Introduction First identified by Stevens and Johnson in 1922, SJS and TEN are now recognized as disorders with a continuum of severity, from milder forms (SJS) to the most severe (TEN). SJS/TEN is associated with multiple etiological factors, most notably drug-induced liver injury (DILI), making the identification of the responsible agent crucial for patient management. However, previous studies have lacked uniformity in diagnostic approaches, limiting the ability to draw clear conclusions about causality. Epidemiology The incidence of SJS/TEN varies across regions, with notable differences between studies. For instance, ...

Any patient suffering from new or worsening medical symptoms hopes for a relatively quick and accurate diagnosis. However, for many people with episodic disabilities — periodic or intermittent conditions like migraines, lupus, Crohn’s disease and epilepsy, in which the presence and severity of symptoms fluctuate — a swift diagnosis is not guaranteed. New research from Michigan State University focuses on diagnostic delays experienced by people with one such condition: epilepsy, a neurological disorder characterized by unpredictable seizures that affects over 3 million people in the United States and 50 million worldwide. “Epilepsy ...

Introduction Neglected Tropical Diseases (NTDs) remain a significant health burden in tropical and subtropical regions, with limited treatment options and diagnostic capabilities. These diseases are often neglected in research and policy, yet they contribute to high mortality and morbidity worldwide. Nanotechnology, particularly the conjugation of nanomaterials with drugs, presents an innovative approach to improving both the diagnosis and treatment of these diseases. Nanomaterials have unique properties that allow for enhanced drug delivery, ...

INDIANAPOLIS – It is important that a healthcare team is aware of and understands a patient’s goals of care, both medical and personal. But that information, if documented, typically is not placed in a standardized location and is difficult to find within a patient’s voluminous electronic health record (EHR). A new study by researchers from Regenstrief Institute, the Indiana University School of Medicine and Indiana University Health presents the standardized goals of care note they developed, deployed and evaluated as a quality improvement initiative at ...

New research found that supplementing maternal diet with α-tocopherol, a form of vitamin E, can reduce the development of food allergy and anaphylaxis in newborn mice.   The prevalence of food allergy in children increased 50% from 2007 to 2021 in the United States (US), with the incidence of peanut allergy tripling in that time. This new study, published in The Journal of Immunology, shows the potential for α-tocopherol in prenatal vitamins during pregnancy and lactation to address this alarming increase and reduce development of food allergy early in life.  The study found that ...

Artificial intelligence (AI) is reshaping workplaces by streamlining routine tasks and boosting efficiency, particularly in retail, where innovation is essential for maintaining a competitive edge. Beyond automation, AI supports employee creativity by offering valuable insights and allowing them to focus on innovative tasks. However, research is limited on how AI service quality impacts employees in retail industries, making this an important area to explore. Researchers from Florida Atlantic University and Hanyang University in Seoul, South Korea, examined how perceived AI service quality influences retail employees’ ...

One in five older adults gets an infection up to six months after heart surgery — with women far more likely to develop one, according to studies led by Michigan Medicine. The two studies examined thousands of cases involving Medicare beneficiaries who underwent coronary artery bypass grafting, also known as CABG or heart bypass, or aortic valve replacement. Women had 60% greater odds of developing postoperative infections, the three most common being urinary tract, pneumonia and sepsis. Black patients also had higher rates of overall infection (28%) ...

DALLAS, Feb. 19, 2025 — The conditions in which we are born, live, learn, work, play and age — the social drivers of health — are better predictors of health and life expectancy than our genetic code. In communities nationwide, people living in locations just a handful of miles apart can have a dramatic difference in life expectancy. To help level the playing field, the Grubhub Community Fund awarded the American Heart Association® Social Impact Funds a $2 million grant to support food security, technology innovation and economic resiliency in New York City and Chicago. “We are grateful ...

COLUMBUS, Ohio – Generic drugs manufactured in India are linked to significantly more “severe adverse events” for patients who use them than equivalent drugs produced in the United States, a new study finds.   These adverse events included hospitalization, disability, and in a few cases, death.  Researchers found that mature generic drugs, those that had been on the market for a relatively long time, were responsible for the finding.   The results show that all generic drugs are not equal, even though patients are often told that they are, said John Gray, co-author of the study and professor of operations at The Ohio State University’s ...

Shareholders play a crucial role in corporate governance by voting on key decisions in the companies they invest in. To enhance transparency, regulatory bodies worldwide—such as government agencies and stock exchanges—are increasingly implementing guidelines to hold institutional investors accountable for their voting behavior and ensure they fulfill their fiduciary duties. A study published in the journal Corporate Governance: An International Review on 22 January 2025 demonstrates that these regulations, even if non-binding, can encourage institutional investors to play a more active role and improve corporate governance. The study, conducted ...

Procedure is simple and could be adopted by most U.S. hospitals Roughly 2 million people in the U.S. live with limb loss; number is expected to rise Senior author, a retired U.S. Army colonel, traveled to Ukraine to set up the study CHICAGO --- A reliable method to treat post-amputation pain remains elusive, but a new Northwestern Medicine study conducted in collaboration with Ukrainian physicians suggests that hydrodissection — a simple procedure that injects fluid around nerves — may reduce residual limb pain and opioid dependence. The ...

(Embargo: 19 Feb, 10am GMT) A groundbreaking study led by Professor Ginestra Bianconi from Queen Mary University of London, in collaboration with international researchers, has unveiled a transformative framework for understanding complex systems. Published in Nature Physics, this pioneering study establishes the new field of higher-order topological dynamics, revealing how the hidden geometry of networks shapes everything from brain activity to artificial intelligence.  “Complex systems like the brain, climate, and next-generation artificial intelligence rely on interactions that extend beyond simple pairwise relationships. Our study reveals ...

A new study led by researchers from Oxford Population Health has shown that a range of environmental factors, including lifestyle (smoking and physical activity), and living conditions, have a greater impact on health and premature death than our genes. The researchers used data from nearly half a million UK Biobank participants to assess the influence of 164 environmental factors and genetic risk scores for 22 major diseases on ageing, age-related diseases, and premature death. The study is published today in Nature Medicine. Key findings Environmental factors explained 17% of the variation in risk of death, compared to less than 2% explained by genetic predisposition (as ...

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein. Hiroshi Abe and his colleagues at Nagoya University have identified two applications, among others, in a new study. Their innovative approach, reported in Nature Biotechnology, called the Internal Cap-Initiated Translation (ICIT) mechanism, introduces a novel way to 'switch on' protein synthesis ...

UNIVERSITY PARK, Pa. — There is a big problem with quantum technology — it’s tiny. The distinctive properties that exist at the subatomic scale usually disappear at macroscopic scales, making it difficult to harness their superior sensing and communication capabilities for real-world applications, like optical systems and advanced computing. Now, however, an international team led by physicists at Penn State and Columbia University has developed a novel approach to maintain special quantum characteristics, even in three-dimensional (3D) materials. The researchers published ...

    Illustration   A quantum "miracle material" could support magnetic switching, a team of researchers at the University of Regensburg and University of Michigan has shown.   This recently discovered capability could help enable applications in quantum computing, sensing and more. While earlier studies identified that quantum entities called excitons are sometimes effectively confined to a single line within the material chromium sulfide bromide, the new research provides a ...

Acting in the right place at the right time is the key to effective medical treatment with minimal side effects. However, this feat remains difficult to achieve. Biologists and chemists at the University of Geneva (UNIGE) have succeeded in developing a tool that controls the location at which a molecule is activated by a simple pulse of light lasting only a few seconds. Tested on a protein essential for cell division, this system could be applied to other molecules. The potential applications are vast, both in basic research and in improving ...

New research from the University of Southampton has found that trust in representative institutions, such as parliaments, governments and political parties, has been declining in democratic countries around the world. The study, published in The British Journal of Political Science, presents the largest and most comprehensive analysis of trends in political trust worldwide to date. It brings together results from 3,377 surveys covering 143 countries between 1958 and 2019, representing over five million survey respondents. Whereas trust in representative institutions is generally in decline, trust in non-representative institutions ...

19 February 2025 – London –  The Blavatnik Family Foundation and The New York Academy of Sciences today announced the Finalists for the eighth Blavatnik Awards for Young Scientists in the United Kingdom. The Awards recognise scientific advances by UK researchers across Life Sciences, Chemical Sciences, and Physical Sciences & Engineering. On Wednesday, 4 March, Professor Shitij Kapur, FMedSci, Vice-Chancellor & President, King’s College London, will announce the three 2025 Laureates at a gala dinner and awards ceremony. The three Laureates will each receive an unrestricted award of £100,000 (US$126,000). ...

Conventional drones use visual sensors for navigation. However, environmental conditions like dampness, low light, and dust can hinder their effectiveness, limiting their use in disaster-stricken areas. Researchers from Japan have developed a novel bio-hybrid drone by combining robotic elements with odor-sensing antennae from silkworm moths. Their innovation, which integrates the agility and precision of robots with biological sensory mechanisms, can enhance the applicability of drones in navigation, gas sensing, and disaster response. Technological advances have led to the development of drones with diverse applications, ...

Seizures in newborns are one of the most frequent acute neurological conditions among infants admitted to neonatal care units. A study published in Developmental Medicine & Child Neurology indicates that newborns experiencing such neonatal seizures face an elevated risk of developing epilepsy. For the study, investigators analyzed data on all children born in Denmark between 1997 and 2018, with the goal of comparing the risk of epilepsy in children with and without neonatal seizures. Among 1,294,377 children, the researchers identified 1,998 who experienced neonatal seizures. The cumulative risk of epilepsy was 20.4% among children with neonatal seizures compared with 1.15% among children ...

Although a woman’s ovaries produce the most estrogen, various types of estrogen are also synthesized throughout different tissues in the body, including the brain’s neurons. New research in The FEBS Journal indicates that such neuroestrogens help suppress appetite. Knowing that the enzyme aromatase is important for the production of estrogens, investigators depleted or knocked out the gene encoding aromatase in mice, so that the animals were unable to synthesize estrogens in a systemic or body-wide manner. These mice demonstrated increased food intake and body weight compared with their aromatase-expressing counterparts. Restoring aromatase expression specifically ...

New research published in Health Economics indicates that a national prohibition of menthol cigarettes in the United States could increase the number of people who attempt to quit smoking but also support an illegal menthol cigarette market. For the research, 639 adult menthol smokers made hypothetical choices between menthol and non-menthol cigarettes, menthol and non-menthol e-cigarettes, and attempting to quit. Participants were presented with situations where menthol cigarettes and menthol e-cigarettes were described as either legal, prohibited but available under-the-counter and online from retailers who continue ...

Results from the Systolic Blood Pressure Intervention Trial (SPRINT) have supported lower blood pressure targets among community-dwelling older adults with hypertension to reduce the risk of cardiovascular disease and early death, but intensive blood pressure lowering can also increase risks of developing acute kidney injury and experiencing dangerously low blood pressure. A recent analysis in the Journal of the American Geriatrics Society looked closely at the benefits and harms of intensive blood pressure lowering in patients with different characteristics. The analysis found that nearly all older adults in SPRINT had a positive ...

Research published in New Phytologist provides insights into why the invasive plant Japanese knotweed is so successful at outcompeting native plants. Japanese knotweed (Reynoutria japonica), which is native to eastern Asia and is a highly invasive plant species across Europe and North America, is known to damage infrastructure and ecosystems. By comparing growth and reproduction traits of introduced plants with native plants, investigators discovered that introduced plants had gained the ability to reproduce faster by clonal propagation, a method ...