How to reduce suffering in children with advanced cancer remains an ongoing but urgent question. A Mass General Brigham-led study examined whether systematically surveying children with advanced cancer and their parents about their symptoms and quality of life, providing feedback to children, families, and clinicians—and acting on that information by implementing personalized palliative care—could improve patients’ experiences. Their findings, published in the Journal of Clinical Oncology, suggest that integrating feedback along ...

Every year, millions of newborns undergo routine screening as a preventive strategy to detect inherited disorders before symptoms emerge. Newborn screening (NBS) programs have traditionally relied on biochemical markers to identify specific groups of treatable conditions, achieving remarkable success at a population level. However, as researchers increasingly uncover genetically driven diseases that manifest early in life, questions are emerging about whether existing screening frameworks are adequate ...

Researchers from The University of Texas at Dallas and their international colleagues have determined the molecular signature of human sleeping —­ or silent —­ nociceptors: sensory neurons that are unresponsive to touch or pressure yet are key culprits in neuropathic pain. The findings suggest a potential pathway for finding drug targets to relieve chronic pain, said Dr. Ted Price BS’97, Ashbel Smith Professor of neuroscience in the School of Behavioral and Brain Sciences (BBS) ...

Selecting the healthiest embryo is one of the most important steps in in‑vitro fertilization (IVF), yet it remains one of the most uncertain. Roughly 15 percent of couples worldwide experience infertility, and IVF success rates often remain below 33 percent. A major challenge is that embryologists must choose a single embryo to implant, relying on what they can see under a microscope. Even small visual details, such as how cells divide or how the embryo’s internal structures form, can signal whether it is likely to lead to a healthy pregnancy. Clear imaging, therefore, is essential. With that goal in mind, researchers have explored newer “well‑of‑the‑well” ...

Chlamydia pneumoniae—a common bacterium that causes pneumonia and sinus infections—can linger in the eye and brain for years and may aggravate Alzheimer’s disease, according to a study from Cedars-Sinai. Published in Nature Communications, the discovery suggests this bacterium can amplify Alzheimer’s disease and points to potential interventions including inflammation-limiting therapies and early antibiotic treatment. The study shows for the first time that Chlamydia pneumoniae can reach the retina—the tissue lining the back of the eye—where it triggers ...

People with a relatively neurotic personality report having more frequent sexual fantasies, while people who are relatively conscientious or agreeable report less frequent fantasizing. Emily Cannoot of Michigan State University, U.S., and colleagues present these findings from their new 5,225-person study in the open-access journal PLOS One on February 4, 2026. Prior research suggests that sexual fantasies are common and might benefit people’s happiness and relationships. A deeper understanding ...

The ideal scent detection dog is confident, persistent and resilient, without insecurities or neuroticism, according to a study featuring Dutch police dog handlers Article URL: https://plos.io/3Nsw2Gv Article title: Exploring ideal scent detection dog characteristics for successful professional deployment as derived from face-to-face structured interviews with professional scent detection dog handlers Author countries: The Netherlands Funding: The author(s) received no specific funding for this work. END ...

Elusive beaked whales off the Louisiana coast may sometimes be diving right to the seafloor, finds new 3D acoustic technology which accurately pinpoints their locations using their echolocation clicks Article URL: https://plos.io/4qHMqBy Article title: Beaked whale dive behavior and acoustic detection range off Louisiana using three-dimensional acoustic tracking Author countries: U.S. Funding: Funding for this study (sites GC 01 and 02) was part of the “Assessing long-term trends and processes driving variability in cetacean density throughout the Gulf using passive acoustic ...

The vulnerable Amazonian manatee is most often found where human activity is low, with a new eDNA-based method most commonly detecting the freshwater mammal in the remote western Amazon Article URL: https://plos.io/4pYyIZW Article title: Survey of vulnerable Amazonian manatees using environmental DNA (eDNA): A method for survey in remote field settings Author countries: U.S., Brazil Funding: Donation to the International Sportfish Fund from the estate of George and Carolyn Kelso (KR and KOW), and a productivity research fellowship from the Brazilian National and Technological Development Council—CNPq: IPF (CNPq #316531/2023-5), and TH (CNPq #316532/2023-1). ...

Dogs who scored well on the Wesen test, which is used to analyze a dog’s temperament, tended to have lower levels of cortisol, often called the “stress hormone,” and higher levels of serotonin, often called the “happiness hormone”, according to a study published February 4, 2026 in the open-access journal PLOS One by Minjung Yoon from Kyungpook National University, Republic of Korea, and colleagues. In the new research, twenty-four dogs (of various breeds) were analyzed with a version of the Wesen test, in which a human observer judges a dog’s temperament by watching their reaction ...

Researchers at Baylor College of Medicine report in Science Advances a breakthrough in human norovirus (HuNoV) research. Norovirus is a leading cause of acute viral gastroenteritis worldwide with severe outcomes mostly among young children, the elderly and people with weakened or compromised immune systems. There are currently no approved vaccines or antiviral therapies, and management strategies rely solely on supportive care, including fluid and electrolyte replacement. Until now, HuNoV research has been limited by the amount of virus scientists could grow in the lab. In the current study, the Baylor team has overcome ...

The journal Big Earth Data was first launched in 2017 and has since stood out as the world’s first scholarly journal dedicated to Earth-related big data, emerging as a flagship platform at the intersection of Earth science, space science, information science, and sustainability science. Over the past decade, we have witnessed and fostered transformative advancements, from multi-source data fusion to large-model-driven analysis and from cloud computing platforms to digital twin Earth, while upholding a commitment to supporting ...

A new study, jointly led by Liverpool School of Tropical Medicine and the Centre for Research in Infectious Diseases (CRID) in Cameroon, has detected a DNA marker in a gene encoding for a key enzyme, known as cytochrome P450, that helps mosquitoes to break down and survive exposure to pyrethroids, the main insecticides used for treating bed nets. This new finding, published in Science Translational Medicine, will help to better implement insecticide resistance management strategies and contribute to reducing the burden of malaria in sub-Saharan Africa, home to 90% of cases globally.  Professor Charles Wondji, Professor of Genetics and Vector Biology at Liverpool School of Tropical ...

Large increases in PM2.5 exposure from wildfires have exaggerated progress in reducing inequities in traditional sources of PM2.5 in California, especially across racial groups and in years with severe wildfires like 2018.    Article URL: https://plos.io/45zJHSm Article Title: The diverging role of increasing wildfire smoke to ambient PM2.5 exposure disparity in California, 2006 to 2018  Author Countries: France, United States Funding: This work was supported by the National Institute on Aging (RF1AG071024 to JAC; RF1AG071024 to TB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation ...

A team of researchers from Peking University, Beijing Institute of Technology, and the Chinese Academy of Sciences has developed a new optical device capable of asymmetrically transmitting and transforming images in two opposite directions. Dubbed the “Janus meta-imager,” the device is based on diffractive deep neural networks (D²NNs) and metasurfaces, and operates without external power or nonlinear materials. Unlike conventional asymmetric imaging systems that rely on active components or limited unidirectional functions, the Janus meta-imager can perform different imaging tasks in forward and backward directions. For example, in simulations, ...

Early detection and accurate typing of cancer are critical for improving patient survival rates. While traditional pathology remains the gold standard, it often requires complex sample processing and chemical staining. In a study published in the journal PhotoniX, researchers from the State Key Laboratory of Millimeter Waves at Southeast University and the Zhongda Hospital of Southeast University have unveiled a new "label-free" screening method. They have developed a sub-terahertz biosensor that leverages the physical ...

Antioxidants have been marketed as miracle supplements, touted for preventing chronic diseases and cancers; treating COPD and dementia; and slowing aging. While antioxidant therapies are widely used to treat male infertility, a new study from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) found that regularly consuming high doses of antioxidants negatively influences sperm DNA and may lead to offspring born with differences in craniofacial development. In a study, published in the journal Frontiers in Cell and Developmental Biology, a team of researchers led by Dr. ...

Results from the largest-ever clinical trial of its kind found administering a synthetic protein can reduce bleeding and improve outcomes for certain patients at the highest risk of continued bleeding following a type of stroke called an intracerebral hemorrhage (ICH). The University of Cincinnati’s Joseph Broderick, MD, presented results from the FASTEST trial at the International Stroke Conference on Feb. 4. Findings were additionally published in The Lancet, with Broderick serving as corresponding author. An ICH occurs when a blood vessel bursts inside the brain and causes ...

Quantum-enhanced measurement schemes promise sensitivities beyond the shot noise limit, but their practical implementation in atomic systems has long been hindered by optical loss and decoherence. In particular, squeezed states of light—one of the most accessible quantum resources—are extremely fragile when interacting with resonant atomic media, where absorption and scattering rapidly degrade their noise suppression advantage. In this work, researchers report the first realization of a Rydberg electromagnetically induced transparency (EIT) system operating in the quantum regime, where optical readout noise is reduced below the shot noise limit using a squeezed ...

Broadband achromatic wavefront control, a cornerstone of next-generation photonic systems that supports full-color imaging, multi-spectral sensing, has seen important progress reported in PhotoniX by the research group led by Professor Yijun Feng and Professor Ke Chen from Nanjing University. They proposed a hybrid-phase cooperative dispersion-engineering strategy that combines Aharonov–Anandan (AA) and Pancharatnam–Berry (PB) geometric phases in a single-layer metasurface to unlock independent, dual-spin achromatic wavefront control. Dispersion ...

Accurate gas detection is a cornerstone of energy security, environmental monitoring, and medical diagnosis. However, developing a miniaturized device that achieves both high selectivity (distinguishing specific gases) and high sensitivity (detecting trace amounts) has long presented a significant challenge. Traditional spectroscopic methods often struggle to identify complex gas mixtures without relying on bulky equipment or broad spectral bandwidths. Research group at the University of Electronic Science and Technology of China (UESTC) has achieved a major breakthrough in this field. Published in the journal PhotoniX, their study introduces ...

Bar Harbor, Maine — As people age, muscles naturally lose mass and strength, a condition known as sarcopenia. The decline can make everyday activities harder and increases the risk of falls, disability and early death. At the moment, the best defense is regular exercise throughout our lives, as effective treatments to slow or prevent muscle atrophy are limited. Progress has been slowed in part because in most vertebrates, aging unfolds over many years, making it difficult for biomedical researchers to study quickly in the laboratory. Now, MDI Biological Laboratory Associate Professor Romain Madelaine, ...

A key molecular mechanism drives the growth of liver cell cancer while simultaneously suppressing the body's immune response to the tumor. This has now been published in the journal Nature by a team led by researchers from the German Cancer Research Center (DKFZ), the University Hospital of Tübingen, and the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California. However, the results also show that this very mechanism could help identify patients who respond particularly well to immunotherapy in the future, thus opening up new therapeutic approaches. Liver cell cancer is particularly difficult to treat ...

MADISON — Parts of the ancient Earth may have formed continents and recycled crust through subduction far earlier than previously thought. New research led by scientists at the University of Wisconsin–Madison has uncovered chemical signatures in zircons, the planet’s oldest minerals, that are consistent with subduction and extensive continental crust during the Hadean Eon, more than 4 billion years ago. The findings challenge models that have long considered Earth's earliest times as dominated by a rigid, unmoving ...

Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors—a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain. The findings will be published on Wednedsay, February 4 in the renowned scientific journal Cell. Approximately ten percent of the population lives with neuropathic (nerve-related) pain, which is frequently associated with abnormal activity of sleeping nociceptors. ...