Pathogenic germline variants in cancer susceptibility genes

JAMA

2025-10-16

(Press-News.org) About The Study: This study identified 5.05% of individuals carrying pathogenic or likely pathogenic variants, suggesting a higher-than-expected prevalence of key cancer susceptibility genes in a large, unselected population.

Corresponding Author: To contact the corresponding author, Joshua Arbesman, MD, email Arbesmj@ccf.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.16372)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Pathogenic germline variants in cancer susceptibility genes

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