(Press-News.org) A new international study involving researchers from Durham University has revealed that climate change is accelerating the rate of development and global abundances of antibiotic resistance bacteria in soils.
The findings, published in the journal Nature Ecology & Evolution, highlight a new and deeply concerning less seen consequence of global warming to public health.
The study shows that rising global temperatures are significantly increasing the abundance of antibiotic resistance genes (ARGs) and virulence factors in soil microbial communities.
These genes can make bacteria less susceptible to the effects of antibiotics, increasing the probability of acquiring antibiotic resistant infections, including from dangerous pathogens.
The research, which integrates field data, metagenomic analysis, and laboratory experiments, provides compelling evidence that warmer conditions will favour the survival and evolution of pathogenic and other bacteria that are resistant to therapeutic treatment – bacteria that often originate in the natural environment.
Professor David W. Graham of Durham University, co-author of this study, a water engineer and expert in antibiotic resistance, says “the study exemplifies how closely connected human health is with environmental change.”
This research provides compelling evidence that climate change is more than an environmental crisis, it also is impacting global antibiotic resistance due to warming.
This research forms part of a growing body of evidence that environmental factors, including global warming, are playing a crucial role in the spread of antimicrobial resistance.
It underscores the importance of a ‘One Health’ approach that recognises the interconnected nature of human, animal, and environmental health.
Professor Graham said: “Most people do not realise that most of the pathogens that cause infectious disease humans actually originate from the environment.
“Therefore, increasing resistance in soils will almost certainly translate into increased levels of untreatable infections in human and veterinary practice. This is why One Health solutions are important”.
The study found that the impact of warming will be more pronounced in colder regions. In the past, colder temperatures normally kill off bacteria, especially human pathogens, but as temperatures increases, such strains will survive longer, which this study shows.
As temperatures rise, bacteria also appear to changing on an evolutionary level, with an increased probability of genetic changes and the appearance of ‘new’ pathogens to which no antibiotic options exist.
Professor Graham said: “The relationship between climate and antibiotic resistance was predicted in the 2023 United Nations report: Bracing for Superbugs: Strengthening environmental action in the One Health response to antimicrobial resistance and the new work here provides concrete evidence for that prediction.”
The research team found that even modest increases in temperature can trigger significant rises in the abundance of ARGs, particularly in bacterial groups such as Proteobacteria and Bacteroidetes, which are known carriers of resistance and virulence genes.
Laboratory experiments with Escherichia coli confirmed that elevated temperatures lead to increased expression of antibiotic resistance genes, including those involved in efflux pumps and stress response proteins, which are key mechanisms in bacterial defence.
Moreover, machine learning models used in the study project that, under high-emission climate scenarios, global levels of soil ARGs could rise by up to 23 percent by the end of this century.
The researchers warn that climate-driven changes to microbial communities could undermine efforts to control antibiotic resistance and may lead to greater risks of infection from previous antibiotic-susceptable bacteria from soils and, more importantly, an increased probability new pathogen ‘jumping’ from environmental sources to human health systems, as exemplified by SARS-CoV-2 and the COVID-19 pandemic.
ENDS
Media Information
Professor David W. Graham from Durham University is available for interview and can be contacted on david.w.graham@durham.ac.uk.
Alternatively, please contact Durham University Communications Office for interview requests on communications.team@durham.ac.uk or +44 (0)191 334 8623.
Source
‘Climate warning fuels the global antibiotic resistome by altering soil bacterial, (2025), D. Lin, S. Du, Z. Zhao, T. Zhang, L. Wang, Q. Zhang, S. Zhou, D. W. Graham, D. Tissue, D. Zhu, Y. Zhu, J. Penuelas and P. Reich, Nature Ecology & Evolution.
An embargoed copy of the paper is available from Durham University Communications Office. Please email communications.team@durham.ac.uk.
This study was a collaboration between institutions in China, the United Kingdom, Spain, Australia, and the United States. Durham University researchers contributed to the analysis of bacterial community dynamics, the modelling of resistance risks, and the interpretation of global soil data.
Graphics
Associated images are available via the following link: https://www.dropbox.com/scl/fo/rppoyc5q2u116gwylfxxf/ACAFz59Q1wYStxLt1b4ytHc?rlkey=6k48n1wyzso7tgydb2mdzgpc3&st=c2zjywyh&dl=0
About Durham University
Durham University is a globally outstanding centre of teaching and research based in historic Durham City in the UK.
We are a collegiate university committed to inspiring our people to do outstanding things at Durham and in the world.
We conduct research that improves lives globally and we are ranked as a world top 100 university with an international reputation in research and education (QS World University Rankings 2025).
We are a member of the Russell Group of leading research-intensive UK universities and we are consistently ranked as a top 10 university in national league tables (Times and Sunday Times Good University Guide, Guardian University Guide and The Complete University Guide).
For more information about Durham University visit: www.durham.ac.uk/about/
END OF MEDIA RELEASE – issued by Durham University Communications Office.
END
New study reveals global warming accelerates antibiotic resistance in soils
2025-06-05
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