Background and Aims Cirrhotic cardiomyopathy (CCM) is a significant complication of cirrhosis, but its progression and underlying mechanisms remain incompletely understood. This study aimed to investigate dynamic changes in cardiac function, pathology, inflammation, and mitochondrial damage in a mouse model of CCM, and to compare echocardiographic characteristics in patients with cirrhosis. Methods Bile duct ligation was performed in male C57BL/6J mice to induce cirrhosis. Longitudinal analyses were conducted over eight weeks. Cardiac function was assessed using serum biomarkers, echocardiography, and electrocardiography. Pathology was examined with hematoxylin and eosin, ...

The Great Bear Nature Writing Retreat                                                January, 2026 Great Bear Rainforest, BC. The Great Bear Lodge on the Central Coast of British Columbia is collaborating with internationally acclaimed science journalist Lesley Evans Ogden to host a nature writing retreat from May 31 - June 4, 2026. Located in the remote and beautiful Smith Inlet, ...

New research led by King’s College London, in collaboration with the University of Westminster, has shed light on the diversity and characteristics of E. coli strains that drive diabetic foot infections. Published in Microbiology Spectrum, the research provides the first comprehensive genomic characterisation of E. coli strains isolated directly from diabetic foot ulcers across multiple continents. The findings could help to explain why some infections become particularly difficult to treat and why they can lead to severe, sometimes life-threatening, outcomes. Diabetic foot infections remain one of the most serious complications ...

Automatic mesh generation, recognized as the “Holy Grail” of Computational Fluid Dynamics (CFD), was highlighted as a critical objective in the NASA CFD Vision 2030 study. Adaptive Cartesian grid generation has attracted significant interest due to its high level of automation and low manual intervention. However, its broad use in multicore parallel environments has been hindered by significant load imbalance. Traditional parallel techniques distribute grid cells evenly after each adaptive mesh refinement (AMR) cycle, ...

A new study reveals how entrepreneurs can win support for their ideas from audiences who never speak up. The research shows that the way entrepreneurs engage with a few vocal participants in online discussions can crucially shape how the larger, silent audience perceives and supports their ideas.  The study “Mobilizing the silent majority: Discourse broadening and audience support for entrepreneurial innovations,” by Jamie Song, assistant professor of strategy at ESMT Berlin, has been published in the ...

For years, wide-speed-range waveriders that can balance both high-speed and low-speed flight states have attracted significant attention in aerospace engineering. Such designs are crucial for developing reusable space shuttles capable of horizontal takeoff and landing. However, the significant degradation in performance exhibited by traditional waveriders across a wide-speed-range remains a major obstacle to the engineering application. At the core of this challenge is the difficulty in reconciling two conflicting aerodynamic requirements: effective shock wave control ...

PASADENA, CA – January 13, 2026 – The GMTO Corporation, the international consortium building the Giant Magellan Telescope, today announced it has appointed Daniel T. Jaffe as president, succeeding Robert N. Shelton, who announced his retirement last year after guiding the observatory through a period of significant growth. “Dan brings decades of leadership in research, astronomy instrumentation, public-private partnerships, and academia,” said Taft Armandroff, board chair of the GMTO Corporation. “His deep understanding ...

As lunar exploration intensifies, the cislunar space is experiencing increasing congestion. Traditional two-body Keplerian elements, which have long been the standard for Earth-orbiting objects, prove insufficient for accurately describing the complex orbits near the Earth–Moon Lagrange points due to the chaotic and non-integrable nature of three-body dynamics. This fundamental deficiency has hindered the development of an effective space situational awareness (SSA) framework for this strategically vital region. A research team from the National University of Defense Technology (NUDT) ...

Researchers propose a new citation index that balances productivity and impact in academic publishing. The h-index of citations was introduced in 2005 by a physicist Jorge E. Hirsch. This index is defined simply as the maximum number h of an author’s published papers with at least h citations each. For example, h = 3 means that there are three papers with 3 or more citations, but if a fourth paper exists, it has fewer than four citations. The h-index has quickly gained popularity and is now widely used to measure productivity ...

MINNEAPOLIS / ST. PAUL (01/13/2026) — Researchers at the University of Minnesota Twin Cities and Universit´e Paris-Saclay have challenged a decades-old dark matter theory. Their new research shows that the Universe’s most mysterious material could have been “incredibly hot”–moving at nearly the speed of light–when it was first born.  The study was recently published in Physical Review Letters, the premier journal of the American Physical Society. The research gives new clues about the origins of our Universe and opens up a broader range of possibilities for dark matter and how it ...

Playing linear number board games, those where players move pieces along a straight numbered path, can significantly strengthen young children’s math skills, according to a new report  by the HEDCO Institute for Evidence-Based Educational Practice at the UO. Even better, the report found just a few short, 10-minute sessions of game play may have lasting benefits. The findings are from a meta-analysis, or systematic review, of 18 studies looking at number board games and early math skills in children preschool ...

MINNEAPOLIS / ST. PAUL (01/12/2026) — A new study by researchers at the University of Minnesota Twin Cities challenges previous classifications paleontologists use to determine how the fossil record is formed. They investigated how dinosaur and mammal bones are transported and buried by floodwaters to understand how the remains of animals might disperse prior to being buried and becoming fossils. The research provides new clues for understanding animal extinction and environmental changes. The paper was recently published in Paleobiology, ...

An automated cell culture system reduces hands-on time and improves seeding consistency in 96-well microplates. Manuel Leonetti, Rafael Gómez-Sjöberg, and colleagues developed the Automated Cell Culture Splitter, an open-source robotic system built around the Opentrons OT-2 liquid handling robot equipped with a custom cell counting imaging instrument. The system automates passaging—the transfer of cells from one culture plate to another when they grow too numerous—of either adherent or suspended cells in 96-well plates, a process conventionally requiring tedious manual work. The authors tested the system with a commonly ...

A study in mice on small RNAs in sperm helps explain how the health of fathers can influence the health of their offspring. Bin He and colleagues explored how paternal immune activation in mice affects a specific class of small RNAs in sperm, known as 28S-rsRNAs. Mice were injected with lipopolysaccharides derived from the bacteria Escherichia coli, to prompt an immune response. A week later, the mice were found to have fewer sperm and an increased number of 28S-rsRNAs in what sperm they did have. Notably, these effects largely subsided six weeks post-injection—spanning ...

Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models. Traditional animal models often fail to capture human-specific cardiac biology, while conventional two-dimensional cell cultures lack the functional and structural complexity of heart tissue. These challenges have fueled growing interest in regenerative medicine approaches that more accurately model human heart development, disease mechanisms, and therapeutic responses, with stem ...

Using muon spin rotation spectroscopy, researchers from Japan and Canada successfully captured the rapid conversion of an imidoyl radical into a quinoxalinyl radical occurring within nanoseconds. The technique enabled real time detection of a highly reactive aromatic heterocyclic radical generated during the isocyanide insertion reaction, using muonium as a molecular tracker. The discovery is expected to advance particle-driven radical chemistry—exploring functional properties and offering new strategies for ...

Environmentally friendly buildings are highly attractive for sustainable development and efficient energy consumption. Recently, scientists have made significant strides towards the development of energy-efficient smart windows—with features such as optical modulation, high transparency, low thermal conductivity, and ultraviolet (UV) blocking and heat shielding capabilities—to replace traditional glass windows. The smart windows are a lucrative technology to protect household items as well as human health from the adverse effects of UV radiation. In a recent breakthrough, a team of researchers from the Republic of Korea, led by Professor ...

AMOLF researchers discovered a mysterious interplay of insulin signals in the worm C. elegans. The insulin-driven protein DAF-16 does not only move in and out of the cell nucleus in a complex rhythm, it does so at exactly the same moment in all cells of the body. Because of the many similarities between C. elegans and humans, the research may contribute to a better understanding of diseases such as diabetes, cancer and of ageing. The researchers published their findings in the journal Nature Communications on December 11. Cells experience many different types of stress, such as starvation or ...

University of Leeds news  Embargoed: 13 January 2026 10:00 GMT  Images available here     Tropical forests can recover twice as quickly after deforestation if they have adequate soil nitrogen, according to new research published today.  A team of scientists led by the University of Leeds established the world’s largest and longest experiment to see how nutrients affect forest regrowth in areas cleared for activities such as logging and ...

Young tropical forests play a crucial role in slowing climate change. Growing trees absorb carbon dioxide from the air, using photosynthesis to build it into their roots, trunks, and branches, where they can store carbon for decades or even centuries. But, according to a new study, this CO2 absorption may be slowed down by the lack of a crucial element that trees need to grow: nitrogen.  Published in Nature Communications and coauthored by Cary Institute of Ecosystem Studies ecologist Sarah Batterman, the study estimates that ...

“What should I eat?” is perhaps the most common question patients with inflammatory bowel disease ask their doctors. It’s notoriously difficult to answer. There have been few large studies of dietary interventions for IBD, a group of disorders that includes ulcerative colitis and Crohn’s disease. Now, new research by Stanford Medicine investigators and their colleagues provides one potential answer. Their national, randomized controlled clinical trial found that a short-term, calorie-restrictive diet significantly improved both physical symptoms and biological indicators of mild-to-moderate Crohn’s ...

The number of vehicles in Africa is expected to double between now and 2050 – faster than on any other continent. The question is not whether mobility will increase, but how. A new study led by researchers at ETH Zurich and the Paul Scherrer Institute PSI, in collaboration with African partners from Makerere University, University of Port Harcourt and Stellenbosch University, shows that electric vehicles, combined with solar-powered off-grid charging systems, could be economically competitive in many African countries well before 2040. “Many models have assumed that combustion engine vehicles will continue to dominate in Africa through ...

A test that rapidly detects signs of inflammatory bowel disease (IBD) in stool samples could improve future diagnosis and monitoring of the condition, a study suggests. Scientists have developed a tool to measure the activity of a molecule linked to gut inflammation within faecal samples. The optical tool, known as a luminescent reporter, lights up when it detects the molecule, with higher readouts indicating increased activity and inflammation. The new technique could boost the accuracy of stool sample tests for IBD, reducing the need ...

Widely-used eye ointments can cause glaucoma implants to swell and potentially rupture, according to new research from Nagoya University in Japan. This study is the first to show, using clinical and experimental evidence, that petrolatum-based eye ointments can compromise the PRESERFLO® MicroShunt, an implant used in over 60 countries to treat glaucoma. Glaucoma is an eye disease that damages the optic nerve and can lead to vision loss. It often results from increased intraocular pressure caused by blocked drainage of eye fluid. A recent study estimated that 76 million ...

Amsterdam, 13 January 2026. Today, the ACCESS-AD consortium is announcing the launch of a transformative European initiative that will accelerate the implementation of scientific innovations for Alzheimer’s disease (AD) management in real-world health systems. The international consortium - bringing together academic institutions, industry partners, SMEs and patient organisations - is co-led by Amsterdam UMC, Siemens Healthineers, King’s College London and Gates Ventures, with funding from the European Commission’s Innovative Health Initiative for a five-year period. The project begins at a pivotal moment for AD care in Europe. In 2025, two new disease-modifying therapies ...