evolution of the mosasaurs. "Mosasaurs are a textbook example of macroevolution, ...

Genova (Italy), 12th December 2024 – A specific brain mechanism modulates how animals respond empathetically to others’ emotions. This is the latest finding from the research unit Genetics of Cognition, led by Francesco Papaleo, Principal Investigator at the Istituto Italiano di Tecnologia (IIT - Italian Institute of Technology) and affiliated with IRCCS Ospedale Policlinico San Martino in Genova. The study, recently published in Nature Neuroscience, provides new insights into psychiatric ...

The Korea Institute of Materials Science (KIMS) announced that Dr. Yong-Hun Kim from the Energy & Environment Materials Research Division and Dr. Kyung Song from the Material Characterization Center, in collaboration with Professor Hyun-Sang Hwang's team from POSTECH, have successfully developed a groundbreaking heterojunction technology. This technology integrates tungsten disulfide (WS₂), a two-dimensional (2D) material, with hafnium zirconium oxide (HZO), a ferroelectric material, achieving both interfacial stability and superior crystallinity. The results have been accepted by the International Electron Devices Meeting 2024 (IEDM 2024), ...