Open-label placebos as adjunct for the preventive treatment of migraine

JAMA Network Open

2025-10-08

(Press-News.org) About The Study: In this randomized clinical trial, open-label placebo treatment did not reduce headache frequency but was associated with improvements in quality of life and pain-related disability. Future research should clarify the mechanisms underlying these effects and determine their potential supportive role in migraine care for selected patients.

Corresponding Author: To contact the corresponding author, Julian Kleine-Borgmann, MD, email julian.kleineborgmann@uk-essen.de.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.35739)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Open-label placebos as adjunct for the preventive treatment of migraine

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