A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson’s disease in which a patient’s stem cells are reprogrammed to replace dopamine cells in the brain damaged by the disease. The first-of-its-kind trial of an autologous stem cell transplant, based on research and technologies invented and validated preclinically at McLean Hospital’s Neuroregeneration Research Institute (NRI), has enrolled and treated three patients at Brigham and Women’s ...

Rocky Mountain spotted fever is a bacterial infection spread by biting ticks to humans and dogs. Found on every continent except Antarctica, the infectious disease has been spreading since the early 2000s, most notably in Mexico and Brazil. Of the cases reported, more than half of infected people and dogs die. A paper led by the University of California, Davis, highlights one of the most effective but often missing solutions to surviving this preventable, deadly disease: awareness. Most fatal cases stem from delays in diagnosis and treatment. “The No. 1 thing that prevents human death from Rocky Mountain spotted fever is for everyone at high risk to know ...

The prestigious journal Advanced Materials recently published a groundbreaking study introducing a new method for monitoring molecular processes deep within tissue. Developed at the Technion - Israel Institute of Technology, the innovation is expected to accelerate key advancements in personalized medicine, cancer diagnosis, and early disease detection. The research was led by Prof. Hossam Haick, postdoctoral fellow Dr. Arnab Maity, and Ph.D. student Vivian Darsa Maidantchik from the Wolfson Faculty of Chemical Engineering at the Technion. The study also involved Dr. Dalit Barkan, research assistant Dr. Keren ...

(Boston)—Sun Lee, MD, MSc, assistant professor of medicine at Boston University Chobanian & Avedisian School of Medicine, has been awarded an American Association of Clinical Endocrinology (AACE) Rising Star in Endocrinology Award.   The honor is presented to a physician who is within 10 years of completing their endocrine fellowship and has demonstrated actionable outcomes in outstanding leadership, teamwork and/or innovation in support of AACE’s mission to elevate clinical endocrinology ...

The Center for Stress, Resilience and Personal Growth at Mount Sinai—a first-of-its-kind initiative launched in April 2020 at the height of the COVID-19 pandemic to address its psychosocial impact on Mount Sinai Health System’s workforce—is now offering confidential behavioral health treatment services to New Yorkers generally. A team of clinical psychologists, psychiatrists, and licensed clinical social workers from the Center is now available to individuals 18 years and older who are interested in and could benefit from behavioral health treatment. Clinical services include cognitive behavioral therapy, ...

(Boston)—More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes often have worse outcomes. A new study by researchers from Boston University Chobanian & Avedisian School of Medicine helps explain why this happens and suggests a potential way to improve treatment for these patients. At present, oncologists do not consider patients with breast cancer and obesity-driven diabetes differently in any significant way from patients with breast cancer who are otherwise healthy. The new study, "Insulin Resistance Increases ...

Two main manufacturers dominate the EV (electric vehicle) market: Tesla, which is most popular in Europe and North America, and BYD, which leads the Chinese EV market. However, both manufacturers have released limited data about their batteries, so the mechanical structure and characteristics of these battery cells has remained mysterious. To compare the batteries used by each manufacturer and better understand how EV batteries function overall, a team of researchers took one of each apart.  The results publish on March 6 in the Cell Press journal Cell Reports Physical Science and show that Tesla’s batteries prioritize high-energy density and performance, ...

Researchers at UC San Francisco have enabled a man who is paralyzed to control a robotic arm through a device that relays signals from his brain to a computer.   He was able to grasp, move and drop objects just by imagining himself performing the actions.   The device, known as a brain-computer interface (BCI), worked for a record 7 months without needing to be adjusted. Until now, such devices have only worked for a day or two.   The BCI relies on an AI model that can adjust to the small changes ...

Ice may be present a few centimetres below the Moon’s surface in more areas of the lunar polar regions than was previously thought due to large, yet highly localised, variations in surface temperatures. The results, published in Communications Earth & Environment, are derived from direct measurements taken at the lunar surface in 2023 by the Indian Chandrayaan-3 mission. Future long-term exploration (or habitation) of the Moon will likely depend on the availability of ice to provide water, with the likelihood of ice formation in a ...

UCSF researchers are the first to demonstrate that the approach works for the patients who need it the most.  Patients who struggle to take daily HIV pills can benefit from long-acting injectable treatments, a new study by researchers at UCSF has found.    The strategy could also help stop the spread of HIV by keeping more patients from being infectious. In 2021, federal regulators approved the first long-acting antiretroviral (LA-ART) injectable, which is a combination of long-acting cabotegravir and ...

Multidrug-resistant bacteria pose a major threat to human health. Manipulation of bacterial genes at the transcriptional level is a potential strategy to fight antibiotic-resistant bacterial infections by silencing their resistance genes. However, siRNAs have not been applied to regulate bacterial genes due to the lack of RNAi regulatory machinery, i.e., RNA-induced silencing complexes (RISCs), in bacteria. In addition, efficient methods for delivering siRNAs to bacteria in vivo are not currently available. In this study, ...

COLUMBUS, Ohio – Just a few days of eating a diet high in saturated fat could be enough to cause memory problems and related brain inflammation in older adults, a new study in rats suggests. Researchers fed separate groups of young and old rats the high-fat diet for three days or for three months to compare how quickly changes happen in the brain versus the rest of the body when eating an unhealthy diet. As expected based on previous diabetes and obesity research, eating fatty foods for three months led to metabolic problems, gut inflammation and dramatic shifts in gut bacteria in all rats compared to those that ate normal chow, while just three days of ...

Key points: Slim and lightweight HASEL artificial muscles effectively suppress human tremor Reproduction of patient recordings of tremor episodes in a robotic platform/mechanical patient Computer simulation of tremor arm validates that forces are sufficient for practical applications Avoiding time consuming clinical testing in early stages of technology development   Stuttgart/Tübingen – It is estimated that around 80 million people worldwide live with a tremor. For example, those who live with Parkinson's disease. The involuntary periodic movements sometimes strongly affect how patients are able ...

— By Rachel Berkowitz  Composite adhesives like epoxy resins are excellent tools for joining and filling materials including wood, metal, and concrete. But there’s one problem: once a composite sets, it’s there forever. Now there’s a better way. Researchers have developed a simple polymer that serves as a strong and stable filler that can later be dissolved. It works like a tangled ball of yarn that, when pulled, unravels into separate fibers. A new study led by researchers ...

WASHINGTON, March 6, 2025—The American Educational Research Association (AERA) has announced the selection of 29 exemplary scholars as 2025 AERA Fellows. The AERA Fellows Program honors scholars for their exceptional contributions to, and excellence in, education research. Nominated by their peers, the 2025 Fellows were selected by the Fellows Committee and approved by the AERA Council, the association’s elected governing body. They will be inducted during a ceremony at the 2025 Annual Meeting in Denver on April 24. With this cohort, there will be a total of 791 AERA Fellows. “The ...

A team of researchers from Nottingham Trent University (UK), Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and Free University of Bozen-Bolzano (Italy) has created washable and durable magnetic field sensing electronic textiles – thought to be the first of their kind – which they say paves the way to transform use in clothing, as they report in the journal Communications Engineering (DOI: 10.1038/s44172-025-00373-x). This technology will allow users to interact with everyday textiles or specialized clothing by simply pointing their finger above a sensor. The researchers show how they placed tiny flexible ...

(Toronto, March 6, 2025) JMIR Publications invites submissions to a new theme issue titled Social and Cultural Drivers of Health in Aging Populations in its open access journal JMIR Aging. The premier, peer-reviewed journal is indexed in PubMed, PubMed Central, MEDLINE, DOAJ, Scopus, and the Science Citation Index Expanded (Clarivate). As aging populations grow worldwide, understanding the social and cultural factors that impact health outcomes in older adults has become a critical area of study. This theme issue aims to highlight the role of digital health ...

Two new studies led by researchers at Hospital for Special Surgery (HSS) have uncovered key biological mechanisms driving systemic sclerosis (SSc), or scleroderma – a rare and often devastating autoimmune disease that causes fibrosis (tissue hardening) and inflammation. The research, published in the March issue of the Journal of Experimental Medicine, helps explain why the disease disproportionately affects women and reveals potential treatment targets, some of which are already in development.  Scleroderma affects approximately 300,000 people in the U.S., with about one-third ...

Miami (March 6, 2025) – Mental health disorders in people with chronic obstructive pulmonary disease (COPD) are underdiagnosed and undertreated, leading to worsened symptoms and decreased quality of life, according to a new study. The study is published in the January 2025 issue of Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, a peer-reviewed, open-access journal. COPD is an inflammatory lung disease, comprising several conditions, including chronic bronchitis and emphysema, and ...

We commonly consider spiritual practices sources of peace and inspiration. A recent study led by researchers of the University of Vienna shows that they can also be experienced differently: Many persons feel bored during these practices – and this can have far-reaching consequences. The results recently published in the academic journal Communications Psychology open up an entirely new field of research and provide fascinating insights into a phenomenon that has received only scant attention so far. Even though boredom is a heavily researched subject at the moment, spiritual boredom has so far been largely neglected in research. Psychologists at the University of ...

The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging. These proteins although exhibit chaotic and ‘disordered’ structures, they still perform essential functions. The IDPs comprise approximately 30% of the human proteome and play important functional roles in transcription, translation, and signalling. Many mutations linked to neurological diseases, including amyotrophic lateral sclerosis (ALS), are located in intrinsically disordered protein regions (IDRs). Powerful machine-learning algorithms, including ...

A new study by researchers including those at the University of Tokyo revealed that atmospheric gravity waves play a crucial role in driving latitudinal air currents on Mars, particularly at high altitudes. The findings, based on long-term atmospheric data, offer a fresh perspective on the behaviors of Mars' middle atmosphere, highlighting fundamental differences from Earth’s. The study applied methods developed to explore Earth’s atmosphere to quantitatively estimate the influence of gravity waves on Mars’ planetary circulation. Despite it being a very cold planet, Mars is quite a hot topic these days. With human visitation seemingly ...

A team of scientists from University College Cork (UCC) , the University of Connecticut, and the Natural History Museum of Vienna have uncovered how plants responded to catastrophic climate changes 250 million years ago. Their findings, published in GSA Bulletin, reveal the long, drawn-out process of ecosystem recovery following one of the most extreme periods of warming in Earth’s history: the ‘End-Permian Event’. With more than 80% of ocean species wiped out, the end-Permian event was the worst mass extinction of all time. But the impacts of this event for life on land have been elusive. By examining fossil plants and ...

ANN ARBOR, Mich. –  A new clinical trial will allow researchers to study 3D-printed bioresorbable devices aimed at treating children with rare and life-threatening airway condition tracheobronchomalacia. The trial, launched by Michigan Medicine and Materialise, marks a crucial step towards full Food and Drug Administration (FDA) approval for the innovative devices designed to support the airways of infants with the severest forms of the disease. Tracheobronchomalacia causes the airway to collapse, making breathing difficult and, in severe cases, can be fatal. Currently, infants with this ...

Background and objectives Sepsis involves a complex cascade of inflammatory reactions and immune system dysregulation. Neutrophils play a crucial role in modulating the anti-inflammatory response, which is vital for managing sepsis. Impaired chemotaxis of granulocytes can significantly impact the outcome of sepsis. Shenfu Decoction, by tonifying Qi and warming Yang, enhances the propelling function of Qi for promoting the chemotactic function of neutrophils. This study aimed to investigate the effects of Shenfu Decoction on the chemotactic function of neutrophils in septic mice and the underlying ...