(Monday 14 October 2024, Vienna, Austria) Groundbreaking research presented today at UEG Week 2024 reveals a promising new treatment strategy for type 2 diabetes (T2D) that could significantly reduce or even eliminate the need for insulin therapy.1 This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients. Globally, T2D affects 422 million people, with obesity recognised as a significant ...

Copenhagen, Denmark: Severely injured children who are brought to an emergency medical department by their parents or carers are often not seen as quickly as those who arrive at hospital via ambulance, according to findings presented at the European Emergency Medicine Congress today (Monday). [1]   The study’s researchers identified three key trauma features that should prompt doctors to review these patients immediately and potentially prioritise their treatment: boggy swelling to the head, abdominal bruising, and thigh swelling or deformity.   The study was carried out in an inner-city ...

Copenhagen, Denmark: International experts in emergency medicine have warned that climate change is likely to have a severe impact on emergency services around the world. Despite this, few countries have assessed the scale of the impact or have a plan to deal with it.   In a special session at the European Emergency Medicine Congress today (Sunday), Luis Garcia Castrillo, a professor in emergency medicine, now retired, at the Hospital Marqués de Valdecilla, Santander, Spain, described how he and colleagues from EUSEM’s Emergency Medicine Day working group had asked 42 focus groups, consisting of experts in emergency medicine, prehospital care ...

(13 October 2024, Vienna, Austria) Cutting-edge research has uncovered how chronic stress disrupts the balance of gut microbiota to speed up the progression of colorectal cancer (CRC), opening new avenues for CRC prevention and treatment.1 By eliminating certain gut bacteria and inducing stress, researchers were able to conclude a relationship between stress and gut microbiota in the progression of CRC, identifying a particular bacterial species as a potential therapeutic target. Presenting the study at UEG Week 2024, lead researcher Dr Qing Li explained, “In our study, we used an antibiotic ...

Researchers at the Federal University of São Carlos (UFSCar), the State University of Campinas (UNICAMP) and the University of São Paulo (USP) in Brazil have characterized for the first time a class of proteins present in the parasite Leishmania infantum and involved in regulating its cell cycle. In an article published in PLOS Pathogens, they describe potential pharmaceutical targets for the treatment of visceral leishmaniasis. Existing therapeutic strategies are considered insufficiently effective. In eukaryotic organisms, which have cells with a defined nucleus and include all plants and animals, the ubiquitin-proteasome system (UPS) ...

With the help of deep learning, University of California, Berkeley, scientists have leveraged citizen science data from the app iNaturalist to create the highest resolution maps yet of plant distributions throughout California. iNaturalist is a widely-used cellphone app, originally developed by UC Berkeley students, that allows people to upload photos and the location data of plants, animals or any other life they encounter and then crowdsource their identity. The app currently has more than 8 million users worldwide who collectively have uploaded more than 200 million observations. The researchers used a ...

Respiratory syncytial virus (RSV) is the leading cause of hospitalization in young children due to respiratory complications such as bronchiolitis and pneumonia. Yet little is understood about why some children develop only mild symptoms while others develop severe disease. To better understand what happens in these cases, clinician-scientists from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, and Boston Children’s Hospital analyzed samples from patients’ airways and ...

SAN ANTONIO, Oct. 11, 2024 – David Gius, MD, PhD, professor in the Department of Radiation Oncology and assistant dean of research at The University of Texas Health Science Center at San Antonio (UT Health San Antonio), was named this year’s recipient of the prestigious American Society for Radiation Oncology (ASTRO) Career Recognition Mentorship Award. Gius is associate cancer center director for translational research at Mays Cancer Center at UT Health San Antonio. He is among three awardees receiving this recognition. The award honors individuals who have made significant contributions to mentorship ...

Hitting the bull’s eye to target ‘undruggable’ diseases – researchers reveal new levels of detail in targeted protein degradation   Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously ‘undruggable’ diseases Dundee researchers have revealed new levels of details of how protein degraders work The work means new drugs can be much more accurately targeted at the molecular level, creating and hitting a metaphorical ...

WASHINGTON —The Society for Cardiovascular Angiography & Interventions (SCAI) is pleased to announce the publication of the Expert Consensus Statement on the Management of Patients with STEMI Referred for Primary PCI. Published in JSCAI, the consensus statement provides detailed suggestions for clinicians, particularly for nuanced situations not covered by general guidelines. It highlights the strengths and limitations of various diagnostic and therapeutic interventions for treating patients with STEMI, provides ...

Researchers have developed and demonstrated a technique that allows them to engineer a class of materials called layered hybrid perovskites (LHPs) down to the atomic level, which dictates precisely how the materials convert electrical charge into light. The technique opens the door to engineering materials tailored for use in next-generation printed LEDs and lasers – and holds promise for engineering other materials for use in photovoltaic devices. Perovskites, which are defined by their crystalline ...

East Hanover, NJ – October 11, 2024 – A new Kessler Foundation survey of supervisors in the hospitality industry – focused on restaurant and traveler accommodations – has revealed critical insights into the recruitment, support, and accommodation of workers with disabilities. The findings, released today in a special live Zoom webinar, offer actionable takeaways for employers looking to diversify their workforce and enhance workplace inclusion. Key points revealed that proactive recruitment, effective partnerships, and ...

NEWPORT NEWS, VA – Radiation therapy techniques have been used for more than a century to treat cancers. Physicists in the Radiation Detector and Imaging group and associated with the Biomedical Research & Innovation Center (BRIC) at the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility have been for several years pursuing radiation therapy technology improvements in collaboration with the Hampton University Proton Cancer Institute (HUPCI). Now, BRIC physicists are launching a study into how best to advance different types of radiation therapy. BRIC scientists plan to evaluate the ability of accelerator-based ...

In a new study, UCLA Health researchers have found that motor delay and low muscle tone were common signs of an underlying genetic diagnosis in children with neurodevelopment disorders.   Given the limited existing data on the early neurodevelopmental symptoms that predict a positive genetic diagnosis, the study authors aimed to research which factors in this subset of children indicated the need of a genetic test. “With genetic testing, a diagnostic result can have benefits on medical care, but ...

About The Study: In a nationwide randomized clinical implementation trial, electronically delivered letter-based nudges markedly increased influenza vaccination compared with usual care among young and middle-aged patients with chronic diseases. The results of this study suggest that simple, scalable, and cost-efficient electronic letter strategies may have substantial public health implications. Corresponding Author: To contact the corresponding author, Tor Biering-Sorensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com. To access the embargoed ...

Plants form new leaves, flowers and roots at the tips of shoots and roots, in specific growth regions known as meristems. These meristems contain stem cells that divide as needed and form new cells that develop into specialised tissue. Using the example of plant roots, researchers from Freiburg have now been able to decipher which regulatory mechanisms ensure that growth in the meristem occurs in a controlled manner. The results have been published in the journal Nature Plants. Stem cells are dependent on ...

CHAMPAIGN, Ill. — In 1898, two male lions terrorized an encampment of bridge builders on the Tsavo River in Kenya. The lions, which were massive and maneless, crept into the camp at night, raided the tents and dragged off their victims. The infamous Tsavo “man-eaters” killed at least 28 people before Lt. Col. John Henry Patterson, the civil engineer on the project, shot them dead. Patterson sold the lions’ remains to the Field Museum of Natural History in Chicago in 1925. In a new study, Field Museum researchers collaborated with scientists at the University of Illinois Urbana-Champaign on an in-depth analysis of hairs carefully extracted ...

By isolating and sequencing DNA in compacted hairs collected from the teeth of two Tsavo lion museum specimens from the 1890s, researchers have found that the historic lions from Kenya preyed on a variety of species, including humans, giraffes, and wildebeests. These so-called “Tsavo Man-Eaters” are estimated to have killed at least dozens of people, including those working along the Kenya-Uganda Railway in the late 1890’s. The findings appear in the Cell Press journal Current Biology on October 11. “As ...

Promising findings by researchers at Baylor College of Medicine and collaborating institutions could lead to the development of a non-invasive stool test and a new therapy for endometriosis, a painful condition that affects nearly 200 million women worldwide. The study appeared in the journal Med. “Endometriosis develops when lining inside the womb grows outside its normal location, for instance attached to surrounding intestine or the membrane lining the abdominal cavity. This typically causes bleeding, pain, inflammation and infertility,” said corresponding author Dr. Rama Kommagani, associate professor in the Department of Pathology ...

About The Study: In this cross-sectional study of the U.S. population during the COVID-19 public health emergency, excess mortality occurred in all racial and ethnic groups, with disparities affecting several minoritized populations. The greatest relative increases occurred in populations ages 25 to 64. Documented differences deviated from pre-pandemic disparities. Corresponding Author: To contact the corresponding author, Jeremy Samuel Faust, MD, MS, email jsfaust@bwh.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.38918) Editor’s ...

Delft scientists discover how innate immunity envelops bacteria The protein GBP1 is a vital component of our body’s natural defence against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now. Researchers from Delft University of Technology have now unravelled how this protein operates. This new knowledge, published in Nature Structural & Molecular Biology, could aid in the development of medications ...

[Vienna, October 11, 2024] – A new article highlights a critical issue in the One Health approach—an emerging global framework for tackling complex health challenges at the intersection of human, animal, and environmental health. In the article in The Lancet Planetary Health, scientists Amélie Desvars-Larrive and Fariba Karimi from the Complexity Science Hub (CSH) point out that One Health's current framework fails to explicitly address workforce diversity. According to Desvars-Larrive and Karimi, ...

October 11, 2024 – Genome Research (https://genome.org) publishes a special issue highlighting novel advances in computational biology. In collaboration with the International Conference on Research in Computational Molecular Biology (RECOMB), Genome Research publishes a collection of 20 computational methods and their applications in genomics including spatial, single-cell, and long-read sequencing. These include algorithmic innovations in genomic variation analysis, privacy-preserving algorithms, DNA structural properties, cancer genomics, ...

The research team led by Dr. Daeho Kim and Dr. Jong Hwan Park at the Nano Hybrid Technology Research Center of the Korea Electrotechnology Research Institute (KERI) has developed a groundbreaking process technology that enables for ultrafast, 30-second preparation of hard carbon anodes for sodium-ion batteries using microwave induction heating. One of the next-generation secondary batteries, the sodium-ion battery uses sodium (Na) in lieu of the current mainstay, lithium (Li). Sodium, the main component of salt, is more than a thousand times more abundant than lithium and is easier to extract and refine. Furthermore, its lower reactivity compared ...

Astronomers have used the NASA/ESA James Webb Space Telescope (JWST) to observe the ‘inside-out’ growth of a galaxy in the early universe, only 700 million years after the Big Bang. This galaxy is one hundred times smaller than the Milky Way, but is surprisingly mature for so early in the universe. Like a large city, this galaxy has a dense collection of stars at its core but becomes less dense in the galactic ‘suburbs’. And like a large city, this galaxy is starting to sprawl, with star formation accelerating in the outskirts. This is the earliest-ever detection of inside-out galactic growth. ...