https://doi.org/10.1016/j.apsb.2025.04.020 This new article publication from Acta Pharmaceutica Sinica B, discusses a high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.   An ideal dermal filler should integrate filling, repair, and anti-aging effects, with immediate tissue augmentation, slow degradation, and progressive stimulation of collagen regeneration. However, commonly used hyaluronic ...

A traditionally overlooked type of RNA plays an important role in promoting resilience to depression—but only in females. According to a new study led by the Icahn School of Medicine at Mount Sinai, researchers have now discovered a novel role this molecule plays in how the female brain makes decisions. The authors revealed brain-region-specific and sex-dependent effects of this biomarker, translated from humans to animals, on how individuals make only certain types of choices. This study uncovered ...

Analyzed 174 donated brains, including from former high school, college football players Larger studies needed to understand how p-tau relates to aging and the extent to which repetitive impact from contact sport predisposes to p-tau accumulation Whether such changes cause or are associated with clinical problems during life remains unclear CHICAGO --- In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer’s disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain. But a new ...

An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a cell protein to become active itself, as occurs in tumours. At the same time, the researchers have also deciphered the cell's appropriate countermeasure to prevent conditions such as tumour formation or chronic inflammation. The results have been published in the journal Nature Communications. Cellular sleepers "Sleepers" are the name the Secret Service gives agents who live inconspicuously in ...

LA JOLLA, CA—A new microchip invented by Scripps Research scientists can reveal how a person’s antibodies interact with viruses—using just a drop of blood. The technology offers researchers faster, clearer insights that could help accelerate vaccine development and antibody discovery. “This lets us take a quick snapshot of antibodies as they are evolving after a vaccine or pathogen exposure,” says Andrew Ward, professor in the Department of Integrative Structural and Computational Biology at Scripps Research and senior author of the new paper published ...

Why do some communities unite in times of crisis, while others fall apart? The study of Kaunas University of Technology researchers revealed a surprising link – cultural heritage is not just a historical asset, but also a powerful tool that helps people build a sense of belonging and act collectively when challenges arise. Along with trust and emotional attachment to place, it becomes a foundation for communities to care for their environment, maintain relationships, and respond to crises together. “A resilient community is a group of people who can unite, ...

For decades, the story of Alzheimer’s research has been dominated by a battle between A-beta and tau amyloids, both of which can kill neurons and impact the brain’s ability to function. A new study suggests, however, that these sticky brain plaques may not be operating alone.   Johns Hopkins University researchers have identified more than 200 types of misfolded proteins in rats that could be associated with age-related cognitive decline.  The findings could lead the way to finding new therapeutic targets and treatments in humans that could provide relief for the millions of people over 65 who suffer from Alzheimer’s, ...

Study finds autistic people describe nonverbal communication as "decoding a complex, unwritten language in real time" Autistic adults take acting classes and study gestures to emulate neurotypical body language Research shows communication breakdowns aren't one-sided - non-autistic adults also struggle to understand autistic communication  Peer-reviewed, data analysis, people Imagine having a conversation where every gesture and glance feels like a test. You're juggling eye contact, facial expressions, and tone of voice, all while trying to keep up with the words. You might miss ...

Despite a warming climate, bone-chilling winter cold can grip parts of the U.S.—and this study explains why. Researchers found that two specific patterns in the polar vortex, a swirling mass of cold air high in the stratosphere, steer extreme cold to different regions of the country. One pattern drives Arctic air into the Northwest U.S., the other into the Central and Eastern areas. Since 2015, the Northwest has experienced more of these cold outbreaks, thanks to a shift in stratospheric behavior tied to broader climate cycles. In short: what happens high above the Arctic can shape the winter on your doorstep. As winters in the United States continue ...

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory. Results of the study, published in the journal Science Advances, could point the way to new treatments for traumatic brain injuries and diseases, such as Parkinson’s and Alzheimer’s, the scientists said. Their research, led by a Rutgers University-New Brunswick professor, uncovered a previously unknown role for cypin, a brain protein. Members of the research team found that cypin promotes the presence ...

Hollywood has shaped how many people imagine a heart attack—someone clutching their chest and collapsing dramatically. But those portrayals are misleading and shouldn’t be expected, says Ann Eckhardt, a nursing professor and researcher at The University of Texas at Arlington. “We did ourselves a disservice in the 1980s and 1990s with what’s known as ‘The Hollywood Heart Attack,’” Dr. Eckhardt said. “That’s unfortunately not real life. It’s not always intense. Sometimes it’s just discomfort that doesn’t feel quite ...

The International Human Frontier Science Program Organization (HFSPO) is pleased to award the 2026 HFSP Nakasone Award to Erin Schuman for her breakthrough related to the function and plasticity of neuronal synapses, their mRNA triggered function, and change during memory formation. Schuman’s groundbreaking research revealed that proteins critical for neuron communication, plasticity and memory storage, are produced locally at synapses, the junctions between neurons. This insight overturns the previous belief that all proteins are made in the cell body and then shipped out to synapses where they function. “HFSPO is thrilled to honor Dr. Erin Schuman as her discovery is influencing ...

A new study reveals that global ocean analysis products can effectively replace expensive in-situ sound speed measurements for precise seafloor positioning. The research demonstrates that using sound speed profiles (SSPs) from the HYbrid Coordinate Ocean Model (HYCOM) global ocean analysis achieves centimeter-level accuracy in seafloor positioning, comparable to traditional methods. This innovation could significantly reduce costs and logistical challenges in marine geodetic surveys, particularly for unmanned vehicles ...

New UCLA research finds that small group professional coaching can reduce physician burnout rates by up to 30%, suggesting that it is more effective than the traditional, and more expensive, one-on-one coaching method. Nearly half of physicians in the US suffer from burnout, which is marked by emotional exhaustion, depersonalization and decreased personal accomplishment. These can lead to medical errors and other harmful consequences to the healthcare system and patient outcomes, said lead author Dr. Joshua Khalili, director of physician wellness in the UCLA Department of Medicine and ...

A recent study published in Engineering offers a comprehensive review of the synergistic impact of Carbon Capture, Utilization, and Storage (CCUS) coupled with Enhanced Oil Recovery (EOR) technologies. The research, led by Zhenhua Rui from the China University of Petroleum (Beijing), delves into the key factors influencing the efficiency of CO2-EOR and geological storage, proposing a novel coupled two-stage CCUS-EOR process to optimize the dual objectives of enhanced oil production and carbon reduction.   The study highlights that CCUS-EOR represents a critical technological pathway for global carbon emission reduction, contributing to 77% of the world’s total carbon ...

A novel dispersed particle gel (DPG) suspension has been developed by researchers from Chengdu University of Technology and University of Alberta, offering enhanced profile control in high-temperature carbon capture, utilization, and storage (CCUS) applications. The study, published in Engineering, details the creation of a DPG suspension that exhibits significant improvements in thermal stability and plugging efficiency compared to traditional CO2-responsive gels.   CCUS is a crucial strategy for mitigating climate change by capturing CO2 from industrial sources ...

About The Study: In this cross-sectional study, stronger gun laws correlated with decreased overall firearm mortality, with the strongest correlations for decreased suicides. For firearm suicide, this analyses lend support to policies that regulate firearm sales, transfers, and permitting laws. While some gun law categories were correlated with decreased firearm homicide, sociodemographic factors, such as unemployment, poverty, and insurance status, correlated with larger changes, suggesting policies that address root causes of violence through economic mobility and access to robust ...

About The Study: In this longitudinal cohort study, recreational cannabis legalization was associated with more cannabis and electronic nicotine delivery systems use after 5 years and no significant change in cigarette use. Furthermore, cannabis use increased over time, underscoring the importance of studying commercialization policy going forward. Based on the present results, it is unlikely recreational cannabis legalization has been associated with a large increase in cigarette use, but increases in use of cannabis and vaped nicotine bear close monitoring as retail cannabis rapidly expands.  Corresponding Author: To contact the corresponding author, Andrew S. Hyatt, ...

About The Study: In this multiple-events case-control study, long-term obesity was associated with the expression of biochemical aging markers in adults ages 28 to 31, consistent with epigenetic alterations, telomere attrition, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and compromised intercellular communication. In young adults, chronic health issues may emerge from accelerated biological aging associated with long-term obesity. Corresponding Authors: To contact the corresponding authors, email Paulina Correa-Burrows, PhD, (paulina.correa@inta.uchile.cl) and Christian ...

(Eindhoven, Netherlands & Toronto, Canada, July 10, 2025)  The Eindhoven University of Technology (TU/e) and JMIR Publications, a leading open access publisher of digital health research, are pleased to announce a new agreement that will provide TU/e faculty and affiliated researchers with unlimited opportunities for open access publishing in JMIR's extensive portfolio of journals. This landmark partnership marks a significant step forward in TU/e's commitment to advancing open science and ensuring the widest possible dissemination ...

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. Its pathogenesis involves complex interactions between genetic predisposition, metabolic dysregulation, inflammation, and cellular stress responses. Orphan nuclear receptors (ONRs), a subfamily of nuclear receptors lacking identified ...

Artificial intelligence systems like ChatGPT are notorious for being power-hungry. To tackle this challenge, a team from the Centre for Optics, Photonics and Lasers (COPL) has come up with an optical chip that can transfer massive amounts of data at ultra-high speed. As thin as a strand of hair, this technology offers unrivalled energy efficiency.   Published in Nature Photonics, the innovation harnesses the power of light to transmit information. Unlike traditional systems that rely solely on light intensity, this chip also uses ...

Modern manufacturing operates in complex environments where traditional management approaches are no longer enough. This highlights the need for real-time, dynamic and self-adaptive management strategies. Manufacturing data analytics (MDA) has emerged as a powerful solution for transforming traditional manufacturing into smart manufacturing. Through MDA, manufacturers can identify hidden patterns in external and internal data, allowing them to better anticipate and respond to geopolitical risks and rapidly changing customer expectations and demands. However, despite these benefits, adoption of MDA remains surprisingly low, with ...

Coordination nanosheets are a unique class of two-dimensional (2D) materials that are formed by coordination bonds between planar organic ligands and metal ions. These 2D nanomaterials are increasingly utilized in energy storage, electronic devices, and as electrode-based catalysts due to their excellent electronic, optical, redox properties, and catalytic activity. Over the last decade, coordination nanosheets composed of various transition metal ions, such as nickel (Ni) ions linked to benzenehexathiol (BHT)—an ...

Autism spectrum disorder (ASD), a neurodevelopmental condition, is often associated with difficulties in social communication and repetitive behavior. Previous research reveals that people with ASD often find it challenging to interpret intentions from body language and have difficulty recognizing faces and emotions, which may contribute to their social communication problems. Scientists speculate that these challenges might arise from differences in how the brain perceives faces and body parts, i.e., how individuals with ASD represent the human body. However, until now, no study had clearly mapped how ...