About The Study: In this cross-sectional study, older adults hospitalized with sepsis were more likely to die or experience major morbidity as the hospital COVID-19 burden increased. These increases in adverse outcomes were greater in magnitude among members of minority populations than for white individuals.  Corresponding Author: To contact the corresponding author, Laurent G. Glance, MD, email laurent_glance@urmc.rochester.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.38563) Editor’s Note: Please see the article for additional information, ...

A critical transition in early human development is regulated not by our own genes, but by DNA elements called transposons that can move around the genome, Sinai Health researchers have found. This remarkable discovery challenges our previous understanding of these elusive DNA segments, shedding new light on the roles they play in human development and disease. “People tend to think of transposons as akin to viruses where they hijack our cells for the sole purpose of propagating themselves,” says study’s senior co-author Dr. Miguel Ramalho-Santos, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health, and Professor ...

Bonobos, endangered great apes that are among our closest relatives, might be more vulnerable than previously understood, finds a genetics study led by a UCL researcher that reveals three distinct populations. The three groups of bonobos have been living separately in different regions in Central Africa for tens of thousands of years, according to the study published in Current Biology by an international research team co-led by UCL, University of Vienna, and Max Planck Institute for Evolutionary Anthropology ...

LA JOLLA, CA—Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1). FOXA1 mutations can enable these types of cancers to grow and proliferate. Today, FOXA1 is notoriously difficult to block with drugs—but that may soon change. Scripps Research scientists have identified a crucial binding site on FOXA1 that could pave the way for future cancer treatments. The team’s findings, which were published in Molecular Cell on October 15, 2024, also mapped out how tiny drug-like chemical compounds—called small molecules—interact with the protein. While ...

TUCSON, AZ — October 15, 2024 — The Giant Magellan Telescope today announced the successful installation of one of its completed 8.4-meter-diameter primary mirrors into a support system prototype at the University of Arizona’s Richard F. Caris Mirror Lab. This highly sophisticated system — comparable in size to half a basketball court and containing three times the number of parts of a typical car — is vital to the telescope’s optical performance and precision control. The milestone marks the start of a six-month optical testing phase to demonstrate that the support system can control the mirror as required, validating the revolutionary capabilities ...

In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses. Patients with breast cancer and bone metastasis have limited treatment options and often rely on palliative care to ease difficult symptoms, including frailty and pain. In most cases, breast cancer with bone metastasis is incurable. Now, corresponding author Venu Raman, Ph.D., ...

A majority of Floridians expressed support for political candidates who fight climate change in a new Florida Atlantic University survey. The survey found that nearly 52% of respondents agreed that a candidate with a record of reducing climate impacts was more likely to get their vote.    The Invading Sea’s Florida Climate Survey also revealed strong support in the state for increasing renewable energy use and teaching climate science in K-12 classrooms. The survey is the 11th conducted by the FAU Center for Environmental Studies ...

LOS ANGELES – Oct. 15, 2024 – Stand Up To Cancer® (SU2C) today announced grants to several teams of leading cancer investigators in support of cutting-edge research in a variety of cancers including head and neck, pediatric, pancreatic, breast, rectal and gastro-esophageal cancers, as well as research focused on how the microbiome communicates with the immune system. “These new grants emphasize SU2C’s support of collaborative, trailblazing research that pushes the field forward and helps people impacted by some of the most common or difficult-to-treat cancers,” said Julian Adams, Ph.D., president and CEO of SU2C. “With an emphasis on answering ...

CLEVELAND—With a new four-year, $1.3 million grant from the U.S. Department of Veterans Affairs, researchers at Case Western Reserve University are investigating a new approach to treat Acute Myeloid Leukemia (AML) in military Veterans.   AML is the most common form of blood cancer in adults, and many patients suffer relapses—especially Veterans, due to exposure to harmful chemicals and radiation during active duty, according to the National Center for Biotechnology Information. There is no effective treatment for AML and, according to the National Institutes of Health, half of treated patients suffer a relapse after therapy—mainly  ...

Zeuthen, Germany – On 14 October 2024, the Cherenkov Telescope Array Observatory (CTAO), along with hosting partners and shareholders Deutsches Elektronen-Synchrotron DESY, celebrated the official inauguration of the Science Data Management Centre (SDMC) on the DESY campus in Zeuthen, Germany. The ceremony, chaired by Prof. Christian Stegmann, Head of DESY Zeuthen, was opened by Mario Brandenburg, Parliamentary State Secretary at the German Federal Ministry of Education and Research (BMBF), and Tobias Dünow, State Secretary at ...

Toronto, ON (October 14, 2024) – JMIR Publications is proud to announce that Gunther Eysenbach, founder, CEO and executive editor, has once again been named the #1 most cited researcher in the subfield of medical informatics by Stanford/Elsevier’s Top 2% Scientists rankings. This marks the fifth consecutive year that Dr Eysenbach has secured this prestigious position, reaffirming his status as a leading authority and driving force in the field. He is also ranked #36 in the Top 100 Scientists in Information & Communication ...

Dr. Levent Beker from the Department of Mechanical Engineering at Koç University, once again received European Research Council (ERC) support for his scientific research that focuses on improving the quality of our daily lives.  His previous project on an implant that can detect signs of heart failure and degrade in the body without surgery was granted €2.5 million Starting Grant from the ERC. Last year, his research on a wireless micro sensor that enables real-time monitoring of food spoilage at supermarkets, was published in Nature FoodMagazine. Currently leading the Bio-integrated ...

The National Institutes of Health (NIH) has announced the winners of the Rapid Acceleration of Diagnostics Technology (RADx® Tech) for Maternal Health Challenge, an $8 million prize competition to encourage development of postpartum maternal health diagnostics for use in regions that have limited access to maternity care. The eight winning teams developed home-based and point-of-care diagnostics, wearables and other accessible technologies to improve postpartum health outcomes during the period when most maternal deaths occur—up to one year after delivery or the end of ...

October 15, 2024 – The American Pediatric Society (APS) and the Society for Pediatric Research (SPR) are pleased to announce Cynthia F. Bearer, MD, PhD, as the 2025 Mary Ellen Avery Neonatal Research Award recipient. This award honors a pediatric investigator who has made important contributions to neonatal health through basic or translational research. Dr. Bearer is the William & Lois Briggs Chair of Neonatology and Chief, Division of Neonatology, Rainbow Babies & Children’s Hospital and Professor of Pediatrics & Neurosciences at Case Western Reserve University. ...

A pre-registered survey of nearly 10,000 Americans shows that delays in declaring the winners of elections cause distrust in the electoral process, but that reassuring voters before polls close that delays are normal can prevent this distrust from taking root. National elections in the United States were not definitively settled for days after election day in 2020 and 2022. There are legitimate reasons for such delays, including state rules about when counting can commence and laws about whether mailed ballots postmarked on election day must be counted. However, delayed results ...

The lack of air-quality monitoring capabilities across the U.S. affects the health of millions of people and disproportionately impacts minority and low socioeconomic-status communities, say researchers in ACS’ Environmental Science & Technology Letters. Motivated by a new U.S. Environmental Protection Agency (EPA) standard for air pollution, the team employed a model for fine-scale air pollution mapping using real-world data, and it indicates there is an urgent need to address gaps in the agency’s monitoring ...

A system of wearable sensors and machine learning can continuously monitor factory workers for signs of physical fatigue. Factory work can be physically strenuous, and a safe and ethical workplace must ensure that workers do not become overly fatigued, which can increase the risk of injury and accident, cause chronic health problems, and also impair performance. A system designed by Ping Guo, Qi Zhu, and colleagues measures heart rate, heart rate variability, skin temperature, and locomotor patterns ...

A study investigates the evolution of beneficial bacteria that live inside and on the surface of farming ants. Attine ants farm fungi, in one of the natural world’s best-studied mutualistic symbioses. In the 1990s, the picture of this mutualism was expanded to include another partner: an actinobacteria, Pseudonocardia, which lives on the ants’ cuticle—their hard exoskeleton—where its cultures are fed by secretions of subcuticular glands. Pseudonocardia is known to kill the fungal pathogen Escovopsis, that might destroy the ants’ mutualistic fungus. Jacobus J. Boomsma and colleagues sequenced samples ...

A collection of 15 articles from the Polarization and Trust Special Feature explores the complex nature of the emotional divide between political opponents, using approaches from a variety of disciplines, including political science, psychology, sociology, and economics. The articles emerged from a 2023 workshop on “Directions of Polarization, Social Norms, and Trust in Societies,” held at MIT and organized by  Kati Kish Bar-On,  Eugen Dimant,  Yphtach Lelkes and  David Rand. Researchers from a number of teams identified ways in which partisans mistrust and inaccurately perceive their political opponents, and other teams  examined why such inaccurate ...

The silkworm moth (Bombyx mori) is an insect that no longer flies due to domestication. The males use their antennae to detect pheromones emitted by females and respond very acutely, and have been used as model insects for the study of their odor source localization. Flying insects flap their wings when they fly, and silkworm moths are also known to flap their wings (called fanning) when they detect pheromones, even though they do not fly. As pheromone molecules move through space in the air, the air flows ...

Obesity is a widespread public health challenge in the Middle East, maintaining prevalence in 54.2% of women and 31.4% of men in this region. Overweight and obese women have a higher risk of hypertension and cardiovascular risk factors than women with a standard BMI, according to an analysis of the ANCORS-YW STUDY presented at ACC Middle East 2024. The findings highlight the urgent need for targeted interventions that address socioeconomic determinants of health to reduce the cardiovascular risk ...

In a growing and changing world, we need to find ways of putting food on everyone’s table. Pesticides have enabled mass cultivation on an incredible scale, but they can have harmful secondary effects on humans and wildlife, and pests are rapidly evolving to overcome them. To overcome this challenge and develop the sustainable and resilient agriculture of the future, scientists writing in Frontiers in Science explore the potential of induced resistance. Like a vaccination for plants, it deliberately triggers a plant’s immune system, so that when the plant encounters a similar ...

Seven New Frog Species Discovered in Madagascar: Sounds Like Something from Star Trek An international team of researchers have discovered seven new species of tree frogs that make otherworldly calls in the rainforests of Madagascar. Their strange, high-pitched whistling calls sound more like sound effects from the sci-fi series Star Trek. As a result, the researchers have named the new species after seven of the series' most iconic If you think all frogs croak, you’d be wrong. Seven newly discovered species from the tree frog genus Boophis, found across the rainforests of Madagascar, emit special bird-like whistling ...

Two thirds of Key Biodiversity Areas (KBAs) in tropical forests are experiencing new temperature conditions as our climate changes, research shows. KBAs identify the most important places on Earth for species and their habitats. The new study – by Exeter, Manchester Metropolitan and Cambridge universities – assessed 30 years of temperature conditions below the forest canopy in KBAs in tropical forests worldwide. It found that 66% of KBAs in tropical forests have recently transitioned to new “temperature regimes” (more than 40% of temperature measurements being outside the range previously recorded ...

NEW YORK, NY — How do we distinguish threat from safety? It’s a question important not just in our daily lives, but for human disorders linked with fear of others, such as social anxiety or post-traumatic stress disorder (PTSD). The microscope image accompanying this press release, from the laboratory of Steven A. Siegelbaum, PhD, at Columbia’s Zuckerman Institute, displays a powerful technique scientists used to help us find an answer. The scientists were investigating the hippocampus, a brain area that plays a key role in memory in humans and mice. Specifically, they focused on the CA2 region, which is ...