Researchers from the Brigham detail how the spray they created may offer broad-spectrum protection from respiratory infections by COVID-19, influenza, everyday cold viruses, and pneumonia-causing bacteria A new study details how a nasal spray formulated by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, may work to protect against viral and bacterial respiratory infections. Based on their preclinical studies, the researchers say the broad-spectrum nasal spray is long-lasting, safe, and, if validated in humans, could play a key role in reducing respiratory diseases ...

Bacterial infections resulting in enteritis, sometimes extra-intestinal infections such as sepsis, continue to be a global health concern. A leading cause of diarrheal and extra-intestinal infectious mortality among children under 5 and elderly persons is infection with Campylobacter bacteria, against which there is no effective vaccine or medication. An Osaka Metropolitan University-led team has recently uncovered what could be an important step toward preventing, diagnosing, and treating a species of Campylobacter bacteria. Researchers including Professor Shinji Yamasaki and Associate Professor Noritoshi Hatanaka of the Graduate School ...

Martin Obr is on edge, anxiously waiting for his train to the airport. A storm called “Sabine” is brewing, shutting down all public transport. He catches his flight from Frankfurt to Vienna just in time. Obr spent the last days in Germany meticulously analyzing what he calls the “perfect sample”. This sample helped him and Florian Schur from the Institute of Science and Technology Austria (ISTA) decode the structure of a virus called HTLV-1 (Human T-cell Leukemia Virus Type 1). In collaboration with the University of Minnesota and Cornell University, ...

Physics-informed virtual reality could be key to reducing the exposure of pedestrians and cyclists to harmful, non-exhaust vehicle emissions, according to a study published today (25 Sep) in the Royal Society Open Science journal. The research lead by the University of Birmingham (supported by Rosetrees Trust and Research England QR Funding), targets the issue of major health risks and chronic diseases caused by exposure to unregulated particle pollutants from road, tyre and brake sources by providing easy, accessible guidance to the public, policy makers, and city planners, through immersive VR experiences. Detailed ...

In a compelling Genomic Press Interview published in Brain Medicine on September 25, 2024, Professor Hermona Soreq of the Hebrew University of Jerusalem in Israel unveils the profound implications of her groundbreaking research on the cholinergic system and small RNA regulators in brain-body communication. Prof. Soreq, holder of the Endowed Slesinger Professorship of Molecular Neuroscience, has dedicated her career to unraveling the complexities of the parasympathetic nervous system, with a particular focus on acetylcholine's role in stress responses and neurodegenerative diseases. Her work has revolutionized our understanding of how the brain ...

Will modern coral reefs go extinct? The answer is uncertain, but some of their ancient counterparts managed to dodge a bullet — for a while, at least. Scientists from Osaka Metropolitan University have discovered that ancient reef-building organisms called stromatoporoids survived the Late Devonian mass extinction event and continued to thrive as major reef-builders long after their presumed extinction. These findings shed light on how life on Earth has responded to past environmental changes, offering ...

The global production of plastics and the resulting plastic waste has increased to such an extent that plastics have become ubiquitous in our environment. Plastics of various sizes are also found along the German North Sea and Baltic coasts. Previous studies of microplastic pollution on German beaches have often been limited to a few locations. In the citizen science project “Microplastic Detectives”, researchers from the Alfred Wegener Institute, together with citizens, have now collected samples from beaches along the entire German coast to be analyzed for microplastics. The resulting dataset is the first to be large enough to ...

Sunlight filters through the canopy of pines, holly, sweet gum, and red maple while bird calls echo in the distance. These coastal forests may seem like others in the Mid-Atlantic, but a hidden challenge looms. Standing tall next to their salt marsh neighbors, where the wind carries the sharp scent of sulfidic seawater, these trees are more than just part of the landscape—they are living monuments to a rapidly changing environment. As sea levels rise, the future of these forests is uncertain. While the adjacent salt marshes can adapt to encroaching waters, the trees, vulnerable to the increasing frequency ...

Noise from aircraft at night is linked with disturbed sleep quality and sleep-wake cycle, a new study using movement trackers has shown. Environmental health experts at the University of Leicester combined measurements from activity monitors and self-reported sleep information for the first time to put together a more detailed picture of how aircraft noise impacts sleep, in the largest such study to date. The results, published in Environmental Health Perspectives, show that people exposed to higher levels of night-time aircraft noise experienced more restlessness during sleep and disruption in daily sleep rhythm, even if they had a full night’s sleep. The team was led from the ...

If you’d stopped monitoring the Adriatic Sea’s marine life in the mid-20th century, the outlook would have been promising. Snails and the clams they hunt for food increased in abundance for several decades during the late 1800s and early 1900s, evidence of a vibrant and healthy ecosystem. Then, a threshold was crossed. Populations of both predator and prey abruptly plummeted and in some cases disappeared entirely. They were replaced by the common corbulid clam (Varicorbula gibba), which has the ability to slow down its metabolism in unfavorable conditions. Whenever paleontologists find an abundance of this species in the marine fossil record, it often means ...

KANEOHE, HI (Sept 24, 2024 1:05 p.m. HST)- In a study published today in Proceedings of the Royal Society B, researchers at the UH Hawaiʻi Institute of Marine Biology (HIMB) Toonen- Bowen “ToBo” Lab have identified scenarios under which eight of the most common species of coral found in Hawaiʻi can adapt to and survive ocean warming and acidification. The corals in the study are prevalent throughout the Indo-Pacific, a region that comprises more than two-thirds of the coral reefs on planet Earth, and were found to be capable of surviving a “low ...

Around 1 in 3 children and teens around the world is short (near)-sighted, with the global prevalence of myopia set to top 740 million cases by 2050 in this age group, finds a pooled data analysis of the available evidence, published online in the British Journal of Ophthalmology. Female sex, East Asian or urban area residence, and educational level all seem to be key factors influencing prevalence, the findings indicate. Short (near)-sightedness (myopia), which describes difficulty seeing objects at a distance, typically starts in early childhood and tends to worsen with age, explain the researchers. It has emerged ...

The huge and growing toll bottled water is taking on human and planetary health warrants an urgent rethink of its use as 1 million bottles are bought every minute around the globe, with that figure set to rise further still amid escalating demand, warn population health experts in a commentary published in the open access journal BMJ Global Health. Some 2 billion people around the world with limited or no access to safe drinking water rely on bottled water. But for the rest of us, it’s largely a matter of convenience and the unshaken belief—aided and abetted by industry marketing—that bottled water is safer and often healthier than tap ...

Women in the UK, and elsewhere, are still missing out on vital treatment for their No 1 killer—cardiovascular disease—despite significant progress in the medical management of heart disease and stroke, concludes a consensus statement published online in the journal Heart. They continue to be underdiagnosed, undertreated, and underrepresented in clinical trials in all areas of cardiovascular disease, says the statement. Among other things, it calls for dedicated women’s heart champions and heart hubs, plus a women’s ...

The ongoing war in Gaza will set children and young people’s education back by up to five years and risks creating a lost generation of permanently traumatised Palestinian youth, a new study warns. The report, by a team of academics working in partnership with the United Nations Relief and Works Agency for Palestinian Refugees in the Near East (UNRWA), is the first to comprehensively quantify the war’s toll on learning since it began in October 2023. It also details the devastating impact on children, young people and teachers, supported by new accounts from frontline staff and ...

(Wednesday, 25 September 2024, Amsterdam, Netherlands) A pioneering study, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, demonstrates the significant potential of semaglutide in treating hidradenitis suppurative (HS), a common and chronic skin condition, in people with obesity.1 This is the first study to explore the use of semaglutide for HS, marking a critical milestone in the search for effective treatments for this painful and debilitating condition. HS is currently estimated to affect approximately 1 in 100 people, with obesity being a significant risk factor. The condition is characterised ...

GLP1RA agonists have been increasing in popularity for treating obesity and type 2 diabetes.  With this novel treatment proving to be very effective, researchers are curious to know more about what other potential treatments it could also hold. Researchers at the University of Michigan investigated another potential way GLP1RA drugs can be useful in treating type two diabetes associated with a genetic condition that causes high levels of iron, called hereditary hemochromatosis. High iron levels with hereditary hemochromatosis can cause predisposition to liver disease ...

TUCSON, Ariz., Sept. 19, 2024 — Critical Path Institute (C-Path) is thrilled to announce its Polycystic Kidney Disease Outcomes Consortium (PKDOC) has been awarded an Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) focused Broad Agency Announcement (BAA) contract from the U.S. Food and Drug Administration (FDA). The overarching objective of the work supported by the BAA award is to leverage collaboration with the Wake Forest Rare Inherited Kidney Disease team and its ADTKD registry, to analyze clinical and laboratory data that will help evaluate prognosis in ADTKD and help set the stage for future clinical trials.  ADTKD only affects ...

Hot carrier solar cells, a concept introduced several decades ago, have long been seen as a potential breakthrough in solar energy technology. These cells could surpass the Shockley–Queisser efficiency limit, which is a theoretical maximum efficiency for single-junction solar cells. Despite their promise, practical implementation has faced significant challenges, particularly in managing the rapid extraction of hot electrons across material interfaces. Recent research has focused on using satellite valleys in the conduction band to temporarily store hot electrons before collection. However, ...

(MEMPHIS, Tenn. – Sept. 24, 2024) – Clinical trial results from St. Jude Children’s Research Hospital demonstrate benefits to using genomics and early treatment response to guide risk classification of children with B-cell acute lymphoblastic leukemia (B-ALL). Traditionally, the intensity of a patient’s chemotherapy regime is guided by the National Cancer Institute (NCI) risk classification, which is largely determined by clinical characteristics such as age and white blood cell count at presentation. Through the flagship St. Jude ...

Researchers at the Beckman Institute for Advanced Science and Technology demonstrated that emotion enhances memory for contextual details, challenging the view that emotion impairs the ability to remember such information. The report was led by doctoral student Paul Bogdan, currently a postdoc at Duke University, and Florin and Sanda Dolcos, professors of psychology and neuroscience at the University of Illinois Urbana-Champaign. Their research appears in the Journal of Experimental Psychology: ...

In a review of previous studies, a Johns Hopkins Children’s Center team concludes that some video games created as mental health interventions can be helpful – if modest – tools in improving the mental well-being of children and teens with anxiety, depression and attention-deficit/hyperactivity disorder (ADHD). A report on the review of studies from peer-reviewed journals between 2011 and March 20, 2024, was published Sept. 23, 2024, in JAMA Pediatrics. An estimated 20% of children and teenagers between the ages of three and 17 in the U.S. have a mental, emotional, developmental or behavioral ...

Following Barack Obama’s reelection as U.S. president in 2012, the mental health of college-educated Black men improved significantly, while those who didn’t attend college reported worse mental health, according to new research from Rice University sociologists.  “Four More Years! Or So What? The Mental Health Significance of Barack Obama’s 2012 Presidential Re-Election among Black Adults” will appear in an upcoming edition of Du Bois Review: Social Science Research on Race.  Lead researcher Tony Brown, distinguished professor of sociology at Rice, said he and his co-authors were interested in following up ...

Toronto -- Modern crowdfunding has grown from relatively modest beginnings in the late 1990s to a multi-billion-dollar financing market for all kinds of early-stage innovations. The platform Kickstarter alone went from $276 million pledged in 2012 to $7.8 billion in 2024. There are even professional project designers to help craft that winning proposal. With stakes like those, getting the pitch right is everything. Enter machine learning to assist. Researchers from the University of Toronto’s Rotman School of Management put four different types of this artificial intelligence application to the test, including Deep Learning. Machine learning proved not only superior ...

Pharmacists now have more guidance in combatting the opioid crisis and providing treatment to patients thanks to new national guidelines developed at the University of Houston College of Pharmacy. The Pharmacy Access to Resources and Medication for Opioid Use Disorder Guideline, released today, addresses critical barriers in the treatment of Opioid Use Disorder across the nation’s community pharmacies.   With approximately 2.7 million individuals in the U.S. affected by OUD, the need for effective management strategies has never been more urgent. The PhARM-OUD Guideline marks a significant advancement as ...