New discovery rewrites the rules of antigen presentation
A new discovery about how cells communicate with each other in the body’s immune system has revealed deeper insights for an international team of scientists into fundamental immune system function.
The new study, published in Nature Communications, overturns a long held understanding about how T cells – white blood cells that make up a key part of the immune system – recognise lipid antigens, a chemical class of molecules that make up cell membranes.
Lipids are presented to T cells by a distinct family of molecules called CD1, yet one member of this family, CD1c, has remained poorly understood despite its significant role in human immunity.
For more than 30 years, ...