Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. Cold Spring Harbor Laboratory (CSHL) Professor and Cancer Center Director David Tuveson offers a telling analogy: “We all have moles on our skin. Most of your moles are fine. But some of your moles you have a dermatologist looking at to make sure it’s always fine. They ...

Bottom Line: Precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation delayed KRAS-mutated PDAC development in mice. Journal in Which the Study was Published: Cancer Research, a journal of the American Association for Cancer Research Author: Claudia Tonelli, PhD, a research investigator in the laboratory of AACR Past President David A. Tuveson, MD, PhD, FAACR, at Cold Spring Harbor Laboratory Background: PDAC is the most common ...

They say music is the universal language of humankind, but some stars in our galaxy exhibit their own rhythm, offering fresh clues into how they and our galaxy evolved over time.  According to an international team of researchers, including scientists from The Australian National University (ANU) and UNSW Sydney, some stars exhibit fluctuations in their brightness over time, which are caused by continuous ‘starquakes’.  These fluctuations can be translated into frequencies, which can be used to determine a star’s age and other properties ...

Investigation how microorganisms communicate enhances our understanding of the complex ecological interactions that shape our environment – a major focus of the Cluster of Excellence “Balance of the Microverse”. A research team of the Cluster at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (Leibniz-HKI) and the Friedrich Schiller University, Jena has studied the interaction between amoebae, bacteria, and plants. Researchers from the ...

About The Study: The findings of this study suggest that both nurse overtime and nurse agency hours are associated with increased rates of pressure ulcers, a measure that is one of the most sensitive to nursing care. In future research, hospitals could use their own data to track safe thresholds. Corresponding Author: To contact the corresponding author, Patricia Pittman, PhD, email ppittman@gwu.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.2875) Editor’s ...

About The Study: Spending on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) increased from 2018 to 2023, with the largest growth rates from 2022 to 2023. Although spending for certain GLP-1 RAs increased substantially, spending declined for others. This study estimated that more than $71 billion was spent on GLP-1 RAs and more than $50 billion on a product based on either semaglutide or tirzepatide molecules. Corresponding Author: To contact the corresponding author, Stavros Tsipas, MA, email stavros.tsipas@ama-assn.org. To ...

About The Study: In this cohort study with relatively low ambient ozone exposure, early-life ozone was associated with asthma and wheeze outcomes at age 4 to 6 and in mixture with other air pollutants but not at age 8 to 9. Regulating and reducing exposure to ambient ozone may help reduce the significant public health burden of asthma among U.S. children. Corresponding Author: To contact the corresponding author, Logan C. Dearborn, MPH, email dearbl@uw.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.4121) Editor’s ...

Researchers have made a new discovery that changes our understanding of Earth’s early geological history, challenging beliefs about how our continents formed and when plate tectonics began. A study published in Nature on 2 April reveals that Earth's first crust, formed about 4.5 billion years ago, probably had chemical features remarkably like today’s continental crust. This suggests the distinctive chemical signature of our continents was established at the very beginning of Earth’s history. Professor Emeritus Simon ...

A study recently published in Nature indicates that human activities have a negative effect on the biodiversity of wildlife hundreds of kilometres away. A research collaboration led by the University of Tartu assessed the health of ecosystems worldwide, considering both the number of plant species found and the dark diversity – the missing ecologically suitable species. For the study, over 200 researchers studied plants at nearly 5,500 sites in 119 regions worldwide, including all continents. At each site, they recorded all plant species on 100 m2 and identified the dark diversity – native species that could live there but were absent. ...

Lung cancer screening has the potential to catch lung cancer early and save lives—but only if people get screened. Although lung cancer screening is recommended in the U.S. for certain individuals with a history of smoking, only 18% of eligible individuals in the U.S. get screened. One suggested explanation has been that those eligible are resistant to receiving preventive healthcare, but a new study published in JAMA and led by researchers at Mass General Brigham indicates otherwise. Researchers from Mass General Brigham sought to investigate use of other preventive healthcare services among individuals eligible for lung cancer screening. ...

A new study led by UNSW Sydney researchers into a cluster of stars 2700 light years away reveals their stages of evolution through the ‘sounds’ they make. This discovery will allow scientists to map the history of the Milky Way and other galaxies, accelerating knowledge in the field of astrophysics. Dr Claudia Reyes is the lead author of the study published today in Nature. While undertaking her PhD at the UNSW School of Physics, she studied 27 stars in a cluster of stars called M67. The stars in ...

As global temperatures continue to rise, extreme heatwaves pose a significant threat to agricultural productivity. Studies estimate that for every 1°C increase above pre-industrial levels, crop yields decline by approximately 6-8%. The ability of plants to withstand heat stress is therefore critical for ensuring food security, yet the underlying molecular mechanisms have largely remained elusive. Now, however, a new study led by Prof. XU Cao's team at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences sheds light on an adaptive strategy that may ...

When spring arrives and the heating season comes to an end, keeping warm becomes less of an issue. However, scientists remind us that it is not just a seasonal necessity – heat is also a valuable energy resource that can be stored and used when needed most. Researchers at Kaunas University of Technology (KTU) have discovered an innovative solution beneath our feet: using soil as an efficient thermal energy storage system. KTU professor Dr Tadas Ždankus and his team have been investigating how the ground can serve not only for construction purposes but also as a medium for heat storage. At the ...

The American Sociological Association has led a coalition of leading sociological organizations to issue an open letter defending the vital role of sociology in universities and society while condemning recent federal actions that threaten academic inquiry and free speech. Signed by the presidents of ten major sociological associations, the letter calls on university leaders, policymakers, and the public to resist efforts that undermine the discipline and stifle research that benefits society.  The signatories express their growing concerns over abruptly canceled federal contracts, looming job losses for sociologists ...

As the chemical industry seeks sustainable transformation, decarbonization requires intelligent solutions across multiple scales to enhance efficiency and reduce emissions. A research team led by Professor Xiaonan Wang at Tsinghua University has systematically reviewed AI-driven multi-scale smart systems for decarbonizing this energy-intensive sector. Published in Technology Review for Carbon Neutrality, the study explores innovations from materials discovery to industrial park optimization, highlighting ...

Recently, Dr. Renheng Bo, Research Associate Professor at the State Key Laboratory of Flexible Electronics Technology, Tsinghua University, and his colleagues published a new review article entitled "Structured Locomotive Magnetic Soft Robots" in Flextech. This article focuses on the relationship between structural configurations and locomotion modes of magnetic soft robots, which systematically summarizes the material compositions, fabrication methods, locomotion mechanisms, and applications of existing magnetic soft robots. Furthermore, it emphasizes current challenges and future research directions in the field of structured ...

ORLANDO, FL [April 2, 2025] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—celebrated 30 years of helping people with cancer to live better lives during the NCCN 2025 Annual Conference, March 28-30 in Orlando, Florida. The yearly event brings together leading minds and subject matter experts in front of a multidisciplinary audience to share the latest recommendations for cancer treatment and prevention. “We are proud to honor our founders’ vision of sharing evidence-based, expert consensus-driven recommendations through clinical practice guidelines to improve ...

“Our findings suggest a role for NSD2 in maintaining MM cell identity, with potential implications for future therapeutic strategies based on targeting of NSD2.” BUFFALO, NY – April 2, 2025 – A new research paper was published in Oncotarget, Volume 16, on March 21, 2025, titled “NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma.” Researchers Andrea Gunnell, Scott T. Kimber, Richard Houlston, and Martin Kaiser from The Institute of Cancer Research, London, studied how a gene called ...

NEW YORK—Thirty-two early career researchers, tackling issues from improving food security to developing better medical implants, were awarded up to two years of grant funding to pursue innovative interdisciplinary science, Schmidt Science Fellows announced today. Now in its eighth year, the fellowship, a program of Schmidt Sciences, provides financial support for a postdoctoral placement of one to two years at a world-class research institution. The funding equips scientists to apply their knowledge to a new field of study with the goal ...

Recent guidelines have restricted aspirin use in the primary prevention of cardiovascular disease. The American Heart Association (AHA)/American College of Cardiology (ACC) guidelines restricted aspirin to patients under 70, and more recently, the United States Preventive Services Task Force restricted aspirin use to patients under 60. However, heart attack and stroke risks both rise with age, leaving health care providers unsure about when to stop prescribing aspirin, whether it should be used for primary prevention, and which patients would benefit most. Researchers from Florida Atlantic University’s ...

A new study by McGill University researchers yields insights into how the disruption of calcium transport in the brain is linked to autism and intellectual disability. The findings, published in the journal Nature, not only upend a long-held belief among neuroscientists, but could pave the way for treatments. The researchers discovered that tiny protein structures on brain cells, known as AMPA receptors, can transport calcium. While previous research had suggested that disruptions in calcium ...

In Sweden, around 18,000 workers are exposed to hexavalent chromium in their workplace. Hexavalent chromium is a powerful carcinogen that is released, for example, during welding of stainless steel or the manufacture of paints and rustproofing. Thirty years ago, the limit for hexavalent chromium in Sweden was set at 5 micrograms per cubic metre of air. It is a technically calculated value that was determined based on what industry was considered to be able to handle at the time, rather than medical studies examining the level at which people start developing ...

PULLMAN, Wash. — Reflecting on how fitness posts on social media make them feel may help young women reduce the harmful tendency to compare themselves to idealized influencers and content online. That’s according to a new study published in Health Communication that explores the impact of “fitspiration”—fitness-themed inspirational content—on young women’s body image, and whether short, daily reflections could lead to meaningful changes in their emotions and self-perception. Led by Jessica Willoughby, associate professor of communication at Washington State University, the research found that sending young women twice-daily ...

Urban trees and plants do more than just beautify city landscapes. They purify the air, reduce urban heat islands, provide recreational spaces, and even boost property values. As essential components of sustainable urban ecosystems, plants silently contribute to our well-being. However, urban trees face many threats, including pests, diseases, and climate change, making it essential to keep their health in check. Urban greenery monitoring has traditionally been a very labor-intensive process, requiring botanical expertise and considerable resources. With cities expanding ...

UPTON, N.Y. — High temperatures and ionizing radiation create extremely corrosive environments inside a nuclear reactor. To design long-lasting reactors, scientists must understand how radiation-induced chemical reactions impact structural materials. Chemists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory and Idaho National Laboratory recently performed experiments showing that radiation-induced reactions may help mitigate the corrosion of reactor metals in a new type of reactor cooled by molten salts. Their findings are published in the journal Physical ...