A year after undermining Bredt’s rule, UCLA scientists have made cage-shaped, double-bonded molecules that defy expectations
Organic chemistry is packed with rules about structure and reactivity, especially when it comes to making and breaking chemical bonds. The rules governing how these bonds, which hold atoms together in molecules, form and the shapes they give molecules are often thought to be absolute, but UCLA organic chemists are pushing the boundaries of the possible.
In 2024, Neil Garg’s lab violated Bredt’s rule, a 100-year-old rule stating that molecules cannot have a carbon-carbon double bond at the “bridgehead” position (the ring junction of a bridged bicyclic molecule). Now, they’ve developed the chemistry of ...