WASHINGTON, Oct. 9, 2024 — On behalf of the American Chemical Society (ACS), President Mary K. Carroll congratulates today’s winners of the Nobel Prize in Chemistry: David Baker, of the University of Washington; Demis Hassabis, of Google DeepMind; and John M. Jumper, of Google DeepMind. The Royal Swedish Academy of Sciences awarded the prize with one half to Baker “for computational protein design” and the other half jointly to Hassabis and Jumper “for protein structure prediction.” “This incredibly complex problem of predicting the 3D structures of proteins from the sequence of amino acids has been one of the biggest challenges ...

About The Study: Daily multidisciplinary rounds conducted by a board-certified intensivist through telemedicine did not reduce intensive care unit (ICU) length of stay in critically ill adult patients. Corresponding Author: To contact the corresponding author, Adriano J. Pereira, M.D., Ph.D., email adrianojop@einstein.br. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.20651) Editor’s Note: Please ...

About The Study: Patients with acute brain injury and anemia randomized to a liberal transfusion strategy were less likely to have an unfavorable neurological outcome than those randomized to a restrictive strategy. Corresponding Author: To contact the corresponding author, Fabio Silvio Taccone, MD, PhD, email fabio.taccone@ulb.be. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.20424) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict ...

About The Study: The use of a nonselective extracorporeal blood purification device connected to the cardiopulmonary bypass circuit in a nonemergent population of patients undergoing cardiac surgery was associated with a significant reduction of cardiac surgery–associated acute kidney injury in the first 7 days after surgery. Corresponding Author: To contact the corresponding author, Xose L. Perez-Fernandez, PhD, MD, email xose74@gmail.com. To access the embargoed study: Visit our For The Media website ...

About The Study: Among critically ill adults who received invasive mechanical ventilation for more than 24 hours, screening frequency (once-daily vs more frequent screening) and spontaneous breathing trial (SBT) technique (pressure-supported vs T-piece SBT) did not change the time to successful extubation. However, an unexpected and statistically significant interaction was identified; protocolized more frequent screening combined with pressure-supported SBTs increased the time to first successful ...

PLYMOUTH MEETING, PA [October 9, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers in the United States—announces a renewed collaboration with the Latin American Cooperative Oncology Group (LACOG) to improve cancer outcomes in South America. The international oncology organizations worked together to publish new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Prostate Cancer: Brazil Edition. The NCCN Guidelines® for Prostate Cancer: Brazil Edition are now available free-of-charge at NCCN.org/global. Additional Brazilian adaptations of NCCN Guidelines ...

The secret to losing weight could all be down to a combination of 14 ‘skinny genes’, a new study has found.   University of Essex researchers discovered they helped people drop twice as much weight when they ran for half an hour three times a week.   The team - led by Dr Henry Chung, from the School of Sport, Rehabilitation and Exercise Sciences - found those with more of the genes slimmed the most across eight weeks.   People with the most markers lost up to 5kg during the study and people without ...

EMBARGOED UNTIL OCTOBER 9, 2024 AT 6:30 AM ET Brigham researchers found people with wide-ranging long COVID symptoms were twice as likely to have SARS-CoV-2 proteins in their blood, compared to those without long COVID symptoms A persistent infection could explain why some people experience long COVID symptoms, according to a new study led by researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system. The team found evidence of persistent infection in 43 percent of participants with cardiopulmonary, ...

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year follow-up period after COVID infection. The elevated risk of heart attack, stroke and death linked to COVID-19 infection was found to be comparable to cardiovascular risk factors such as Type 2 diabetes, peripheral artery disease and cardiovascular disease. The study found that having a non-O blood type (A, B, AB) was associated with an increased risk of heart attack and stroke among ...

Wednesday, October 9, 2024, Cleveland:  A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California. The study found that people with any type of COVID-19 infection were twice as likely to have a major cardiac event, such as heart attack, stroke or even death, for up to three years after diagnosis. The risk was significantly higher for patients hospitalized for COVID-19 and more of a determinant than a previous history of heart disease. Further genetic analysis ...

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes to nearly half a million deaths worldwide each year. Researchers from the University of Geneva (UNIGE) have discovered a molecule, called nanobody NbE, which binds tightly and durably to the cell receptors that usually bind to opioids, thereby blocking the drugs’ activity. Moreover, the scientists were able to create even smaller molecules that retain the same properties, which could prove far more effective than current treatments in ...

New research identifies for the first time the genes that help plants grow under stressful conditions - with implications for producing more sustainable food crops in the face of global climate change. Led by the University of East Anglia (UEA), the study reveals the genes that enable plants to make a novel anti-stress molecule called dimethylsulfoniopropionate, or DMSP. It shows that most plants make DMSP, but that high-level DMSP production allows plants to grow at the coast, for example in salty conditions. The research also shows that plants can be grown under other ...

It’s one of the basic tenets of biology: We get our DNA from our mom and our dad. But one notable exception has perplexed scientists for decades: Most animals, including humans, inherit the DNA inside their mitochondria —the cell’s energy centers – from their mothers alone, with all traces of their father’s mitochondrial genome destroyed the moment sperm joins egg. A new University of Colorado Boulder study published Oct. 4 in the journal Science Advances sheds new light on why this happens, showing that when the process fails, and paternal mitochondria slips into a developing embryo, it can lead to lasting neurological, behavioral and reproductive ...

Plant-based diets, compassionate agriculture, Indigenous methods, consumer pressure, new laws, international agreements and even vegan pets – these are the solutions for fixing our broken food and farming systems, say dozens of environmental advocates, researchers, farmers and industry pioneers in a new book. Editors Joyce D’Silva and Carol McKenna sound the alarm in their introduction to Regenerative Farming and Sustainable Diets, warning that ‘our food system is broken’.  Radical change is needed, they say, in our world where one‑third of food is lost or wasted, 780 million people ...

Step aside tropical rainforests and coral reefs — the latest hotspot to offer awe-inspiring biodiversity lies no further than your bathroom. In a new Northwestern University-led study, microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses — most of which have never been seen before. Although this might sound ominous, the good news is these viruses don’t target people. They target bacteria. The microorganisms collected in the study are bacteriophage, or “phage,” a type of virus that infects and replicates inside of bacteria. Although researchers know little about them, phage recently ...

Obesity and type 2 diabetes are risk factors for various malignancies, including pancreatic cancer, which has a high death rate. A new analysis in Diabetes/Metabolism Research and Reviews suggests that weight-loss surgery—also called metabolic-bariatric surgery—may lower the risk of developing pancreatic cancer in people with obesity, especially in those who also have type 2 diabetes. In the systematic review and meta-analysis, investigators identified 12 relevant studies that explored the effects of metabolic-bariatric surgery on pancreatic cancer incidence, with a total of 3,711,243 adults ...

In research published in Advanced Science, investigators drew inspiration from the octopus to develop an adhesive that achieves strong attachment and controlled release on varied substrates in wet and underwater environments. The feat could have numerous applications in fields ranging from healthcare and underwater robotics to infrastructure repair. By studying the octopus’s suckers—specifically, the exposed disc-like portion called the infundibulum—the researchers designed an elastic, curved stalk with a membrane that can change its shape ...

Individuals at risk of anaphylaxis—an acute systemic hypersensitivity reaction to an allergen or trigger, typically associated with skin reactions, nausea/vomiting, difficulty breathing, and shock—are often prescribed adrenaline (epinephrine) autoinjectors such as EpiPens. A recent review published in Clinical & Experimental Allergy finds that these autoinjectors, which people use to self-administer adrenaline into the muscle, can deliver high doses of adrenaline into the blood, but these levels are short-lived and may not be sufficient to save lives in cases of fatal anaphylaxis. Investigators noted that data from animal and human studies ...

New research in Medical and Veterinary Entomology reveals that when rhinoceros are found dead after being illegally killed by poachers, analyzing insects on the decomposing body aids in estimating the time since death. This information has been used by investigators and officials to construct cases against suspected perpetrators. The study included 19 rhinoceros that were illegally killed and dehorned in the Republic of South Africa between 2014 and 2021. Scientists collected 74 samples of insect evidence from these rhinoceros remains, ...

New research published in Acta Paediatrica suggests that children who engage in outdoor play during their preschool years have a lower risk of developing obesity later in childhood. The study included children born in Japan during two weeks in January and July 2001. Of 53,575 children born, 42,812 had data on outdoor play habits at age 2.5 years. In a survey, parents were asked, “Where do your children usually play (excluding home residences and daycare centers attended)?” Available options for answers included “in my garden or on the grounds of my apartment complex,” “in parks,” “in natural areas such as ...

A new paper in Rheumatology, published by Oxford University Press, finds that consuming more caffeine may improve heart health. Vascular disease, damage of blood vessels, and their resulting consequences, heart attack and stroke, are among the leading causes of death in the general population. In patients with inflammatory rheumatic diseases, such as lupus and rheumatoid arthritis, these risks are even much higher. This is both due to the diseases themselves and some of the treatments for them, particularly cortisone derivatives. Until ...

Many insects are naturally infected with symbiotic bacteria, which are typically transmitted vertically from mother to offspring but are not transmitted horizontally. Understanding the effects of these symbionts is important in terms of insect pest management as they can significantly affect the biology and reproduction of insects. The predatory mirid bug, Nesidiocoris tenuis, which preys on agricultural pests such as whiteflies and thrips, is an important biological control agent. Although the symbiotic bacterium Rickettsia is often found in N. tenuis, its effects on the host have not been clarified. A research team led by NARO and the University of Miyazaki has revealed that Rickettsia ...

Laser direct writing (LDW) employing multi-photon 3D polymerisation is a scientific and industrial lithography tool used in various fields such as micro-optics, medicine, metamaterials, programmable materials, etc., due to the fusion of high-throughput and fine features down to hundreds of nm. Some limitations of technology applicability emerge from photo-resin properties as any material modifications can strongly affect its printability due to applied photoexcitation conditions.   In a paper published at Light: Advanced Manufacturing, a team of scientists, led by Professor Mangirdas Malinauskas from Laser Research Center at Vilnius University, Vilnius, Lithuania,  coworkers ...

Duke-NUS alumnus Dr Marjorie Hoang (Class of 2023) and her mentor, Professor Pierce Chow, have brought clarity to the complex decision-making process patients diagnosed with intermediate-stage liver cancer and their doctors face by creating an algorithm that can accurately calculate the likely overall survival and recurrence-free survival following surgery. Dr Hoang, whose interest in the liver stems from her first year at Duke-NUS, undertook a transformative third-year research project under the guidance of Prof Chow, a senior consultant specialising in liver cancer surgery at the National Cancer Centre ...

Engineers have worked out how to give robots complex instructions without electricity for the first time which could free up more space in the robotic ‘brain’ for them to ‘think’.  Mimicking how some parts of the human body work, researchers from King’s College London have transmitted a series of commands to devices with a new kind of compact circuit, using variations in pressure from a fluid inside it.    They say this world first opens up the possibility of a new generation of robots, whose bodies could operate independently ...