(Press-News.org) SAN ANTONIO — People 60 and older who are excessively sleepy during the day may have more problems with memory and thinking after surgery, suggests a study presented at the ANESTHESIOLOGY® 2025 annual meeting. Daytime sleepiness is a symptom of sleep deficiency that affects up to 20% of adults and may increase the risk of perioperative neurocognitive disorders (PNDs), researchers found.
“Asking patients, their family or caregivers if they doze frequently during the day or have trouble staying alert might provide an important clue to brain health after surgery,” said Jeffry Takla, M.D., lead author of the study and a postdoctoral associate in anesthesiology at Duke University School of Medicine, Durham, North Carolina. “Excessive daytime sleepiness is often overlooked in preoperative evaluations, but it can elevate the risk of PNDs. PNDs have been associated with worse postoperative quality of life and increased hospital length of stay. In some cases, patients may not fully recover their previous level of independence and may need extra help from caregivers or even transition to assisted living.”
A PND is a problem with thinking and awareness that can affect up to 40% of older patients after surgery. It often appears as delirium, a sudden state of confusion that can come and go within days after surgery and include symptoms like being disoriented, having trouble focusing or not following instructions. In some cases, it can continue for weeks or months as a longer-term neurocognitive disorder and include confusion, memory problems and difficulty concentrating, which can reduce quality of life.
In the study, 96 patients aged 60 or older scheduled for non-cardiac surgery completed the Epworth Sleepiness Scale, a short questionnaire that measures daytime sleepiness based on how likely the person is to fall asleep during common activities such as reading or watching TV. They also underwent home sleep apnea testing and had cognitive and delirium assessments before and after surgery. Of that group, 11 (11.5%) had experienced moderate to severe daytime sleepiness. Six weeks after surgery, 82 patients returned for cognitive and delirium tests and 14 of them (17.1%) experienced postoperative neurocognitive disorder. The eight patients with moderate to severe excessive daytime sleepiness who completed follow up testing were found to have greater global cognitive decline — meaning worse problems with memory and thinking — six weeks after surgery.
Families and caretakers can help reduce the likelihood of PNDs by spending time with the patient. They should alert the health care team if they notice the patient is showing new signs of memory problems, trouble paying attention or agitation. This alerts the care team to check for possible causes of PNDs, while also focusing on supportive steps like re-orienting the patient, getting them moving early and ensuring they are eating and drinking enough.
“Excessive daytime sleepiness isn’t a normal part of aging,” said Dr. Takla. “It often stems from poor or fragmented sleep, sleep disorders such as sleep apnea, medication side effects, or other health or mental health conditions.”
Good sleep habits can help. They include regular bed and wake times, getting natural sunlight and daily activity, limiting evening caffeine and alcohol and a quiet, comfortable bedroom. If sleepiness continues, people should see their primary care doctor or sleep specialist to determine the cause and find treatment.
“Future studies should examine whether excessive daytime sleepiness is linked to the incidence of PND. If such a relationship exists, researchers should explore whether detecting and treating excessive daytime sleepiness can lower the risk of PNDs, such as delirium, in older patients after surgery,” said Dr. Takla. “People who have this problem may consider having a sleep study or sleep hygiene counseling, especially if their symptoms continue or interfere with daily function.”
*** ANESTHESIOLOGY 2025 news releases may contain updated data that was not originally available at the time abstracts were submitted.
THE AMERICAN SOCIETY OF ANESTHESIOLOGISTS
Founded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 59,000 members organized to advance the medical practice of anesthesiology and secure its future. ASA is committed to ensuring anesthesiologists evaluate and supervise the medical care of all patients before, during and after surgery. ASA members also lead the care of critically ill patients in intensive care units, as well as treat pain in both acute and chronic settings.
For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at asahq.org. To learn more about how anesthesiologists help ensure patient safety, visit asahq.org/madeforthismoment. Join the #ANES25 conversation on social media. Follow ASA on Facebook, X, Instagram, Bluesky and LinkedIn.
# # #
END
Osaka, Japan – Infertility affects about one in six couples, and male factors account for roughly half of all cases—often because sperm don’t swim well. Researchers from the University of Osaka uncovered a key component of the “switch” that keeps the movement signal strong, offering a promising new avenue for both diagnosis and treatment. When this switch is absent, sperm slow down, and fertilization fails. By restoring that signal in the lab, the team rescued swimming and achieved healthy births in mice.
For sperm to successfully fertilize an egg, they must be able to swim, a process driven by their tail. This movement is activated by an ...
NEW YORK, October 13, 2025 — Scientists at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have discovered a groundbreaking way to control sound and vibrations using a concept inspired by “twistronics,” a phenomenon originally developed for electronics. Their research, published in the journal PNAS, introduces “twistelastics”— a technique that uses tiny rotations between layers of engineered surfaces to manipulate how mechanical waves ...
Deep inside caves, water dripping from the ceiling creates one of nature’s most iconic formations: stalagmites. These pillars of calcite, ranging from centimeters to many meters in height, rise from the cave floor as drip after drip of mineral-rich water deposits a tiny layer of stone. Beyond their beauty—echoed in fanciful nicknames like the “Minaret” or the “Wedding Cake”—stalagmites are also natural archives, recording ancient climatic changes in their layered growth, much like tree rings.
But what determines the shape of a stalagmite? Why do some grow into slender cones, others into massive columns, and still others into curious flat-topped forms? ...
Osaka, Japan - For many couples facing infertility, medicine offers a range of solutions. But for men with non-obstructive azoospermia (NOA)—a genetic condition where sperm production stalls—options remain limited. Researchers at The University of Osaka in collaboration with Baylor College of Medicine have developed a pioneering approach to combat NOA. By delivering mRNA through lipid nanoparticles (LNPs) targeting specific testicular genes, they successfully restored sperm production and achieved the birth of viable offspring in a mouse model. This treatment led to healthy, fertile offspring ...
A major international study has uncovered a new vulnerability in prostate cancer cells that could help improve treatment for one of the most common cancers affecting men.
The research, published in the journal Proceedings of the National Academy of Sciences (PNAS), was led by scientists from Flinders University in Australia and South China University of Technology.
It reveals that two enzymes — PDIA1 and PDIA5 — play a crucial role in helping prostate cancer cells grow, survive, and resist treatment.
These enzymes act as molecular bodyguards for the androgen receptor (AR), a protein that fuels prostate cancer. When PDIA1 ...
How do people keep the beat to music? When people listen to songs, slow waves of activity in the brain correspond to the perceived beat so that they can tap their feet, nod their heads, or dance along. In a new JNeurosci paper, researchers led by Cédric Lenoir, from Université catholique de Louvain (UCLouvain), explored whether this ability is unique to hearing or whether it also happens when rhythm is delivered by touch.
The researchers recorded brain activity as study volunteers finger tapped to the beat of music delivered via sound or rhythmic vibration. ...
Hypothermia can preserve neuron health following brain injury, but complications from external cooling make it less promising therapeutically. Recent evidence suggests that activating a specific neuron population triggers a reversible, hibernation-like hypothermic state without external cooling, but does this form of hypothermia still preserve neuron health? In a new JNeurosci paper, researchers led by Takeshi Sakurai at the University of Tsukuba explored this question using male mice.
The researchers found that triggering this specific hypothermic state in mice improved motor performance ...
Many advanced cancers develop resistance to treatment and become highly aggressive, often leaving patients with limited treatment options. In some cancers, including lung, pancreatic and prostate tumors, a key driver of treatment resistance and metastasis is a protein called integrin αvβ3, which is absent in normal tissues but enriched in aggressive tumors. Previous attempts to target αvβ3 with antibody therapies worked by activating a specific type of cell in the immune system called natural killer cells, but this approach ultimately failed to significantly improve patient survival in clinical trials, potentially because the tumors ...
About The Article: Artificial intelligence carries promise and uncertainty for clinicians, patients, and health systems. This JAMA Summit Report presents expert perspectives on the opportunities, risks, and challenges of AI in health care, including how AI is developed, evaluated, regulated, and implemented across clinical and business domains.
This content is the result of JAMA Summit AI that was held in October 2024. Reflecting the multidisciplinary nature of JAMA Summit, this report features a diverse group of authors ...
University of California San Diego of Medicine researchers, in collaboration with the genetic testing company 23andMe, have identified regions of the human genome associated with cannabis use, uncovering new relationships with psychiatric, cognitive and physical health. The findings may inform the development of prevention and treatment strategies for cannabis use disorder. The study was published on October 13, 2025 in Molecular Psychiatry.
“Cannabis is widely used, but its long-term effects ...