Fresh insights show how cancer gene mutations drive tumor growth
Scientists have created a complete map showing how hundreds of possible mutations in a key cancer gene influence tumour growth.
The study focused on CTNNB1, a gene that produces the protein β-catenin, which helps regulate tissue growth and repair. When β-catenin is disrupted, cells can begin uncontrolled growth – a hallmark of cancer.
By systematically testing all possible mutations in a priority area of the gene in mouse cells, the map helps explain why certain mutations appear in specific cancers and could guide the development of new treatments, experts say.
Many cancers carry mutations ...