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TTUHSC researchers find blood-brain barrier remains resilient in Alzheimer’s disease model

2025-09-29
A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain’s protective shield — known as the blood-brain barrier (BBB) — remains largely intact in a commonly used mouse model of Alzheimer’s disease. The discovery challenges long-standing assumptions that Alzheimer’s disease causes the BBB to “leak,” potentially reshaping how researchers think about drug delivery for the disease. The study, published July 23 in Fluids and Barriers of the CNS, was conducted by a research team ...

Scalable and efficient quantum error correction for fault-tolerant quantum computing

2025-09-29
A new class of highly efficient and scalable quantum low-density parity-check error correction codes, capable of performance approaching the theoretical hashing bound, has been developed by scientists at Institute of Science Tokyo, Japan. These novel error-correction codes can handle quantum codes with hundreds of thousands of qubits, potentially enabling large-scale fault-tolerant quantum computing, with applications in diverse fields, including quantum chemistry and optimization problems. In recent years, quantum computers have begun to handle double-digit quantum bits, or qubits. However, many essential applications targeted by quantum computers, such as quantum chemistry, ...

Japan’s national standardized health checkup program: impacts on self-employed and unemployed populations

2025-09-29
Rapidly aging populations and rising cases of lifestyle-related diseases (LRDs), like diabetes and hypertension, are driving significant financial strain on government budgets. While regular health checkups under a standardized government program can be a solution, it is not well understood how these initiatives benefit different socioeconomic sections of the society and their economic feasibility. Most studies have documented how health checkup programs affect salaried or employed workers, examining the program’s role in informing individuals about their health status and risks. However, ...

APSS accepting sleep and circadian research abstracts and session proposals for SLEEP 2026 in Baltimore

2025-09-29
DARIEN, IL – The Associated Professional Sleep Societies is accepting research abstracts and session proposal submissions for SLEEP 2026, the 40th annual meeting of the APSS, which will be held June 14 to 17 at the Baltimore Convention Center. Research abstracts will be accepted for oral and poster presentations in two tracks: basic and translational sleep and circadian science and clinical sleep science and practice. Accepted abstracts will be published online in a supplement of the journal Sleep. The APSS Program Committee is also accepting proposals for postgraduate courses and other sessions including bench-to-bedside sessions, clinical workshops, discussion ...

Startling images show how antibiotic pierces bacteria’s armor

2025-09-29
A team led by UCL (University College London) and Imperial College London researchers has shown for the first time how life-saving antibiotics called polymyxins pierce the armour of harmful bacteria. The findings, published in the journal Nature Microbiology, could lead to new treatments for bacterial infections – especially urgent since drug-resistant infections already kill more than a million people a year. Polymyxins were discovered more than 80 years ago and are used as a last-resort treatment for infections caused ...

Patients with intellectual and developmental disabilities substantially over-represented among long-stay psychiatric inpatients

2025-09-29
Toronto, ON, September 29, 2025 – Individuals with intellectual and developmental disabilities (IDD) account for more than one in five patients who have been in Ontario’s mental health beds for over a year, according to a new study from researchers at ICES and the Centre for Addiction and Mental Health (CAMH). The findings suggest that people with IDD have different support needs compared with patients without IDD as they are more likely to have moderate or severe cognitive impairment, difficulty caring for themselves, and few social supports, which may contribute to challenges transitioning out of hospital and into the community. Enhancing specialized ...

AI distinguishes glioblastoma from look-alike cancers during surgery

2025-09-29
At a glance: Correctly distinguishing between look-alike tumors found in the brain during surgery can guide critical decisions in real time while patient is still in the operating room. A new AI tool outperformed humans and other models in distinguishing glioblastoma from another type of cancer that appears similar under a microscope. The new AI tool has a built-in uncertainty feature that flags tumors the model has not encountered before and marks them for human review. A Harvard Medical School–led research team has developed an AI tool that can reliably tell apart two look-alike cancers found in the ...

Many older adults – especially Gen X women – show signs of addiction to ultra-processed foods

2025-09-29
They were the first generation of Americans to grow up with ultra-processed foods all around them – products typically loaded with extra fat, salt, sugar and flavorings. They were children and young adults at a time when such products, designed to maximize their appeal, proliferated. Now, a study shows, 21% of women and 10% of men in Generation X and the tail end of the Baby Boom generation, now in their 50s and early 60s, meet criteria for addiction to these ultra-processed foods. That rate is far higher than it is among ...

Simple test can predict risk of severe liver disease

2025-09-29
A new study from Karolinska Institutet, published in the scientific journal The BMJ, shows how a simple blood analysis can predict the risk of developing severe liver disease. The method may already start to be applied in primary care to enable the earlier detection of cirrhosis and cancer of the liver. “These are diseases that are growing increasingly common and that have a poor prognosis if detected late,” says Rickard Strandberg, affiliated researcher at Karolinska Institutet’s Department of Medicine in ...

RSV vaccines safe and effective, Cochrane review finds

2025-09-29
The review demonstrates that vaccines for respiratory syncytial virus (RSV) are both safe and effective in protecting groups who are most at risk for serious illness, including older adults and infants.   RSV is a common virus that causes coughs and colds but can also lead to life-threatening lung infections like pneumonia. Children under the age of two months are at the highest risk of severe RSV infection and death, with older adults also vulnerable to severe disease.   An international group of researchers analysed 14 ...

Unplanned, premature, out-of-hospital births pose challenges for emergency team

2025-09-28
Vienna, Austria: The first detailed analysis of unplanned births that occurred outside the hospital setting in Austria has shown that, although such deliveries are rare, they pose challenges for emergency teams that attend, especially if babies are born prematurely [1]. In a study presented at the European Emergency Medicine Congress today (Monday), the researchers found that between 2017 and 2024 there were 173 unplanned, out-of-hospital births in the Styria region of Austria, of which 16 (9%) were premature (less than 37 weeks’ gestation). The most premature ...

Hypnosis can make ventilation masks more acceptable to patients with breathing problems

2025-09-28
Vienna, Austria: Hypnosis can significantly improve patients’ tolerance of masks to help them breathe when they are suffering from acute respiratory failure, according to a pilot study presented at the European Emergency Medicine Congress today (Monday) [1]. People who come to hospital with breathing problems are often given non-invasive ventilation (NIV) via a mask and tubes connected to a machine in order increase the amount of oxygen in their blood and lower carbon dioxide levels. However, some ...

‘Staggering’ costs of e-scooter injuries are quantified for the first time for hospitals in Ireland

2025-09-28
Vienna, Austria: Injuries occurring to people who ride e-scooters cost Irish hospitals an average of €1,726 per patient, and researchers have calculated the total overall cost to one hospital in a single year was €128,650. Dr Thomas Suttie, a senior house officer in emergency medicine at Connolly Hospital Blanchardstown, Abbotstown, Dublin, Ireland, told the European Emergency Medicine Congress today (Monday): “In 2021 we published the number of patients who came to the emergency department of ...

People may age faster if their dad smoked during puberty

2025-09-28
People whose fathers smoked during puberty seem to age faster than expected, according to research presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands [1].   The researchers found signs of faster biological ageing, compared to chronological age, in people whose fathers began smoking at age 15 or younger. They say smoking during puberty may create damage in boys’ developing sperm cells that can be passed on to their children.   The researchers call for stronger efforts to prevent tobacco use in teenagers, not only ...

Higher levels of air pollution linked to worsening of sleep apnea

2025-09-28
People who have obstructive sleep apnoea (OSA) may suffer worse symptoms if they live in areas with higher levels of air pollution, according to a multi-national study presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands [1].   Patients with OSA often snore loudly, their breathing starts and stops during the night, and they may wake up several times. Not only does this cause excessive sleepiness, but it can also increase the risk of high blood pressure, stroke, heart disease and type 2 diabetes. OSA is very common, ...

ASTRO: New therapy delays progression of recurrent prostate cancer

2025-09-28
Patients with recurring prostate cancer who were treated with a new PSMA-targeted radioligand therapy before stereotactic body radiotherapy (SBRT) went more than twice as long without their disease worsening compared with those who received SBRT alone, according to new clinical trial results from UCLA Health Jonsson Comprehensive Cancer Center researchers.    Findings from the trial, presented today at the 2025 American Society for Radiation Oncology Annual Meeting in San Francisco, showed that men who received the radioligand drug ...

Low-dose radiation therapy offers substantial relief to people with painful knee osteoarthritis

2025-09-28
SAN FRANCISCO, September 28, 2025 — A single course of low-dose radiation therapy may provide a safe and effective alternative treatment option for people with painful knee osteoarthritis according to a new randomized, placebo-controlled clinical trial. The study showed patients with mild to moderate knee osteoarthritis reported significant reductions in pain and improved physical function in the four months after receiving the low dose of radiation, which was just a small fraction of what’s used to treat cancer. Because the study included a control group with simulated treatment, the researchers could distinguish ...

Radiopharmaceutical added to stereotactic radiation delays prostate cancer progression in patients with limited metastatic disease

2025-09-28
SAN FRANCISCO, September 28, 2025 — A new clinical trial finds that people with a limited number of metastases from recurrent prostate cancer lived significantly longer without disease progression when they received a radiopharmaceutical drug before targeted radiation, compared with radiation alone. The phase II LUNAR trial is the first randomized study to show that a treatment established for later-stage prostate cancer can delay progression and defer hormone therapy when added to high-precision radiation ...

First-of-its-kind genomic test predicts benefit from hormone therapy added to radiation for recurrent prostate cancer

2025-09-28
SAN FRANCISCO, September 28, 2025 — A new randomized study finds that a lab test that reads tumor genes can identify which patients with recurrent prostate cancer will benefit from adding hormone therapy to radiation after surgery — the first predictive biomarker in this setting. In the first prospective, randomized trial to validate a predictive gene expression test for hormone therapy in prostate cancer, patients with a prostate tumor subtype known as luminal B had much lower risks of recurrence and metastasis when radiation was complemented by apalutamide, a type of hormone therapy. Patients without this tumor subtype, however, saw no improvement. ...

Specialised singing programmes can improve the symptoms and quality of life of people with lung disease

2025-09-28
Singing can improve the quality of life of people with lung disease and help reduce their symptoms, according to a gold-standard randomised-controlled trial presented at the European Respiratory Society Congress in Amsterdam, the Netherlands [1]. The study was presented by Professor Natasha Smallwood from Monash University, Melbourne, Australia. Professor Smallwood told the Congress: “Chronic breathlessness is a common and highly distressing symptom for people with chronic obstructive pulmonary disease and interstitial lung disease. Yet there is a lack ...

Children with asthma who use at-home monitoring are half as likely to need hospital care

2025-09-28
Children with asthma who use at-home monitoring are around half as likely to visit the emergency department or be hospitalised, compared to those who only receive care from their medical team, according to research presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands [1]. Remote monitoring also helped keep children’s symptoms under control.   At-home monitoring involved children and their families using an app approximately once a month to answer questions ...

Combination inhaler reduces asthma attacks in children by almost half

2025-09-28
Findings from a trial comparing the real-world effectiveness of asthma inhalers could reshape how children with asthma are treated. In the first randomised controlled trial to investigate the use of a 2-in-1 inhaler as the sole reliever therapy for children aged 5 to 15, an international team found the combined treatment to be more effective than salbutamol, the current standard for asthma symptom relief in children, with no additional safety concerns.  The results show that using a single 2-in-1 anti-inflammatory reliever inhaler – ...

Low-cost drug shows promise for patients with life threating respiratory infections

2025-09-28
A widely available and affordable drug has been shown to be effective in treating seriously ill COVID-19 patients, according to a new international study led by researchers at the Australian National University (ANU) in collaboration with King’s College London. The study analysed data from almost 500 patients hospitalised with COVID-19 across six countries. Patients who inhaled heparin were half as likely to require ventilation and had a significantly lower risk of dying compared with those receiving standard care. Heparin, a drug traditionally injected to treat blood clots, was tested in this study in an inhaled form, targeting the lungs directly. As well as acting as an anticoagulant, ...

Emergency medicine workers report job satisfaction, though burnout and staff retention remain major problems

2025-09-27
Vienna, Austria: One of the largest international surveys into job satisfaction among emergency department workers has revealed that while the majority found their work satisfying and rewarding, there are still many areas where improvements are needed, according to research presented at the European Emergency Medicine Congress today (Sunday) [1]. The paper, “Global Job Satisfaction Among Emergency Medicine Professionals: Results from the 2025 Emergency Medicine Day Survey”, is published today in the European Journal ...

Eating fruit may reduce the effects of air pollution on lung function

2025-09-27
Eating fruit may reduce the effects of air pollution on lung function Eating fruit may reduce the effects of air pollution on lung function, according to research presented at the European Respiratory Society Congress in Amsterdam, the Netherlands [1]. The study was presented by Pimpika Kaewsri, a PhD student from the Centre for Environmental Health and Sustainability at the University of Leicester, UK. She explains: “Over 90% of the global population is exposed to air pollution levels that exceed WHO guidelines, and ample ...
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